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ClinicalTrials.gov 3 recruiting now official registry

Immunodeficiencies clinical trials

3 of 9 indexed Immunodeficiencies trials are currently recruiting.

9 US clinical trials · 3 currently recruiting

Immunodeficiencies is the subject of 9 registered US clinical trials on ClinicalTrials.gov, 3 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is Children's Hospital of Philadelphia, running 3 of these trials.

The research picture

Immunodeficiencies has 9 registered US clinical trials, 3 of them open to new participants right now, about 33% of the total.

3
recruiting participants now
33%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
3
top sponsor: Children's Hospital of Philadelphia
Phase 12Phase 23

Active & Recent Trials

9 total, page 1 of 1

RECRUITING 2,419 participants

Studies of the Pathogenesis of HIV Infection in Human Peripheral Blood Cells and/or Body Fluids in People Living With and Without HIV

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00001281

RECRUITING Early Phase 1 100 participants

Expanded Access Protocol Using CD3+/CD19+ Depleted PBSC

Children's Hospital of Philadelphia

NCT02356653

RECRUITING NA 30 participants

Second or Greater Allogeneic Hematopoietic Stem Cell Transplant Using Reduced Intensity Conditioning (RIC)

Masonic Cancer Center, University of Minnesota

NCT01666080

ACTIVE NOT RECRUITING Phase 2 75 participants

Reduced Intensity Conditioning (RIC) Regimen for Patients With Non-malignant Disorders

Children's Hospital of Philadelphia

NCT01050855

ACTIVE NOT RECRUITING Phase 2 60 participants

Alpha/Beta T and CD19+ Depleted Peripheral Stem Cells for Patients With Primary Immunodeficiencies

Children's Hospital of Philadelphia

NCT02990819

COMPLETED 308 participants

COVID-19 Vaccination and Outcomes in Individuals With and Without Immune Deficiencies and Dysregulations

National Institute of Allergy and Infectious Diseases (NIAID)

NCT04852276

COMPLETED 25 participants

Study of Melphalan Drug Exposure in Pediatric Hematopoietic Stem Cell Transplant Patients

University of California, San Francisco

NCT03609827

COMPLETED Phase 1 22 participants

Reduced Intensity Conditioning for Umbilical Cord Blood Transplant in Pediatric Patients With Non-Malignant Disorders

Duke University

NCT00744692

COMPLETED Phase 2 20 participants

CD34+Selection for Partially Matched Family or Matched Unrelated Adult Donor Transplant

New York Medical College

NCT01049854

Phase Distribution

PhaseTrial count
Phase 1 2
Phase 2 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Immunodeficiencies Trial Landscape

9 indexed Immunodeficiencies studies · 3 recruiting (33%).

Phase mix: 0 late (III/IV) vs 5 early (I/II).

Top sponsor: Children's Hospital of Philadelphia (3 trials), 5 others listed. 9 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Immunodeficiencies?

PlainTrial tracks 9 US clinical trials for Immunodeficiencies, of which 3 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Immunodeficiencies?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.