Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 3

OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events

NCT07136012 · View on ClinicalTrials.gov ↗

Study Summary

The primary objective is to evaluate the effect of olpasiran, compared to placebo, on the risk for coronary heart disease death (CHD death), myocardial infarction, or urgent coronary revascularization in participants at risk for a first major cardiovascular event with elevated lipoprotein(a) (Lp\[a\]).

Conditions Studied

Interventions

  • DRUG Placebo
  • DRUG Olpasiran

Study Locations (20)

Alabama

  • Advanced Cardiovascular LLC — Alexander City
  • University of Alabama Birmingham Saint Vincents Birmingham — Birmingham
  • Birmingham Clinical Research — Birmingham
  • Alliance For Multispecialty Research - Daphne — Daphne
  • Eastern Shore Research Institute — Fairhope
  • Heart Center Research LLC — Huntsville
  • CB Flock Research Corporation — Mobile

California

  • National Heart Institute — Beverly Hills
  • 310 Clinical Research — Inglewood
  • University of California San Diego — La Jolla
  • InvivoCure — Los Angeles
  • Valley Clinical Trials — Northridge
  • Clinical Trials Research - Sacramento — Roseville
  • Alliance Clinical Research — San Diego

Arizona

  • Phoenix Clinical — Phoenix
  • Elite Clinical Studies LLC — Phoenix
  • Hero Clinical Research — Phoenix
  • HonorHealth Research Institute — Scottsdale
  • Eclipse Clinical Research — Tucson

Arkansas

  • Lynn Institute of the Ozarks — Little Rock

Trial Details

FieldValue
Enrollment Target 11,000 participants
Start Date 2025-08-22
Est. Completion 2031-10-20
Phase Phase 3

Sponsor

Amgen

266 total trials

Interested in This Trial?

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07136012

The ClinicalTrials.gov registry entry for NCT07136012 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 11,000 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Amgen, which has 266 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Cardiovascular Disease appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07136012 reports 20 study locations spanning 4 distinct geographic areas — top geographies include Alabama, California, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07136012 about?

NCT07136012 is a clinical study titled "OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events". The primary objective is to evaluate the effect of olpasiran, compared to placebo, on the risk for coronary heart disease death (CHD death), myocardial infarction, or urgent coronary revascularization in participants at risk for a first major cardiovascular event with elevated lipoprotein(a) (Lp\[a\...

What is the current status of trial NCT07136012?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 11,000 participants. The study started on 2025-08-22. Estimated completion is 2031-10-20.

What conditions does trial NCT07136012 study?

This clinical trial studies the following conditions: Cardiovascular Disease. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07136012?

The interventions under investigation include: Placebo (DRUG), Olpasiran (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07136012?

This trial is sponsored by Amgen, which has 266 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07136012 being conducted?

This trial has 20 study locations across Alabama, Arizona, Arkansas, California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial