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NCT04405180 · ClinicalTrials.gov registry record · Phase 2
Nitrites, Skeletal Muscle Mitochondrial Bioenergetics, and Physical Activity in Old Age
A Phase 2 study of Aging and Frailty, sponsored by Gladwin, Mark, MD.
- Completed
- Registry status
- Phase 2
- Development phase
- 64
- Enrollment target
- 1
- Study location
NCT04405180 is a Phase 2 study of Aging and Frailty that has completed, run by Gladwin, Mark, MD. The registered enrollment target is 64 participants, below the 2,194-participant average among 262 other Aging trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state.
The verdict
NCT04405180, a Phase 2 study of Aging and Frailty, has completed, sponsored by Gladwin, Mark, MD.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 64 participants
- Enrollment target
- 1
- Study location
Study Summary
This 2-site randomized double blinded controlled trial is to confirm and more definitively clarify the impact of a 12-week course of nitrite versus placebo on mitochondrial bioenergetics in older sedentary adults. This investigator will take an integrative physiology approach to determine the effect of nitrite therapy on a comprehensive assessment of mitochondrial energetics, skeletal muscle vascular function, and whole body physical function (cardiorespiratory function, exercise endurance, strength, balance, and physical activity) and fatigability.
Conditions Studied
Interventions
- DRUG Placebos
- DRUG 20mg sodium nitrite tid
Study Locations (1)
Pennsylvania
- University Of Pittsburgh - Pittsburgh
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 64 participants |
| Start Date | 2021-04-23 |
| Est. Completion | 2023-07-14 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04405180
The ClinicalTrials.gov registry entry for NCT04405180 describes a study currently listed as completed, categorized as Phase 2. The registered enrollment target is 64 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 2,194-participant average among 262 other Aging trials with a reported enrollment target (97% lower). The listed sponsor is Gladwin, Mark, MD, which has 11 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Aging appearing as the primary indexed condition, and to 2 interventions - of which Placebos is the first listed.
NCT04405180 reports 1 study location spanning 1 distinct geographic area - top geographies include Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT04405180 about?
NCT04405180 is a clinical study titled "Nitrites, Skeletal Muscle Mitochondrial Bioenergetics, and Physical Activity in Old Age". This 2-site randomized double blinded controlled trial is to confirm and more definitively clarify the impact of a 12-week course of nitrite versus placebo on mitochondrial bioenergetics in older sedentary adults. This investigator will take an integrative physiology approach to determine the effect...
What is the current status of trial NCT04405180?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 64 participants. The study started on 2021-04-23. Estimated completion is 2023-07-14.
What conditions does trial NCT04405180 study?
This clinical trial studies the following conditions: Aging, Frailty, Sedentary Lifestyle.
What interventions are being tested in trial NCT04405180?
The interventions under investigation include: Placebos (DRUG), 20mg sodium nitrite tid (DRUG).
Who is sponsoring clinical trial NCT04405180?
This trial is sponsored by Gladwin, Mark, MD, which has 11 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04405180 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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