Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Mitochondrial Diseases: early-phase trial registry
5 of 8 indexed Mitochondrial Diseases trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #2,176 of 28,707 conditions by registered trial count.
8 US clinical trials · 5 currently recruiting · #2,176 of 28,707 conditions by registered trial count
Mitochondrial Diseases: 8 US clinical trials tracked, 5 recruiting.
Mitochondrial Diseases is the subject of 8 registered US clinical trials on ClinicalTrials.gov, 5 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is Children's Hospital of Philadelphia, running 3 of these trials.
Enrollment posture brief
Registry condition mitochondrial-diseases
OPEN 5 | RECR 63% | LATE 2 | EARLY 4 | RANK #2176 | SPON 3
Volume-matched condition peers
Nearest open-share peer: Adolescent (63% recruiting · 16 trials)
Mitochondrial Diseases lists 5 open slots (63% of 8 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Mitochondrial Diseases on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Mitochondrial Diseases is recruiting above its size-band peers.
5 of 8 indexed trials (62.5%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Mitochondrial Diseases research.
Children's Hospital of Philadelphia accounts for 3 of 8 trials (37.5%). 6 distinct sponsors appear on at least one study for this condition label.
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Most Mitochondrial Diseases trials plan to enrol fewer than 100 people.
Median target enrolment is 90 among the 8 trials that report a genuine target (sentinel values excluded). 5 of those (62.5%) plan for fewer than 100 participants.
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Mitochondrial Diseases research is mostly interventional.
6 interventional and 2 observational studies make up this index (75% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
8 total, page 1 of 1
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)
Columbia University
NCT01694940
Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders
Southwest Autism Research & Resource Center
NCT04322734
KHENERFIN Study: A Trial to Evaluate the Efficacy and Safety of Sonlicromanol in Primary Mitochondrial Diseases
Khondrion
NCT06451757
Applying pGz in Mitochondrial Disease
Children's Hospital of Philadelphia
NCT05569122
Validation of Oxygen Nanosensor in Mitochondrial Myopathy
Children's Hospital of Philadelphia
NCT04086329
Heart Rate Variability in Response to Metformin Challenge
Woodinville Psychiatric Associates
NCT02500628
Phase III Trial of Coenzyme Q10 in Mitochondrial Disease
University of Florida
NCT00432744
Promoting Resilience in Stress Management (PRISM) and Clinical-focused Narrative (CFN) Pilot in Adults With Primary Mitochondrial Disease (PMD).
Children's Hospital of Philadelphia
NCT06051448
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 1 |
| Phase 3 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Mitochondrial Diseases records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Mitochondrial Diseases trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Mitochondrial Diseases page
8 registered trials, 5 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 5 Mitochondrial Diseases trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Children's Hospital of Philadelphia sponsors the most Mitochondrial Diseases trials on record, review their full trial history before evaluating a specific study. See Children's Hospital of Philadelphia's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Mitochondrial Diseases condition card totals 8 registered trials; most-linked intervention Placebo; top US site state Pennsylvania. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.