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NCT07114510 · ClinicalTrials.gov registry record · NA
Optimal Ventilation for Cardiac Arrest
A NA study of Cardiac Arrest (CA), sponsored by Children's Hospital of Philadelphia.
- Recruiting
- Registry status
- NA
- Development phase
- 1,530
- Enrollment target
- 20
- Study locations
NCT07114510: Recruiting NA study of Cardiac Arrest (CA), sponsored by Children's Hospital of Philadelphia.
NCT07114510 is a NA study of Cardiac Arrest (CA) that is actively recruiting participants, run by Children's Hospital of Philadelphia. The registered enrollment target is 1,530 participants, above the 56-participant average among 3 other Cardiac Arrest (CA) trials with a reported enrollment target (2632% higher). The trial reports 20 study locations across 16 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07114510, a NA study of Cardiac Arrest (CA), is actively recruiting participants, sponsored by Children's Hospital of Philadelphia.
- RECRUITING
- Registry status
- NA
- Development phase
- 1,530 participants
- Enrollment target
- 20
- Study locations
Study Summary
Pediatric cardiac arrest is a life-threatening problem affecting \>15,000 hospitalized children each year. Less than half of these children survive to hospital discharge, and neurologic morbidity is common among survivors. The objective of this study is to evaluate the effectiveness of the OPTI-VENT bundle to improve survival to discharge with favorable neurological outcome (Pediatric Cerebral Performance Category Score 1-2 or no change from baseline) among children receiving at least 1 minute of CPR.
Primary Outcome
Survival to hospital discharge with a favorable neurologic outcome (Pediatric Cerebral Performance Category (PCPC) score (scored on a scale of 1-6) at hospital discharge of 1 (normal), 2 (mild disability) or no worse than baseline). Percentage of subjects in control vs. intervention will be compared.
Conditions Studied
Interventions
- OTHER OPTI-VENT Bundle
- OTHER Transition
- OTHER None - control
Study Locations (20)
Texas
- Dell Children's Medical Center - Austin
- Medical City Children's Hospital - Dallas
- UT Southwestern Medical Center - Dallas
California
- CHOC - Orange
- Lucile Packard Children's Hospital Stanford - Palo Alto
Ohio
- Cincinnati Children's Hospital Medical Center - Cincinnati
- Nationwide Children's Hospital - Columbus
Colorado
- Children's Hospital Colorado - Denver
Delaware
- Nemours Children's Health - Wilmington
Georgia
- Children's Healthcare of Atlanta - Atlanta
Indiana
- Riley Children's Health - Indianapolis
Iowa
- Stead Family Children's Hospital - Iowa City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,530 participants |
| Start Date | 2025-10-01 |
| Est. Completion | 2030-03-31 |
| Phase | NA |
What NCT07114510 shows while recruiting
NCT07114510 is an interventional study that assigns participants to a tested intervention. Its 1,530 participants enrollment target places it among the larger protocols in the corpus, above the 56-participant average among 3 other Cardiac Arrest (CA) trials with a reported enrollment target (2632% higher).
The record links to 1 condition, with Cardiac Arrest (CA) appearing as the primary indexed condition, and to 3 interventions - of which OPTI-VENT Bundle is the first listed.
NCT07114510 names 20 study sites across 16 states, led by Texas, California, Ohio.
Frequently Asked Questions
What is clinical trial NCT07114510 about?
NCT07114510 is a clinical study titled "Optimal Ventilation for Cardiac Arrest". Pediatric cardiac arrest is a life-threatening problem affecting \>15,000 hospitalized children each year. Less than half of these children survive to hospital discharge, and neurologic morbidity is common among survivors. The objective of this study is to evaluate the effectiveness of the OPTI-VENT...
What is the current status of trial NCT07114510?
This trial is currently recruiting. It is a NA study. The enrollment target is 1,530 participants. The study started on 2025-10-01. Estimated completion is 2030-03-31.
What conditions does trial NCT07114510 study?
This clinical trial studies the following conditions: Cardiac Arrest (CA).
What interventions are being tested in trial NCT07114510?
The interventions under investigation include: OPTI-VENT Bundle (OTHER), Transition (OTHER), None - control (OTHER).
Who is sponsoring clinical trial NCT07114510?
This trial is sponsored by Children's Hospital of Philadelphia, which has 431 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07114510 being conducted?
This trial has 20 study locations across California, Colorado, Delaware, Georgia, Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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