Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT06355284 · ClinicalTrials.gov registry record
Overcontrol and Suicide in PTSD
A clinical trial of Stress Disorders, Post-Traumatic and Compulsive Personality Disorder, sponsored by VA Office of Research and Development.
- Recruiting
- Registry status
- 74
- Enrollment target
- 1
- Study location
NCT06355284: Recruiting study of Stress Disorders, Post-Traumatic and Compulsive Personality Disorder, sponsored by VA Office of Research and Development.
NCT06355284 is a study of Stress Disorders, Post-Traumatic and Compulsive Personality Disorder that is actively recruiting participants, run by VA Office of Research and Development. The registered enrollment target is 74 participants, below the 155-participant average among 66 other Stress Disorders, Post-Traumatic trials with a reported enrollment target (52% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06355284, a study of Stress Disorders, Post-Traumatic and Compulsive Personality Disorder, is actively recruiting participants, sponsored by VA Office of Research and Development.
- RECRUITING
- Registry status
- 74 participants
- Enrollment target
- 1
- Study location
Study Summary
High standards and self-discipline are prized in military culture, but drawbacks of overcontrol are often ignored. Overcontrol is characterized by over-regulated behavior and cognitive rigidity, driven by an intense need for perfection and control. It is frequently observed in people with obsessive-compulsive (OC) spectrum disorders, especially OC Personality Disorder (OCPD). Their inclination to set high expectations for others can strain social bonds. When grappling with mental health challenges, overcontrolled individuals often do so with limited social support, and as a result, tend to be at greater risk of developing more severe mental health symptoms, or suicidal thoughts and behaviors, over time. New treatments are needed to improve social functioning in these vulnerable Veterans. Adding brain stimulation to psychotherapy is one method that might speed learning of social skills discussed in therapy. However, before this technology can be developed and tested more broadly, the investigators must make sure that the methods used to measure social functioning and related brain circuits are acceptable to most potential patients and can be used consistently. In this pilot project, the investigators aim to recruit trauma-exposed Veterans with overcontrolled traits and study the feasibility and acceptability of: 1. Our recruitment strategy and social functioning and mental health symptom assessments 2. A three-session, weekly fMRI protocol. 3. A three-week online protocol for remote monitoring of social and emotional functioning.
Primary Outcome
Indexes feasibility of recruitment and enrollment screening strategy.
Conditions Studied
Interventions
- OTHER Functional MRI
Study Locations (1)
Rhode Island
- Providence VA Medical Center, Providence, RI - Providence
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 74 participants |
| Start Date | 2024-07-01 |
| Est. Completion | 2026-04-30 |
What NCT06355284 shows while recruiting
NCT06355284 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 74 participants, a relatively small participant target, below the 155-participant average among 66 other Stress Disorders, Post-Traumatic trials with a reported enrollment target (52% lower).
The record links to 2 conditions, with Stress Disorders, Post-Traumatic appearing as the primary indexed condition, and to 1 intervention - of which Functional MRI is the first listed.
NCT06355284 reports a single indexed study location in Rhode Island.
Frequently Asked Questions
What is clinical trial NCT06355284 about?
NCT06355284 is a clinical study titled "Overcontrol and Suicide in PTSD". High standards and self-discipline are prized in military culture, but drawbacks of overcontrol are often ignored. Overcontrol is characterized by over-regulated behavior and cognitive rigidity, driven by an intense need for perfection and control. It is frequently observed in people with obsessive-...
What is the current status of trial NCT06355284?
This trial is currently recruiting. The enrollment target is 74 participants. The study started on 2024-07-01. Estimated completion is 2026-04-30.
What conditions does trial NCT06355284 study?
This clinical trial studies the following conditions: Stress Disorders, Post-Traumatic, Compulsive Personality Disorder.
What interventions are being tested in trial NCT06355284?
The interventions under investigation include: Functional MRI (OTHER).
Who is sponsoring clinical trial NCT06355284?
This trial is sponsored by VA Office of Research and Development, which has 1,668 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06355284 being conducted?
This trial has 1 study location across Rhode Island. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Stress Disorders, Post-Traumatic
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06355284's enrollment target sits among peer trials
74 39th of 66 higher than 28 of 66 other Stress Disorders, Post-Traumatic trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Stress Disorders, Post-Traumatic trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Manage Emotions to Reduce Aggression (MERA)
RECRUITING · NA
-
SMART Therapist Training: A Hybrid Factorial-SMART Design
RECRUITING · NA
-
Postpartum Care in the NICU (PeliCaN) Transitions
RECRUITING · NA
-
Healthy Recovery After Trauma Study
RECRUITING · NA
-
MDMA for Co-occurring PTSD and OUD After Childbirth
RECRUITING · Phase 2
-
Intervention to Enhance Coping and Help-seeking Among Youth in Foster Care
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT03422731 · 74 participants · Early Phase 1
Multi-modality Imaging and Collection of Biospecimen Samples in Understanding Bone Marrow Changes in Patients With Acute Myeloid Leukemia Undergoing TBI and Chemotherapy
- NCT03804853 · 74 participants · NA
Rehabilitation Following Reverse Total Shoulder Arthroplasty
- NCT04065776 · 74 participants · NA
Evaluation of Hippocampal-Avoidance Using Proton Therapy in Low-Grade Glioma
- NCT04771156 · 74 participants · Phase 4
Ketorolac in Palatoplasty
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI