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Cardiovascular Radiologic and Metabolic Assessment in HIV: An Investigation of Pathophysiology
NCT01089114 · View on ClinicalTrials.gov ↗
Study Summary
Background: \- Antiretroviral therapy has increased the lifespan of people with human immunodeficiency virus (HIV), but recent research suggests that people with HIV also have an increased risk of developing cardiovascular disease. To better understand the prevalence and effects of heart disease in people with HIV, researchers are interested in comparing heart imaging and metabolism studies to see if there are differences between HIV-positive and HIV-negative people. Objectives: \- To study metabolism and heart function in people with HIV compared with healthy HIV-negative volunteers. Eligibility: \- Individuals at least 18 years of age who either have been diagnosed with HIV or are healthy HIV-negative volunteers. Design: * Participants will be evaluated with a physical exam, detailed medical history, and routine blood and urine tests including HIV testing. * Participants will have the following imaging scans: * Cardiac magnetic resonance imaging (MRI) to study the health of the heart and blood vessels * Magnetic resonance spectroscopy (MRS) of the heart, liver, and skeletal muscle * Cardiac computerized tomography (CT) scan to measure calcium levels in the heart and nearby arteries * Dual-energy x-ray absorptiometry (DEXA) scan to measure body fat and muscle mass. * Stable isotope infusion to evaluate how the body processes fat (which will require an overnight stay before the test) * Participants will also have blood tests, an echocardiogram, and an electrocardiogram to evaluate heart function.
Conditions Studied
Study Locations (1)
Maryland
- National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 168 participants |
| Start Date | 2010-03-08 |
| Est. Completion | 2015-08-07 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01089114
The ClinicalTrials.gov registry entry for NCT01089114 describes a study currently listed as completed. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 168 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Institute of Allergy and Infectious Diseases (NIAID), which has 1,295 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with HIV appearing as the primary indexed condition, and to 0 interventions. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT01089114 reports 1 study location spanning 1 distinct geographic area — top geographies include Maryland. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT01089114 about?
NCT01089114 is a clinical study titled "Cardiovascular Radiologic and Metabolic Assessment in HIV: An Investigation of Pathophysiology". Background: \- Antiretroviral therapy has increased the lifespan of people with human immunodeficiency virus (HIV), but recent research suggests that people with HIV also have an increased risk of developing cardiovascular disease. To better understand the prevalence and effects of heart disease in...
What is the current status of trial NCT01089114?
This trial is currently completed. The enrollment target is 168 participants. The study started on 2010-03-08. Estimated completion is 2015-08-07.
What conditions does trial NCT01089114 study?
This clinical trial studies the following conditions: HIV, Cardiovascular Disease. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
Who is sponsoring clinical trial NCT01089114?
This trial is sponsored by National Institute of Allergy and Infectious Diseases (NIAID), which has 1,295 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT01089114 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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