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NCT06678100 · ClinicalTrials.gov registry record
Swallowing Impairments in Adults With and Without Alzheimer's Disease
A clinical trial of Alzheimer Disease and Caregiver Burden, sponsored by Vanderbilt University Medical Center.
- Recruiting
- Registry status
- 240
- Enrollment target
- 1
- Study location
NCT06678100: Recruiting study of Alzheimer Disease and Caregiver Burden, sponsored by Vanderbilt University Medical Center.
NCT06678100 is a study of Alzheimer Disease and Caregiver Burden that is actively recruiting participants, run by Vanderbilt University Medical Center. The registered enrollment target is 240 participants, below the 2,750-participant average among 306 other Alzheimer Disease trials with a reported enrollment target (91% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06678100, a study of Alzheimer Disease and Caregiver Burden, is actively recruiting participants, sponsored by Vanderbilt University Medical Center.
- RECRUITING
- Registry status
- 240 participants
- Enrollment target
- 1
- Study location
Study Summary
This research study is investigating whether people with Alzheimer's disease (AD) experience more changes to swallowing than their healthy age-matched peers. The prevalence of swallowing impairments in moderate-severe AD is high (85-93%), yet little is known about how swallow function evolves throughout the disease course in people with AD. The overall objective of this study is to evaluate swallowing function in adults with and without Alzheimer's disease. The investigator will also be involving the primary caregivers of individuals with Alzheimer's that are enrolled in the study to better understand the impact of swallowing impairments on the primary caregivers of those with Alzheimer's Disease. Healthy adults and individuals with Alzheimer's disease will: * undergo tests of cough and swallow function * undergo tests of grip and tongue strength * complete questionnaires Caregivers of individuals with Alzheimer's disease will also complete questionnaires.
Primary Outcome
The penetration aspiration scale is a validated 8-point ordinal rating scale that measures the depth of airway invasion and the patient's response during swallowing. Scores range from 1 to 8 with a score of 1 indicating a safe swallow (best score) and 8 indicating silent aspiration (worst score).
Conditions Studied
Study Locations (1)
Tennessee
- Vanderbilt University Medical Center - Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 240 participants |
| Start Date | 2025-04-21 |
| Est. Completion | 2028-02 |
What NCT06678100 shows while recruiting
NCT06678100 is an observational study that tracks outcomes without assigning an intervention. The registered 240 participants enrollment target is mid-sized for trials with a published cap, below the 2,750-participant average among 306 other Alzheimer Disease trials with a reported enrollment target (91% lower).
The record links to 4 conditions, with Alzheimer Disease appearing as the primary indexed condition, and to 0 interventions.
NCT06678100 reports a single indexed study location in Tennessee.
Frequently Asked Questions
What is clinical trial NCT06678100 about?
NCT06678100 is a clinical study titled "Swallowing Impairments in Adults With and Without Alzheimer's Disease". This research study is investigating whether people with Alzheimer's disease (AD) experience more changes to swallowing than their healthy age-matched peers. The prevalence of swallowing impairments in moderate-severe AD is high (85-93%), yet little is known about how swallow function evolves throug...
What is the current status of trial NCT06678100?
This trial is currently recruiting. The enrollment target is 240 participants. The study started on 2025-04-21. Estimated completion is 2028-02.
What conditions does trial NCT06678100 study?
This clinical trial studies the following conditions: Alzheimer Disease, Caregiver Burden, Healthy Aging, Dysphagia.
Who is sponsoring clinical trial NCT06678100?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06678100 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Alzheimer Disease
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06678100's enrollment target sits among peer trials
240 94th of 306 higher than 209 of 306 other Alzheimer Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Alzheimer Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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