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NCT03778515 · ClinicalTrials.gov registry record
Novel Quantitative MRI for Axial Spondyloarthritis
A clinical trial, sponsored by The Cleveland Clinic.
- Terminated
- Registry status
- 1
- Enrollment target
NCT03778515: Clinical Trial study, sponsored by The Cleveland Clinic.
NCT03778515 is a clinical trial that was terminated before completion, run by The Cleveland Clinic. The registered enrollment target is 1 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03778515 was terminated before completion, sponsored by The Cleveland Clinic.
- TERMINATED
- Registry status
- 1 participants
- Enrollment target
Study Summary
This proposal aims to develop novel MR imaging and image processing techniques that will provide reliable and fully quantitative evaluation of inflammation, chronic structural changes and vascularity in patients with Ankylosing Spondylitis (AS). The quantitative evaluation will be more objective and reproducible, more sensitive to subtle changes, and less time consuming, as compared to the current semi-quantitative evaluation. It will allow radiologists and rheumatologists to evaluate the inflammation and structural changes more reliably to improve early diagnosis and treatment response evaluation. The developed quantification tools can be disseminated to other research and clinical sites for retrospective and prospective data analysis, and used as outcome measures for future multi-center trials. The evaluation of vascularity will enhance Investigators understanding of disease pathophysiology and serve as a novel marker to improve investigators capability of evaluating and predicting treatment response in AS. The successful implementation will greatly assist clinicians to optimize individualized therapeutic strategies and ultimately improve patient care for AS.
Primary Outcome
Fully quantitative evaluation of volume of bone marrow edema (in cm\^3) will be developed and applied in the study. Volume of BME will be calculated in both SIJ and Spine in high-resolution MR images to evaluate the active inflammation in the patients.
Interventions
- DIAGNOSTIC_TEST MRI
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1 participants |
| Start Date | 2020-01-15 |
| Est. Completion | 2021-07-31 |
Why NCT03778515 stopped before completion
NCT03778515 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 1 participants, a relatively small participant target.
The record links to 0 conditions, and to 1 intervention - of which MRI is the first listed.
NCT03778515 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03778515 about?
NCT03778515 is a clinical study titled "Novel Quantitative MRI for Axial Spondyloarthritis". This proposal aims to develop novel MR imaging and image processing techniques that will provide reliable and fully quantitative evaluation of inflammation, chronic structural changes and vascularity in patients with Ankylosing Spondylitis (AS). The quantitative evaluation will be more objective and...
What is the current status of trial NCT03778515?
This trial is currently terminated. The enrollment target is 1 participants. The study started on 2020-01-15. Estimated completion is 2021-07-31.
What interventions are being tested in trial NCT03778515?
The interventions under investigation include: MRI (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT03778515?
This trial is sponsored by The Cleveland Clinic, which has 688 total clinical trials registered on ClinicalTrials.gov.
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