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NCT05932589 · ClinicalTrials.gov registry record
Neurophysiologic Biomarkers in Rett Syndrome
A clinical trial of Rett Syndrome and Rett Syndrome, Atypical, sponsored by Children's Hospital of Philadelphia.
- Recruiting
- Registry status
- 202
- Enrollment target
- 6
- Study locations
NCT05932589: Recruiting study of Rett Syndrome and Rett Syndrome, Atypical, sponsored by Children's Hospital of Philadelphia.
NCT05932589 is a study of Rett Syndrome and Rett Syndrome, Atypical that is actively recruiting participants, run by Children's Hospital of Philadelphia. The registered enrollment target is 202 participants, below the 515-participant average among 18 other Rett Syndrome trials with a reported enrollment target (61% lower). The trial reports 6 study locations across 6 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05932589, a study of Rett Syndrome and Rett Syndrome, Atypical, is actively recruiting participants, sponsored by Children's Hospital of Philadelphia.
- RECRUITING
- Registry status
- 202 participants
- Enrollment target
- 6
- Study locations
Study Summary
The goal of this observational study is to identify candidate biomarkers in individuals with Rett Syndrome (RTT). The main questions it aims to answer are: * Do these biomarkers change during clinical changes in individuals with RTT? * Are biomarkers stable over time in clinically stable individuals? * Do these biomarkers correlate with severity of RTT? Participants will be asked to undergo an electroencephalogram (EEG) with measurements of Evoked Potentials (EP) to measure electrical activity in the brain. Researchers will compare findings in individuals with RTT to those in typically developing individuals to see if there are differences between the two groups.
Primary Outcome
Calculated N1, P1 latencies in Cz and other electrodes \[posterior temporal region (T5/P3/T3) electrodes\], will be used for analysis.
Conditions Studied
Interventions
- OTHER EEG and Auditory and Visual Evoked Potentials (AEP and VEP)
- OTHER Clinical assessment
Study Locations (6)
California
- Children's Hospital of Los Angeles - Los Angeles
Colorado
- Children's Hospital Colorado - Aurora
Massachusetts
- Boston Children's Hospital - Brookline
Pennsylvania
- Children's Hospital of Philadelphia - Philadelphia
Tennessee
- Vanderbilt University Medical Center - Nashville
Texas
- Texas Children's Hospital - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 202 participants |
| Start Date | 2023-10-11 |
| Est. Completion | 2029-03-31 |
What NCT05932589 shows while recruiting
NCT05932589 is an observational study that tracks outcomes without assigning an intervention. The registered 202 participants enrollment target is mid-sized for trials with a published cap, below the 515-participant average among 18 other Rett Syndrome trials with a reported enrollment target (61% lower).
The record links to 3 conditions, with Rett Syndrome appearing as the primary indexed condition, and to 2 interventions - of which EEG and Auditory and Visual Evoked Potentials (AEP and VEP) is the first listed.
NCT05932589 lists 6 locations in 6 states (California, Colorado, Massachusetts).
Frequently Asked Questions
What is clinical trial NCT05932589 about?
NCT05932589 is a clinical study titled "Neurophysiologic Biomarkers in Rett Syndrome". The goal of this observational study is to identify candidate biomarkers in individuals with Rett Syndrome (RTT). The main questions it aims to answer are: * Do these biomarkers change during clinical changes in individuals with RTT? * Are biomarkers stable over time in clinically stable individual...
What is the current status of trial NCT05932589?
This trial is currently recruiting. The enrollment target is 202 participants. The study started on 2023-10-11. Estimated completion is 2029-03-31.
What conditions does trial NCT05932589 study?
This clinical trial studies the following conditions: Rett Syndrome, Rett Syndrome, Atypical, RTT.
What interventions are being tested in trial NCT05932589?
The interventions under investigation include: EEG and Auditory and Visual Evoked Potentials (AEP and VEP) (OTHER), Clinical assessment (OTHER).
Who is sponsoring clinical trial NCT05932589?
This trial is sponsored by Children's Hospital of Philadelphia, which has 431 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05932589 being conducted?
This trial has 6 study locations across California, Colorado, Massachusetts, Pennsylvania, Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT05932589's enrollment target sits among peer trials
202 5th of 18 higher than 14 of 18 other Rett Syndrome trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Rett Syndrome trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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