The Cleveland Clinic

Open enrollment across a mixed-phase pipeline

According to ClinicalTrials.gov-derived indexes, The Cleveland Clinic sits in the top decile of US sponsors by registered trial count (#50 of 15,742 sponsors by registered trial count).

688 total trials 99 currently recruiting 437 completed top decile by trial count

The Cleveland Clinic: 688 sponsored US clinical trials, 99 recruiting.

The Cleveland Clinic sponsors 688 registered US clinical trials on ClinicalTrials.gov, 99 of them currently recruiting, and 437 completed. 81 of these trials are in Phase 3-4 (later-stage) and 76 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Atrial Fibrillation, with 9 trials.

Top-decile sponsor footprint

The Cleveland Clinic ranks in the top decile of sponsors by registered trial count (#50 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

F 42/100

437 of 539 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (81.1%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

688 total, page 6 of 14

COMPLETED

Feasibility of the IC-Flow Device for Fluorescent Perfusion Evaluation During Feasibility of the IC-Flow Device

NCT03860493

COMPLETED

Screening for Systemic Amyloidosis Via the Ligamentum Flavum

NCT03923920

COMPLETED

Cardiac Amyloidosis Screening at Trigger Finger Release

NCT03886155

COMPLETED

Bariatric Surgery-Induced Shift in Gut Microbiome and NAFLD

NCT04263376

COMPLETED NA

Cost-effectiveness of Forced Aerobic Exercise for Stroke Rehabilitation

NCT03819764

COMPLETED NA

SAMPAP Trial -Impact of a Novel Sleep Apnea Management Group Intervention on Positive Airway Pressure Adherence

NCT03835702

COMPLETED Early Phase 1

A Novel Approach for Brain Stimulation in Severe Stroke

NCT03868410

COMPLETED NA

Long QT Syndrome and Sleep Apnea

NCT03678311

COMPLETED NA

Urinary Retention After Laparoscopic Inguinal Hernia Repair: Comparing the Use of the Intraoperative Urinary Catheter

NCT03835351

TERMINATED

Driving Skills Recovery Following Procedural Sedation for Gastrointestinal Endoscopy

NCT04350424

COMPLETED

Efficacy of the Dabir Surfaces Micropressure Overlay for Decubitus Ulcer Prevention During Cardiac Surgery

NCT03884634

COMPLETED Phase 3

Lamotrigine in Reducing Psychologic Side-Effect of Perioperative Ketamine

NCT03831854

COMPLETED NA

Patient Satisfaction With Initial Phone Call Versus Office Visit Following Minimally Invasive Hysterectomy, a Randomized Controlled Trial.

NCT03809468

TERMINATED

Comparison of Dorsal Column Stimulation to Dorsal Root Ganglion Stimulation for Complex Regional Pain Syndrome

NCT03794024

COMPLETED NA

Accuracy of the Apple Watch Series 4 for Detection of Heart Rhythm: A Pilot Study

NCT03798613

COMPLETED

Multicenter Imaging in Lead Extraction Study

NCT03772704

COMPLETED NA

Enhancing Caregiver Empathy by Empowering Patients to Discuss Their Values

NCT05055141

COMPLETED NA

Bridging Resources Improve the Development of Guideline-based Exercise

NCT03678974

COMPLETED NA

Online Mindfulness Program for Stress Management

NCT03753360

COMPLETED Phase 4

Reduction of Postoperative Gastrointestinal Dysmotility Following Total Laparoscopic Hysterectomy.

NCT03800745

COMPLETED NA

Telehealth Delivery of Treatment for Sleep Disturbances in Young Children With Autism Spectrum Disorder

NCT03668873

COMPLETED Early Phase 1

Pectoral Fascial Plane and Serratus Anterior Plane Blocks With Bupivacaine v. Liposomal Bupivacaine

NCT03731221

TERMINATED

The Effect of Bariatric Surgery on Spermatogenesis

NCT03725696

COMPLETED

Diagnostic Utility of a Novel Point-of-Care Test of Calprotectin for Revision Total Knee Arthroplasty

NCT03694925

COMPLETED NA

Same Day Discharge After Minimally-invasive Sacrocolpopexy

NCT03730103

COMPLETED NA

Restorelle® Y Mesh vs. Vertessa® Lite Y Mesh for Laparoscopic and Robotic-assisted Laparoscopic Sacrocolpopexy

NCT03681223

COMPLETED NA

Ventilation Strategy During General Anesthesia for Orthopedic Surgery: A Quality Improvement Project

NCT03657368

COMPLETED

Genomic Sequencing in Patients With HCM Undergoing Septal Myectomy

NCT03043209

TERMINATED Phase 4

Threshold Response of Lumbar Selective Nerve Root Block in Predicting Good Outcome Following Lumbar Foraminotomy

NCT03801356

COMPLETED NA

Improving Frailty With a Rigorous Ambulation Intervention in Lung Transplant Patients

NCT03636412

COMPLETED NA

Virtual Visits in Heart Failure Care Transitions

NCT03675828

COMPLETED NA

Danger Signs in Heart Failure- Effects of Video Education

NCT03657459

COMPLETED NA

A Computerized CBTi for Insomnia in Epilepsy

NCT03632889

COMPLETED NA

Accuracy of Commercially Available Heart Rate Monitors in Athletes

NCT03612063

COMPLETED NA

McGrath Videolaryngoscopy and Direct Laryngoscopy in Morbidly Obese Patients

NCT03467048

COMPLETED

Study of the Ability of a New Technique to Effectively Diagnose Movement Disorders

NCT03661021

COMPLETED NA

Hypotension Prediction Index for Blood Pressure Management

NCT03610165

TERMINATED Phase 4

Comparison of Clenpiq vs Golytely Bowel Preparation

NCT03198221

COMPLETED NA

Euflexxa for the Treatment of Osteoarthritis

NCT03459365

COMPLETED Phase 4

Exparel vs. Bupivacaine Hydrochloride vs. Placebo for Hernia Repair

NCT03541941

COMPLETED

Telemedicine in Total Knee Arthroplasty Using Wearable Technology

NCT03406455

COMPLETED

Mirror Box Therapy As a Treatment Option for Functional Movement Disorders

NCT03660098

COMPLETED NA

A Fib Clinic of the Future Using KardiaPro Platform for Chronic Care of Patients With AF After Ablation Procedure

NCT03557034

COMPLETED NA

Comparing the Efficacy of Epidural and Quadratus Lumborum Analgesia After Open Nephrectomy Surgery

NCT03110081

COMPLETED NA

Improvement of Patient Satisfaction and Clinical Outcomes Using JointCOACH

NCT03499028

COMPLETED NA

Improvement of Patient Satisfaction and Overall Outcomes Using HealthLoop

NCT03481595

TERMINATED NA

Precision Pain Management for Major Abdominal Surgery in Colorectal Surgery

NCT03455751

TERMINATED

Correlation Between Peripheral Venous Pressure and Central Venous Pressure in the Cardiac Intensive Care Unit

NCT03526497

COMPLETED

Patient Status Engine (PSE): EARLY FEASIBILITY AND USABILITY STUDY

NCT03480204

TERMINATED

Evaluation of a Novel Technique to Diagnose Carotid Artery Stenosis

NCT03464851

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Phase Distribution

PhaseTrial count
Phase 1 38
Phase 2 38
Phase 3 22
Phase 4 59

What is open in the The Cleveland Clinic pipeline

99 recruiting of 688 indexed (14% open); 437 completed (64%).

Phase mix: 81 late (III/IV) vs 76 early (I/II) (balanced across stages).

Top condition: Atrial Fibrillation (9 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

The Cleveland Clinic: open-pipeline peers nationwide

Peers matched on 688 registered trials and 14% open enrollment, not the therapeutic-area sidebar.

The Cleveland Clinic sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 02004006008001,000 5%10%15%20%25% Total trials Recruiting share The Cleveland ClinicVanderbilt University Medical CenterWeill Medical College of Cornell UniversityIcahn School of Medicine at Mount SinaiSanofiDana-Farber Cancer InstituteModernaTXMasonic Cancer Center, University of MinnesotaAcademic and Community Cancer Research United
The Cleveland Clinic sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

The Cleveland Clinic sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 688 trials (± recruiting share)

Sponsors near 14% open enrollment (± trial volume)

What to do with this The Cleveland Clinic page

688 registered trials is a research-attention snapshot, not an endorsement of The Cleveland Clinic or any single study.

  • 99 of The Cleveland Clinic's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Atrial Fibrillation is the condition The Cleveland Clinic studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Atrial Fibrillation trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. The Cleveland Clinic pipeline card: 688 registered trials from official public datasets. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.