Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05975671 · ClinicalTrials.gov registry record · NA
Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis
A NA study of Sepsis and Septic Shock, sponsored by Children's Hospital of Philadelphia.
- Recruiting
- Registry status
- NA
- Development phase
- 52,500
- Enrollment target
- 4
- Study locations
NCT05975671: Recruiting NA study of Sepsis and Septic Shock, sponsored by Children's Hospital of Philadelphia.
NCT05975671 is a NA study of Sepsis and Septic Shock that is actively recruiting participants, run by Children's Hospital of Philadelphia. The registered enrollment target is 52,500 participants, above the 5,981-participant average among 90 other Sepsis trials with a reported enrollment target (778% higher). The trial reports 4 study locations across 4 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05975671, a NA study of Sepsis and Septic Shock, is actively recruiting participants, sponsored by Children's Hospital of Philadelphia.
- RECRUITING
- Registry status
- NA
- Development phase
- 52,500 participants
- Enrollment target
- 4
- Study locations
Study Summary
The goal of this quasi-experimental interventional study is to determine the effectiveness of a multifaceted stewardship intervention in reducing overall vancomycin use in five tertiary care Pediatric Intensive Care Units (PICU). There are two groups of subjects in this study: PICU clinicians/sepsis stakeholders and patients admitted to one of the participating PICUs during the study period. The intervention will at a minimum include: * Implementation of a clinical guideline indicating when vancomycin should and should not be used * Unit-level feedback on overall vancomycin use within and across centers * Clinician education.
Primary Outcome
Vancomycin use will be measured as DOT per 1000 PICU patient days, measured monthly. Every day in which one or more doses of parenteral vancomycin is administered is classified as one vancomycin DOT. Every day or portion of a day a patient is admitted to the PICU is classified as one PICU patient day.
Conditions Studied
Interventions
- BEHAVIORAL Multifaceted de-implementation strategy to reduce vancomycin overuse
Study Locations (4)
Georgia
- Children's Healthcare of Atlanta - Atlanta
Maryland
- Johns Hopkins Children's Center - Baltimore
Missouri
- St. Louis Children's Hospital - St Louis
Pennsylvania
- Children's Hospital of Philadelphia - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 52,500 participants |
| Start Date | 2023-08-21 |
| Est. Completion | 2026-05 |
| Phase | NA |
What NCT05975671 shows while recruiting
NCT05975671 is an interventional study that assigns participants to a tested intervention. Its 52,500 participants enrollment target places it among the larger protocols in the corpus, above the 5,981-participant average among 90 other Sepsis trials with a reported enrollment target (778% higher).
The record links to 7 conditions, with Sepsis appearing as the primary indexed condition, and to 1 intervention - of which Multifaceted de-implementation strategy to reduce vancomycin overuse is the first listed.
NCT05975671 reports a single indexed study location in Georgia, Maryland, Missouri.
Frequently Asked Questions
What is clinical trial NCT05975671 about?
NCT05975671 is a clinical study titled "Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis". The goal of this quasi-experimental interventional study is to determine the effectiveness of a multifaceted stewardship intervention in reducing overall vancomycin use in five tertiary care Pediatric Intensive Care Units (PICU). There are two groups of subjects in this study: PICU clinicians/sepsi...
What is the current status of trial NCT05975671?
This trial is currently recruiting. It is a NA study. The enrollment target is 52,500 participants. The study started on 2023-08-21. Estimated completion is 2026-05.
What conditions does trial NCT05975671 study?
This clinical trial studies the following conditions: Sepsis, Septic Shock, Sepsis, Severe, Sepsis Mrsa, Sepsis Bacteremia.
What interventions are being tested in trial NCT05975671?
The interventions under investigation include: Multifaceted de-implementation strategy to reduce vancomycin overuse (BEHAVIORAL).
Who is sponsoring clinical trial NCT05975671?
This trial is sponsored by Children's Hospital of Philadelphia, which has 431 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05975671 being conducted?
This trial has 4 study locations across Georgia, Maryland, Missouri, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Sepsis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05975671's enrollment target sits among peer trials
52,500 2nd of 90 the highest of 90 other Sepsis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Sepsis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
The RightCall: Implementing a Sepsis Diagnostic Toolkit to Improve Pediatric Diagnosis in ED Transfer Calls
RECRUITING · NA
-
External Drainage of Thoracic Duct Lymph to Reduce Inflammatory Cytokines in Septic Shock Patients
RECRUITING · NA
-
BLOOM: Pragmatic Feasibility Trial
RECRUITING · NA
-
TriVerity™ for Improved Management of Emergency Department (ED) Patients With Suspected Infections
RECRUITING · NA
-
Clean Trial - Chlorination to Reduce Enteric and Antibiotic Resistant Infections in Neonates
RECRUITING · NA
-
Evaluation of Pediatric eCART Implementation
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT06355934 · 52,121 participants
OverTTuRe: Characteristics, Treatment Patterns and Outcomes of Patients With ATTR Amyloidosis
- NCT07224243 · 54,000 participants · NA
Impact of Intraoperative Oxygenation Practices on Patient Outcomes
- NCT00500123 · 50,000 participants
The Alpha-1 Foundation's and University of Florida's Alpha-1 Coded Testing (ACT) Study
- NCT01885299 · 50,000 participants
RSSearch Patient Registry-Long Term Study of Use of SRS/SBRT
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI