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ClinicalTrials.gov 34 recruiting now official registry

Crohn Disease clinical trials

34 of 72 indexed Crohn Disease trials are currently recruiting.

72 US clinical trials · 34 currently recruiting

Crohn Disease is the subject of 72 registered US clinical trials on ClinicalTrials.gov, 34 of them currently open to new participants. 13 are in Phase 3-4 (later-stage) and 20 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 6 of these trials.

The research picture

Crohn Disease has 72 registered US clinical trials, 34 of them open to new participants right now, about 47% of the total.

34
recruiting participants now
47%
of trials open to enrollment
13
in Phase 3–4 (later-stage)
6
top sponsor: Massachusetts General Hospital
Phase 111Phase 29Phase 35Phase 48

Active & Recent Trials

72 total, page 1 of 2

RECRUITING Phase 3 1,380 participants

Extension Study of Long-term Safety and Efficacy of Tulisokibart in Participants With Crohn's Disease or Ulcerative Colitis (MK-7240-011)

Merck Sharp & Dohme

NCT06651281

RECRUITING 1,250 participants

Urine Metabolites in the Diagnosis of Disease

Luventix

NCT06710067

RECRUITING Phase 2 1,092 participants

A Study of Icotrokinra in Participants With Moderately to Severely Active Crohn's Disease

Janssen Research & Development

NCT07196722

RECRUITING 1,056 participants

A Study to Assess the Long-Term Safety of Ustekinumab Versus Other Biologics in Patients With Crohn's Disease and Ulcerative Colitis

Janssen Scientific Affairs

NCT04372108

RECRUITING 1,000 participants

Registry and Biorepository for IBD in Central Texas

University of Texas at Austin

NCT04617184

RECRUITING Phase 4 900 participants

Clinical, Imaging, and Endoscopic Outcomes of Children Newly Diagnosed With Crohn's Disease

Connecticut Children's Medical Center

NCT05781152

RECRUITING Phase 4 304 participants

VECTORS - A Study to Evaluate Transmural Healing as a Treatment Target in Crohn's Disease

Alimentiv

NCT06257706

RECRUITING Phase 1 300 participants

Nivolumab in Treating Patients With Autoimmune Disorders and Advanced, Metastatic, or Unresectable Cancer

National Cancer Institute (NCI)

NCT03816345

RECRUITING NA 250 participants

Treat-to-Target of Endoscopic Remission in Patients With IBD in Symptomatic Remission

University of California, San Diego

NCT05230173

RECRUITING 200 participants

Stelara and Tremfya Pregnancy Exposure Registry OTIS Autoimmune Diseases in Pregnancy Project

University of California, San Diego

NCT02103361

RECRUITING 200 participants

Seattle Spatial Transcriptomic Research in Inflammatory Bowel Disease Evaluation (STRIDE)

Seattle Children's Hospital

NCT06315179

RECRUITING NA 181 participants

MeSenteric SpAring Versus High Ligation Ileocolic Resection for the Prevention of REcurrent Crohn's DiseaSe (SPARES)

The Cleveland Clinic

NCT04578392

RECRUITING Phase 2 180 participants

Precise Infliximab Exposure and Pharmacodynamic Control

Children's Hospital Medical Center, Cincinnati

NCT05660746

RECRUITING NA 152 participants

Use of Psychologist-administered Cognitive Behavioral Therapy (CBT) or Self-administered CBT for the Treatment of Anxiety and/or Depression in Inflammatory Bowel Disease (IBD)

Yale University

NCT05377840

RECRUITING 125 participants

Testing of an Educational Tool for Patients With Melanoma and Pre-Existing Autoimmune Disease Who Are Candidates for Immune Checkpoint Inhibitors

M.D. Anderson Cancer Center

NCT04751396

RECRUITING Phase 2 120 participants

Standardized Microbiota Transplant Therapy in Crohn's Disease

University of Minnesota

NCT06631586

RECRUITING Phase 1 116 participants

Pilot and Feasibility Study of 2'-FL as a Dietary Supplement in IBD Patients Receiving Stable Maintenance Anti-TNF Therapy

Children's Hospital Medical Center, Cincinnati

NCT03847467

RECRUITING 92 participants

Skeletal Health and Bone Marrow Composition in Newly Diagnosed Adolescents With Crohn Disease

Massachusetts General Hospital

NCT04508088

RECRUITING NA 83 participants

RISE: A Remote Study of Insomnia Treatment in Crohn's Disease

Dartmouth-Hitchcock Medical Center

NCT05956158

RECRUITING NA 80 participants

Personalized Risk Estimation for Crohn's Disease (PRE-Crohn's): Implementation and Feasibility

Massachusetts General Hospital

NCT05332639

RECRUITING NA 70 participants

Impact of Prebiotics in Ulcerative Colitis

University of California, Los Angeles

NCT06495658

RECRUITING NA 68 participants

IBD-Sleep: A Pilot Study Looking at Changes in Sleep Timing and IBD Symptoms

University of Michigan

NCT06094608

RECRUITING 60 participants

Therapeutic Endpoint in Pediatric IBD Conditions

Children's National Research Institute

NCT06065228

RECRUITING NA 60 participants

Reverse-Engineering of Exclusive Enteral Nutrition (RE-EEN) in Crohn's Disease: A Multi-Center Trial

Seattle Children's Hospital

NCT06216899

RECRUITING Early Phase 1 50 participants

Cranberry and Gut Health in Crohn's Disease

Ana Maldonado-Contreras

NCT07170462

RECRUITING 50 participants

High Dose Interval Vitamin D Supplementation in Patients With Inflammatory Bowel Disease Receiving Biologic Therapy

Boston Children's Hospital

NCT04331639

RECRUITING Phase 2 50 participants

Autologous Stem Cell Transplant for Crohn's Disease

Aaron Etra

NCT03219359

RECRUITING Phase 1 30 participants

Low Dose IL-2 for the Treatment of Crohn's Disease

Boston Children's Hospital

NCT04263831

RECRUITING NA 30 participants

A Study for Imaging the Lower Gastrointestinal Tract Using a Retro-TCE Capsule

Massachusetts General Hospital

NCT07219537

RECRUITING 25 participants

Value of PET/MR Enterography in the Assessment of Crohn's Disease Using a Collagen-binding Radiotracer.

Massachusetts General Hospital

NCT06252493

RECRUITING Phase 4 24 participants

Glucagon-like Peptide-1 Receptor Agonist (GLP-1 RA) and Diet in Inflammatory Bowel Disease (IBD) Patients

University of Miami

NCT06774079

RECRUITING Early Phase 1 20 participants

Effect of Statins on Crohn's Disease

Stanford University

NCT06538649

RECRUITING Phase 1 15 participants

Stem Cell Transplantation in Crohn's Disease

Cedars-Sinai Medical Center

NCT04224558

RECRUITING NA 10 participants

Feasibility of a Wireless Thermal Capsule Endoscopy to Detect Gastrointestinal Thermal Variance

Massachusetts General Hospital

NCT07033208

ACTIVE NOT RECRUITING Phase 3 350 participants

A Study of Guselkumab Subcutaneous Therapy in Participants With Moderately to Severely Active Crohn's Disease

Janssen Research & Development

NCT05197049

ACTIVE NOT RECRUITING 292 participants

Volatile Organic Compounds (VOCs) in Active Inflammatory Bowel Disease

The Cleveland Clinic

NCT04827368

ACTIVE NOT RECRUITING Phase 2 247 participants

A Study to Evaluate the Long-Term Effect of TEV-48574 in Moderate to Severe Ulcerative Colitis or Crohn's Disease

Teva Branded Pharmaceutical Products R&D

NCT05668013

ACTIVE NOT RECRUITING 232 participants

Biomarkers of Intestinal Fibrosis in Small Bowel Crohn's Disease

Children's Hospital Medical Center, Cincinnati

NCT04088773

ACTIVE NOT RECRUITING NA 194 participants

Modulating Early Life Microbiome Through Dietary Intervention in Crohn's Disease

Icahn School of Medicine at Mount Sinai

NCT03850600

ACTIVE NOT RECRUITING 178 participants

Combinatorial Single Cell Strategies for a Crohn's Disease Gut Cell Atlas

Vanderbilt University Medical Center

NCT04113733

ACTIVE NOT RECRUITING Phase 3 159 participants

A Long-term Extension Study of Ustekinumab in Pediatric Participants

Janssen Research & Development

NCT05092269

ACTIVE NOT RECRUITING NA 150 participants

A Culturally Tailored Dietary Intervention to Treat Crohn's Disease

University of Massachusetts, Worcester

NCT05627128

ACTIVE NOT RECRUITING Phase 4 124 participants

Proactive Infliximab Optimization Using a Pharmacokinetic Dashboard Versus Standard of Care in Patients With Inflammatory Bowel Disease: The OPTIMIZE Trial

Beth Israel Deaconess Medical Center

NCT04835506

ACTIVE NOT RECRUITING NA 123 participants

A Novel Remote Patient and Medication Monitoring Solution to Improve Adherence and PerSiStence With IBD Therapy

University of Maryland, Baltimore

NCT05316584

ACTIVE NOT RECRUITING Phase 1 30 participants

Safety and Efficacy of EcoActive on Intestinal Adherent Invasive E. Coli in Patients With Inactive Crohn's Disease

Intralytix

NCT03808103

ACTIVE NOT RECRUITING 25 participants

Contrast Enhanced Ultrasound in Human Crohn's Disease-Lumason

Children's Hospital Medical Center, Cincinnati

NCT03492944

ACTIVE NOT RECRUITING Phase 2 20 participants

A Phase 2 Clinical Trial: Xanthohumol Metabolism and Signature (XMaS) in Crohn's Disease

National University of Natural Medicine

NCT04590508

ACTIVE NOT RECRUITING NA 15 participants

Feasibility Study to Assess a Trans-nasal Intestinal Potential Difference Probe

Massachusetts General Hospital

NCT04565821

COMPLETED NA 715 participants

Addressing Disability Effectively With Psychosocial Telemedicine

University of Pennsylvania

NCT05635292

COMPLETED Phase 2 388 participants

Safety and Efficacy Study of JNJ-64304500 in Participants With Moderately to Severely Active Crohn's Disease

Janssen Research & Development

NCT02877134

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Phase Distribution

PhaseTrial count
Phase 1 11
Phase 2 9
Phase 3 5
Phase 4 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Crohn Disease Trial Landscape

72 indexed Crohn Disease studies · 34 recruiting (47%).

Phase mix: 13 late (III/IV) vs 20 early (I/II).

Top sponsor: Massachusetts General Hospital (6 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Crohn Disease?

PlainTrial tracks 72 US clinical trials for Crohn Disease, of which 34 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Crohn Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.