Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT00832702 · ClinicalTrials.gov registry record
Women's Ischemia Syndrome Evaluation (WISE) Coronary Vascular Dysfunction
A clinical trial of Cardiovascular Disease, sponsored by Cedars-Sinai Medical Center.
- Active
- Registry status
- 433
- Enrollment target
- 2
- Study locations
NCT00832702: Active study of Cardiovascular Disease, sponsored by Cedars-Sinai Medical Center.
NCT00832702 is a study of Cardiovascular Disease that is active but no longer recruiting, run by Cedars-Sinai Medical Center. The registered enrollment target is 433 participants, below the 2,694-participant average among 137 other Cardiovascular Disease trials with a reported enrollment target (84% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00832702, a study of Cardiovascular Disease, is active but no longer recruiting, sponsored by Cedars-Sinai Medical Center.
- ACTIVE NOT RECRUITING
- Registry status
- 433 participants
- Enrollment target
- 2
- Study locations
Study Summary
This research study is designed to investigate the approaches to noninvasive detection and assessment of coronary vascular dysfunction in women by comparing the testing results from the invasive standard care diagnostic procedure Angiogram and from the additional noninvasive diagnostic procedure CMR Imaging. The investigators want to specifically study 375 female patients who have signs or symptoms suggestive of heart disease but don't have obstructive coronary artery disease. Two study sites (Cedars-Sinai Medical Center and University of Florida) are recruiting participants. The standard of care procedures include demographics, review of recent clinical symptoms, review of medications being taken, a physical exam, pre-angiogram blood collection, chest x-ray, ECG and heart angiogram. The research procedures for this study are the cold pressor testing, blood/urine collection, health questionnaire, the post-angiogram ECG and cardiac MRI. Patients will be asked to undergo heart angiogram testing to test for abnormalities in their heart arteries. If the heart angiogram shows that the patients do not have blockages in major heart arteries, then the patients will have coronary flow reserve measurement test (as part of the heart angiogram) to determine whether the patients have abnormally functioning of the small heart arteries. This test will be performed by infusing the three drugs: adenosine, acetylcholine and nitroglycerin. The three drugs are naturally occurring substances and have been used for routine heart angiograms. Cardiac Magnetic Resonance (CMR) imaging may help us more easily and non-invasively detect abnormalities in the inner layer of the heart muscle resulting from the abnormal function of the heart arteries. All the 375 participants will undergo baseline CMR imaging test and a subgroup of 200 participants will undergo a second CMR imaging test at their at least 1-year followup visit. Patients will be followed up using phone questionnaires at 6 weeks,
Primary Outcome
Subjects will be contacted at 6-week followup and then annually indefinitely.
Conditions Studied
Interventions
- PROCEDURE Cardiac MRI
Study Locations (2)
California
- Cedars-Sinai Barbra Streisand Women's Heart Center - Los Angeles
Florida
- University of Florida - Gainesville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 433 participants |
| Start Date | 2008-09-17 |
| Est. Completion | 2051-08-31 |
What the registry record for NCT00832702 still lists
NCT00832702 is an observational study that tracks outcomes without assigning an intervention. The registered 433 participants enrollment target is mid-sized for trials with a published cap, below the 2,694-participant average among 137 other Cardiovascular Disease trials with a reported enrollment target (84% lower).
The record links to 1 condition, with Cardiovascular Disease appearing as the primary indexed condition, and to 1 intervention - of which Cardiac MRI is the first listed.
NCT00832702 reports a single indexed study location in California, Florida.
Frequently Asked Questions
What is clinical trial NCT00832702 about?
NCT00832702 is a clinical study titled "Women's Ischemia Syndrome Evaluation (WISE) Coronary Vascular Dysfunction". This research study is designed to investigate the approaches to noninvasive detection and assessment of coronary vascular dysfunction in women by comparing the testing results from the invasive standard care diagnostic procedure Angiogram and from the additional noninvasive diagnostic procedure CMR...
What is the current status of trial NCT00832702?
This trial is currently active not recruiting. The enrollment target is 433 participants. The study started on 2008-09-17. Estimated completion is 2051-08-31.
What conditions does trial NCT00832702 study?
This clinical trial studies the following conditions: Cardiovascular Disease.
What interventions are being tested in trial NCT00832702?
The interventions under investigation include: Cardiac MRI (PROCEDURE).
Who is sponsoring clinical trial NCT00832702?
This trial is sponsored by Cedars-Sinai Medical Center, which has 339 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00832702 being conducted?
This trial has 2 study locations across California, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Cardiovascular Disease
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00832702's enrollment target sits among peer trials
433 37th of 137 higher than 101 of 137 other Cardiovascular Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Cardiovascular Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Single-tracer Multiparametric PET Imaging
RECRUITING · Early Phase 1
-
WISE CVD - Continuation (WISE HFpEF)
RECRUITING
-
A RAndomizeD Intervention for Cardiovascular and Lifestyle Risk Factors in Prostate Cancer Patients
RECRUITING · NA
-
A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event
RECRUITING · Phase 3
-
Human Biospecimen Procurement Protocol: Biorepository to Support Translational Research to Identify Disease Mechanism(s)
RECRUITING
-
Dietary Omega-7 Palmitoleic Acid-Rich Oil on Lipoprotein Metabolism and Satiety in Adults
RECRUITING · Phase 2
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT04743245 · 434 participants · NA
Delivery SSO2 Therapy for 60 Min in Anterior MI Patients With PCI ≤ 6 Hours of Symptoms Onset Compared to Standard.
- NCT06471920 · 434 participants · NA
Improving Health for Patients With Chronic LBP in Rural Communities Through Telerehabilitation
- NCT07094113 · 434 participants · Phase 1
AMG 410 Alone and in Combination With Other Agents in Participants With KRAS Altered Advanced or Metastatic Solid Tumors
- NCT05271240 · 432 participants · Phase 3
Repeated Superselective Intraarterial Cerebral Infusion (SIACI) of Bevacizumab With Temozolomide and Radiation Compared to Temozolomide and Radiation Alone in Newly Diagnosed GBM
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI