Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Acute Coronary Syndrome

Open-data reference.

41 US clinical trials · 6 currently recruiting

Active & Recent Trials

RECRUITING Phase 3 2,000 participants

Effect of Dalcetrapib on CV Risk in a Genetically Defined Population With a Recent ACS

DalCor Pharmaceuticals

NCT05918861

RECRUITING Phase 2 1,000 participants

A Polypill for Acute Coronary Syndrome

University of Texas Southwestern Medical Center

NCT07032389

RECRUITING 500 participants

AngelMed Guardian® System PMA Post Approval Study

Angel Medical Systems

NCT05412927

RECRUITING NA 280 participants

Positive Emotions Following Acute Cardiac Events

Massachusetts General Hospital

NCT05412862

RECRUITING 200 participants

Left Ventricular Physiological Effects of Veno-Arterial Extracorporeal Membrane Oxygenation Support During Cardiogenic Shock

University of Minnesota

NCT05426083

RECRUITING 150 participants

A Prospective Research Investigation of Ischemia Using MCG

SB Technology

NCT06481943

ACTIVE NOT RECRUITING Phase 3 14,194 participants

A Study of Milvexian in Participants After a Recent Acute Coronary Syndrome

Janssen Research & Development

NCT05754957

ACTIVE NOT RECRUITING 2,000 participants

COmparisoN of High-sensitivity Cardiac TRoponin I and T ASsays Trial

Hennepin Healthcare Research Institute

NCT03214029

ACTIVE NOT RECRUITING 1,500 participants

MERITnI - Mindray-hs-cTnI Assay: Analytical and Clinical Evaluation for the Diagnosis and RIsk AssessmenT of Myocardial InfarctIon.

Hennepin Healthcare Research Institute

NCT05853042

ACTIVE NOT RECRUITING NA 1,203 participants

LEADERS FREE II: BioFreedom™ Pivotal Study

Biosensors Europe

NCT02843633

ACTIVE NOT RECRUITING NA 233 participants

Post Acute Cardiac Event Smoking (PACES) Study

Hennepin Healthcare Research Institute

NCT03413423

ACTIVE NOT RECRUITING 215 participants

Enhancing Rural Health Via Cardiovascular Telehealth for Rural Patients Implementation (E-VICTORS)

Wake Forest University Health Sciences

NCT04617834

ACTIVE NOT RECRUITING Phase 2 70 participants

Online Tai Chi Plus Fitbit After ACS

Beth Israel Deaconess Medical Center

NCT05699642

ACTIVE NOT RECRUITING NA 60 participants

Healthy Heart Habits-2

The Miriam Hospital

NCT06440278

ACTIVE NOT RECRUITING NA 12 participants

OPTIMIZE Sirolimus-Eluting Coronary Stent Systems Pharmacokinetics (PK) Study

Svelte Medical Systems

NCT03716102

COMPLETED Phase 3 18,624 participants

A Comparison of Ticagrelor (AZD6140) and Clopidogrel in Patients With Acute Coronary Syndrome

AstraZeneca

NCT00391872

COMPLETED Phase 3 15,526 participants

An Efficacy and Safety Study for Rivaroxaban in Patients With Acute Coronary Syndrome

Johnson & Johnson Pharmaceutical Research & Development, L.L.C.

NCT00809965

COMPLETED 14,717 participants

HEART Pathway Implementation

Wake Forest University Health Sciences

NCT02056964

COMPLETED 12,227 participants

Treatment With Adenosine Diphosphate (ADP) Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome

Eli Lilly and Company

NCT01088503

COMPLETED Phase 3 6,068 participants

Evaluation of Cardiovascular Outcomes in Patients With Type 2 Diabetes After Acute Coronary Syndrome During Treatment With AVE0010 (Lixisenatide)

Sanofi

NCT01147250

COMPLETED 6,000 participants

ECG Methods for the Prompt Identification of Coronary Events

University of Pittsburgh

NCT04237688

COMPLETED NA 2,800 participants

GRAVITAS: Gauging Responsiveness With A VerifyNow Assay-Impact On Thrombosis And Safety

Accumetrics

NCT00645918

COMPLETED Phase 2 2,753 participants

Safety and Efficacy of TAK-442 in Subjects With Acute Coronary Syndromes

Takeda

NCT00677053

COMPLETED 1,949 participants

5th Generation cTnT in ED ACS

Columbia University

NCT03590535

COMPLETED NA 862 participants

Pharmacist Intervention to Decrease Medication Errors in Heart Disease Patients (The PILL-CVD Study)

Vanderbilt University Medical Center

NCT00632021

COMPLETED Phase 2 526 participants

A Study to Evaluate the Safety of 12 Weeks of Dosing With GW856553 and Its Effects on Inflammatory Markers, Infarct Size, and Cardiac Function in Subjects With Myocardial Infarction Without ST-segment Elevation

GlaxoSmithKline

NCT00910962

COMPLETED 511 participants

PARA-HEART Pilot Implementation

Wake Forest University Health Sciences

NCT02709135

COMPLETED Phase 2 510 participants

Safety and Efficacy Iodofiltic Acid I 123 in the Treatment of Acute Coronary Syndrome

Molecular Insight Pharmaceuticals

NCT00514501

COMPLETED NA 509 participants

Assessment of Prospective CYP2C19 Genotype Guided Dosing of Anti-Platelet Therapy in Percutaneous Coronary Intervention

University of Pennsylvania

NCT02508116

COMPLETED Phase 3 400 participants

Management of LDL-cholesterol With Inclisiran + Usual Care Compared to Usual Care Alone in Participants With a Recent Acute Coronary Syndrome

Novartis Pharmaceuticals

NCT04873934

COMPLETED 368 participants

Rule Out Myocardial Infarction by Computer Assisted Tomography

Massachusetts General Hospital

NCT00990262

COMPLETED NA 290 participants

Pragmatic Collaborative Care for Cardiac Inpatients With Depression or Anxiety

Massachusetts General Hospital

NCT03118752

COMPLETED Phase 1 150 participants

Comparison of Depression Interventions After Acute Coronary Syndrome

Columbia University

NCT01032018

COMPLETED NA 110 participants

Cost Comparison of Cardiac Magnetic Resonance Imaging (MRI) Use in Emergency Department (ED) Patients With Chest Pain

Wake Forest University Health Sciences

NCT00678639

COMPLETED 101 participants

Magnetocardiography Using a Novel Analysis System (Cardioflux) in the Evaluation of Emergency Department Observation Unit Chest Pain Patients

Genetesis

NCT03255772

COMPLETED Phase 4 77 participants

The Effect of Reloading Prasugrel in a Patient Who Has Already Received a Loading Dose (LD) of Clopidogrel

Medstar Health Research Institute

NCT01365221

COMPLETED NA 60 participants

Mind-body Interventions in Cardiac Patients

Massachusetts General Hospital

NCT01270568

COMPLETED Phase 1 56 participants

A Study to Evaluate the Effect of Losmapimod on Cardiac Conduction as Compared to Placebo and Moxifloxacin

GlaxoSmithKline

NCT01756495

COMPLETED 40 participants

Apixaban + DAPT in Lowering Platelet Reactivity and Thrombin Generation

CirQuest Labs

NCT03746782

COMPLETED NA 14 participants

HeartHome: A Nurse-Driven, Home-Based Cardiac Rehabilitation Program

University of North Carolina, Chapel Hill

NCT04131816

COMPLETED Phase 1 8 participants

Healthy Heart Habits

Hennepin Healthcare Research Institute

NCT04158219

Phase Distribution

PhaseTrial count
Early Phase 1 3
Phase 2 5
Phase 3 6
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Acute Coronary Syndrome Trial Landscape

ClinicalTrials.gov lists 41 US studies indexed under Acute Coronary Syndrome, and 6 of those are currently open to recruitment — roughly 15% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Acute Coronary Syndrome shows 7 late-stage studies (Phase 3 and Phase 4 combined) alongside 8 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Acute Coronary Syndrome is led by Hennepin Healthcare Research Institute with 4 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 41 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Acute Coronary Syndrome?

PlainTrial tracks 41 US clinical trials for Acute Coronary Syndrome, of which 6 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Acute Coronary Syndrome?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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