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Alzheimer Disease clinical trials
155 of 312 indexed Alzheimer Disease trials are currently recruiting.
312 US clinical trials · 155 currently recruiting
Alzheimer Disease is the subject of 312 registered US clinical trials on ClinicalTrials.gov, 155 of them currently open to new participants. 26 are in Phase 3-4 (later-stage) and 104 in Phase 1-2 (earlier-stage). The most active sponsor is Eli Lilly and Company, running 13 of these trials.
The research picture
Alzheimer Disease has 312 registered US clinical trials, 155 of them open to new participants right now, about 50% of the total.
- 155
- recruiting participants now
- 50%
- of trials open to enrollment
- 26
- in Phase 3–4 (later-stage)
- 13
- top sponsor: Eli Lilly and Company
Active & Recent Trials
312 total, page 3 of 7
Individual Closed-Loop Neuromodulation Therapy for Alzheimer's Disease
Massachusetts General Hospital
NCT05904132
Promoting Independence With Compensatory Cognitive Rehabilitation
University of Delaware
NCT04820335
Comparing Structured Retrieval Practice and Reading-Based Education for Dementia Caregivers
Virginia Wesleyan University
NCT07413406
Beta Amyloid PET Imaging for Alzheimer Disease With [18F]-Fluselenamyl
Washington University School of Medicine
NCT06439992
Gamma-Music Based Intervention for Mild Alzheimer's Disease
Northeastern University
NCT05984524
I-CARE Rural Pilot: Intervention for Rural-Dwelling Dementia Caregivers
Richard Holden
NCT07054385
TREAD: Time Restricted Eating Intervention for Alzheimer's Disease
University of California, San Diego
NCT06548191
Music Therapy for Patients With Alzheimer's Disease
Johns Hopkins University
NCT05151562
Aβ Dynamics in LLMD
NYU Langone Health
NCT05004987
Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia
University of Texas at Austin
NCT05741853
Senicapoc in Alzheimer's Disease
University of California, Davis
NCT04804241
Deep Repetitive Transcranial Magnetic Stimulation (rTMS) of the Precuneus for Alzheimer Disease (AD)
University of California, Los Angeles
NCT06597942
Glutathione, Brain Metabolism and Inflammation in Alzheimer's Disease
Baylor College of Medicine
NCT04740580
Trial of CORT108297 to Attenuate the Effects of Acute Stress in the Allocortex (CORT-X)
Johns Hopkins University
NCT04601038
Chronic Treatment of Alzheimer's Disease by Gamma Light and Sound Therapy
Massachusetts Institute of Technology
NCT05655195
ExAblate Blood-Brain Barrier (BBB) Disruption for the Treatment of Alzheimer's Disease
InSightec
NCT03671889
MR Evaluation of Cerebrospinal Fluid (CSF) Dynamics
Mayo Clinic
NCT04099823
A First-In-Human Study of LY3954068 in Participants With Early Symptomatic Alzheimer's Disease
Eli Lilly and Company
NCT06297590
Phase II Trial to Evaluate Safety and Efficacy of GM-CSF/Sargramostim in Alzheimer's Disease
University of Colorado, Denver
NCT04902703
Systemic and Central Inflammation in AD
The Methodist Hospital Research Institute
NCT06384378
Pulsed Electromagnetic Field Treatment In Patients With Alzheimer's Disease
Herrick Medical
NCT05295615
A Feasiblity Study of Green Activity Program for People Living With Memory Challenges
Indiana University
NCT06403345
DECIDE: Dyads and Families
Emory University
NCT05139290
Phase II Clinical Trial of Interleukin-2 in AD
The Methodist Hospital Research Institute
NCT06096090
Rapamycin - Effects on Alzheimer's and Cognitive Health
The University of Texas Health Science Center at San Antonio
NCT04629495
Health Behavior Change in Midlife Adults at Risk for Alzheimer's Disease
Rhode Island Hospital
NCT05599425
Passive Sensor Identification of Digital Biomarkers to Assess Effects of Orally Administered Nicotinamide Riboside
Mclean Hospital
NCT05245903
Bumetanide in Patients With Alzheimer's Disease
Stanford University
NCT06052163
I-CARE 2: Mobile Telehealth to Reduce Alzheimer'S-related Symptoms in Hispanic Individuals
Indiana University
NCT06099197
R21 Roche: 3-Way Tau Tracers in AD
Washington University School of Medicine
NCT05464368
An Objective Assessment Tool for Evaluating Functioning in Older Adults
Stanford University
NCT06489847
Nicotinic Acid for the Treatment of Alzheimer's Disease
Indiana University
NCT06582706
Assess Fibrin in Brains With AD/ADRD
Massachusetts General Hospital
NCT05336695
Perturbation Training Reduces Falls in People With Alzheimer's Disease (AD)
Georgia State University
NCT05205980
Combating Alzheimer's Through Sleep and Exercise
University of Miami
NCT04855630
Clinical Trial Protocol: Alzheimer's Dementia Underlying Encephalopathy
Covenant Health, US
NCT07222280
Improving Access to Care for Veterans With Memory Loss
VA Pittsburgh Healthcare System
NCT07117162
Open-Label Extension Protocol to SNK01-AD01 Study
NKGen Biotech
NCT07228078
Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease
Massachusetts General Hospital
NCT06538311
Indian Transforming Alzheimer's Care Training (INTACT)
Washington State University
NCT06397339
A Study of AMDX-2011P in Participants With Alzheimer's Disease
Amydis
NCT06514001
Advancing Alzheimer's Care: Home-based tDCS for Affective Symptoms
The University of Texas Health Science Center at San Antonio
NCT06801639
Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's Disease
Johns Hopkins University
NCT04123314
Neuroinflammation Imaging in AD
University of Pennsylvania
NCT04274998
Sensory-Evoked Cortical Gamma Oscillation
University of Tennessee Medical Center
NCT05206305
Novel Brain Stimulation Treatment for Neuropsychiatric Symptoms in Alzheimer's Disease
Baylor College of Medicine
NCT06835283
ALA-enriched Nutrition for Prevention of Cognitive Decline in APOE4 Older Adults
Michal Schnaider Beeri, Ph.D.
NCT07392723
OCT Angiography and NRAI in Dementia
Oregon Health and Science University
NCT03761381
Autologous Activated Adipose-derived Stem Cells (RB-ADSC) Injected Directly Into the Brain for Mild to Moderate Alzheimer's Disease
Regeneration Biomedical
NCT05667649
Low-Intensity Focused Ultrasound (LIFU) Neuromodulation
Ali Rezai
NCT05997030
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 53 |
| Phase 2 | 51 |
| Phase 3 | 18 |
| Phase 4 | 8 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Alzheimer Disease Trial Landscape
312 indexed Alzheimer Disease studies · 155 recruiting (50%).
Phase mix: 26 late (III/IV) vs 104 early (I/II).
Top sponsor: Eli Lilly and Company (13 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Alzheimer Disease?
PlainTrial tracks 312 US clinical trials for Alzheimer Disease, of which 155 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Alzheimer Disease?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.