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ClinicalTrials.gov 155 recruiting now official registry

Alzheimer Disease clinical trials

155 of 312 indexed Alzheimer Disease trials are currently recruiting.

312 US clinical trials · 155 currently recruiting

Alzheimer Disease is the subject of 312 registered US clinical trials on ClinicalTrials.gov, 155 of them currently open to new participants. 26 are in Phase 3-4 (later-stage) and 104 in Phase 1-2 (earlier-stage). The most active sponsor is Eli Lilly and Company, running 13 of these trials.

The research picture

Alzheimer Disease has 312 registered US clinical trials, 155 of them open to new participants right now, about 50% of the total.

155
recruiting participants now
50%
of trials open to enrollment
26
in Phase 3–4 (later-stage)
13
top sponsor: Eli Lilly and Company
Phase 153Phase 251Phase 318Phase 48

Active & Recent Trials

312 total, page 3 of 7

RECRUITING NA 70 participants

Individual Closed-Loop Neuromodulation Therapy for Alzheimer's Disease

Massachusetts General Hospital

NCT05904132

RECRUITING NA 65 participants

Promoting Independence With Compensatory Cognitive Rehabilitation

University of Delaware

NCT04820335

RECRUITING NA 65 participants

Comparing Structured Retrieval Practice and Reading-Based Education for Dementia Caregivers

Virginia Wesleyan University

NCT07413406

RECRUITING 60 participants

Beta Amyloid PET Imaging for Alzheimer Disease With [18F]-Fluselenamyl

Washington University School of Medicine

NCT06439992

RECRUITING NA 60 participants

Gamma-Music Based Intervention for Mild Alzheimer's Disease

Northeastern University

NCT05984524

RECRUITING NA 60 participants

I-CARE Rural Pilot: Intervention for Rural-Dwelling Dementia Caregivers

Richard Holden

NCT07054385

RECRUITING Phase 1 60 participants

TREAD: Time Restricted Eating Intervention for Alzheimer's Disease

University of California, San Diego

NCT06548191

RECRUITING NA 60 participants

Music Therapy for Patients With Alzheimer's Disease

Johns Hopkins University

NCT05151562

RECRUITING Phase 4 60 participants

Aβ Dynamics in LLMD

NYU Langone Health

NCT05004987

RECRUITING NA 60 participants

Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia

University of Texas at Austin

NCT05741853

RECRUITING Phase 2 55 participants

Senicapoc in Alzheimer's Disease

University of California, Davis

NCT04804241

RECRUITING Phase 1 54 participants

Deep Repetitive Transcranial Magnetic Stimulation (rTMS) of the Precuneus for Alzheimer Disease (AD)

University of California, Los Angeles

NCT06597942

RECRUITING Early Phase 1 52 participants

Glutathione, Brain Metabolism and Inflammation in Alzheimer's Disease

Baylor College of Medicine

NCT04740580

RECRUITING Phase 2 52 participants

Trial of CORT108297 to Attenuate the Effects of Acute Stress in the Allocortex (CORT-X)

Johns Hopkins University

NCT04601038

RECRUITING NA 50 participants

Chronic Treatment of Alzheimer's Disease by Gamma Light and Sound Therapy

Massachusetts Institute of Technology

NCT05655195

RECRUITING NA 50 participants

ExAblate Blood-Brain Barrier (BBB) Disruption for the Treatment of Alzheimer's Disease

InSightec

NCT03671889

RECRUITING NA 50 participants

MR Evaluation of Cerebrospinal Fluid (CSF) Dynamics

Mayo Clinic

NCT04099823

RECRUITING Phase 1 48 participants

A First-In-Human Study of LY3954068 in Participants With Early Symptomatic Alzheimer's Disease

Eli Lilly and Company

NCT06297590

RECRUITING Phase 2 42 participants

Phase II Trial to Evaluate Safety and Efficacy of GM-CSF/Sargramostim in Alzheimer's Disease

University of Colorado, Denver

NCT04902703

RECRUITING Phase 2 40 participants

Systemic and Central Inflammation in AD

The Methodist Hospital Research Institute

NCT06384378

RECRUITING NA 40 participants

Pulsed Electromagnetic Field Treatment In Patients With Alzheimer's Disease

Herrick Medical

NCT05295615

RECRUITING NA 40 participants

A Feasiblity Study of Green Activity Program for People Living With Memory Challenges

Indiana University

NCT06403345

RECRUITING NA 40 participants

DECIDE: Dyads and Families

Emory University

NCT05139290

RECRUITING Phase 2 40 participants

Phase II Clinical Trial of Interleukin-2 in AD

The Methodist Hospital Research Institute

NCT06096090

RECRUITING Phase 2 40 participants

Rapamycin - Effects on Alzheimer's and Cognitive Health

The University of Texas Health Science Center at San Antonio

NCT04629495

RECRUITING NA 40 participants

Health Behavior Change in Midlife Adults at Risk for Alzheimer's Disease

Rhode Island Hospital

NCT05599425

RECRUITING 40 participants

Passive Sensor Identification of Digital Biomarkers to Assess Effects of Orally Administered Nicotinamide Riboside

Mclean Hospital

NCT05245903

RECRUITING Phase 2 40 participants

Bumetanide in Patients With Alzheimer's Disease

Stanford University

NCT06052163

RECRUITING NA 40 participants

I-CARE 2: Mobile Telehealth to Reduce Alzheimer'S-related Symptoms in Hispanic Individuals

Indiana University

NCT06099197

RECRUITING Phase 1 38 participants

R21 Roche: 3-Way Tau Tracers in AD

Washington University School of Medicine

NCT05464368

RECRUITING 30 participants

An Objective Assessment Tool for Evaluating Functioning in Older Adults

Stanford University

NCT06489847

RECRUITING Phase 1 30 participants

Nicotinic Acid for the Treatment of Alzheimer's Disease

Indiana University

NCT06582706

RECRUITING Phase 1 30 participants

Assess Fibrin in Brains With AD/ADRD

Massachusetts General Hospital

NCT05336695

RECRUITING NA 30 participants

Perturbation Training Reduces Falls in People With Alzheimer's Disease (AD)

Georgia State University

NCT05205980

RECRUITING NA 30 participants

Combating Alzheimer's Through Sleep and Exercise

University of Miami

NCT04855630

RECRUITING NA 30 participants

Clinical Trial Protocol: Alzheimer's Dementia Underlying Encephalopathy

Covenant Health, US

NCT07222280

RECRUITING NA 30 participants

Improving Access to Care for Veterans With Memory Loss

VA Pittsburgh Healthcare System

NCT07117162

RECRUITING Phase 2 30 participants

Open-Label Extension Protocol to SNK01-AD01 Study

NKGen Biotech

NCT07228078

RECRUITING Early Phase 1 30 participants

Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease

Massachusetts General Hospital

NCT06538311

RECRUITING NA 28 participants

Indian Transforming Alzheimer's Care Training (INTACT)

Washington State University

NCT06397339

RECRUITING Phase 2 25 participants

A Study of AMDX-2011P in Participants With Alzheimer's Disease

Amydis

NCT06514001

RECRUITING NA 24 participants

Advancing Alzheimer's Care: Home-based tDCS for Affective Symptoms

The University of Texas Health Science Center at San Antonio

NCT06801639

RECRUITING Early Phase 1 20 participants

Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's Disease

Johns Hopkins University

NCT04123314

RECRUITING Early Phase 1 20 participants

Neuroinflammation Imaging in AD

University of Pennsylvania

NCT04274998

RECRUITING NA 20 participants

Sensory-Evoked Cortical Gamma Oscillation

University of Tennessee Medical Center

NCT05206305

RECRUITING NA 20 participants

Novel Brain Stimulation Treatment for Neuropsychiatric Symptoms in Alzheimer's Disease

Baylor College of Medicine

NCT06835283

RECRUITING Phase 2 20 participants

ALA-enriched Nutrition for Prevention of Cognitive Decline in APOE4 Older Adults

Michal Schnaider Beeri, Ph.D.

NCT07392723

RECRUITING 20 participants

OCT Angiography and NRAI in Dementia

Oregon Health and Science University

NCT03761381

RECRUITING Phase 1 18 participants

Autologous Activated Adipose-derived Stem Cells (RB-ADSC) Injected Directly Into the Brain for Mild to Moderate Alzheimer's Disease

Regeneration Biomedical

NCT05667649

RECRUITING NA 15 participants

Low-Intensity Focused Ultrasound (LIFU) Neuromodulation

Ali Rezai

NCT05997030

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Phase Distribution

PhaseTrial count
Phase 1 53
Phase 2 51
Phase 3 18
Phase 4 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Alzheimer Disease Trial Landscape

312 indexed Alzheimer Disease studies · 155 recruiting (50%).

Phase mix: 26 late (III/IV) vs 104 early (I/II).

Top sponsor: Eli Lilly and Company (13 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Alzheimer Disease?

PlainTrial tracks 312 US clinical trials for Alzheimer Disease, of which 155 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Alzheimer Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.