Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Hodgkin Lymphoma

Open-data reference.

72 US clinical trials · 28 currently recruiting

Active & Recent Trials

RECRUITING 2,000 participants

Evaluating the Impact of Social and Genetic Factors on Outcomes in Adolescent and Young Adult Cancer Survivors

ECOG-ACRIN Cancer Research Group

NCT06002828

RECRUITING Phase 3 1,042 participants

Brentuximab Vedotin in Early Stage Hodgkin Lymphoma

University College, London

NCT04685616

RECRUITING Phase 2 257 participants

Phase II Study of Second- Line Pembrolizumab Plus GVD for Relapsed or Refractory Hodgkin Lymphoma

Memorial Sloan Kettering Cancer Center

NCT03618550

RECRUITING Phase 2 216 participants

CMV-MVA Triplex Vaccination in HLA-Matched Related Stem Cell Donors for the Prevention of CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplant

City of Hope Medical Center

NCT06059391

RECRUITING Phase 2 150 participants

Auto Stem Cell Transplant for Lymphoma Patients

Masonic Cancer Center, University of Minnesota

NCT03125642

RECRUITING NA 140 participants

Lifestyle Intervention of Food and Exercise for Lymphoma Survivors

University of Miami

NCT05839210

RECRUITING Phase 1 110 participants

AZD3470 as Monotherapy and in Combination With Anticancer Agents in Participants With Relapsed/Refractory Haematologic Malignancies.

AstraZeneca

NCT06137144

RECRUITING NA 110 participants

Improving Exercise Capacity With a Tailored Physical Activity Intervention

Wake Forest University Health Sciences

NCT05595577

RECRUITING Phase 2 100 participants

Mozobil for Autologous Hematopoietic Stem Cell Transplantation

Thomas Jefferson University

NCT07188090

RECRUITING Phase 1 90 participants

Constitutive IL7R (C7R) Modified Banked Allogeneic CD30.CAR EBVSTS for CD30-Positive Lymphomas

Baylor College of Medicine

NCT06176690

RECRUITING Phase 2 80 participants

Chemoradiotherapy With Targeted Immunotherapy in Pediatric Lymphoma

New York Medical College

NCT05253495

RECRUITING Phase 1 80 participants

Phase I/II Study of CAR.70- Engineered IL15-transduced Cord Blood-derived NK Cells in Conjunction With Lymphodepleting Chemotherapy for the Management of Relapse/Refractory Hematological Malignances

M.D. Anderson Cancer Center

NCT05092451

RECRUITING Phase 1 79 participants

Safety and Preliminary Efficacy of MT-601 in Patients With Relapsed/Refractory Lymphoma

Marker Therapeutics

NCT05798897

RECRUITING Phase 1 73 participants

A Phase 1 of CTX-8371 in Patients With Advanced Malignancies

Compass Therapeutics

NCT06150664

RECRUITING Phase 2 71 participants

A Study of BV-AVD in People With Bulky Hodgkin Lymphoma

Memorial Sloan Kettering Cancer Center

NCT06377566

RECRUITING Phase 2 63 participants

Two Step Haplo With Radiation Conditioning

Thomas Jefferson University

NCT05031897

RECRUITING Phase 2 60 participants

Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Total-Body Irradiation for the Treatment of Hematological Malignancies

Fred Hutchinson Cancer Center

NCT04195633

RECRUITING Phase 1 54 participants

Tagraxofusp in Pediatric Patients With Relapsed or Refractory CD123 Expressing Hematologic Malignancies

Therapeutic Advances in Childhood Leukemia Consortium

NCT05476770

RECRUITING Phase 1 54 participants

Nivolumab With Ruxolitinib in Relapsed or Refractory Classical Hodgkin Lymphoma

Veronika Bachanova

NCT03681561

RECRUITING Phase 2 49 participants

A Study of Carmustine With and Without Ethanol in Subjects With Lymphoma

VIVUS

NCT06915246

RECRUITING Phase 2 48 participants

BrECADD Therapy in Stage 2 B-IV Hodgkin Lymphoma

University of Miami

NCT07002216

RECRUITING Phase 2 36 participants

A Phase II Trial of Mosunetuzumab, Polatuzumab, Tafasitamab, and Lenalidomide in Patients With Relapsed B-cell NHL

M.D. Anderson Cancer Center

NCT05615636

RECRUITING Phase 1 31 participants

ATLCAR.CD30.CCR4 for CD30+ HL ATLCAR.CD30.CCR4 Cells

UNC Lineberger Comprehensive Cancer Center

NCT06090864

RECRUITING Phase 1 22 participants

Alpha/Beta CD19+ Depleted Haploidentical Transplantation + Zometa for Pediatric Hematologic Malignancies and Solid Tumors

University of Wisconsin, Madison

NCT02508038

RECRUITING Phase 2 20 participants

ABBA CORD: dCBT w/ Abatacept for aGVHD Prophylaxis

Leland Metheny

NCT06680661

RECRUITING Phase 2 20 participants

AlloSCT for Malignant and Non-malignant Hematologic Diseases Utilizing Alpha/Beta T Cell and CD19+ B Cell Depletion

Mitchell Cairo

NCT04099966

RECRUITING Phase 2 9 participants

Evaluating Combination of Nivolumab and Axatilimab in Patients With Relapsed/Refractory Classical Hodgkin Lymphoma

University of Utah

NCT05723055

RECRUITING Early Phase 1 8 participants

Darzalex Faspro (Daratumumab and Hyaluronidase-fihj) Before Standard Desensitization and Allogeneic Peripheral Blood Stem Cell Transplantation in Adult Patients at High-risk for Primary Graft Failure Secondary to Donor Specific Antibodies

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT06398457

ACTIVE NOT RECRUITING 1,564 participants

A Longitudinal Assessment of Frailty in Young Adult Survivors of Childhood Cancer

St. Jude Children's Research Hospital

NCT02256137

ACTIVE NOT RECRUITING Phase 2 503 participants

Methionine PET/CT Studies In Patients With Cancer

St. Jude Children's Research Hospital

NCT00840047

ACTIVE NOT RECRUITING 434 participants

Obstructive Sleep Apnea in Survivors of Hodgkin Lymphoma Treated With Thoracic Radiation

St. Jude Children's Research Hospital

NCT03361020

ACTIVE NOT RECRUITING 350 participants

Cardiovascular Reserve Evaluation in Survivors of Transplant, CREST Study

City of Hope Medical Center

NCT04537871

ACTIVE NOT RECRUITING Phase 2 340 participants

Safety and Efficacy of Pembrolizumab (MK-3475) in Children and Young Adults With Classical Hodgkin Lymphoma (MK-3475-667/KEYNOTE-667)

Merck Sharp & Dohme

NCT03407144

ACTIVE NOT RECRUITING Phase 2 232 participants

Pediatric Classical Hodgkin Lymphoma Consortium Study: cHOD17

St. Jude Children's Research Hospital

NCT03755804

ACTIVE NOT RECRUITING NA 118 participants

Brentuximab Vedotin Combined With AVD Chemotherapy in Patients With Newly Diagnosed Early Stage, Unfavorable Risk Hodgkin Lymphoma

Memorial Sloan Kettering Cancer Center

NCT01868451

ACTIVE NOT RECRUITING Phase 2 102 participants

Multi-antigen CMV-MVA Triplex Vaccine in Reducing CMV Complications in Patients Previously Infected With CMV and Undergoing Donor Hematopoietic Cell Transplant

City of Hope Medical Center

NCT02506933

ACTIVE NOT RECRUITING Phase 2 88 participants

Combination Chemotherapy With or Without Radiation Therapy in Treating Young Patients With Favorable-Risk Hodgkin Lymphoma

St. Jude Children's Research Hospital

NCT00846742

ACTIVE NOT RECRUITING Phase 1 83 participants

A Study of Cobolimab Plus Dostarlimab in Pediatric and Young Adult Participants With Cancer

GlaxoSmithKline

NCT06521567

ACTIVE NOT RECRUITING Phase 1 82 participants

A(B)VD Followed by Nivolumab as Frontline Therapy for Higher Risk Patients With Classical Hodgkin Lymphoma (HL)

Memorial Sloan Kettering Cancer Center

NCT03033914

ACTIVE NOT RECRUITING Phase 2 69 participants

TCRαβ-depleted Progenitor Cell Graft With Additional Memory T-cell DLI, Plus Selected Use of Blinatumomab, in Naive T-cell Depleted Haploidentical Donor Hematopoietc Cell Transplantation for Hematologic Malignancies

St. Jude Children's Research Hospital

NCT03849651

ACTIVE NOT RECRUITING Phase 1 67 participants

Study of the Monoclonal Antibody IMT-009 in Patients With Advanced Solid Tumors or Lymphomas

Immunitas Therapeutics

NCT05565417

ACTIVE NOT RECRUITING NA 44 participants

Use of Transcranial Photobiomodulation to Improve Cognition and Self-Reported Outcomes in Survivors of Childhood Cancer

St. Jude Children's Research Hospital

NCT05550948

ACTIVE NOT RECRUITING Phase 1 36 participants

Administration of TAA-Specific CTLs; Hodgkin or Non-Hodgkin Lymphoma; TACTAL

Baylor College of Medicine

NCT01333046

ACTIVE NOT RECRUITING Phase 1 35 participants

Chemotherapy, Total Body Irradiation, and Post-Transplant Cyclophosphamide in Reducing Rates of Graft Versus Host Disease in Patients With Hematologic Malignancies Undergoing Donor Stem Cell Transplant

Roswell Park Cancer Institute

NCT03192397

ACTIVE NOT RECRUITING NA 35 participants

Integrated Actionable Aging Assessment for Cancer Patients Pilot

University of Colorado, Denver

NCT05871008

ACTIVE NOT RECRUITING Phase 1 34 participants

CMV-MVA Triplex Vaccination of Stem Cell Donors in Preventing CMV Viremia in Participants With Allogeneic Transplant

City of Hope Medical Center

NCT03560752

ACTIVE NOT RECRUITING Phase 1 30 participants

A Clinical Trial of BP1002 in Patients With Advanced Lymphoid Malignancies

Bio-Path Holdings

NCT04072458

ACTIVE NOT RECRUITING NA 30 participants

Radiation Dose Study for Relapsed/Refractory Hodgkin/Non-Hodgkin Lymphoma

University of Chicago

NCT05019976

ACTIVE NOT RECRUITING NA 30 participants

Geriatric Optimization Plan to Improve Survival in Older Adult Allogeneic Hematopoietic Cell Transplant Candidates, OTIS Study

Ohio State University Comprehensive Cancer Center

NCT05972577

ACTIVE NOT RECRUITING Phase 2 25 participants

PET Adapted Brentuximab Vedotin and Pembrolizumab in Combination With Doxorubicin and Dacarbazine in Classic Hodgkin Lymphoma

M.D. Anderson Cancer Center

NCT05922904

ACTIVE NOT RECRUITING Phase 2 22 participants

Pembrolizumab and Involved Site Radiation Therapy for Early Stage Relapsed or Primary Refractory Hodgkin Lymphoma

Memorial Sloan Kettering Cancer Center

NCT03179917

ACTIVE NOT RECRUITING Phase 2 22 participants

Trial Evaluating MGTA-456 in Patients With High-Risk Malignancy

Masonic Cancer Center, University of Minnesota

NCT03674411

ACTIVE NOT RECRUITING Phase 1 18 participants

Tumor Associated Antigen Specific T Cells (TAA-T) With PD1 Inhibitor for Lymphoma

Catherine Bollard

NCT03843294

ACTIVE NOT RECRUITING Phase 1 16 participants

Cytokine-Treated Veto Cells in Treating Patients With Hematologic Malignancies Following Stem Cell Transplant

M.D. Anderson Cancer Center

NCT03622788

ACTIVE NOT RECRUITING Phase 2 13 participants

Ipilimumab With or Without Nivolumab in Relapsed/Refractory cHL

Dana-Farber Cancer Institute

NCT04938232

ACTIVE NOT RECRUITING Phase 2 8 participants

Study of Magrolimab and Pembrolizumab in Relapsed or Refractory Classic Hodgkin Lymphoma

Stanford University

NCT04788043

ACTIVE NOT RECRUITING Phase 2 7 participants

Triplex Vaccine in Preventing CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplantation

City of Hope Medical Center

NCT04060277

COMPLETED 1,340 participants

Genome Expression in Lymphoma, Leukemia and Multiple Myeloma

National Cancer Institute (NCI)

NCT00339963

COMPLETED Phase 1 320 participants

An Investigational Immuno-Therapy Study to Determine the Safety and Effectiveness of Nivolumab and Daratumumab in Patients With Multiple Myeloma

Bristol-Myers Squibb

NCT01592370

COMPLETED Phase 2 203 participants

A Study of Coformulated Favezelimab/Pembrolizumab (MK-4280A) Versus Physician's Choice Chemotherapy in PD-(L)1-refractory, Relapsed or Refractory Classical Hodgkin Lymphoma (MK-4280A-008)

Merck Sharp & Dohme

NCT05508867

COMPLETED Phase 2 82 participants

Pembrolizumab After ASCT for Hodgkin Lymphoma, DLBCL and T-NHL

Dana-Farber Cancer Institute

NCT02362997

COMPLETED Phase 1 57 participants

Pralatrexate + Romidepsin in Relapsed/Refractory Lymphoid Malignancies

Jennifer Amengual

NCT01947140

COMPLETED Phase 2 40 participants

Brentuximab for Newly Diagnosed Hodgkin Disease

Mitchell Cairo

NCT02398240

COMPLETED NA 40 participants

Effects of Prebiotics on Gut Microbiome in Patients Undergoing HSCT

University of Virginia

NCT04629430

COMPLETED Phase 2 34 participants

Brentuximab Vedotin Plus AD in Non-bulky Limited Stage Hodgkin Lymphoma

Massachusetts General Hospital

NCT02505269

COMPLETED Early Phase 1 30 participants

Pilot Study of Non-Myeloablative, HLA-Matched Allogeneic Stem Cell Transplantation for Pediatric Hematopoietic Malignancies

National Cancer Institute (NCI)

NCT00013533

COMPLETED Phase 1 28 participants

A Study to Assess AFM13 in Patients With Hodgkin Lymphoma

Affimed

NCT01221571

COMPLETED Phase 1 23 participants

Safety Study of XmAb®2513 to Treat Hodgkin Lymphoma or Anaplastic Large Cell Lymphoma

Xencor

NCT00606645

COMPLETED Phase 2 22 participants

Total Body Irradiation +/- Total Lymphoid Irradiation & Anti-Thymocyte Globulin in Non-myeloablative Hematopoietic Cell Transplantation

Stanford University

NCT03734601

COMPLETED Phase 2 18 participants

CD8+ Memory T-Cells as Consolidative Therapy After Donor Non-myeloablative Hematopoietic Cell Transplant in Treating Patients With Leukemia or Lymphoma

Robert Lowsky

NCT02424968

COMPLETED Phase 1 14 participants

Duvelisib in Combination With BMS-986345 in Lymphoid Malignancy

H. Lee Moffitt Cancer Center and Research Institute

NCT05065866

COMPLETED Phase 1 14 participants

Targeted Marrow Irradiation, Fludarabine Phosphate, and Busulfan Before Donor Progenitor Cell Transplant in Treating Patients With Hematologic Malignancies

Case Comprehensive Cancer Center

NCT02129582

Phase Distribution

PhaseTrial count
Early Phase 1 26
Phase 2 32
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Hodgkin Lymphoma Trial Landscape

ClinicalTrials.gov lists 72 US studies indexed under Hodgkin Lymphoma, and 28 of those are currently open to recruitment — roughly 39% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Hodgkin Lymphoma shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 58 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Hodgkin Lymphoma is led by St. Jude Children's Research Hospital with 7 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 72 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Hodgkin Lymphoma?

PlainTrial tracks 72 US clinical trials for Hodgkin Lymphoma, of which 28 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Hodgkin Lymphoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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