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Stress Disorders, Post-Traumatic clinical trials
19 of 66 indexed Stress Disorders, Post-Traumatic trials are currently recruiting.
66 US clinical trials · 19 currently recruiting
Stress Disorders, Post-Traumatic is the subject of 66 registered US clinical trials on ClinicalTrials.gov, 19 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 10 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 17 of these trials.
The research picture
Stress Disorders, Post-Traumatic has 66 registered US clinical trials, 19 of them open to new participants right now, about 29% of the total.
- 19
- recruiting participants now
- 29%
- of trials open to enrollment
- 6
- in Phase 3–4 (later-stage)
- 17
- top sponsor: VA Office of Research and Development
Active & Recent Trials
66 total, page 1 of 2
An Evaluation of Two PTSD Assessments in an Active Duty and Military Veteran Sample
U.S. Army Medical Research and Development Command
NCT04180930
A Study of a Novel EEG Neurofeedback System for PTSD Treatment
Foundation for Atlanta Veterans Education and Research
NCT06770998
SMART Therapist Training: A Hybrid Factorial-SMART Design
VA Office of Research and Development
NCT07010770
Whole Health in VA Mental Health: Omnis Salutis
VA Office of Research and Development
NCT05400252
Manage Emotions to Reduce Aggression (MERA)
VA Office of Research and Development
NCT04793776
Massed Prolonged Exposure for PTSD in Substance Use Treatment
Veterans Medical Research Foundation
NCT06296186
Trauma-Informed Guilt Reduction Therapy Compared to Prolonged Exposure
Veterans Medical Research Foundation
NCT06296589
Computational Assessment of GABA Receptor Modulation in PTSD
VA Office of Research and Development
NCT06852469
Combining Stellate Ganglion Block With Prolonged Exposure for PTSD
The University of Texas Health Science Center at San Antonio
NCT05889741
Intervention to Enhance Coping and Help-seeking Among Youth in Foster Care
Portland State University
NCT06019377
Transcutaneous Vagal Nerve Stimulation in Veterans With Posttraumatic Stress Disorder
VA Office of Research and Development
NCT05517304
Mismatch vs. Standard Intervention During Memory Reconsolidation Blockade With Propranolol: Effect on Psychophysiological Reactivity During Traumatic Imagery
Massachusetts General Hospital
NCT05853627
Overcontrol and Suicide in PTSD
VA Office of Research and Development
NCT06355284
Computer Monitor vs Augmented Reality 3MDR for PTSD PTSD: A Randomized Controlled Trial
Uniformed Services University of the Health Sciences
NCT05244564
Enhancing PTSD Treatment Outcomes by Improving Patient-Provider Communication
Boston University
NCT06088303
Enhancing Memory in CPT for PTSD
VA Office of Research and Development
NCT06000475
Postpartum Care in the NICU (PeliCaN) Transitions
University of Pennsylvania
NCT06521398
MDMA for Co-occurring PTSD and OUD After Childbirth
University of New Mexi
NCT05219175
Healthy Recovery After Trauma Study
Christal L Badour
NCT04585685
Neuropsychological and Mental Outcomes of Operation Iraqi Freedom (OIF): A Longitudinal Cohort Study
VA Office of Research and Development
NCT00748995
Resettled Refugee Families for Healing
Washington University School of Medicine
NCT06176638
Using the Multiphase Optimization Strategy to Adapt Cognitive Processing Therapy
VA Office of Research and Development
NCT05220137
Multi-site, Longitudinal Trial Evaluating the Efficacy, Mechanisms, and Moderators of Service Dogs for Military Veterans With PTSD
University of Arizona
NCT05900479
A Randomized Controlled Trial of Coaching Into Care With VA-CRAFT to Promote Veteran Engagement in PTSD Care
VA Office of Research and Development
NCT04501328
A Randomized Controlled Trial of Doxazosin for Nightmares, Sleep Disturbance, and Non-Nightmare Clinical Symptoms in PTSD
San Francisco Veterans Affairs Medical Center
NCT03339258
Psilocybin for the Treatment of Veterans With Post-Traumatic Stress Disorder
Ohio State University
NCT05554094
Integrating Clinical Practice Guidelines for Smoking Cessation Into Mental Health Care for Veterans With Posttraumatic Stress Disorder
US Department of Veterans Affairs
NCT00118534
Development and Validation of a PTSD-Related Functional Impairment Scale
Boston VA Research Institute
NCT00651872
Cognitive Behavioral Therapy (CBT) for Posttraumatic Stress Disorder (PTSD) in Community Addiction Treatment
Dartmouth-Hitchcock Medical Center
NCT01457391
Homecoming Line: Telephone Support for Veterans
VA Palo Alto Health Care System
NCT02655991
Comparing Effects of a Holistic Yoga Program and a Wellness Program on PTSD Symptoms
VA Office of Research and Development
NCT02234622
Prolonged Exposure Therapy for Post Traumatic Stress Disorder Following Sexual Assault
University of Pennsylvania
NCT00057629
Exposure Therapy for Active Duty Soldiers With Post Traumatic Stress Disorder
National Center for Telehealth and Technology
NCT01193725
Collaborative Care for Women Veterans
VA Office of Research and Development
NCT02950961
Project QueST 2023: Queer Survivors of Trauma
Syracuse University
NCT05569915
Clinical Trial of a Supporter-Targeted Intervention to Improve Outcomes in Recent Sexual Assault Survivors
University of Washington
NCT05345405
CPT-SMART for Treatment of PTSD and Cigarette Smoking
VA Office of Research and Development
NCT03978442
Implementation of CPT for PTSD in Diverse Communities
Massachusetts General Hospital
NCT01702168
Evaluation of a Mobile Phone App for Veterans With PTSD
VA Palo Alto Health Care System
NCT03199742
Prazosin for Treatment of Patients With Alcohol Dependence (AD) and Post Traumatic Stress Disorder (PTSD).
Yale University
NCT00744055
Mindfulness Meditation for the Treatment of Women With Comorbid PTSD and SUD
Medical University of South Carolina
NCT02755103
The Effects of Oxytocin on Startle Hyperreactivity in Patients With AUD and PTSD
University of California, San Francisco
NCT02469259
Improving Mind/Body Health and Functioning With Integrative Exercise
VA Office of Research and Development
NCT02856412
Novel Therapeutics in Posttraumatic Stress Disorder (PTSD): A Randomized Clinical Trial of Mifepristone
VA Office of Research and Development
NCT01739335
Wraparound for High-risk Families with Substance Use Disorders: Examining Family, Child, and Parent Outcomes
Dartmouth-Hitchcock Medical Center
NCT04637581
Examining Effects of a Therapeutic Focus on Positive Memories on Post-Trauma Health
University of North Texas, Denton, TX
NCT05523453
The Effects of Home-Based Telemental Health for Rural Veterans With PTSD
VA Pacific Islands Health Care System
NCT02295410
Feasibility of Using Holographic Memory Resolution® (HMR) in Patients/Clients With Pain
Billings Clinic
NCT05001399
Trial of Paroxetine-CR for the Treatment of Patients With Post Traumatic Stress Disorder Remaining Symptomatic After Initial Exposure Therapy
Massachusetts General Hospital
NCT00121888
Cornerstone Program for Transition-Age Youth Study Protocol for a Randomized Controlled Trial
New York University
NCT02696109
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 7 |
| Phase 3 | 3 |
| Phase 4 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Stress Disorders, Post-Traumatic Trial Landscape
66 indexed Stress Disorders, Post-Traumatic studies · 19 recruiting (29%).
Phase mix: 6 late (III/IV) vs 10 early (I/II).
Top sponsor: VA Office of Research and Development (17 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Stress Disorders, Post-Traumatic?
PlainTrial tracks 66 US clinical trials for Stress Disorders, Post-Traumatic, of which 19 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Stress Disorders, Post-Traumatic?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.