Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
REDEFINE 3: A Research Study to See the Effects of CagriSema in People Living With Diseases in the Heart and Blood Vessels
NCT05669755 · View on ClinicalTrials.gov ↗
Study Summary
This study will look at the effects of CagriSema on cardiovascular events (for example heart attack and stroke) in people living with cardiovascular disease. Participants will either get CagriSema or a dummy medicine (also called "placebo") which has no effect on the body. Which treatment participants will get will be decided by chance. Participant's chance of getting CagriSema or placebo is the same. Participants will inject the study medicine once a week. The study medicine will be injected briefly with a thin needle, typically in the stomach, thighs or upper arms. The study will last for up to 4.5 years.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Semaglutide
- DRUG Cagrilintide
Study Locations (20)
California
- National Heart Institute Cal — Beverly Hills
- Valley Clinical Trials — Covina
- Scripps Wht Diab Inst La Jolla — La Jolla
- First Valley Medical Group — Lancaster
- Clinical Trials Research_Sacramento — Lincoln
- Torrance Clin Res Inst, Inc. — Lomita
- Pacific Clinical Studies — Los Alamitos
- Monterey Endocrine & Diabetes Institute, Inc — Monterey
- Valley Clinical Trials, Inc. — Northridge
- Desert Oasis Hlthcr Med Group — Palm Springs
- Western University of Health Sciences — Pomona
- Linda Vista Health Care Ctr — San Diego
- N America Res Inst - San Dimas — San Dimas
- Encompass Clinical Research_Spring Valley — Spring Valley
- Lundquist Inst.-Biom Inno-UCLA — Torrance
Alabama
- Univ of Alabama Birmingham — Birmingham
- Chambliss Clinical Trials LLC — Montgomery
Arizona
- Honor Health — Scottsdale
Connecticut
- Bridgeport Hospital — Bridgeport
Florida
- Innovative Research of W FL — Clearwater
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 7,101 participants |
| Start Date | 2023-03-01 |
| Est. Completion | 2027-10-13 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05669755
The ClinicalTrials.gov registry entry for NCT05669755 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 7,101 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Novo Nordisk A/S, which has 189 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Cardiovascular Disease appearing as the primary indexed condition, and to 3 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05669755 reports 20 study locations spanning 5 distinct geographic areas — top geographies include California, Alabama, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05669755 about?
NCT05669755 is a clinical study titled "REDEFINE 3: A Research Study to See the Effects of CagriSema in People Living With Diseases in the Heart and Blood Vessels". This study will look at the effects of CagriSema on cardiovascular events (for example heart attack and stroke) in people living with cardiovascular disease. Participants will either get CagriSema or a dummy medicine (also called "placebo") which has no effect on the body. Which treatment participan...
What is the current status of trial NCT05669755?
This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 7,101 participants. The study started on 2023-03-01. Estimated completion is 2027-10-13.
What conditions does trial NCT05669755 study?
This clinical trial studies the following conditions: Cardiovascular Disease. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05669755?
The interventions under investigation include: Placebo (DRUG), Semaglutide (DRUG), Cagrilintide (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05669755?
This trial is sponsored by Novo Nordisk A/S, which has 189 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05669755 being conducted?
This trial has 20 study locations across Alabama, Arizona, California, Connecticut, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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