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ClinicalTrials.gov 20 recruiting now official registry

Cardiovascular Disease clinical trials

20 of 137 indexed Cardiovascular Disease trials are currently recruiting.

137 US clinical trials · 20 currently recruiting

Cardiovascular Disease is the subject of 137 registered US clinical trials on ClinicalTrials.gov, 20 of them currently open to new participants. 22 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 10 of these trials.

The research picture

Cardiovascular Disease has 137 registered US clinical trials, 20 of them open to new participants right now, about 15% of the total.

20
recruiting participants now
15%
of trials open to enrollment
22
in Phase 3–4 (later-stage)
10
top sponsor: VA Office of Research and Development
Phase 17Phase 28Phase 314Phase 48

Active & Recent Trials

137 total, page 1 of 3

RECRUITING Phase 3 15,100 participants

A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event

AstraZeneca

NCT07000357

RECRUITING 12,000 participants

Cardiology Biobank Registry

Emory University

NCT00378924

RECRUITING Phase 3 11,000 participants

OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events

Amgen

NCT07136012

RECRUITING 10,000 participants

Human Biospecimen Procurement Protocol: Biorepository to Support Translational Research to Identify Disease Mechanism(s)

National Heart, Lung, and Blood Institute (NHLBI)

NCT02543996

RECRUITING NA 6,000 participants

A RAndomizeD Intervention for Cardiovascular and Lifestyle Risk Factors in Prostate Cancer Patients

McMaster University

NCT03127631

RECRUITING 3,400 participants

Technical Development of Cardiovascular Magnetic Resonance Imaging

National Heart, Lung, and Blood Institute (NHLBI)

NCT04927429

RECRUITING 1,150 participants

Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT03374215

RECRUITING 1,099 participants

Williams Syndrome (WS) and Supravalvar Aortic Stenosis (SVAS) DNA and Tissue Bank

National Heart, Lung, and Blood Institute (NHLBI)

NCT02706639

RECRUITING 220 participants

WISE CVD - Continuation (WISE HFpEF)

Cedars-Sinai Medical Center

NCT02582021

RECRUITING 200 participants

Heart Health Study in Washington D.C. to Develop a Community-Based Behavioral Weight Loss Intervention

National Heart, Lung, and Blood Institute (NHLBI)

NCT01927783

RECRUITING Phase 4 200 participants

Randomized Trial of SGLT2i in Heart Transplant Recipients

VA Office of Research and Development

NCT06625073

RECRUITING 155 participants

Natural History Study of CADASIL

National Heart, Lung, and Blood Institute (NHLBI)

NCT05072483

RECRUITING Phase 4 120 participants

Beta-Blocker Influences on Inflammatory and Neural Responses to Stress

University of North Carolina, Chapel Hill

NCT06263452

RECRUITING Phase 2 110 participants

Dietary Omega-7 Palmitoleic Acid-Rich Oil on Lipoprotein Metabolism and Satiety in Adults

National Heart, Lung, and Blood Institute (NHLBI)

NCT03372733

RECRUITING NA 100 participants

Gauging Outcomes of Total Milk Ingestion on Lipid and gControl

University of California, San Francisco

NCT07087184

RECRUITING NA 72 participants

A Novel Digital Tool Physicians Can Use to Prescribe Exercise to Patients With Cardiovascular Disease Risk Factors

University of Connecticut

NCT07238556

RECRUITING Phase 1 64 participants

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Fx-5A in Healthy Volunteers

National Heart, Lung, and Blood Institute (NHLBI)

NCT04216342

RECRUITING Early Phase 1 60 participants

Single-tracer Multiparametric PET Imaging

University of California, Davis

NCT06014515

RECRUITING Phase 2 45 participants

The Role of Anifrolumab in Improving Markers of Vascular Risk in Patients With Systemic Lupus Erythematosus (SLE) - IFN-CVD

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

NCT05440422

RECRUITING NA 10 participants

Determining the Benefits of Exercise on Cardiovascular Risk in PTSD

Massachusetts General Hospital

NCT07260032

ACTIVE NOT RECRUITING 32,658 participants

Gulf Long-Term Follow-Up Study

National Institute of Environmental Health Sciences (NIEHS)

NCT01287000

ACTIVE NOT RECRUITING 30,000 participants

Database Registry of the Intermountain Heart Collaborative Study

Intermountain Health Care

NCT00406185

ACTIVE NOT RECRUITING Phase 3 25,871 participants

Vitamin D and Omega-3 Trial (VITAL)

Brigham and Women's Hospital

NCT01169259

ACTIVE NOT RECRUITING Phase 3 25,119 participants

VITAL Rhythm Study

Brigham and Women's Hospital

NCT02178410

ACTIVE NOT RECRUITING 16,400 participants

Hispanic Community Health Study / Study of Latinos

National Heart, Lung, and Blood Institute (NHLBI)

NCT02060344

ACTIVE NOT RECRUITING Phase 3 7,101 participants

REDEFINE 3: A Research Study to See the Effects of CagriSema in People Living With Diseases in the Heart and Blood Vessels

Novo Nordisk A/S

NCT05669755

ACTIVE NOT RECRUITING Phase 4 6,019 participants

EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction

Amgen

NCT05284747

ACTIVE NOT RECRUITING 5,000 participants

Technical Development for Pediatric Cardiovascular MRI

Children's National Research Institute

NCT02892136

ACTIVE NOT RECRUITING 4,000 participants

The Miami Heart Study at Baptist Health South Florida

Baptist Health South Florida

NCT02508454

ACTIVE NOT RECRUITING 3,720 participants

Healthy Aging in Neighborhoods of Diversity Across the Life Span (HANDLS)

National Institute on Aging (NIA)

NCT01323322

ACTIVE NOT RECRUITING Phase 3 3,046 participants

A Phase III Study to Assess the Effect of AZD0780 on LDL-C in Patients With Clinical ASCVD or at Risk for a First ASCVD Event

AstraZeneca

NCT07000123

ACTIVE NOT RECRUITING 1,545 participants

Epidemiology of Sleep-Disordered Breathing in Adults

University of Wisconsin, Madison

NCT00005557

ACTIVE NOT RECRUITING NA 1,085 participants

Century Trial, a Randomized Lifestyle Modification Study for Management of Stable Coronary Artery Disease

The University of Texas Health Science Center, Houston

NCT00756379

ACTIVE NOT RECRUITING 433 participants

Women's Ischemia Syndrome Evaluation (WISE) Coronary Vascular Dysfunction

Cedars-Sinai Medical Center

NCT00832702

ACTIVE NOT RECRUITING 130 participants

Passive Limb Movement: A Tool to Assess Vascular Health and Guide Rehabilitation

VA Office of Research and Development

NCT03625349

ACTIVE NOT RECRUITING 105 participants

Impact of Ketogenic Diets on Cardiovascular Health in Adults With Epilepsy

Johns Hopkins University

NCT02694094

ACTIVE NOT RECRUITING NA 87 participants

Mortality Reductions Based on AUD/Heavy Alcohol Use, HIV Risk, and Cardiovascular Risk

NYU Langone Health

NCT05828849

ACTIVE NOT RECRUITING NA 74 participants

Nitric Oxide Bioavailability and Early Life Stress (NO-Stress)

Augusta University

NCT02115724

ACTIVE NOT RECRUITING NA 62 participants

Home-Based Measures of Physical Activity and Body Composition

M.D. Anderson Cancer Center

NCT00542438

COMPLETED NA 92,057 participants

Implementation of Practice Standards for ECG Monitoring

Yale University

NCT01269736

COMPLETED Phase 3 10,010 participants

PeriOperative ISchemic Evaluation-2 Trial

Hamilton Health Sciences Corporation

NCT01082874

COMPLETED Phase 3 9,901 participants

Researching Cardiovascular Events With a Weekly Incretin in Diabetes (REWIND)

Eli Lilly and Company

NCT01394952

COMPLETED Phase 3 9,016 participants

Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events (ACTIVE I)

Sanofi

NCT00249795

COMPLETED 4,219 participants

Long Term Health Outcomes of Women Veterans' Service During the Vietnam Era

VA Office of Research and Development

NCT00958061

COMPLETED Phase 2 4,110 participants

Folic Acid for Vascular Outcome Reduction In Transplantation (FAVORIT)

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00064753

COMPLETED 2,601 participants

Cardiogenomics Registry

Piedmont Healthcare

NCT00861575

COMPLETED 1,012 participants

World Trade Center (WTC) CHEST

Icahn School of Medicine at Mount Sinai

NCT01466218

COMPLETED Phase 4 1,000 participants

Cholesterol and Pharmacogenetic Study

UCSF Benioff Children's Hospital Oakland

NCT00451828

COMPLETED Phase 3 646 participants

[E]PANOVA Combined With a [S]TATIN in [P]ATIENTS With HYPERT[R]IGLYCER[I]DEMIA to Reduce Non-HDL CHOLES[T]EROL

AstraZeneca

NCT01408303

COMPLETED NA 645 participants

NCGENES: North Carolina Clinical Genomic Evaluation by NextGen Exome Sequencing

University of North Carolina, Chapel Hill

NCT01969370

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Phase Distribution

PhaseTrial count
Phase 1 7
Phase 2 8
Phase 3 14
Phase 4 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Cardiovascular Disease Trial Landscape

137 indexed Cardiovascular Disease studies · 20 recruiting (15%).

Phase mix: 22 late (III/IV) vs 15 early (I/II).

Top sponsor: VA Office of Research and Development (10 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Cardiovascular Disease?

PlainTrial tracks 137 US clinical trials for Cardiovascular Disease, of which 20 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Cardiovascular Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.