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Diabetic Foot Ulcer
Open-data reference.
68 US clinical trials · 42 currently recruiting
Active & Recent Trials
DFC 004 Biomarkers for Active Diabetic Foot Ulcers
University of Michigan
NCT06104969
Non-Invasive Testing to Evaluate Wound Healing in Diabetes
University of Texas Southwestern Medical Center
NCT04232631
Trial Assessing the Efficacy of Human Placental Membrane Products and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot Ulcers and Venous Leg Ulcers
BioLab Holdings
NCT07089602
Trial to Evaluate the Safety and Effectiveness of Treatment With COMS One Device in Subjects With Diabetic Foot Ulcers
Piomic Medical
NCT05758545
Randomized Evaluation of Nonhealing Diabetic Foot Ulcers With Exclusive Wound Therapy
Sequence LifeScience
NCT07086443
A Modified Platform Trial of Multiple CAMPs for the Management of Diabetic Foot Ulcers and Venous Leg Ulcers
Integra LifeSciences Corporation
NCT06453187
Evaluating Several Cellular, Acellular, and Matrix-like Products (CAMPs) and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot and Venous Leg Ulcers.
Tiger Biosciences
NCT06826339
Modified Multi-Platform Trial Assessing Multiple CAMPs and SOC vs SOC Alone in the Treatment of DFU and VLUs
Stability Biologics
NCT06560502
EDX110 Randomized Control Trial for Treatment of DFUs
ConvaTec
NCT07209358
Comprehensive Assistance and Resources for Effective Diabetic Foot Navigation
Emory University
NCT07223268
Clinical Utility of an Amniotic Membrane Allograft for Diabetic Foot Ulcer Wound Management
Legacy Medical Consultants
NCT06420245
A Study to Evaluate ENERGI-F703 GEL in Diabetic Foot Ulcer
Energenesis Biomedical Co.
NCT05930210
Smart Boot Use to Measure Offloading Adherence
University of Southern California
NCT04460573
Study Assessing Complete Wound Healing by Comparing Surgenex® PelloGraft in Treating DFU and SanoGraft® in Treating VLU to SOC
Surgenex
NCT06515093
Real World Evidence with the Debritom+ TM Novel Micro Water Jet Technology At a Single Wound Center
Medaxis
NCT04920253
Orthotic Treatment of Diabetic Foot Ulcers
VA Office of Research and Development
NCT05094037
Modified Platform Trial Evaluating PpLHACM and SOC Versus SOC Alone in the Treatment of Nonhealing DFUs
MiMedx Group
NCT06600724
Evaluating the Efficacy of Perinatal Membrane Allografts in Addition to the Standard of Care for the Treatment of Non-healing Diabetic Foot Ulcers.
Samaritan Biologics
NCT06437028
A Study to Evaluate the Efficacy of a Purified Native Type 1 Collagen Extracellular Matrix With Polyhexamethylene Biguanide Antimicrobial (PCMP) and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot Ulcers
Organogenesis
NCT06618612
Derm-Maxx in Patients With Diabetic Foot Ulcers Unresponsive to Standard of Care Treatment Alone
Capsicure
NCT06455475
Amnio-Maxx in Patients With Diabetic Foot Ulcers Unresponsive to Standard of Care Treatment Alone
Capsicure
NCT06572839
Evaluating the Efficacy NeoThelium FT in the Treatment of Diabetic Foot Ulcers
NuScience Medical Biologics
NCT06938685
Evaluating the Efficacy of OCM™ (Omeza® Complete Matrix) in the Treatment of Diabetic Foot Ulcers
Omeza
NCT07161830
Evaluating the Efficacy of a Single Layer Placental-based Allograft and Standard of Care Versus Standard of Care
Applied Biologics
NCT06564831
Feasibility and Effectiveness of a Remote Monitoring Program for the Treatment of Diabetic Foot Ulcers
Johns Hopkins University
NCT05579743
Nonhealing Diabetic Foot Ulcers Treated With Standard of Care (SOC) Alone or Standard of Care and Amnion-Intermediate-Chorion (AIC)
Cellution Biologics
NCT07014176
Total Contact Soft Cast in Diabetic Foot Ulcers
University of Minnesota
NCT04210089
Dehydrated Human Amnion Membrane and Standard of Care Versus Standard of Care Alone in Nonhealing Diabetic Foot Ulcers
Axolotl Biologix
NCT06550596
Noraxon myoRESEARCH™ Software Gait Analysis Evaluation and Orthotic Gait Correction in Reducing Diabetic Foot Ulceration Or Subsequent Amputation in Patients With a History of a Diabetic Foot Ulceration
Johns Hopkins University
NCT04164641
A Clinical Investigation to Follow the Progress of Exuding Chronic Wounds Using Mepilex® Up as the Primary Dressing.
Molnlycke Health Care AB
NCT05588583
A Multicenter, Prospective, Controlled Clinical Trial Evaluating the Efficacy of a Single Layer Placental-based Allograft and Standard of Care in the Management of Nonhealing Diabetic Foot Ulcers
Applied Biologics
NCT07159282
Exercise Enhances Wound Healing in Patients With Diabetic Foot Ulcers
University of New Mexi
NCT04791449
Evaluating a Lifestyle Intervention to Prevent Recurrence of Diabetic Foot Ulcers
University of Southern California
NCT06487780
A Phase 2a Proof of Concept Open-Label, Randomized, Controlled Study to Evaluate the Safety and Efficacy of MDI-1228-mesylate Gel Compared With Standard of Care Alone in Patients With Diabetic Foot Ulcers
Zhuhai Rui-Inno Pharmaceutical Technology Co.
NCT06852976
Evaluating the Durability of Closure for Diabetic Foot Ulcers Following a Randomized, Controlled, Modified Platform Trial.
Applied Biologics
NCT07360418
A Multicenter, Prospective, Controlled Modified Multi-Platform Trial Assessing the Efficacy of Human Placental Membrane Products and Standard of Care in the Management of Nonhealing Diabetic Foot Ulcers and Venous Leg Ulcers.
BioLab Holdings
NCT07364630
NOX1416 in Treatment of Chronic Non-Healing Diabetic Foot Ulcers
NOxy Health Products
NCT06402565
Evaluate Use of Tropocells(R) Autologous Platelet-rich Fibrin (PRF) for Wagner Grade 1 and Grade 2, Mild to Mod Neuroischemic Plantar Diabetic Foot Ulcer Wound Care.
Estar Medical dba Medical Technologies
NCT06810726
Adapting Lifestyle Offloading for DFUs
University of Southern California
NCT06278935
Mirragen Diabetic Foot Ulcer Study
The University of Texas Health Science Center at San Antonio
NCT06598241
Evaluation of ELU42 Topical Spray for the Treatment of Diabetic Foot Ulcers
Eluciderm
NCT07396376
Prospective Case Series Evaluating the Efficacy and Safety of NeoThelium FT for Diabetic Foot Ulcers
NuScience Medical Biologics
NCT07039396
Geko™ Cross Therapy Registry - Wound
Firstkind
NCT05007301
Study Evaluating Several CAMPs in Nonhealing Diabetic Foot and Venous Leg Ulcers
Cellution Biologics
NCT06562296
A Unique Micro Water Jet Technology Device Versus Standard Debridement in the Treatment of Diabetic Foot
Medaxis
NCT04564443
Efficacy of ProgenaMatrix™ in the Management of DFUs
ProgenaCare Global
NCT06292026
Omega3 Wound Fish Skin Graft in the Treatment of DFUs
Kerecis
NCT04133493
Non-healing Diabetic Foot Ulcers Treated With Standard Care With or Without BR-AM
BioStem Technologies
NCT06565156
Sterilised, Porcine Placental Tissue in the Treatment of Chronic Diabetic Foot Ulcers
ConvaTec
NCT05687656
Wound Assessment Using Spectral Imaging US
SpectralMD
NCT05415683
DermACELL in Subjects With Chronic Wounds of the Lower Extremities
LifeNet Health
NCT01970163
Clinical Study Evaluating Symphony™ Versus Standard of Care in the Treatment of Non-Healing Diabetic Foot Ulcers
Aroa Biosurgery Limited
NCT06035536
Diabetic Foot Ulcers-Comparing Transforming Powder to Standard of Care
ULURU
NCT05046158
VA MERIT: A Comparative Efficacy Study: Treatment of Non-Healing Diabetic
VA Office of Research and Development
NCT01450943
AMNIOEXCEL® Plus vs A Marketed Comparator vs SOC in the Management of Diabetic Foot Ulcers
Integra LifeSciences Corporation
NCT03547635
Implementation of Telemedicine for Patient With Lower Extremity Wounds
University of California, Davis
NCT04440839
Phase 2a Multi-Center Prospective, Randomized Trial to Evaluate the Safety & Efficacy of Topical PEP-TISSEEL for Diabetic Foot Ulcers (DFU)
Rion
NCT06319287
Diabetic Foot Ulcer (DFU) Rapid Pathogen Identification
University of Michigan
NCT06569238
Evaluation Of An Advanced Borderless Dressing
Smith & Nephew
NCT03146845
Comparative Effectiveness of Two Acellular Matrices (Dermacell vs. Integra) for Management of Deep Diabetic Foot Ulcers
Baylor College of Medicine
NCT03476876
The Effects of Nutrition Supplementation and Education on the Healing of Diabetic Foot Ulcer (DFU)
Florida State University
NCT04055064
Evaluating The Efficacy Of A Keratin Graft In Treating Non-Healing Diabetic Foot Ulcers
ProgenaCare Global
NCT05797285
Comparative Study of Amniotic Membrane Wound Graft In the Management of Diabetic Foot Ulcers
MiMedx Group
NCT01552499
Clinical Study to Compare Two Skin Substitute Categories for Their Effectiveness to Treat Diabetic Foot Ulcers
Encoll
NCT06557122
Multi Center Site , Controlled Trial Comparing a Bioengineered Skin Substitute to a Human Skin Allograft
Solsys Medical
NCT01676272
Topical PluroGel PN for the Treatment of Mildly Infected Diabetic Foot Ulcers
PluroGen Therapeutics
NCT02119754
Pilot Study of PHOENIX Wound Matrix® Impact on Chronic DFU Wound Microbiome
RenovoDerm
NCT04437537
Evaluating Clinical Acceptance of a NPWT Wound Care System
Medela
NCT03670225
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 2 |
| Phase 2 | 6 |
| Phase 3 | 2 |
| Phase 4 | 7 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Diabetic Foot Ulcer Trial Landscape
ClinicalTrials.gov lists 68 US studies indexed under Diabetic Foot Ulcer, and 42 of those are currently open to recruitment — roughly 62% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Diabetic Foot Ulcer shows 9 late-stage studies (Phase 3 and Phase 4 combined) alongside 8 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Diabetic Foot Ulcer is led by Applied Biologics with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 68 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Diabetic Foot Ulcer?
PlainTrial tracks 68 US clinical trials for Diabetic Foot Ulcer, of which 42 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Diabetic Foot Ulcer?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.