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NCT06890520 · ClinicalTrials.gov registry record
Neurometabolic Profile of Individuals With Primary Mitochondrial Disease
A clinical trial of Primary Mitochondrial Disease, sponsored by Children's Hospital of Philadelphia.
- Recruiting
- Registry status
- 30
- Enrollment target
- 1
- Study location
NCT06890520: Recruiting study of Primary Mitochondrial Disease, sponsored by Children's Hospital of Philadelphia.
NCT06890520 is a study of Primary Mitochondrial Disease that is actively recruiting participants, run by Children's Hospital of Philadelphia. The registered enrollment target is 30 participants. The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06890520, a study of Primary Mitochondrial Disease, is actively recruiting participants, sponsored by Children's Hospital of Philadelphia.
- RECRUITING
- Registry status
- 30 participants
- Enrollment target
- 1
- Study location
Study Summary
Primary Mitochondrial Disease (PMD) is a genetic neurometabolic disorder, leading to central nervous system degeneration and increased risk of early mortality. There is a strong link between the pathophysiology of mitochondrial disease and biomarkers related to the biochemistry of redox imbalance, involving the levels of glutathione. Investigators will use Magnetic Resonance Imaging and Spectroscopy to non-invasively measure glutathione and other chemicals in the brain to identify redox imbalance in patients with PMD.
Primary Outcome
Metabolite concentrations from H Magnetic Resonance Spectroscopy (MRS) will be processed in Osprey followed by linear combination modelling of MRS spectra. Water-scaled metabolite estimates will be calculated and corrected for tissue composition and relaxation effects to generate metabolite concentrations.
Conditions Studied
Study Locations (1)
Pennsylvania
- The Children's Hospital of Philadelphia - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2025-02-25 |
| Est. Completion | 2029-01-01 |
What NCT06890520 shows while recruiting
NCT06890520 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 30 participants, a relatively small participant target.
The record links to 1 condition, with Primary Mitochondrial Disease appearing as the primary indexed condition, and to 0 interventions.
NCT06890520 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT06890520 about?
NCT06890520 is a clinical study titled "Neurometabolic Profile of Individuals With Primary Mitochondrial Disease". Primary Mitochondrial Disease (PMD) is a genetic neurometabolic disorder, leading to central nervous system degeneration and increased risk of early mortality. There is a strong link between the pathophysiology of mitochondrial disease and biomarkers related to the biochemistry of redox imbalance, i...
What is the current status of trial NCT06890520?
This trial is currently recruiting. The enrollment target is 30 participants. The study started on 2025-02-25. Estimated completion is 2029-01-01.
What conditions does trial NCT06890520 study?
This clinical trial studies the following conditions: Primary Mitochondrial Disease.
Who is sponsoring clinical trial NCT06890520?
This trial is sponsored by Children's Hospital of Philadelphia, which has 431 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06890520 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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