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NCT00832702 · ClinicalTrials.gov registry record
Women's Ischemia Syndrome Evaluation (WISE) Coronary Vascular Dysfunction
A clinical trial of Cardiovascular Disease, sponsored by Cedars-Sinai Medical Center.
- Active
- Registry status
- 433
- Enrollment target
- 2
- Study locations
NCT00832702 is a study of Cardiovascular Disease that is active but no longer recruiting, run by Cedars-Sinai Medical Center. The registered enrollment target is 433 participants, below the 2,710-participant average among 136 other Cardiovascular Disease trials with a reported enrollment target (84% lower). The trial reports 2 study locations across 2 states.
The verdict
NCT00832702, a study of Cardiovascular Disease, is active but no longer recruiting, sponsored by Cedars-Sinai Medical Center.
- ACTIVE NOT RECRUITING
- Registry status
- 433 participants
- Enrollment target
- 2
- Study locations
Study Summary
This research study is designed to investigate the approaches to noninvasive detection and assessment of coronary vascular dysfunction in women by comparing the testing results from the invasive standard care diagnostic procedure Angiogram and from the additional noninvasive diagnostic procedure CMR Imaging. The investigators want to specifically study 375 female patients who have signs or symptoms suggestive of heart disease but don't have obstructive coronary artery disease. Two study sites (Cedars-Sinai Medical Center and University of Florida) are recruiting participants. The standard of care procedures include demographics, review of recent clinical symptoms, review of medications being taken, a physical exam, pre-angiogram blood collection, chest x-ray, ECG and heart angiogram. The research procedures for this study are the cold pressor testing, blood/urine collection, health questionnaire, the post-angiogram ECG and cardiac MRI. Patients will be asked to undergo heart angiogram testing to test for abnormalities in their heart arteries. If the heart angiogram shows that the patients do not have blockages in major heart arteries, then the patients will have coronary flow reserve measurement test (as part of the heart angiogram) to determine whether the patients have abnormally functioning of the small heart arteries. This test will be performed by infusing the three drugs: adenosine, acetylcholine and nitroglycerin. The three drugs are naturally occurring substances and have been used for routine heart angiograms. Cardiac Magnetic Resonance (CMR) imaging may help us more easily and non-invasively detect abnormalities in the inner layer of the heart muscle resulting from the abnormal function of the heart arteries. All the 375 participants will undergo baseline CMR imaging test and a subgroup of 200 participants will undergo a second CMR imaging test at their at least 1-year followup visit. Patients will be followed up using phone questionnaires at 6 weeks,
Conditions Studied
Interventions
- PROCEDURE Cardiac MRI
Study Locations (2)
California
- Cedars-Sinai Barbra Streisand Women's Heart Center - Los Angeles
Florida
- University of Florida - Gainesville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 433 participants |
| Start Date | 2008-09-17 |
| Est. Completion | 2051-08-31 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00832702
The ClinicalTrials.gov registry entry for NCT00832702 describes a study currently listed as active not recruiting, categorized as an unspecified phase. The registered enrollment target is 433 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 2,710-participant average among 136 other Cardiovascular Disease trials with a reported enrollment target (84% lower). The listed sponsor is Cedars-Sinai Medical Center, which has 339 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Cardiovascular Disease appearing as the primary indexed condition, and to 1 intervention - of which Cardiac MRI is the first listed.
NCT00832702 reports 2 study locations spanning 2 distinct geographic areas - top geographies include California, Florida.
Frequently Asked Questions
What is clinical trial NCT00832702 about?
NCT00832702 is a clinical study titled "Women's Ischemia Syndrome Evaluation (WISE) Coronary Vascular Dysfunction". This research study is designed to investigate the approaches to noninvasive detection and assessment of coronary vascular dysfunction in women by comparing the testing results from the invasive standard care diagnostic procedure Angiogram and from the additional noninvasive diagnostic procedure CMR...
What is the current status of trial NCT00832702?
This trial is currently active not recruiting. The enrollment target is 433 participants. The study started on 2008-09-17. Estimated completion is 2051-08-31.
What conditions does trial NCT00832702 study?
This clinical trial studies the following conditions: Cardiovascular Disease.
What interventions are being tested in trial NCT00832702?
The interventions under investigation include: Cardiac MRI (PROCEDURE).
Who is sponsoring clinical trial NCT00832702?
This trial is sponsored by Cedars-Sinai Medical Center, which has 339 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00832702 being conducted?
This trial has 2 study locations across California, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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