Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Cardiovascular Disease clinical trials
20 of 137 indexed Cardiovascular Disease trials are currently recruiting.
137 US clinical trials · 20 currently recruiting
Cardiovascular Disease is the subject of 137 registered US clinical trials on ClinicalTrials.gov, 20 of them currently open to new participants. 22 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 10 of these trials.
The research picture
Cardiovascular Disease has 137 registered US clinical trials, 20 of them open to new participants right now, about 15% of the total.
- 20
- recruiting participants now
- 15%
- of trials open to enrollment
- 22
- in Phase 3–4 (later-stage)
- 10
- top sponsor: VA Office of Research and Development
Active & Recent Trials
137 total, page 1 of 3
A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event
AstraZeneca
NCT07000357
Cardiology Biobank Registry
Emory University
NCT00378924
OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events
Amgen
NCT07136012
Human Biospecimen Procurement Protocol: Biorepository to Support Translational Research to Identify Disease Mechanism(s)
National Heart, Lung, and Blood Institute (NHLBI)
NCT02543996
A RAndomizeD Intervention for Cardiovascular and Lifestyle Risk Factors in Prostate Cancer Patients
McMaster University
NCT03127631
Technical Development of Cardiovascular Magnetic Resonance Imaging
National Heart, Lung, and Blood Institute (NHLBI)
NCT04927429
Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT03374215
Williams Syndrome (WS) and Supravalvar Aortic Stenosis (SVAS) DNA and Tissue Bank
National Heart, Lung, and Blood Institute (NHLBI)
NCT02706639
WISE CVD - Continuation (WISE HFpEF)
Cedars-Sinai Medical Center
NCT02582021
Heart Health Study in Washington D.C. to Develop a Community-Based Behavioral Weight Loss Intervention
National Heart, Lung, and Blood Institute (NHLBI)
NCT01927783
Randomized Trial of SGLT2i in Heart Transplant Recipients
VA Office of Research and Development
NCT06625073
Natural History Study of CADASIL
National Heart, Lung, and Blood Institute (NHLBI)
NCT05072483
Beta-Blocker Influences on Inflammatory and Neural Responses to Stress
University of North Carolina, Chapel Hill
NCT06263452
Dietary Omega-7 Palmitoleic Acid-Rich Oil on Lipoprotein Metabolism and Satiety in Adults
National Heart, Lung, and Blood Institute (NHLBI)
NCT03372733
Gauging Outcomes of Total Milk Ingestion on Lipid and gControl
University of California, San Francisco
NCT07087184
A Novel Digital Tool Physicians Can Use to Prescribe Exercise to Patients With Cardiovascular Disease Risk Factors
University of Connecticut
NCT07238556
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Fx-5A in Healthy Volunteers
National Heart, Lung, and Blood Institute (NHLBI)
NCT04216342
Single-tracer Multiparametric PET Imaging
University of California, Davis
NCT06014515
The Role of Anifrolumab in Improving Markers of Vascular Risk in Patients With Systemic Lupus Erythematosus (SLE) - IFN-CVD
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NCT05440422
Determining the Benefits of Exercise on Cardiovascular Risk in PTSD
Massachusetts General Hospital
NCT07260032
Gulf Long-Term Follow-Up Study
National Institute of Environmental Health Sciences (NIEHS)
NCT01287000
Database Registry of the Intermountain Heart Collaborative Study
Intermountain Health Care
NCT00406185
Vitamin D and Omega-3 Trial (VITAL)
Brigham and Women's Hospital
NCT01169259
VITAL Rhythm Study
Brigham and Women's Hospital
NCT02178410
Hispanic Community Health Study / Study of Latinos
National Heart, Lung, and Blood Institute (NHLBI)
NCT02060344
REDEFINE 3: A Research Study to See the Effects of CagriSema in People Living With Diseases in the Heart and Blood Vessels
Novo Nordisk A/S
NCT05669755
EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction
Amgen
NCT05284747
Technical Development for Pediatric Cardiovascular MRI
Children's National Research Institute
NCT02892136
The Miami Heart Study at Baptist Health South Florida
Baptist Health South Florida
NCT02508454
Healthy Aging in Neighborhoods of Diversity Across the Life Span (HANDLS)
National Institute on Aging (NIA)
NCT01323322
A Phase III Study to Assess the Effect of AZD0780 on LDL-C in Patients With Clinical ASCVD or at Risk for a First ASCVD Event
AstraZeneca
NCT07000123
Epidemiology of Sleep-Disordered Breathing in Adults
University of Wisconsin, Madison
NCT00005557
Century Trial, a Randomized Lifestyle Modification Study for Management of Stable Coronary Artery Disease
The University of Texas Health Science Center, Houston
NCT00756379
Women's Ischemia Syndrome Evaluation (WISE) Coronary Vascular Dysfunction
Cedars-Sinai Medical Center
NCT00832702
Passive Limb Movement: A Tool to Assess Vascular Health and Guide Rehabilitation
VA Office of Research and Development
NCT03625349
Impact of Ketogenic Diets on Cardiovascular Health in Adults With Epilepsy
Johns Hopkins University
NCT02694094
Mortality Reductions Based on AUD/Heavy Alcohol Use, HIV Risk, and Cardiovascular Risk
NYU Langone Health
NCT05828849
Nitric Oxide Bioavailability and Early Life Stress (NO-Stress)
Augusta University
NCT02115724
Home-Based Measures of Physical Activity and Body Composition
M.D. Anderson Cancer Center
NCT00542438
Implementation of Practice Standards for ECG Monitoring
Yale University
NCT01269736
PeriOperative ISchemic Evaluation-2 Trial
Hamilton Health Sciences Corporation
NCT01082874
Researching Cardiovascular Events With a Weekly Incretin in Diabetes (REWIND)
Eli Lilly and Company
NCT01394952
Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events (ACTIVE I)
Sanofi
NCT00249795
Long Term Health Outcomes of Women Veterans' Service During the Vietnam Era
VA Office of Research and Development
NCT00958061
Folic Acid for Vascular Outcome Reduction In Transplantation (FAVORIT)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00064753
Cardiogenomics Registry
Piedmont Healthcare
NCT00861575
World Trade Center (WTC) CHEST
Icahn School of Medicine at Mount Sinai
NCT01466218
Cholesterol and Pharmacogenetic Study
UCSF Benioff Children's Hospital Oakland
NCT00451828
[E]PANOVA Combined With a [S]TATIN in [P]ATIENTS With HYPERT[R]IGLYCER[I]DEMIA to Reduce Non-HDL CHOLES[T]EROL
AstraZeneca
NCT01408303
NCGENES: North Carolina Clinical Genomic Evaluation by NextGen Exome Sequencing
University of North Carolina, Chapel Hill
NCT01969370
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 7 |
| Phase 2 | 8 |
| Phase 3 | 14 |
| Phase 4 | 8 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Cardiovascular Disease Trial Landscape
137 indexed Cardiovascular Disease studies · 20 recruiting (15%).
Phase mix: 22 late (III/IV) vs 15 early (I/II).
Top sponsor: VA Office of Research and Development (10 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Cardiovascular Disease?
PlainTrial tracks 137 US clinical trials for Cardiovascular Disease, of which 20 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Cardiovascular Disease?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.