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NCT01505621 · ClinicalTrials.gov registry record
Novel Methodology to Measure Protein Accumulation
A clinical trial of Aging, sponsored by Mayo Clinic.
- Completed
- Registry status
- 24
- Enrollment target
- 1
- Study location
NCT01505621 is a study of Aging that has completed, run by Mayo Clinic. The registered enrollment target is 24 participants, below the 2,195-participant average among 262 other Aging trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state.
The verdict
NCT01505621, a study of Aging, has completed, sponsored by Mayo Clinic.
- COMPLETED
- Registry status
- 24 participants
- Enrollment target
- 1
- Study location
Study Summary
Accumulation of damaged proteins is thought to underlie many degenerative conditions, including aging, diabetes, Alzheimer's disease, cataracts, and others. Over time, proteins can be irreversibly damaged by a variety of factors, such as reactive oxygen species, and without timely degradation they can accumulate and aggregate. We believe this can contribute to the development of chronic degenerative disorders. The purpose of this study is to develop a novel methodology for measuring protein accumulation and test it in two groups of people: young (18-30 years) and old (≥65 years). This methodology will require that people drink a solution of essential amino acids that includes isotopically labeled L\[ring-13C6\]phenylalanine. We will then collect blood and muscle samples, to isolate plasma and skeletal muscle proteins. Participants will return to the study center four more times on a weekly interval. We hypothesize that older proteins, which persisted in circulation and accumulated over time, will have a higher degree of post-translational oxidative damage than newly synthesized proteins.
Conditions Studied
Interventions
- OTHER L[ring-13C6]phenylalanine
Study Locations (1)
Minnesota
- Mayo Clinic - Rochester
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2011-12 |
| Est. Completion | 2013-08 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01505621
The ClinicalTrials.gov registry entry for NCT01505621 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 24 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 2,195-participant average among 262 other Aging trials with a reported enrollment target (99% lower). The listed sponsor is Mayo Clinic, which has 2,844 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Aging appearing as the primary indexed condition, and to 1 intervention - of which L[ring-13C6]phenylalanine is the first listed.
NCT01505621 reports 1 study location spanning 1 distinct geographic area - top geographies include Minnesota.
Frequently Asked Questions
What is clinical trial NCT01505621 about?
NCT01505621 is a clinical study titled "Novel Methodology to Measure Protein Accumulation". Accumulation of damaged proteins is thought to underlie many degenerative conditions, including aging, diabetes, Alzheimer's disease, cataracts, and others. Over time, proteins can be irreversibly damaged by a variety of factors, such as reactive oxygen species, and without timely degradation they c...
What is the current status of trial NCT01505621?
This trial is currently completed. The enrollment target is 24 participants. The study started on 2011-12. Estimated completion is 2013-08.
What conditions does trial NCT01505621 study?
This clinical trial studies the following conditions: Aging.
What interventions are being tested in trial NCT01505621?
The interventions under investigation include: L[ring-13C6]phenylalanine (OTHER).
Who is sponsoring clinical trial NCT01505621?
This trial is sponsored by Mayo Clinic, which has 2,844 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01505621 being conducted?
This trial has 1 study location across Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
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