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ACTIVE NOT RECRUITING Phase 1

A Study of the Treatment of Recurrent Malignant Glioma With rQNestin34.5v.2

NCT03152318 · View on ClinicalTrials.gov ↗

Study Summary

This research study is evaluating an investigational drug, an oncolytic virus called rQNestin34.5v.2. This research study is a Phase I clinical trial, which tests the safety of an investigational drug and also tries to define the appropriate dose of the investigational drug as a possible treatment for this diagnosis of recurrent or progressive brain tumor.

Interventions

  • DRUG Cyclophosphamide
  • DRUG rQNestin
  • PROCEDURE Stereotactic biopsy

Study Locations (5)

Massachusetts

  • Dana Farber Cancer Institute — Boston
  • Brigham and Women's Hospital — Boston

Maryland

  • Johns Hopkins University Medical Center — Baltimore

New York

  • Memorial Sloan Kettering Cancer Center — New York

Texas

  • MD Anderson Cancer Center — Houston

Trial Details

FieldValue
Enrollment Target 62 participants
Start Date 2017-07-18
Est. Completion 2028-01
Phase Phase 1

Sponsor

Dana-Farber Cancer Institute

819 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03152318

The ClinicalTrials.gov registry entry for NCT03152318 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 62 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Dana-Farber Cancer Institute, which has 819 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 10 conditions, with Brain Tumor appearing as the primary indexed condition, and to 3 interventions — of which Cyclophosphamide is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03152318 reports 5 study locations spanning 4 distinct geographic areas — top geographies include Massachusetts, Maryland, New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03152318 about?

NCT03152318 is a clinical study titled "A Study of the Treatment of Recurrent Malignant Glioma With rQNestin34.5v.2". This research study is evaluating an investigational drug, an oncolytic virus called rQNestin34.5v.2. This research study is a Phase I clinical trial, which tests the safety of an investigational drug and also tries to define the appropriate dose of the investigational drug as a possible treatment f...

What is the current status of trial NCT03152318?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 62 participants. The study started on 2017-07-18. Estimated completion is 2028-01.

What conditions does trial NCT03152318 study?

This clinical trial studies the following conditions: Brain Tumor, Ependymoma, Astrocytoma, Oligodendroglioma, Malignant Glioma of Brain. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03152318?

The interventions under investigation include: Cyclophosphamide (DRUG), rQNestin (DRUG), Stereotactic biopsy (PROCEDURE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03152318?

This trial is sponsored by Dana-Farber Cancer Institute, which has 819 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03152318 being conducted?

This trial has 5 study locations across Maryland, Massachusetts, New York, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial