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Osteoarthritis: full-pipeline trial registry
29 of 136 indexed Osteoarthritis trials are currently recruiting.
Corpus placement: #84 of 28,707 conditions by registered trial count.
136 US clinical trials · 29 currently recruiting · #84 of 28,707 conditions by registered trial count
Osteoarthritis: 136 US clinical trials tracked, 29 recruiting.
Osteoarthritis is the subject of 136 registered US clinical trials on ClinicalTrials.gov, 29 of them currently open to new participants. 20 are in Phase 3-4 (later-stage) and 22 in Phase 1-2 (earlier-stage). The most active sponsor is Zimmer Biomet, running 12 of these trials.
Enrollment posture brief
Registry condition osteoarthritis
OPEN 29 | RECR 21% | LATE 20 | EARLY 22 | RANK #84 | SPON 12
Volume-matched condition peers
Nearest open-share peer: Alcohol Abuse (21% recruiting · 47 trials)
Osteoarthritis lists 29 open slots (21% of 136 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Osteoarthritis on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Osteoarthritis is recruiting below its size-band peers.
29 of 136 indexed trials (21.3%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Osteoarthritis trials is spread across many organizations.
Zimmer Biomet accounts for 12 of 136 trials (8.8%). 87 distinct sponsors appear on at least one study for this condition label.
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Typical Osteoarthritis enrolment sits around 160 participants.
Median target enrolment is 160 among the 136 trials that report a genuine target (sentinel values excluded). 45 of those (33.1%) plan for fewer than 100 participants.
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Osteoarthritis research is mostly interventional.
106 interventional and 30 observational studies make up this index (77.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
136 total, page 1 of 3
A Prospective Total Joint Surgery Registry to Monitor Short- and Long-Term Clinical Outcomes
Spokane Joint Replacement Center
NCT06687109
Clinical Orthopaedic Data Bank (Acute and Chronic)
University of Florida
NCT00411060
Outcomes of Low-Impact Exercise Program for People With Ankle, Knee, and/or Hip Pain
University of Missouri-Columbia
NCT03711773
Safety & Effectiveness of Autologous Regenerative Cell Therapy on Pain & Inflammation of Osteoarthritis of the Knee
VivaTech International
NCT02844751
Safety & Effectiveness of Autologous Regenerative Cell Therapy on Pain & Inflammation of Osteoarthritis of the Shoulder
VivaTech International
NCT02844738
Safety & Effectiveness of Autologous Regenerative Cell Therapy on Pain & Inflammation of Osteoarthritis of the Hip
VivaTech International
NCT02844764
Activating SilverSneakers Benefits for Seniors With Osteoarthritis
Milton S. Hershey Medical Center
NCT06782347
Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight
Eli Lilly and Company
NCT07353931
A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee
Eli Lilly and Company
NCT07153471
An Study to Evaluate Safety and Tolerability of OA-SYS in Subjects With Moderate to Severe Osteoarthritis of the Knee Joint
Ageless Biotech
NCT06485843
The Beat Pain Better Trial
University of Utah
NCT06932887
Dose Response of Exercise for Arthritis Management
University of South Carolina
NCT06880653
A Prospective, Post-Market, Clinical Follow-up Study of the Incompass™ Total Ankle System
Stryker Trauma and Extremities
NCT07118501
A Mobile Intervention to Reduce Pain and Improve Health-III
Wake Forest University
NCT06623669
Sustained Acoustic Medicine for Osteoarthritis Pain
ZetrOZ
NCT05254574
Systemic Oral Glucocorticoids for the Treatment of Acute Osteoarthritis Pain in the Emergency Department
WellSpan Health
NCT06603662
Ketorolac in Upper Extremity Tendinopathy and Arthropathy
Emory University
NCT05292339
The PROACTIVE Study for Black Elders
University of Florida
NCT06512727
EMPHASYS Cup Positioning in THA With Non-Invasive Navigation (Velys Hip Navigation (VHN))
DePuy Orthopaedics
NCT06631638
Conversations in Health Literacy Using AI Technology for Osteoarthritis Patients
University of California, Davis
NCT06778486
Adipose-Derived Biocellular Regenerative Therapy for Osteoarthritis
Healeon Medical
NCT04238143
Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry
Xiaojuan Li
NCT04536103
Reliability of Pupil Response to Acute Pain
Wake Forest University Health Sciences
NCT02628314
Oral Nutritional Optimization in Total Joint Arthroplasty
NYU Langone Health
NCT04210284
Platelet Rich Plasma Injections In Young And Old Human Subjects
University of California, San Francisco
NCT06451120
ARVIS TKA vs Conventional TKA
Foundation for Orthopaedic Research and Education
NCT06663384
The KinematX Midcarpal Total Wrist Arthroplasty Registry
Extremity Medical
NCT05719935
Trans-arterial Embolization for the Treatment of Facet Pain Due to Facet Arthropathy
Northwell Health
NCT06965452
Geniculate Artery Embolization for Osteoarthritis
University of Minnesota
NCT04456569
FORCE-TJR: Improving Orthopedic Outcomes Through a National TJR Registry
University of Massachusetts, Worcester
NCT02566473
Persona Total Knee Arthroplasty Outcomes Study
Zimmer Biomet
NCT02255383
Persona Partial Knee Clinical Outcomes Study
Zimmer Biomet
NCT03034811
14022 ATTUNE Cementless RP Clinical Performance Evaluation
DePuy Orthopaedics
NCT02839850
Comparing Surgery Versus Standard Physical Therapy in Treating People With a Meniscal Tear and Osteoarthritis
Brigham and Women's Hospital
NCT00597012
Cemented vs Cementless Persona Keel RCT
Zimmer Biomet
NCT05630053
A Global Clinical Study Investigating the Safety and Effectiveness of Smith and Nephew's Porous Knee System in Patients Who Need a Total Knee Replacement Due to Degenerative Arthritis, Post-traumatic Arthritis or Inflammatory Arthritis
Smith & Nephew
NCT05197036
Vivacit-E Post-market Follow-up Study
Zimmer Biomet
NCT03226808
A Prospective, Clinical Investigation of the Vanguard 360 Revision Knee
Zimmer Biomet
NCT01542580
Persona Ti-Nidium Post-Market Clinical Follow-up
Zimmer Biomet
NCT04817969
Preoperative Correction of Vitamin D Deficiency in Total Joint Arthroplasty (TJA)
University of Miami
NCT07006714
Outcomes Study of the Trabecular Metal (TM) Reverse Shoulder System
Zimmer Biomet
NCT01480440
Zimmer Continuum Metal on Polyethylene (MoP) PostMarket Clinical Followup (PMCF) Study
Zimmer Biomet
NCT01307384
Evaluation of Biomarkers in Human Synovial Fluid
Duke University
NCT02664870
Post Market Clinical Follow-up (PMCF) Study of the A.L.P.S. Proximal Humerus Plating System
Zimmer Biomet
NCT03626038
Survivorship and Outcomes of Robotic-Arm Assisted Medial Unicompartmental Knee Arthroplasty
St. Helena Hospital Coon Joint Replacement Institute
NCT03668717
Adductor Canal Block
OrthoCarolina Research Institute
NCT04513145
A Multi-Centre Study in Patients Undergoing Total Hip Arthroplasty With the Smith+Nephew CATALYSTEM™ Primary Hip System
Smith & Nephew
NCT06564636
Rotator Cuff Sparing Total Arthroplasty
NYU Langone Health
NCT01961986
SakuraBead Used as Resorbable Embolic for Genicular Artery Embolization
CrannMed
NCT06550024
Effects of tDCS and tUS on Pain Perception in OA of the Knee
Spaulding Rehabilitation Hospital
NCT02723929
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 4 |
| Phase 2 | 18 |
| Phase 3 | 13 |
| Phase 4 | 7 |
Top Sponsors
Named interventions
Most-linked intervention names on Osteoarthritis records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Osteoarthritis trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Osteoarthritis page
136 registered trials, 29 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 29 Osteoarthritis trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Zimmer Biomet sponsors the most Osteoarthritis trials on record, review their full trial history before evaluating a specific study. See Zimmer Biomet's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Osteoarthritis condition card totals 136 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.