Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT00542373 · ClinicalTrials.gov registry record · NA
Widefield Fluorescence and Reflectance Imaging Systems and Oral Tissue Samples in Monitoring Participants at Risk for Developing Oral Cancer
A NA study of Tobacco Use Disorder and Fanconi Anemia, sponsored by M.D. Anderson Cancer Center.
- Active
- Registry status
- NA
- Development phase
- 338
- Enrollment target
- 1
- Study location
NCT00542373: Active NA study of Tobacco Use Disorder and Fanconi Anemia, sponsored by M.D. Anderson Cancer Center.
NCT00542373 is a NA study of Tobacco Use Disorder and Fanconi Anemia that is active but no longer recruiting, run by M.D. Anderson Cancer Center. The registered enrollment target is 338 participants, above the 235-participant average among 70 other Tobacco Use Disorder trials with a reported enrollment target (44% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00542373, a NA study of Tobacco Use Disorder and Fanconi Anemia, is active but no longer recruiting, sponsored by M.D. Anderson Cancer Center.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 338 participants
- Enrollment target
- 1
- Study location
Study Summary
This clinical trial studies widefield fluorescence and reflectance imaging, fluorescence spectroscopy, and tissue samples in regularly examining (monitoring) participants at risk for developing oral cancer. All tissue and cells are made of tiny particles. Some of these particles give off small amounts of light. This light is called fluorescence. Fluorescent imaging use instruments that shine different wavelengths (colors) of light in the mouth taking fluorescence pictures through a portable head light or by taking fluorescent and reflectance pictures through a dental microscope using a digital camera. Fluorescent spectroscopy uses a small probe placed gently against the lining of the mouth and the tissue is exposed to small amounts of fluorescent light that is then collected with a special camera and a computer to be analyzed. Checking mouth tissue samples under a microscope may also help detect abnormal cells. Diagnostic procedures, such as fluorescence and reflectance imaging, fluorescence spectroscopy imaging, and tissue samples, may help doctors detect pre-cancer or early cancer when it may be easier to treat.
Primary Outcome
Oral mucosa obtained at various wavelength combinations including 350 nm, 380 nm, 400 nm, and 450 nm excitation will be compared to standard white light images, pathologic analysis of any biopsied tissue when available, and carcinogenic progression. Diagnostic methods will be compared with each other by forming 2x2 tables and computing the chi-square statistics for the McNemar test. Kappa statistic will also be calculated for comparing the chance corrected agreement between various diagnostic me
Conditions Studied
Interventions
- OTHER Cytology Specimen Collection Procedure
- PROCEDURE Diagnostic Procedure
- PROCEDURE Fluorescence Imaging
- PROCEDURE Diagnostic Microscopy
- PROCEDURE Fluorescence Spectroscopy
Study Locations (1)
Texas
- M D Anderson Cancer Center - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 338 participants |
| Start Date | 2007-08-27 |
| Est. Completion | 2027-04-30 |
| Phase | NA |
What the registry record for NCT00542373 still lists
NCT00542373 is an interventional study that assigns participants to a tested intervention. The registered 338 participants enrollment target is mid-sized for trials with a published cap, above the 235-participant average among 70 other Tobacco Use Disorder trials with a reported enrollment target (44% higher).
The record links to 8 conditions, with Tobacco Use Disorder appearing as the primary indexed condition, and to 5 interventions - of which Cytology Specimen Collection Procedure is the first listed.
NCT00542373 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT00542373 about?
NCT00542373 is a clinical study titled "Widefield Fluorescence and Reflectance Imaging Systems and Oral Tissue Samples in Monitoring Participants at Risk for Developing Oral Cancer". This clinical trial studies widefield fluorescence and reflectance imaging, fluorescence spectroscopy, and tissue samples in regularly examining (monitoring) participants at risk for developing oral cancer. All tissue and cells are made of tiny particles. Some of these particles give off small amoun...
What is the current status of trial NCT00542373?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 338 participants. The study started on 2007-08-27. Estimated completion is 2027-04-30.
What conditions does trial NCT00542373 study?
This clinical trial studies the following conditions: Tobacco Use Disorder, Fanconi Anemia, Premalignant Lesion, Lichen Planus, Erythroplakia.
What interventions are being tested in trial NCT00542373?
The interventions under investigation include: Cytology Specimen Collection Procedure (OTHER), Diagnostic Procedure (PROCEDURE), Fluorescence Imaging (PROCEDURE), Diagnostic Microscopy (PROCEDURE), Fluorescence Spectroscopy (PROCEDURE).
Who is sponsoring clinical trial NCT00542373?
This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00542373 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Tobacco Use Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00542373's enrollment target sits among peer trials
338 14th of 70 higher than 57 of 70 other Tobacco Use Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Tobacco Use Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Smoking Cessation CM for Veterans With or at Risk for Cancer
RECRUITING · NA
-
Smoking Cessation Behavioral Treatment Study
RECRUITING · NA
-
Contingency Management for Veteran Smokers Undergoing Major Elective Surgery
RECRUITING · NA
-
A Future Thinking Intervention for Comorbid Tobacco Use Disorder and Bipolar Disorder
RECRUITING · NA
-
Young Adult Tobacco/Nicotine and Cannabis Co-use
RECRUITING · NA
-
Low Intensity Focused Ultrasound for Tobacco Use Disorder: High Resolution Targeting of the Human Insula
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT03253263 · 338 participants · Phase 2
A Clinical Efficacy and Safety Study of OHB-607 in Preventing Bronchopulmonary Dysplasia in Extremely Premature Infants
- NCT05658731 · 338 participants · NA
Cognitive Outcomes After Brain Substructure-informed Radiation Planning in Pediatric Patients
- NCT06022939 · 338 participants · Phase 3
Comparing Dara-VCD Chemotherapy Plus Stem Cell Transplant to Dara-VCD Chemotherapy Alone for People Who Have Newly Diagnosed AL Amyloidosis
- NCT04176172 · 340 participants · Phase 3
Optimizing Tobacco Use Treatment for PLWHA
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI