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NCT05523453 · ClinicalTrials.gov registry record · NA
Examining Effects of a Therapeutic Focus on Positive Memories on Post-Trauma Health
A NA study of Stress Disorders, Post-Traumatic and Memory, sponsored by University of North Texas, Denton, TX.
- Completed
- Registry status
- NA
- Development phase
- 70
- Enrollment target
- 1
- Study location
NCT05523453: Completed NA study of Stress Disorders, Post-Traumatic and Memory, sponsored by University of North Texas, Denton, TX.
NCT05523453 is a NA study of Stress Disorders, Post-Traumatic and Memory that has completed, run by University of North Texas, Denton, TX. The registered enrollment target is 70 participants, below the 155-participant average among 66 other Stress Disorders, Post-Traumatic trials with a reported enrollment target (55% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05523453, a NA study of Stress Disorders, Post-Traumatic and Memory, has completed, sponsored by University of North Texas, Denton, TX.
- COMPLETED
- Registry status
- NA
- Development phase
- 70 participants
- Enrollment target
- 1
- Study location
Study Summary
Posttraumatic stress disorder (PTSD) has devastating health consequences. Evidence-based PTSD interventions address the substantial burden of PTSD on the health of individuals and societies; however, several individuals receiving these interventions drop out and not all individuals experience improvement in PTSD symptoms. Moreover, these current PTSD interventions primarily target trauma memories. Notably, growing evidence suggests that PTSD symptoms are related to difficulties in the encoding and retrieving of positive memories as well. Thus, the proposed study will examine effects of and targets underlying a novel PTSD technique focused on narrating and detailing positive memories - Processing of Positive Memories Technique (PPMT). Methodologically, 70 individuals will be randomly assigned to PPMT vs. Supportive Counseling (SC) for this study. The aims of the proposed study include (1) examining PPMT's effects on PTSD symptom severity and stress systems' dysregulation (i.e., awakening salivary alpha amylase \[sAA\] and cortisol); (2) examining mechanisms underlying PPMT's effects; and (3) refining PPMT. It is hypothesized that the PPMT arm will report greater decreases in PTSD severity and sAA/cortisol ratios. Further, it is hypothesized that PPMT-related improved affect will mediate the association between study arm (PPMT vs. SC) and changes in PTSD severity. Lastly, feedback will be obtained from study participants on PPMT's feasibility, format, and content to refine PPMT. The proposed study may contribute preliminary evidence on the potential significance of targeting positive memories in PTSD interventions.
Primary Outcome
The 20-item self-report PTSD Checklist for DSM-5 (PCL-5) assessed past-week posttraumatic stress disorder (PTSD) severity. Response options ranged from 0 (not at all) to 4 (extremely), with the possible range being from 0 to 80. Higher scores indicate more PTSD symptom severity.
Conditions Studied
Interventions
- BEHAVIORAL Processing of Positive Memories Technique (PPMT)
- BEHAVIORAL Supportive Counseling (SC)
Study Locations (1)
Texas
- University of North Texas - Denton
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 70 participants |
| Start Date | 2023-02-23 |
| Est. Completion | 2025-02-19 |
| Phase | NA |
What the finished NCT05523453 record still lists
NCT05523453 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 70 participants, a relatively small participant target, below the 155-participant average among 66 other Stress Disorders, Post-Traumatic trials with a reported enrollment target (55% lower).
The record links to 3 conditions, with Stress Disorders, Post-Traumatic appearing as the primary indexed condition, and to 2 interventions - of which Processing of Positive Memories Technique (PPMT) is the first listed.
NCT05523453 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT05523453 about?
NCT05523453 is a clinical study titled "Examining Effects of a Therapeutic Focus on Positive Memories on Post-Trauma Health". Posttraumatic stress disorder (PTSD) has devastating health consequences. Evidence-based PTSD interventions address the substantial burden of PTSD on the health of individuals and societies; however, several individuals receiving these interventions drop out and not all individuals experience improv...
What is the current status of trial NCT05523453?
This trial is currently completed. It is a NA study. The enrollment target is 70 participants. The study started on 2023-02-23. Estimated completion is 2025-02-19.
What conditions does trial NCT05523453 study?
This clinical trial studies the following conditions: Stress Disorders, Post-Traumatic, Memory, Affect.
What interventions are being tested in trial NCT05523453?
The interventions under investigation include: Processing of Positive Memories Technique (PPMT) (BEHAVIORAL), Supportive Counseling (SC) (BEHAVIORAL).
Who is sponsoring clinical trial NCT05523453?
This trial is sponsored by University of North Texas, Denton, TX, which has 8 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05523453 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT05523453's enrollment target sits among peer trials
70 41st of 66 higher than 26 of 66 other Stress Disorders, Post-Traumatic trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Stress Disorders, Post-Traumatic trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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