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NCT03809351 · ClinicalTrials.gov registry record · Phase 1
UAB Alzheimer's Disease Center Core Cohort - Tau Imaging Substudy
A Phase 1 study of Alzheimer Disease, sponsored by University of Alabama at Birmingham.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 160
- Enrollment target
- 1
- Study location
NCT03809351: Recruiting Phase 1 study of Alzheimer Disease, sponsored by University of Alabama at Birmingham.
NCT03809351 is a Phase 1 study of Alzheimer Disease that is actively recruiting participants, run by University of Alabama at Birmingham. The registered enrollment target is 160 participants, below the 2,750-participant average among 306 other Alzheimer Disease trials with a reported enrollment target (94% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03809351, a Phase 1 study of Alzheimer Disease, is actively recruiting participants, sponsored by University of Alabama at Birmingham.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 160 participants
- Enrollment target
- 1
- Study location
Study Summary
The primary objective of this study is to measure the concentration and the regional brain distribution of pathologic tau deposition using the PET tracer AV-1451 in participants in the UAB-ADC cohort. The amount and distribution of AV-1451 in the brain will be correlated to demographic, clinical, genetic, and biospecimen data acquired through the separate ongoing UAB-ADC study. Assessment of interactions between race and vascular risk factors, brain tau levels measured with AV-1451-PET, and cognitive status will be the primary outcome of this imaging study. Individuals participating in this AV-1451-PET/MRI study will also be enrolled in an ongoing \[C-11\]PiB-PET/MRI study (IRB-300001005, IND-138128), and their amyloid, tau and cognitive statuses will be compared in terms of race and vascular risk factors.
Primary Outcome
The amount and regional distribution of pathological tau in the brains of study participants will be measured with \[F-18\]AV-1451-PET/MRI using standardized uptake value ratios (SUVRs) derived from the PET images.
Conditions Studied
Interventions
- DRUG [F-18]AV-1451-PET
Study Locations (1)
Alabama
- UAB - Birmingham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 160 participants |
| Start Date | 2020-07-08 |
| Est. Completion | 2028-07 |
| Phase | Phase 1 |
What NCT03809351 shows while recruiting
NCT03809351 is an interventional study that assigns participants to a tested intervention. The registered 160 participants enrollment target is mid-sized for trials with a published cap, below the 2,750-participant average among 306 other Alzheimer Disease trials with a reported enrollment target (94% lower).
The record links to 1 condition, with Alzheimer Disease appearing as the primary indexed condition, and to 1 intervention - of which [F-18]AV-1451-PET is the first listed.
NCT03809351 reports a single indexed study location in Alabama.
Frequently Asked Questions
What is clinical trial NCT03809351 about?
NCT03809351 is a clinical study titled "UAB Alzheimer's Disease Center Core Cohort - Tau Imaging Substudy". The primary objective of this study is to measure the concentration and the regional brain distribution of pathologic tau deposition using the PET tracer AV-1451 in participants in the UAB-ADC cohort. The amount and distribution of AV-1451 in the brain will be correlated to demographic, clinical, ge...
What is the current status of trial NCT03809351?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 160 participants. The study started on 2020-07-08. Estimated completion is 2028-07.
What conditions does trial NCT03809351 study?
This clinical trial studies the following conditions: Alzheimer Disease.
What interventions are being tested in trial NCT03809351?
The interventions under investigation include: [F-18]AV-1451-PET (DRUG).
Who is sponsoring clinical trial NCT03809351?
This trial is sponsored by University of Alabama at Birmingham, which has 1,160 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03809351 being conducted?
This trial has 1 study location across Alabama. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Alzheimer Disease
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03809351's enrollment target sits among peer trials
160 125th of 306 higher than 181 of 306 other Alzheimer Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Alzheimer Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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