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ClinicalTrials.gov 20 recruiting now official registry

Cardiovascular Disease clinical trials

20 of 137 indexed Cardiovascular Disease trials are currently recruiting.

137 US clinical trials · 20 currently recruiting

Cardiovascular Disease is the subject of 137 registered US clinical trials on ClinicalTrials.gov, 20 of them currently open to new participants. 22 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 10 of these trials.

The research picture

Cardiovascular Disease has 137 registered US clinical trials, 20 of them open to new participants right now, about 15% of the total.

20
recruiting participants now
15%
of trials open to enrollment
22
in Phase 3–4 (later-stage)
10
top sponsor: VA Office of Research and Development
Phase 17Phase 28Phase 314Phase 48

Active & Recent Trials

137 total, page 3 of 3

COMPLETED NA 64 participants

Mindfulness, Yoga, and Cardiovascular Disease

The Cleveland Clinic

NCT00696852

COMPLETED NA 61 participants

Effects of Almonds on Cardiovascular Risk Factors

Penn State University

NCT01101230

COMPLETED NA 60 participants

Soybean Oil Trial of cArdiovascular Risk

USDA Beltsville Human Nutrition Research Center

NCT02404207

COMPLETED NA 60 participants

Low Fat Vegan or American Heart Association Diets & Cardiovascular Risk in Obese 9-18 y.o. With Elevated Cholesterol

The Cleveland Clinic

NCT01817491

COMPLETED 60 participants

The Role of Nitric Oxide Synthase in Circulating Progenitor Cell Function

University of California, San Francisco

NCT00627068

COMPLETED Phase 2 58 participants

Biomarker Guided Therapies in Stage A/B Heart Failure

VA Office of Research and Development

NCT02230891

COMPLETED NA 58 participants

Star-Close Early Ambulation Trial

Ernest Mazzaferri

NCT00590798

COMPLETED NA 51 participants

PCI Alternative Using Sustained Exercise

VA Office of Research and Development

NCT03520400

COMPLETED 47 participants

The Perceived Impact of Children s Risk Status for Hypertrophic Cardiomyopathy on Families: an Exploratory Study

National Human Genome Research Institute (NHGRI)

NCT01160536

COMPLETED NA 46 participants

Individual Variability to Aerobic Exercise Training

Western Colorado University

NCT02868710

COMPLETED NA 46 participants

Effects of Walnuts on Central Blood Pressure, Arterial Stiffness Indices, Lipoproteins, and Other CVD Risk Factors

Penn State University

NCT02210767

COMPLETED NA 44 participants

Exercise and Pioglitazone for HIV-Metabolic Syndromes

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00639457

COMPLETED NA 43 participants

Quality Improvement and Personalization for Statins

VA Office of Research and Development

NCT02820870

COMPLETED NA 43 participants

Canola Oil Multicentre Intervention Trial (COMIT)

Penn State University

NCT01233778

COMPLETED Phase 4 43 participants

Vascular Inflammation in Psoriasis-Ustekinumab (VIP-U)

University of Pennsylvania

NCT02187172

COMPLETED NA 42 participants

Effects of Freeze Dried Strawberry Powder Supplementation on Vascular Function and Blood Markers of Cardiovascular Risk

Penn State University

NCT02557334

COMPLETED Phase 2 42 participants

The Fibrin Pad Cardiovascular Study

Ethicon

NCT01681030

COMPLETED NA 40 participants

IMPACT: Inactivity Monitoring and Physical Activity Controlled Trial

The University of Texas Medical Branch, Galveston

NCT01869348

COMPLETED NA 40 participants

The Metabolic Effects of Short-term Walnut Consumption in Subjects With the Metabolic Syndrome

Christos Mantzoros

NCT00525629

COMPLETED NA 40 participants

STEP AND GO: A Study of Technology-based Exercise Promotion

The University of Texas Medical Branch, Galveston

NCT01953224

COMPLETED NA 39 participants

Change of Fructose to Fat in South Asians

The Rogosin Institute

NCT01562782

COMPLETED 38 participants

Direct Measurements of Cardiometabolic Risk in Treated Schizophrenia Patients

Washington University School of Medicine

NCT00501163

COMPLETED Phase 4 36 participants

MIcrovascular dysfuNction In Moderate-severe Psoriasis

Marcelo F. Di Carli, MD, FACC

NCT04271540

COMPLETED NA 32 participants

The Effect of Processed Tomato Products on CVD Risks

Penn State University

NCT00937742

COMPLETED NA 30 participants

Expression of Longevity Genes in Response to Extended Fasting

Intermountain Health Care

NCT01059760

COMPLETED 30 participants

Periodontal and Periapical Inflammation and Pregnancy

Roger Johnson

NCT00490165

COMPLETED NA 30 participants

Translating the Diabetes Prevention Program Into a Virtual Lifestyle Management Program

University of Pittsburgh

NCT00867425

COMPLETED NA 24 participants

Role of Vitamin D in Secondary Prevention of Cardiovascular Events

Creighton University

NCT01018849

COMPLETED NA 21 participants

Vasoprotective Activities of Low-Fat Milk in Individuals With Metabolic Syndrome

University of Connecticut

NCT01411293

COMPLETED NA 20 participants

Healthy Fatty Acids in Transition

Penn State University

NCT00937963

COMPLETED NA 20 participants

The Effects Grapes on Health Indices

University of California, Davis

NCT01674231

COMPLETED Phase 1 20 participants

A Study of Evacetrapib (LY2484595) in Participants With Severe Renal Impairment and in Healthy Participants

Eli Lilly and Company

NCT01825889

COMPLETED NA 20 participants

Cardioprotective Activities Of Whole Eggs On Vascular Endothelial Function In Prediabetic Adults

Ohio State University

NCT02364570

COMPLETED NA 17 participants

Vascular Mechanisms for the Effects of Loss of Ovarian Hormone Function on Cognition in Women

University of Colorado, Denver

NCT02122198

COMPLETED Phase 1 15 participants

Fructose-Induced Palmitate Synthesis in Overweight Subjects

Rockefeller University

NCT00535535

COMPLETED 14 participants

Fat Biology, Sleep Disorders, and Cardiovascular Disease

Mayo Clinic

NCT01229501

COMPLETED Phase 2 11 participants

Trial of Oral Glutamine on Mitochondrial Function in CKD

University of Washington

NCT02838979

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Phase Distribution

PhaseTrial count
Phase 1 7
Phase 2 8
Phase 3 14
Phase 4 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Cardiovascular Disease Trial Landscape

137 indexed Cardiovascular Disease studies · 20 recruiting (15%).

Phase mix: 22 late (III/IV) vs 15 early (I/II).

Top sponsor: VA Office of Research and Development (10 trials), 9 others listed. 37 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Cardiovascular Disease?

PlainTrial tracks 137 US clinical trials for Cardiovascular Disease, of which 20 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Cardiovascular Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.