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ClinicalTrials.gov 41 recruiting now official registry

Brain Metastases clinical trials

41 of 68 indexed Brain Metastases trials are currently recruiting.

68 US clinical trials · 41 currently recruiting

Brain Metastases is the subject of 68 registered US clinical trials on ClinicalTrials.gov, 41 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 48 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 7 of these trials.

The research picture

Brain Metastases has 68 registered US clinical trials, 41 of them open to new participants right now, about 60% of the total.

41
recruiting participants now
60%
of trials open to enrollment
3
in Phase 3–4 (later-stage)
7
top sponsor: M.D. Anderson Cancer Center
Phase 122Phase 226Phase 32Phase 41

Active & Recent Trials

68 total, page 1 of 2

RECRUITING 10,000 participants

Metachronic Brain Metastases After Esophagectomy for Esophageal Cancer (METABREC)

Universitaire Ziekenhuizen KU Leuven

NCT04654975

RECRUITING Phase 2 316 participants

EXCLAIM: Exploring Combined Local and Systemic Approaches In Brain Metastasis: a Multi-cohort Randomized Phase II Study Evaluating Initial Response to Systemic Therapy and Subsequent Integration of Stereotactic Radiosurgery in Patients With Low-risk Brain Metastases and Central Nervous System-active

M.D. Anderson Cancer Center

NCT06649058

RECRUITING NA 261 participants

REMASTer: REcurrent Brain Metastases After SRS Trial

Monteris Medical

NCT05124912

RECRUITING Phase 3 206 participants

Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases

Canadian Cancer Trials Group

NCT03550391

RECRUITING NA 180 participants

Trial of Differential Margins in Single Isocenter Radiosurgery of Brain Metastases

University of Alabama at Birmingham

NCT06857006

RECRUITING Phase 2 166 participants

Frameless Stereotactic Radiosurgery for Intact Brain Metastases

University of Chicago

NCT02747303

RECRUITING Phase 2 155 participants

Laser Interstitial Thermal Therapy (LITT) or Surgery and Adjuvant Reirradiation for Recurrent Brain Metastases (LaSAR BeaM)

M.D. Anderson Cancer Center

NCT07053033

RECRUITING Phase 2 120 participants

Phase II Trial of the PARP Inhibitor Niraparib and PD-1 Inhibitor Dostarlimab in Patients With Advanced Cancers With Active Progressing Brain Metastases (STARLET)

M.D. Anderson Cancer Center

NCT05700721

RECRUITING 119 participants

Developing a New MRI Technique to Understand Changes in Brain Tumors After Treatment

Memorial Sloan Kettering Cancer Center

NCT05559853

RECRUITING Phase 2 104 participants

Phase II Study of Pembrolizumab in Combination With Lenvatinib in Patients With TNBC, NSCLC, and Other Tumor Types and Brain Metastases

M.D. Anderson Cancer Center

NCT05064280

RECRUITING Phase 1 80 participants

Neurocognitive Decline in Patients With Brain Metastases

University of Texas Southwestern Medical Center

NCT03508752

RECRUITING Phase 2 62 participants

A Study of Stereotactic Radiosurgery (SRS) for People With Lung Cancer That Has Spread to the Brain

Memorial Sloan Kettering Cancer Center

NCT05419076

RECRUITING Phase 2 60 participants

Reducing the Incidence of Symptomatic Brain Metastases With MRI Surveillance

Wake Forest University Health Sciences

NCT05692635

RECRUITING NA 60 participants

Development of MRF for Characterization of Brain Tumors After Radiotherapy

Case Comprehensive Cancer Center

NCT06101069

RECRUITING Phase 2 60 participants

Trial of Relatlimab, Nivolumab, and Ipilimumab in Patients With Asymptomatic and Symptomatic Melanoma Brain Metastases

Stanford University

NCT06712927

RECRUITING Phase 1 56 participants

Delayed or Upfront Brain RAdiotherapy in Treatment naïve Lung Cancer Patients With Asymptomatic or Minimally Symptomatic Brain Metastases and ALK rEarrangements

Joshua Palmer

NCT05987644

RECRUITING Phase 2 54 participants

Brain Metastases in Greater Size - Hypofractionated Options Trial (BIGSHOT)

Medical University of South Carolina

NCT07227610

RECRUITING Phase 2 53 participants

Optimizing Neurocognition With Whole Brain Radiation Therapy (WBRT) Using Upfront Pulsed Reduced Dose-Rate (PRDR) Technique

Medical College of Wisconsin

NCT05045950

RECRUITING Phase 1 50 participants

Stereotactic Radiosurgery Dose Escalation for Brain Metastases

University of Utah

NCT02390518

RECRUITING Early Phase 1 48 participants

Image-Based, In-Vivo Assessment of Tumor Hypoxia to Guide Hypoxia-Driven Adaptive Radiation Therapy

Vanderbilt-Ingram Cancer Center

NCT05996432

RECRUITING Phase 1 46 participants

18F-Fluciclovine PET Amino Acid Evaluation of Brain Metastasis Treated With Stereotactic Radiosurgery

Baptist Health South Florida

NCT06048094

RECRUITING Phase 1 46 participants

Effect of Azeliragon Combined With Stereotactic Radiation Therapy in Patients With Brain Metastases

Baptist Health South Florida

NCT05789589

RECRUITING Phase 1 45 participants

Personalized Radiotherapy for Individualized Treatment Strategies and Monitoring (PRISM)

University of Texas Southwestern Medical Center

NCT07139990

RECRUITING Phase 1 43 participants

Phase I Study of Fractionated Stereotactic Radiation Therapy

Albert Einstein College of Medicine

NCT03726359

RECRUITING Phase 2 41 participants

NTS-WBRT in Brain Metastases

Massachusetts General Hospital

NCT05013892

RECRUITING Phase 1 41 participants

Pembrolizumab And Stereotactic Radiosurgery (Srs) Of Selected Brain Metastases In Breast Cancer Patients

Weill Medical College of Cornell University

NCT03449238

RECRUITING NA 35 participants

MeDex: No Perioperative Dexamethasone in Brain Metastases

University of Louisville

NCT07044557

RECRUITING Phase 1 33 participants

Defactinib and Avutometinib, With or Without Encorafenib, for the Treatment of Patients With Brain Metastases From Cutaneous Melanoma

University of Utah

NCT06194929

RECRUITING Phase 1 31 participants

Stereotactic Radiation & Abemaciclib in the Management of HR+/HER2- Breast Cancer Brain Metastases

H. Lee Moffitt Cancer Center and Research Institute

NCT04923542

RECRUITING NA 30 participants

Evaluation of the CONVIVO System

Dartmouth-Hitchcock Medical Center

NCT05139277

RECRUITING Phase 2 30 participants

A Phase II Study of Tucatinib and Ado-trastuzumab Emtansine (T-DM1) in Patients With HER2-positive Metastatic Solid Tumors and Metastases to Brain (TUCATEMEB)

M.D. Anderson Cancer Center

NCT05673928

RECRUITING NA 24 participants

Neurocognitive Functioning With Genu-Sparing Whole Brain Radiation Therapy for Brain Metastases

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT03223922

RECRUITING Phase 1 20 participants

Assess Use of 18F-Fluciclovine for Patients With Large Brain Metastases Treated With Staged Stereotactic Radiosurgery

Baptist Health South Florida

NCT04689048

RECRUITING Phase 4 20 participants

Brain [18F]-FES PET/CT in Patients With Estrogen-Receptor Positive Breast Cancer

Weill Medical College of Cornell University

NCT06072807

RECRUITING 20 participants

7T Brain MRI Scan for Micro-brain Metastasis (microBM) Detection for Patients With Small-cell Lung Cancer (SCLC), Who Decline Prophylactic Cranial Irradiation (PCI)

University of Missouri-Columbia

NCT07175077

RECRUITING Phase 2 20 participants

Feasibility of 18F-Fluciclovine PET/CT to Identify Brain Metastasis

University of Arizona

NCT06055790

RECRUITING Phase 1 20 participants

Fluorine-18-AlphaVBeta6-Binding Peptide Positron Emission Tomography in Metastatic Non-Small Cell Lung Cancer

University of California, Davis

NCT05452005

RECRUITING Phase 2 20 participants

A Phase II Study of Nivolumab With Ipilimumab and Cabozantinib in Patients With Untreated Renal Cell Carcinoma Brain Metastases

M.D. Anderson Cancer Center

NCT05048212

RECRUITING Phase 2 20 participants

Characterization of 18F-Fluciclovine PET Amino Acid Radiotracer in Resected Brain Metastasis

Baptist Health South Florida

NCT05554302

RECRUITING NA 20 participants

A Pilot Study to Assess the Clinical Utility of 18F-Fluciclovine (Axumin) PET-CT for Detecting True-versus Pseudo-Progression of Brain Metastases on Immunotherapy

M.D. Anderson Cancer Center

NCT06015295

RECRUITING 15 participants

MRI Biomarkers for Radiation-Induced Neurocognitive Decline Following SRS of Newly Diagnosed Brain Mets

UNC Lineberger Comprehensive Cancer Center

NCT04073966

ACTIVE NOT RECRUITING Phase 3 230 participants

Post-Surgical Stereotactic Radiotherapy (SRT) Versus GammaTile-ROADS (Radiation One and Done Study)

GT Medical Technologies

NCT04365374

ACTIVE NOT RECRUITING NA 196 participants

Hippocampal Sparing Whole Brain Radiation Versus Stereotactic Radiation in Patients With 5-20 Brain Metastases: A Phase III, Randomized Trial

Dana-Farber Cancer Institute

NCT03075072

ACTIVE NOT RECRUITING Phase 2 134 participants

Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases

Brigham and Women's Hospital

NCT04899908

ACTIVE NOT RECRUITING Phase 2 101 participants

Pembrolizumab In Central Nervous System Metastases

Massachusetts General Hospital

NCT02886585

ACTIVE NOT RECRUITING NA 100 participants

Stereotactic Radiation in Patients With Small Cell Lung Cancer and 1-10 Brain Metastases

Dana-Farber Cancer Institute

NCT03391362

ACTIVE NOT RECRUITING Phase 2 49 participants

Preop fSRS for Resectable Brain Metastases

H. Lee Moffitt Cancer Center and Research Institute

NCT05267587

ACTIVE NOT RECRUITING Phase 2 48 participants

Secondary BRain Metastases Prevention After Isolated Intracranial Progression on Trastuzumab/Pertuzumab or T-DM1 in Patients With aDvanced Human Epidermal Growth Factor Receptor 2+ brEast Cancer With the Addition of Tucatinib

Carey Anders, M.D.

NCT05323955

ACTIVE NOT RECRUITING NA 25 participants

MRI Following Stereotactic Radiosurgery (SRS) for Brain Metastases

Duke University

NCT04246879

ACTIVE NOT RECRUITING Early Phase 1 25 participants

Dose Escalation Trial of Neoadjuvant Radiosurgery for the Treatment of Metastatic Brain Tumors

Cedars-Sinai Medical Center

NCT03163368

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Phase Distribution

PhaseTrial count
Phase 1 22
Phase 2 26
Phase 3 2
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Brain Metastases Trial Landscape

68 indexed Brain Metastases studies · 41 recruiting (60%).

Phase mix: 3 late (III/IV) vs 48 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (7 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Brain Metastases?

PlainTrial tracks 68 US clinical trials for Brain Metastases, of which 41 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Brain Metastases?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.