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Redesigning Cardiac Surgery to Reduce Neurologic Injury
NCT00432536 · View on ClinicalTrials.gov ↗
Study Summary
Neurologic injuries are frequent and devastating complications following cardiac surgery. Previous work conducted by our research group and others has identified the principal mechanisms creating both overt and subtle neurologic injuries after cardiac surgery. Current work by our group has identified that the causes (thrombotic/lipid emboli, cerebral hypoperfusion \& hypotension, and gaseous emboli) of these injuries are byproducts of processes of surgical and perfusion care. This insight suggests that the redesign of clinical strategies and techniques to prevent the occurrence of these intraoperative sources of damage may provide an opportunity to reduce the risk of neurologic injury after cardiac surgery. The goal of this research is to identify modifiable clinical strategies and techniques of surgical and perfusion care associated with the causes (thrombotic/lipid emboli, cerebral hypoperfusion \& hypotension, and gaseous emboli) of neurologic injury secondary to coronary artery bypass graft (CABG) surgery, and subsequently to redesign these processes to reduce a patient's risk of a neurologic injury.
Conditions Studied
Interventions
- OTHER Quality improvement intervention
Study Locations (3)
New Hampshire
- Dartmouth-Hitchcock Medical Center — Lebanon
- Catholic Medical Center — Manchester
Maine
- Maine Medical Center — Portland
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 469 participants |
| Start Date | 2002-10 |
| Est. Completion | 2012-02 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00432536
The ClinicalTrials.gov registry entry for NCT00432536 describes a study currently listed as completed. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 469 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Dartmouth-Hitchcock Medical Center, which has 396 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Cardiovascular Disease appearing as the primary indexed condition, and to 1 intervention — of which Quality improvement intervention is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT00432536 reports 3 study locations spanning 2 distinct geographic areas — top geographies include New Hampshire, Maine. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT00432536 about?
NCT00432536 is a clinical study titled "Redesigning Cardiac Surgery to Reduce Neurologic Injury". Neurologic injuries are frequent and devastating complications following cardiac surgery. Previous work conducted by our research group and others has identified the principal mechanisms creating both overt and subtle neurologic injuries after cardiac surgery. Current work by our group has identifie...
What is the current status of trial NCT00432536?
This trial is currently completed. The enrollment target is 469 participants. The study started on 2002-10. Estimated completion is 2012-02.
What conditions does trial NCT00432536 study?
This clinical trial studies the following conditions: Cardiovascular Disease, Surgery. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT00432536?
The interventions under investigation include: Quality improvement intervention (OTHER). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT00432536?
This trial is sponsored by Dartmouth-Hitchcock Medical Center, which has 396 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT00432536 being conducted?
This trial has 3 study locations across Maine, New Hampshire. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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