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NCT06880510 · ClinicalTrials.gov registry record · NA
The Locus Coeruleus, Norepinephrine and Cognitive Aging
A NA study of Alzheimer Disease, sponsored by Cornell University.
- Recruiting
- Registry status
- NA
- Development phase
- 150
- Enrollment target
- 1
- Study location
NCT06880510: Recruiting NA study of Alzheimer Disease, sponsored by Cornell University.
NCT06880510 is a NA study of Alzheimer Disease that is actively recruiting participants, run by Cornell University. The registered enrollment target is 150 participants, below the 2,750-participant average among 306 other Alzheimer Disease trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06880510, a NA study of Alzheimer Disease, is actively recruiting participants, sponsored by Cornell University.
- RECRUITING
- Registry status
- NA
- Development phase
- 150 participants
- Enrollment target
- 1
- Study location
Study Summary
The locus coeruleus (LC) has recently been identified as one of the earliest sites of damage in AD with pathological lesions appearing as early as the mid-20s. In this study, the investigators use a variety of techniques including structural MRI, functional MRI, pupillometry, and transcutaneous vagus nerve stimulation to assess the health of the LC and its relation to easily measurable peripheral variables.
Primary Outcome
The investigators will continuously monitor tonic pupillary size to determine whether it is affected by taVNS. To do so, the investigators will use a EyeLink 1000+ eyetracker and measure pupil diameter continuously throughout the completion of computer-based cognitive tasks, such as an Oddball task, Attentional Boost Effect task, Proactive Interference task, or Tone Gap task. Tonic pupil size are measured with custom software, and pupil size is reported in mm.
Conditions Studied
Interventions
- DEVICE t-VNS transcutaneous auricular vagus nerve stimulator
Study Locations (1)
New York
- Cornell University - Ithaca
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 150 participants |
| Start Date | 2025-06-01 |
| Est. Completion | 2026-07-01 |
| Phase | NA |
What NCT06880510 shows while recruiting
NCT06880510 is an interventional study that assigns participants to a tested intervention. The registered 150 participants enrollment target is mid-sized for trials with a published cap, below the 2,750-participant average among 306 other Alzheimer Disease trials with a reported enrollment target (95% lower).
The record links to 1 condition, with Alzheimer Disease appearing as the primary indexed condition, and to 1 intervention - of which t-VNS transcutaneous auricular vagus nerve stimulator is the first listed.
NCT06880510 reports a single indexed study location in New York.
Frequently Asked Questions
What is clinical trial NCT06880510 about?
NCT06880510 is a clinical study titled "The Locus Coeruleus, Norepinephrine and Cognitive Aging". The locus coeruleus (LC) has recently been identified as one of the earliest sites of damage in AD with pathological lesions appearing as early as the mid-20s. In this study, the investigators use a variety of techniques including structural MRI, functional MRI, pupillometry, and transcutaneous vagu...
What is the current status of trial NCT06880510?
This trial is currently recruiting. It is a NA study. The enrollment target is 150 participants. The study started on 2025-06-01. Estimated completion is 2026-07-01.
What conditions does trial NCT06880510 study?
This clinical trial studies the following conditions: Alzheimer Disease.
What interventions are being tested in trial NCT06880510?
The interventions under investigation include: t-VNS transcutaneous auricular vagus nerve stimulator (DEVICE).
Who is sponsoring clinical trial NCT06880510?
This trial is sponsored by Cornell University, which has 66 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06880510 being conducted?
This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Alzheimer Disease
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06880510's enrollment target sits among peer trials
150 129th of 306 higher than 176 of 306 other Alzheimer Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Alzheimer Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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