The Cleveland Clinic

688 total trials 99 currently recruiting 437 completed

The Cleveland Clinic sponsors 688 registered US clinical trials on ClinicalTrials.gov, 99 of them currently recruiting, and 437 completed. 81 of these trials are in Phase 3-4 (later-stage) and 76 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Atrial Fibrillation, with 9 trials.

Trial Pipeline

688 total, page 5 of 14

COMPLETED NA

Effects of Surgical Mask Use on Peak Torque, Total Work and Interset Fatigability During Isokinetic Strength Testing

NCT04706299

COMPLETED Phase 4

Comparing a Virtual vs. Face to Face Weight Management Program Using Phentermine for Patients With Overweight or Obesity

NCT04614545

COMPLETED Phase 3

Postoperative Consequences of Intraoperative NOL Titration

NCT04679818

TERMINATED NA

Operative vs Non-Operative Management of Acute Appendicitis and Acute Cholecystitis in COVID-19 Positive Patients

NCT04748120

TERMINATED Phase 4

Assessing the Effects of Sublingual Sufentanil 30 µg on Postoperative Recovery

NCT04561375

COMPLETED Phase 2

Dual-task Augmented Reality Treatment for Parkinson's Disease

NCT04634331

COMPLETED

Synbiotic Dietary Supplement and Gut Microbiota

NCT04097106

TERMINATED Phase 1

Study of Mesenchymal Stem Cells for the Treatment of Medically Refractory Ulcerative Colitis (UC)

NCT04543994

COMPLETED Phase 3

Hemodynamic Effect of Norepinephrine Versus Vasopressin on the Pulmonary Circulation in Cardiac Surgery Patients:

NCT04501861

TERMINATED Phase 1

Study of Mesenchymal Stem Cells for the Treatment of Medically Refractory Crohn's Colitis

NCT04548583

TERMINATED Phase 4

Early Basal Insulin Administration in Adult Diabetic Ketoacidosis Management

NCT04567225

COMPLETED NA

Pelvic Floor Physical Therapy vs Standard Care in Transgender Women Undergoing Vaginoplasty for Gender Affirmation

NCT05690555

TERMINATED Phase 4

EMI-EHP Weight Management and Type 2 Diabetes Pragmatic Trial

NCT04531176

COMPLETED NA

STandard Versus No Opioid Prescription After Prolapse and Anti-INcontinence Surgery Trial

NCT04491617

COMPLETED NA

Cooling Vest May Reduce Heat Stress During Surgery

NCT04511208

COMPLETED NA

Pain Avoidance Behavior and Its Relation to Risk for Opioid Use in Chronic Pain Patients

NCT04603417

COMPLETED NA

Patient Priority Care for Older Adults With Multiple Chronic Conditions

NCT04510948

COMPLETED NA

Virtual Reality Distraction for Reduction

NCT04416555

TERMINATED NA

Role of Blood Management in Perioperative Outcomes

NCT04475497

COMPLETED

Parallel Mapping for Ventricular Tachycardia

NCT04477499

COMPLETED

Prevention of Opioid-Induced Hypoxemia

NCT04453722

COMPLETED NA

Rhythmic Auditory Stimulation & Gait Training

NCT04314076

COMPLETED NA

Effects of a N95 Respirator vs Cloth Mask on Exercise Capacity During Treadmill Exercise.

NCT04415879

COMPLETED Phase 2

Mavrilimumab to Reduce Progression of Acute Respiratory Failure in COVID-19 Pneumonia and Systemic Hyper-inflammation

NCT04399980

COMPLETED Phase 2

Canakinumab in Covid-19 Cardiac Injury (The Three C Study)

NCT04365153

COMPLETED Phase 4

Comparative Study of Dexamethasone Implant to Intravitreal Aflibercept in Subjects With Diabetic Macular Edema

NCT04411693

COMPLETED NA

Coronavirus 2019 (COVID-19)- Using Ascorbic Acid and Zinc Supplementation

NCT04342728

COMPLETED Phase 2

Post-Operative Constipation Following Total Knee Arthroplasty

NCT04380090

COMPLETED NA

Cleveland Clinic Families Get Fit (CCFit) : A Family-based Activity-Monitor Intervention in Pediatric Obesity

NCT04312919

TERMINATED NA

STandardized Ultra-conservative Or Physician-directed ICD Programming for Continuous Flow LVAD Support

NCT04264182

COMPLETED NA

Modulatory Effects of Deep Brain Stimulation on Cerebral Cortical Activity

NCT04361955

COMPLETED NA

Novel Paradigms of Deep Brain Stimulation for Movement Disorders

NCT04563143

TERMINATED

Novel Quantitative MRI for Axial Spondyloarthritis

NCT03778515

COMPLETED NA

The Impact of Combined Mindfulness-Based Interventions and Nutritional Counseling on Physician Burnout

NCT04336436

COMPLETED NA

Pragmatic Cyclical Lower Extremity Exercise Trial for Parkinson's Disease

NCT04000360

COMPLETED

Validation Study for the Alertgy Non-invasive Continuous Glucose Monitor (ANICGM)

NCT04166032

COMPLETED NA

Comparing eTEP and Laparoscopic Intraperitoneal Onlay Mesh (IPOM) for Ventral Hernias

NCT04150796

COMPLETED NA

Randomized Control Trial Comparing Transfascial Suture for Mesh Fixation to No Mesh Fixation

NCT03938688

COMPLETED Phase 2

Pomalidomide for the Treatment of Bleeding in HHT

NCT03910244

TERMINATED NA

Digital Home Blood Pressure Monitoring in Type B Aortic Dissection Patients

NCT04116684

COMPLETED NA

Tracking Device Guided Feedback to Enhance Patient Physician Interaction

NCT04004806

COMPLETED NA

Feasibility Study for Intrathoracic Nerve Stimulation

NCT04066374

COMPLETED

Imaging of Uveitis Patients Receiving Injectable Fluocinolone Acetonide Implant

NCT04340505

COMPLETED NA

Virtual Visits to Optimize Research Trial Offerings to HF Patients

NCT04064541

COMPLETED NA

Pilot Study of Powered Exoskeleton Use for Gait Rehabilitation in Individuals With Multiple Sclerosis

NCT04000373

COMPLETED Phase 1

Improving SCI Rehabilitation Interventions by Retraining the Brain

NCT03892746

COMPLETED Phase 3

Nitrous Oxide for the Treatment of Complex Regional Pain Syndrome

NCT03879538

COMPLETED

Cardiovascular Outcomes in Bariatric Surgery Patients With Type 2 Diabetes

NCT03955952

COMPLETED NA

Comparison of Lithotripsy Urolithiasis Machines

NCT04069338

COMPLETED NA

A Pilot Study to Assess the Accuracy of Blood Pressure Assessment by the Omron HeartGuide Smartwatch

NCT03986281

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Phase Distribution

PhaseTrial count
Phase 1 38
Phase 2 38
Phase 3 22
Phase 4 59

What the Pipeline for The Cleveland Clinic Shows

According to the ClinicalTrials.gov registry, The Cleveland Clinic is linked to 688 US clinical trials across every stage of research activity. Of those, 99 studies are currently recruiting, about 14% of the sponsor's indexed portfolio, and 437 are already marked complete, representing roughly 64% of the total.

The phase mix for The Cleveland Clinic reports 81 late-stage studies (Phase 3 and Phase 4 combined) and 76 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for The Cleveland Clinic is Atrial Fibrillation with 9 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.