Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

ACTIVE NOT RECRUITING NA

Using the Multiphase Optimization Strategy to Adapt Cognitive Processing Therapy

NCT05220137 · View on ClinicalTrials.gov ↗

Study Summary

Cognitive Processing Therapy (CPT) consists of discrete therapeutic components that are delivered across 12 sessions, but most Veterans never reach session 12, and those who drop out receive only 4 sessions on average. Veterans drop out because of time constraints, logistics, and lack of perceived benefit. Unfortunately, Veterans who drop out prematurely may never receive the most effective components of CPT and continue to experience symptom-related distress and numerous other negative outcomes, including lost productivity, substance use, later-life physical disability, reduced quality of life, and increased risk of suicide. The overall objective of this study is to adapt CPT into a brief, effective format. The rationale is that identifying the most effective intervention components and delivering only those components will make CPT deliverable in a shorter timeframe, thus improving efficiency, reducing drop-out related to poor treatment response, and ensuring that Veterans receive the most beneficial components of treatment, which will significantly improve their quality of life.

Interventions

  • BEHAVIORAL Modified A-B-C: Working with Events, Thoughts, and Feelings
  • BEHAVIORAL Challenging Questions
  • BEHAVIORAL Patterns of Problematic Thinking
  • BEHAVIORAL Challenging Beliefs
  • BEHAVIORAL Veteran's choice of Module (Safety/Trust/Power and Control/Esteem/Intimacy)

Study Locations (3)

Michigan

  • VA Ann Arbor Healthcare System, Ann Arbor, MI — Ann Arbor

Ohio

  • Cincinnati VA Medical Center, Cincinnati, OH — Cincinnati

Utah

  • VA Salt Lake City Health Care System, Salt Lake City, UT — Salt Lake City

Trial Details

FieldValue
Enrollment Target 270 participants
Start Date 2022-08-01
Est. Completion 2026-03-31
Phase NA

Sponsor

VA Office of Research and Development

1,863 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05220137

The ClinicalTrials.gov registry entry for NCT05220137 describes a study currently listed as active not recruiting. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 270 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is VA Office of Research and Development, which has 1,863 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Stress Disorders, Post-Traumatic appearing as the primary indexed condition, and to 5 interventions — of which Modified A-B-C: Working with Events, Thoughts, and Feelings is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05220137 reports 3 study locations spanning 3 distinct geographic areas — top geographies include Michigan, Ohio, Utah. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05220137 about?

NCT05220137 is a clinical study titled "Using the Multiphase Optimization Strategy to Adapt Cognitive Processing Therapy". Cognitive Processing Therapy (CPT) consists of discrete therapeutic components that are delivered across 12 sessions, but most Veterans never reach session 12, and those who drop out receive only 4 sessions on average. Veterans drop out because of time constraints, logistics, and lack of perceived b...

What is the current status of trial NCT05220137?

This trial is currently active not recruiting. It is a NA study. The enrollment target is 270 participants. The study started on 2022-08-01. Estimated completion is 2026-03-31.

What conditions does trial NCT05220137 study?

This clinical trial studies the following conditions: Stress Disorders, Post-Traumatic. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05220137?

The interventions under investigation include: Modified A-B-C: Working with Events, Thoughts, and Feelings (BEHAVIORAL), Challenging Questions (BEHAVIORAL), Patterns of Problematic Thinking (BEHAVIORAL), Challenging Beliefs (BEHAVIORAL), Veteran's choice of Module (Safety/Trust/Power and Control/Esteem/Intimacy) (BEHAVIORAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05220137?

This trial is sponsored by VA Office of Research and Development, which has 1,863 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05220137 being conducted?

This trial has 3 study locations across Michigan, Ohio, Utah. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial