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ClinicalTrials.gov 29 recruiting now official registry

Osteoarthritis clinical trials

29 of 136 indexed Osteoarthritis trials are currently recruiting.

136 US clinical trials · 29 currently recruiting

Osteoarthritis is the subject of 136 registered US clinical trials on ClinicalTrials.gov, 29 of them currently open to new participants. 20 are in Phase 3-4 (later-stage) and 22 in Phase 1-2 (earlier-stage). The most active sponsor is Zimmer Biomet, running 12 of these trials.

The research picture

Osteoarthritis has 136 registered US clinical trials, 29 of them open to new participants right now, about 21% of the total.

29
recruiting participants now
21%
of trials open to enrollment
20
in Phase 3–4 (later-stage)
12
top sponsor: Zimmer Biomet
Phase 14Phase 218Phase 313Phase 47

Active & Recent Trials

136 total, page 1 of 3

RECRUITING 10,000 participants

A Prospective Total Joint Surgery Registry to Monitor Short- and Long-Term Clinical Outcomes

Spokane Joint Replacement Center

NCT06687109

RECRUITING 10,000 participants

Clinical Orthopaedic Data Bank (Acute and Chronic)

University of Florida

NCT00411060

RECRUITING NA 10,000 participants

Outcomes of Low-Impact Exercise Program for People With Ankle, Knee, and/or Hip Pain

University of Missouri-Columbia

NCT03711773

RECRUITING Phase 2 4,000 participants

Safety & Effectiveness of Autologous Regenerative Cell Therapy on Pain & Inflammation of Osteoarthritis of the Knee

VivaTech International

NCT02844751

RECRUITING Phase 2 4,000 participants

Safety & Effectiveness of Autologous Regenerative Cell Therapy on Pain & Inflammation of Osteoarthritis of the Shoulder

VivaTech International

NCT02844738

RECRUITING Phase 2 4,000 participants

Safety & Effectiveness of Autologous Regenerative Cell Therapy on Pain & Inflammation of Osteoarthritis of the Hip

VivaTech International

NCT02844764

RECRUITING NA 1,454 participants

Activating SilverSneakers Benefits for Seniors With Osteoarthritis

Milton S. Hershey Medical Center

NCT06782347

RECRUITING Phase 3 900 participants

Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight

Eli Lilly and Company

NCT07353931

RECRUITING Phase 3 800 participants

A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee

Eli Lilly and Company

NCT07153471

RECRUITING Phase 2 400 participants

An Study to Evaluate Safety and Tolerability of OA-SYS in Subjects With Moderate to Severe Osteoarthritis of the Knee Joint

Ageless Biotech

NCT06485843

RECRUITING Phase 3 346 participants

The Beat Pain Better Trial

University of Utah

NCT06932887

RECRUITING NA 285 participants

Dose Response of Exercise for Arthritis Management

University of South Carolina

NCT06880653

RECRUITING 200 participants

A Prospective, Post-Market, Clinical Follow-up Study of the Incompass™ Total Ankle System

Stryker Trauma and Extremities

NCT07118501

RECRUITING Phase 2 200 participants

A Mobile Intervention to Reduce Pain and Improve Health-III

Wake Forest University

NCT06623669

RECRUITING Phase 1 200 participants

Sustained Acoustic Medicine for Osteoarthritis Pain

ZetrOZ

NCT05254574

RECRUITING Phase 4 192 participants

Systemic Oral Glucocorticoids for the Treatment of Acute Osteoarthritis Pain in the Emergency Department

WellSpan Health

NCT06603662

RECRUITING Phase 4 160 participants

Ketorolac in Upper Extremity Tendinopathy and Arthropathy

Emory University

NCT05292339

RECRUITING NA 120 participants

The PROACTIVE Study for Black Elders

University of Florida

NCT06512727

RECRUITING NA 118 participants

EMPHASYS Cup Positioning in THA With Non-Invasive Navigation (Velys Hip Navigation (VHN))

DePuy Orthopaedics

NCT06631638

RECRUITING NA 100 participants

Conversations in Health Literacy Using AI Technology for Osteoarthritis Patients

University of California, Davis

NCT06778486

RECRUITING NA 100 participants

Adipose-Derived Biocellular Regenerative Therapy for Osteoarthritis

Healeon Medical

NCT04238143

RECRUITING 88 participants

Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry

Xiaojuan Li

NCT04536103

RECRUITING 80 participants

Reliability of Pupil Response to Acute Pain

Wake Forest University Health Sciences

NCT02628314

RECRUITING NA 72 participants

Oral Nutritional Optimization in Total Joint Arthroplasty

NYU Langone Health

NCT04210284

RECRUITING Phase 2 60 participants

Platelet Rich Plasma Injections In Young And Old Human Subjects

University of California, San Francisco

NCT06451120

RECRUITING NA 50 participants

ARVIS TKA vs Conventional TKA

Foundation for Orthopaedic Research and Education

NCT06663384

RECRUITING 50 participants

The KinematX Midcarpal Total Wrist Arthroplasty Registry

Extremity Medical

NCT05719935

RECRUITING NA 40 participants

Trans-arterial Embolization for the Treatment of Facet Pain Due to Facet Arthropathy

Northwell Health

NCT06965452

RECRUITING NA 20 participants

Geniculate Artery Embolization for Osteoarthritis

University of Minnesota

NCT04456569

ACTIVE NOT RECRUITING 30,000 participants

FORCE-TJR: Improving Orthopedic Outcomes Through a National TJR Registry

University of Massachusetts, Worcester

NCT02566473

ACTIVE NOT RECRUITING NA 737 participants

Persona Total Knee Arthroplasty Outcomes Study

Zimmer Biomet

NCT02255383

ACTIVE NOT RECRUITING NA 643 participants

Persona Partial Knee Clinical Outcomes Study

Zimmer Biomet

NCT03034811

ACTIVE NOT RECRUITING NA 540 participants

14022 ATTUNE Cementless RP Clinical Performance Evaluation

DePuy Orthopaedics

NCT02839850

ACTIVE NOT RECRUITING NA 351 participants

Comparing Surgery Versus Standard Physical Therapy in Treating People With a Meniscal Tear and Osteoarthritis

Brigham and Women's Hospital

NCT00597012

ACTIVE NOT RECRUITING NA 300 participants

Cemented vs Cementless Persona Keel RCT

Zimmer Biomet

NCT05630053

ACTIVE NOT RECRUITING 299 participants

A Global Clinical Study Investigating the Safety and Effectiveness of Smith and Nephew's Porous Knee System in Patients Who Need a Total Knee Replacement Due to Degenerative Arthritis, Post-traumatic Arthritis or Inflammatory Arthritis

Smith & Nephew

NCT05197036

ACTIVE NOT RECRUITING NA 258 participants

Vivacit-E Post-market Follow-up Study

Zimmer Biomet

NCT03226808

ACTIVE NOT RECRUITING 255 participants

A Prospective, Clinical Investigation of the Vanguard 360 Revision Knee

Zimmer Biomet

NCT01542580

ACTIVE NOT RECRUITING NA 240 participants

Persona Ti-Nidium Post-Market Clinical Follow-up

Zimmer Biomet

NCT04817969

ACTIVE NOT RECRUITING Phase 4 200 participants

Preoperative Correction of Vitamin D Deficiency in Total Joint Arthroplasty (TJA)

University of Miami

NCT07006714

ACTIVE NOT RECRUITING 200 participants

Outcomes Study of the Trabecular Metal (TM) Reverse Shoulder System

Zimmer Biomet

NCT01480440

ACTIVE NOT RECRUITING 165 participants

Zimmer Continuum Metal on Polyethylene (MoP) PostMarket Clinical Followup (PMCF) Study

Zimmer Biomet

NCT01307384

ACTIVE NOT RECRUITING 149 participants

Evaluation of Biomarkers in Human Synovial Fluid

Duke University

NCT02664870

ACTIVE NOT RECRUITING NA 135 participants

Post Market Clinical Follow-up (PMCF) Study of the A.L.P.S. Proximal Humerus Plating System

Zimmer Biomet

NCT03626038

ACTIVE NOT RECRUITING 133 participants

Survivorship and Outcomes of Robotic-Arm Assisted Medial Unicompartmental Knee Arthroplasty

St. Helena Hospital Coon Joint Replacement Institute

NCT03668717

ACTIVE NOT RECRUITING Phase 2 130 participants

Adductor Canal Block

OrthoCarolina Research Institute

NCT04513145

ACTIVE NOT RECRUITING 119 participants

A Multi-Centre Study in Patients Undergoing Total Hip Arthroplasty With the Smith+Nephew CATALYSTEM™ Primary Hip System

Smith & Nephew

NCT06564636

ACTIVE NOT RECRUITING NA 108 participants

Rotator Cuff Sparing Total Arthroplasty

NYU Langone Health

NCT01961986

ACTIVE NOT RECRUITING NA 89 participants

SakuraBead Used as Resorbable Embolic for Genicular Artery Embolization

CrannMed

NCT06550024

ACTIVE NOT RECRUITING 64 participants

Effects of tDCS and tUS on Pain Perception in OA of the Knee

Spaulding Rehabilitation Hospital

NCT02723929

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Phase Distribution

PhaseTrial count
Phase 1 4
Phase 2 18
Phase 3 13
Phase 4 7

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Osteoarthritis Trial Landscape

136 indexed Osteoarthritis studies · 29 recruiting (21%).

Phase mix: 20 late (III/IV) vs 22 early (I/II).

Top sponsor: Zimmer Biomet (12 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Osteoarthritis?

PlainTrial tracks 136 US clinical trials for Osteoarthritis, of which 29 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Osteoarthritis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.