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NCT06410157 · ClinicalTrials.gov registry record · NA
Cardiac-Control Affecting Learning Through Mindfulness (CALM)
A NA study of Alzheimer Disease and Age-related Cognitive Decline, sponsored by University of Southern California.
- Recruiting
- Registry status
- NA
- Development phase
- 240
- Enrollment target
- 1
- Study location
NCT06410157: Recruiting NA study of Alzheimer Disease and Age-related Cognitive Decline, sponsored by University of Southern California.
NCT06410157 is a NA study of Alzheimer Disease and Age-related Cognitive Decline that is actively recruiting participants, run by University of Southern California. The registered enrollment target is 240 participants, below the 2,750-participant average among 306 other Alzheimer Disease trials with a reported enrollment target (91% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06410157, a NA study of Alzheimer Disease and Age-related Cognitive Decline, is actively recruiting participants, sponsored by University of Southern California.
- RECRUITING
- Registry status
- NA
- Development phase
- 240 participants
- Enrollment target
- 1
- Study location
Study Summary
Some types of meditation lead heart rate to become more steady as breathing quiets whereas others lead to large heart rate swings up and down (oscillations) as breathing becomes deeper and slower. The current study is designed to investigate how daily mindfulness practice with heart rate biofeedback during breathing in a pattern that either increases or decreases heart rate oscillation affect attention and memory and blood biomarkers associated with Alzheimer's disease.
Primary Outcome
Plasma Ab42 levels will be compared for Week 1 (pre-intervention) and Week 10 (post-intervention). Investigators will test for a time X condition interaction in plasma Ab 42 levels (to assess group differences in change).
Conditions Studied
Interventions
- BEHAVIORAL Daily practice
Study Locations (1)
California
- University of Southern California - Los Angeles
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 240 participants |
| Start Date | 2025-01-14 |
| Est. Completion | 2027-11 |
| Phase | NA |
What NCT06410157 shows while recruiting
NCT06410157 is an interventional study that assigns participants to a tested intervention. The registered 240 participants enrollment target is mid-sized for trials with a published cap, below the 2,750-participant average among 306 other Alzheimer Disease trials with a reported enrollment target (91% lower).
The record links to 2 conditions, with Alzheimer Disease appearing as the primary indexed condition, and to 1 intervention - of which Daily practice is the first listed.
NCT06410157 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT06410157 about?
NCT06410157 is a clinical study titled "Cardiac-Control Affecting Learning Through Mindfulness (CALM)". Some types of meditation lead heart rate to become more steady as breathing quiets whereas others lead to large heart rate swings up and down (oscillations) as breathing becomes deeper and slower. The current study is designed to investigate how daily mindfulness practice with heart rate biofeedback...
What is the current status of trial NCT06410157?
This trial is currently recruiting. It is a NA study. The enrollment target is 240 participants. The study started on 2025-01-14. Estimated completion is 2027-11.
What conditions does trial NCT06410157 study?
This clinical trial studies the following conditions: Alzheimer Disease, Age-related Cognitive Decline.
What interventions are being tested in trial NCT06410157?
The interventions under investigation include: Daily practice (BEHAVIORAL).
Who is sponsoring clinical trial NCT06410157?
This trial is sponsored by University of Southern California, which has 617 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06410157 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Alzheimer Disease
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06410157's enrollment target sits among peer trials
240 94th of 306 higher than 209 of 306 other Alzheimer Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Alzheimer Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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