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Osteoarthritis clinical trials
29 of 136 indexed Osteoarthritis trials are currently recruiting.
136 US clinical trials · 29 currently recruiting
Osteoarthritis is the subject of 136 registered US clinical trials on ClinicalTrials.gov, 29 of them currently open to new participants. 20 are in Phase 3-4 (later-stage) and 22 in Phase 1-2 (earlier-stage). The most active sponsor is Zimmer Biomet, running 12 of these trials.
The research picture
Osteoarthritis has 136 registered US clinical trials, 29 of them open to new participants right now, about 21% of the total.
- 29
- recruiting participants now
- 21%
- of trials open to enrollment
- 20
- in Phase 3–4 (later-stage)
- 12
- top sponsor: Zimmer Biomet
Active & Recent Trials
136 total, page 1 of 3
A Prospective Total Joint Surgery Registry to Monitor Short- and Long-Term Clinical Outcomes
Spokane Joint Replacement Center
NCT06687109
Clinical Orthopaedic Data Bank (Acute and Chronic)
University of Florida
NCT00411060
Outcomes of Low-Impact Exercise Program for People With Ankle, Knee, and/or Hip Pain
University of Missouri-Columbia
NCT03711773
Safety & Effectiveness of Autologous Regenerative Cell Therapy on Pain & Inflammation of Osteoarthritis of the Knee
VivaTech International
NCT02844751
Safety & Effectiveness of Autologous Regenerative Cell Therapy on Pain & Inflammation of Osteoarthritis of the Shoulder
VivaTech International
NCT02844738
Safety & Effectiveness of Autologous Regenerative Cell Therapy on Pain & Inflammation of Osteoarthritis of the Hip
VivaTech International
NCT02844764
Activating SilverSneakers Benefits for Seniors With Osteoarthritis
Milton S. Hershey Medical Center
NCT06782347
Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight
Eli Lilly and Company
NCT07353931
A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee
Eli Lilly and Company
NCT07153471
An Study to Evaluate Safety and Tolerability of OA-SYS in Subjects With Moderate to Severe Osteoarthritis of the Knee Joint
Ageless Biotech
NCT06485843
The Beat Pain Better Trial
University of Utah
NCT06932887
Dose Response of Exercise for Arthritis Management
University of South Carolina
NCT06880653
A Prospective, Post-Market, Clinical Follow-up Study of the Incompass™ Total Ankle System
Stryker Trauma and Extremities
NCT07118501
A Mobile Intervention to Reduce Pain and Improve Health-III
Wake Forest University
NCT06623669
Sustained Acoustic Medicine for Osteoarthritis Pain
ZetrOZ
NCT05254574
Systemic Oral Glucocorticoids for the Treatment of Acute Osteoarthritis Pain in the Emergency Department
WellSpan Health
NCT06603662
Ketorolac in Upper Extremity Tendinopathy and Arthropathy
Emory University
NCT05292339
The PROACTIVE Study for Black Elders
University of Florida
NCT06512727
EMPHASYS Cup Positioning in THA With Non-Invasive Navigation (Velys Hip Navigation (VHN))
DePuy Orthopaedics
NCT06631638
Conversations in Health Literacy Using AI Technology for Osteoarthritis Patients
University of California, Davis
NCT06778486
Adipose-Derived Biocellular Regenerative Therapy for Osteoarthritis
Healeon Medical
NCT04238143
Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry
Xiaojuan Li
NCT04536103
Reliability of Pupil Response to Acute Pain
Wake Forest University Health Sciences
NCT02628314
Oral Nutritional Optimization in Total Joint Arthroplasty
NYU Langone Health
NCT04210284
Platelet Rich Plasma Injections In Young And Old Human Subjects
University of California, San Francisco
NCT06451120
ARVIS TKA vs Conventional TKA
Foundation for Orthopaedic Research and Education
NCT06663384
The KinematX Midcarpal Total Wrist Arthroplasty Registry
Extremity Medical
NCT05719935
Trans-arterial Embolization for the Treatment of Facet Pain Due to Facet Arthropathy
Northwell Health
NCT06965452
Geniculate Artery Embolization for Osteoarthritis
University of Minnesota
NCT04456569
FORCE-TJR: Improving Orthopedic Outcomes Through a National TJR Registry
University of Massachusetts, Worcester
NCT02566473
Persona Total Knee Arthroplasty Outcomes Study
Zimmer Biomet
NCT02255383
Persona Partial Knee Clinical Outcomes Study
Zimmer Biomet
NCT03034811
14022 ATTUNE Cementless RP Clinical Performance Evaluation
DePuy Orthopaedics
NCT02839850
Comparing Surgery Versus Standard Physical Therapy in Treating People With a Meniscal Tear and Osteoarthritis
Brigham and Women's Hospital
NCT00597012
Cemented vs Cementless Persona Keel RCT
Zimmer Biomet
NCT05630053
A Global Clinical Study Investigating the Safety and Effectiveness of Smith and Nephew's Porous Knee System in Patients Who Need a Total Knee Replacement Due to Degenerative Arthritis, Post-traumatic Arthritis or Inflammatory Arthritis
Smith & Nephew
NCT05197036
Vivacit-E Post-market Follow-up Study
Zimmer Biomet
NCT03226808
A Prospective, Clinical Investigation of the Vanguard 360 Revision Knee
Zimmer Biomet
NCT01542580
Persona Ti-Nidium Post-Market Clinical Follow-up
Zimmer Biomet
NCT04817969
Preoperative Correction of Vitamin D Deficiency in Total Joint Arthroplasty (TJA)
University of Miami
NCT07006714
Outcomes Study of the Trabecular Metal (TM) Reverse Shoulder System
Zimmer Biomet
NCT01480440
Zimmer Continuum Metal on Polyethylene (MoP) PostMarket Clinical Followup (PMCF) Study
Zimmer Biomet
NCT01307384
Evaluation of Biomarkers in Human Synovial Fluid
Duke University
NCT02664870
Post Market Clinical Follow-up (PMCF) Study of the A.L.P.S. Proximal Humerus Plating System
Zimmer Biomet
NCT03626038
Survivorship and Outcomes of Robotic-Arm Assisted Medial Unicompartmental Knee Arthroplasty
St. Helena Hospital Coon Joint Replacement Institute
NCT03668717
Adductor Canal Block
OrthoCarolina Research Institute
NCT04513145
A Multi-Centre Study in Patients Undergoing Total Hip Arthroplasty With the Smith+Nephew CATALYSTEM™ Primary Hip System
Smith & Nephew
NCT06564636
Rotator Cuff Sparing Total Arthroplasty
NYU Langone Health
NCT01961986
SakuraBead Used as Resorbable Embolic for Genicular Artery Embolization
CrannMed
NCT06550024
Effects of tDCS and tUS on Pain Perception in OA of the Knee
Spaulding Rehabilitation Hospital
NCT02723929
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 4 |
| Phase 2 | 18 |
| Phase 3 | 13 |
| Phase 4 | 7 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Osteoarthritis Trial Landscape
136 indexed Osteoarthritis studies · 29 recruiting (21%).
Phase mix: 20 late (III/IV) vs 22 early (I/II).
Top sponsor: Zimmer Biomet (12 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Osteoarthritis?
PlainTrial tracks 136 US clinical trials for Osteoarthritis, of which 29 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Osteoarthritis?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.