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Alzheimer Disease clinical trials
155 of 312 indexed Alzheimer Disease trials are currently recruiting.
312 US clinical trials · 155 currently recruiting
Alzheimer Disease is the subject of 312 registered US clinical trials on ClinicalTrials.gov, 155 of them currently open to new participants. 26 are in Phase 3-4 (later-stage) and 104 in Phase 1-2 (earlier-stage). The most active sponsor is Eli Lilly and Company, running 13 of these trials.
The research picture
Alzheimer Disease has 312 registered US clinical trials, 155 of them open to new participants right now, about 50% of the total.
- 155
- recruiting participants now
- 50%
- of trials open to enrollment
- 26
- in Phase 3–4 (later-stage)
- 13
- top sponsor: Eli Lilly and Company
Active & Recent Trials
312 total, page 2 of 7
Cognitive Vulnerability to Stress in Individuals at Risk for Alzheimer's Disease
Johns Hopkins University
NCT05795634
Cardiac-Control Affecting Learning Through Mindfulness (CALM)
University of Southern California
NCT06410157
Swallowing Impairments in Adults With and Without Alzheimer's Disease
Vanderbilt University Medical Center
NCT06678100
Visualizing Brain Proteinopathies Using [F-18]Flornaptitril-PET in the Prediction of Clinical Progression of Mild Cognitive Impairment With Either Suspected Chronic Traumatic Encephalopathy or Alzheimer's Disease
CereMark Pharma
NCT06254469
A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses
Arizona State University
NCT05877196
Improving Memory in Alzheimer's Disease With Noninvasive Brain Stimulation
Boston University Charles River Campus
NCT06094192
DORA and LP in Alzheimer's Disease Biomarkers
Washington University School of Medicine
NCT06274528
Effect of LEQEMBI on Cerebral and Retinal Amyloid in Mild Cognitive Impairment Due to Alzheimer's Disease
NeuroVision Imaging
NCT06400368
Sleep Trial to Prevent Alzheimer's Disease
Washington University School of Medicine
NCT04629547
Learning Skills Together Family Caregiver Complex Intervention
Case Western Reserve University
NCT05846984
Gamma Light and Sound Stimulation to Prevent Dementia in Cognitively Normal People At Risk for Alzheimer's Disease
Massachusetts General Hospital
NCT05776641
[18F]PI-2620 Phase 3 Histopathological Study
Life Molecular Imaging
NCT05641688
The Role of the Locus Coeruleus in Age-related Distractibility
Virginia Polytechnic Institute and State University
NCT05574634
Paper-Based and Smartphone-Based Memory Supports
Baylor University
NCT06444841
I-CARE 2: Mobile Telehealth to Reduce Alzheimer'S-related Symptoms
Indiana University
NCT05733520
Clinical Trial on Agitation in Alzheimer's Dementia
IGC Pharma
NCT05543681
UAB Alzheimer's Disease Center Core Cohort - Imaging Substudy
University of Alabama at Birmingham
NCT03503331
UAB Alzheimer's Disease Center Core Cohort - Tau Imaging Substudy
University of Alabama at Birmingham
NCT03809351
Nighttime Agitation and Restless Legs Syndrome in People With Alzheimer's Disease
University of Texas at Austin
NCT03082755
Sleep Disturbance and Emotion Regulation Brain Dysfunction as Mechanisms of Neuropsychiatric Symptoms in Alzheimer's Dementia
Stanford University
NCT04100057
The Locus Coeruleus, Norepinephrine and Cognitive Aging
Cornell University
NCT06880510
Early Age-Related Hearing Loss Investigation (EARHLI)
Columbia University
NCT06174038
Non-invasive Brain Stimulation for Cognitive and Motor Dysfunction in Dementia
Hebrew SeniorLife
NCT05661084
Sleep Healthy Using the Internet Mitigating Insomnia to Address Neurocognitive Difficulties (SHUTi MIND)
University of Virginia
NCT05565833
Dementia Care Partner Hospital Assessment Tool
University of Wisconsin, Madison
NCT05592366
A Study of LY4006895 in Healthy Participants With Early Symptomatic Alzheimer's Disease (AD)
Eli Lilly and Company
NCT06657768
Olfactory Biopsies
Duke University
NCT07021040
Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986368, for the Treatment of Agitation in Participants With Alzheimer's Disease
Celgene
NCT06808984
LEADing Dementia End-of-Life Planning Conversations
University of Utah
NCT05909189
Brain Energy for Amyloid Transformation in Alzheimer's Disease Study
Wake Forest University Health Sciences
NCT03472664
Improving PCP Advance Care Planning for People With ADRD
University of Pittsburgh
NCT06565169
Educational Support Group Program for Bilingual and Spanish-speaking Carepartners and People With Progressive Aphasia
University of Texas at Austin
NCT06511752
The BRAIN App (Phase 2 SBIR)
Hopeful Aging
NCT06298474
Autoimmune Features of Neurodegenerative Disorders
Columbia University
NCT04239079
Repurposing Siponimod for Alzheimer's Disease
St. Joseph's Hospital and Medical Center, Phoenix
NCT06639282
Gut Microbiome and Blood Indices in Patients With AD and Their Spousal Caregivers
University of Virginia
NCT05601856
First-in-Human Evaluation of an Astrocytic Glutamate Transporter (EAAT2) PET Tracer in Dementia
David Wilson
NCT05374278
Longitudinal Imaging of Microglial Activation in Different Clinical Variants of Alzheimer's Disease
Patrick Lao
NCT04576793
Vestibular Therapy in Alzheimer's Disease
Johns Hopkins University
NCT03799991
Studies of Brain and Body Interaction
Rutgers University
NCT03672266
Tau Networks in Psychotic Alzheimer's Disease
Northwell Health
NCT05847192
A Study of Neurodegeneration and Neuronal Fluctuations in Lewy Body Disease and Alzheimer's Disease
Mayo Clinic
NCT06057909
Apolipoprotein E (APOE) Genotype Effects on Triglycerides and Blood Flow in the Human Brain
University of Washington
NCT04692441
Treating Hyperexcitability in AD With Levetiracetam
Beth Israel Deaconess Medical Center
NCT03875638
Brain Outcomes With Lifestyle Change in Down Syndrome
University of Kansas Medical Center
NCT05985486
Investigation of Inflammation in Alzheimer's Disease and Related Dementias (ADRD) Using [11C]-CS1P1
Washington University School of Medicine
NCT06129838
Inspiring Seniors Towards Exercise Promotion to Protect Cognition
Emory University
NCT06496425
A Phase Ia/Ib, First-in-human (FIH) Study for Safety, Tolerability, Pharmacokinetics (PK), and Clinical Activity Evaluation of ADEL-Y01
Alzheimer's Disease Expert Lab (ADEL)
NCT06247345
PET Imaging Tau Accumulation in FTLD and Atypical Alzheimer's Using [18F]-PI-2620
University of Pennsylvania
NCT05456503
Early-Stage Partner in Care Living Alone Plus
Arizona State University
NCT06962111
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 53 |
| Phase 2 | 51 |
| Phase 3 | 18 |
| Phase 4 | 8 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Alzheimer Disease Trial Landscape
312 indexed Alzheimer Disease studies · 155 recruiting (50%).
Phase mix: 26 late (III/IV) vs 104 early (I/II).
Top sponsor: Eli Lilly and Company (13 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Alzheimer Disease?
PlainTrial tracks 312 US clinical trials for Alzheimer Disease, of which 155 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Alzheimer Disease?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.