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NCT03152318 · ClinicalTrials.gov registry record · Phase 1
A Study of the Treatment of Recurrent Malignant Glioma With rQNestin34.5v.2
A Phase 1 study of Brain Tumor and Ependymoma, sponsored by Dana-Farber Cancer Institute.
- Active
- Registry status
- Phase 1
- Development phase
- 62
- Enrollment target
- 5
- Study locations
NCT03152318: Active Phase 1 study of Brain Tumor and Ependymoma, sponsored by Dana-Farber Cancer Institute.
NCT03152318 is a Phase 1 study of Brain Tumor and Ependymoma that is active but no longer recruiting, run by Dana-Farber Cancer Institute. The registered enrollment target is 62 participants, below the 281-participant average among 69 other Brain Tumor trials with a reported enrollment target (78% lower). The trial reports 5 study locations across 4 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03152318, a Phase 1 study of Brain Tumor and Ependymoma, is active but no longer recruiting, sponsored by Dana-Farber Cancer Institute.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 62 participants
- Enrollment target
- 5
- Study locations
Study Summary
This research study is evaluating an investigational drug, an oncolytic virus called rQNestin34.5v.2. This research study is a Phase I clinical trial, which tests the safety of an investigational drug and also tries to define the appropriate dose of the investigational drug as a possible treatment for this diagnosis of recurrent or progressive brain tumor.
Primary Outcome
The primary objective is to determine the maximum tolerated dose of rQNestin34.5v.2 injected into recurrent malignant gliomas, with or without previous immunomodulation with cyclophosphamide.
Conditions Studied
Interventions
- DRUG Cyclophosphamide
- DRUG rQNestin
- PROCEDURE Stereotactic biopsy
Study Locations (5)
Massachusetts
- Dana Farber Cancer Institute - Boston
- Brigham and Women's Hospital - Boston
Maryland
- Johns Hopkins University Medical Center - Baltimore
New York
- Memorial Sloan Kettering Cancer Center - New York
Texas
- MD Anderson Cancer Center - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 62 participants |
| Start Date | 2017-07-18 |
| Est. Completion | 2028-01 |
| Phase | Phase 1 |
What the registry record for NCT03152318 still lists
NCT03152318 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 62 participants, a relatively small participant target, below the 281-participant average among 69 other Brain Tumor trials with a reported enrollment target (78% lower).
The record links to 10 conditions, with Brain Tumor appearing as the primary indexed condition, and to 3 interventions - of which Cyclophosphamide is the first listed.
NCT03152318 lists 5 locations in 4 states (Massachusetts, Maryland, New York).
Frequently Asked Questions
What is clinical trial NCT03152318 about?
NCT03152318 is a clinical study titled "A Study of the Treatment of Recurrent Malignant Glioma With rQNestin34.5v.2". This research study is evaluating an investigational drug, an oncolytic virus called rQNestin34.5v.2. This research study is a Phase I clinical trial, which tests the safety of an investigational drug and also tries to define the appropriate dose of the investigational drug as a possible treatment f...
What is the current status of trial NCT03152318?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 62 participants. The study started on 2017-07-18. Estimated completion is 2028-01.
What conditions does trial NCT03152318 study?
This clinical trial studies the following conditions: Brain Tumor, Ependymoma, Astrocytoma, Oligodendroglioma, Malignant Glioma of Brain.
What interventions are being tested in trial NCT03152318?
The interventions under investigation include: Cyclophosphamide (DRUG), rQNestin (DRUG), Stereotactic biopsy (PROCEDURE).
Who is sponsoring clinical trial NCT03152318?
This trial is sponsored by Dana-Farber Cancer Institute, which has 781 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03152318 being conducted?
This trial has 5 study locations across Maryland, Massachusetts, New York, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT03152318's enrollment target sits among peer trials
62 27th of 69 higher than 43 of 69 other Brain Tumor trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Brain Tumor trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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