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Chronic Low Back Pain: early-phase trial registry
30 of 72 indexed Chronic Low Back Pain trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #191 of 28,707 conditions by registered trial count.
72 US clinical trials · 30 currently recruiting · #191 of 28,707 conditions by registered trial count
Chronic Low Back Pain: 72 US clinical trials tracked, 30 recruiting.
Chronic Low Back Pain is the subject of 72 registered US clinical trials on ClinicalTrials.gov, 30 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 6 of these trials.
Enrollment posture brief
Registry condition chronic-low-back-pain
OPEN 30 | RECR 42% | LATE 5 | EARLY 15 | RANK #191 | SPON 6
Volume-matched condition peers
Nearest open-share peer: Acute Myeloid Leukemia in Remission (42% recruiting · 12 trials)
Chronic Low Back Pain lists 30 open slots (42% of 72 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Chronic Low Back Pain on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Chronic Low Back Pain is recruiting above its size-band peers.
30 of 72 indexed trials (41.7%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Chronic Low Back Pain trials is spread across many organizations.
VA Office of Research and Development accounts for 6 of 72 trials (8.3%). 49 distinct sponsors appear on at least one study for this condition label.
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Typical Chronic Low Back Pain enrolment sits around 70 participants.
Median target enrolment is 70 among the 72 trials that report a genuine target (sentinel values excluded). 39 of those (54.2%) plan for fewer than 100 participants.
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Chronic Low Back Pain research is mostly interventional.
62 interventional and 10 observational studies make up this index (86.1% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
72 total, page 1 of 2
PRECISION Pain Research Registry
University of North Texas Health Science Center
NCT04853732
A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain
Eli Lilly and Company
NCT05986292
Sequential and Comparative Evaluation of Pain Treatment Effectiveness Response
VA Office of Research and Development
NCT04142177
Intracept Minimally-invasive PROcedure for VErtebrogenic Back Pain
Boston Scientific Corporation
NCT06827262
Telerehabilitation for Patients With Chronic Low Back Pain (TeleBACK Clinical Trial)
Johns Hopkins University
NCT06821607
Improving Health for Patients With Chronic LBP in Rural Communities Through Telerehabilitation
Johns Hopkins University
NCT06471920
Clinician Satisfaction With the VERABAND™
University of Michigan
NCT06080464
Integrative Mindfulness-Based Predictive Approach for Chronic Low Back Pain Treatment
Boston Medical Center
NCT06106191
HOnest Placebos With Explanations: Evaluating Open-Label Placebos for Chronic Pain
Rhode Island Hospital
NCT06931158
The Ability of Chronic Pain Patients to Self-diagnose Their Chief Source of Low Back Pain
Northwestern University
NCT06630676
Physical Exam, Static & Dynamic Ultrasound Assessment, & Treatment of Thoracolumbar Fascia (TLF) Mediated Low Back Pain
Edward Via Virginia College of Osteopathic Medicine
NCT06818175
Mobile Neurofeedback for Low Back Pain
Duke University
NCT05669027
Detection of EEG-Based Biomarkers of Chronic Low Back Pain
Stanford University
NCT06025201
Modulation Effect of tACS on Chronic Low Back Pain
Massachusetts General Hospital
NCT06568198
Managing Pain Using Optimized Sequences by Adjusting Parameters With Independent Current Control
Boston Scientific Corporation
NCT07190807
Meditation for Older Adults With Chronic Low Back Pain
Florida State University
NCT06384001
MBM andtaVNS for Low Back Pain and Depressive Symptoms
Florida State University
NCT07415941
AuriculoTherapy NeuroImaging
Keith M Vogt
NCT06825390
Transcutaneous Spinal Cord Stimulation for Chronic Low Back Pain
University of California, San Francisco
NCT05265000
Evaluation of Multi-Tined Expandable Electrode (MEE) Efficacy and Safety in Treatment of Lumbar Facet Arthropathy by Radiofrequency Neurotomies Compared to Conservative Medical Management.
University of Kansas Medical Center
NCT04730700
Safety, Tolerability, and Effectiveness of Intramuscular Injection of CELZ-201-DDT for the Treatment of Chronic Lower Back Pain
Creative Medical Technology Holdings
NCT06053242
Ketamine-assisted Integrative Treatment for Veterans With Chronic Low Back Pain and Comorbid Depression
VA Office of Research and Development
NCT06419439
Brain Imaging Biomarkers for Response to Spinal Cord Stimulation in Patients With Chronic Low Back Pain
University of California, Los Angeles
NCT04658628
Active Music-Based Intervention in Patients With Chronic Low Back Pain
Sharon Wang-Price
NCT06940063
Psilocybin in Chronic Low Back Pain and Depression
Johns Hopkins University
NCT06355414
Transcutaneous Electrical Nerve Stimulation (TENS) and Low Back Pain
University of Hartford
NCT05812885
Psilocybin Therapy for Chronic Low Back Pain
Joshua Woolley, MD, PhD
NCT05351541
Integrative Breathwork Intervention for Chronic Pain
University of Florida
NCT06546956
Phenotyping Response to Spinal Cord Stimulation in Chronic Low Back Pain
University of California, Los Angeles
NCT06310226
DBS of the SCC for the Treatment of Medically Refractory CLBP
University of California, Los Angeles
NCT04085406
EaseVRx-8w+ for the Treatment of Chronic Lower Back Pain
AppliedVR
NCT05263037
Stanford Center for Back Pain
Stanford University
NCT02503475
Efficacy of Spinal Manipulation Therapy or Mindfulness-based Reduction Therapy on Patients With Chronic Low Back Pain
Rush University Medical Center
NCT04744883
Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure
Northwestern University
NCT05463367
Development and Feasibility of Mindfulness Based Pain Reduction
University of California, San Francisco
NCT04980612
Partial Sleep Restriction in Chronic Low Back Pain: A Feasibility Study
University of Kansas Medical Center
NCT07008924
Effects of tDCS and TUS on the Perception of Pain and Functional Limitations Due to Non-Specific Chronic Low Back Pain
Spaulding Rehabilitation Hospital
NCT02954432
Biofreeze® vs. a Placebo on Chronic Low Back Pain Walking Gait Characteristics and Pain
Sport and Spine Rehab Clinical Research Foundation
NCT03888820
Patient Engagement Via Crowdsourcing
RAND
NCT03264521
Safety of Acupuncture Treatments for Chronic Low Back Pain in Older Adults
McLean Center for Complementary and Alternative Medicine
NCT03850717
The Back Pain Consortium Research Program Study
University of Michigan
NCT04870957
Treating Negative Affect in Low Back Pain Patients
Ajay Wasan, MD, Msc
NCT04747314
Aging Back Clinics
VA Office of Research and Development
NCT03564600
Study to Evaluate the Safety and Efficacy of ABT-712 in Subjects With Moderate to Severe Chronic Low Back Pain (CLBP)
AbbVie (prior sponsor, Abbott)
NCT00763321
Manual Therapy and Strengthening for the Hip in Older Adults With Chronic Low Back Pain
University of Delaware
NCT04009837
Chronic Pain Master Protocol (CPMP): A Study of LY3526318 in Participants With Chronic Low Back Pain
Eli Lilly and Company
NCT05086289
Spinal Control During Functional Activities to Improve Low Back Pain Outcomes
Washington University School of Medicine
NCT02027623
Chronic Pain Master Protocol (CPMP): A Study of LY3556050 in Participants With Chronic Low Back Pain
Eli Lilly and Company
NCT04874636
Chiropractic Management of Chronic Lower Back Pain in Older Adults
US Department of Veterans Affairs
NCT00475787
Cooperative Pain Education and Self-management
VA Connecticut Healthcare System
NCT02724930
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 6 |
| Phase 2 | 9 |
| Phase 3 | 1 |
| Phase 4 | 4 |
Top Sponsors
Named interventions
Most-linked intervention names on Chronic Low Back Pain records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Chronic Low Back Pain trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Chronic Low Back Pain page
72 registered trials, 30 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 30 Chronic Low Back Pain trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- VA Office of Research and Development sponsors the most Chronic Low Back Pain trials on record, review their full trial history before evaluating a specific study. See VA Office of Research and Development's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Chronic Low Back Pain condition card totals 72 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.