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2026 data Public-data reference. official source

Diabetic Foot Ulcer

Open-data reference.

68 US clinical trials · 42 currently recruiting

Active & Recent Trials

RECRUITING 5,000 participants

DFC 004 Biomarkers for Active Diabetic Foot Ulcers

University of Michigan

NCT06104969

RECRUITING 700 participants

Non-Invasive Testing to Evaluate Wound Healing in Diabetes

University of Texas Southwestern Medical Center

NCT04232631

RECRUITING Phase 4 650 participants

Trial Assessing the Efficacy of Human Placental Membrane Products and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot Ulcers and Venous Leg Ulcers

BioLab Holdings

NCT07089602

RECRUITING NA 450 participants

Trial to Evaluate the Safety and Effectiveness of Treatment With COMS One Device in Subjects With Diabetic Foot Ulcers

Piomic Medical

NCT05758545

RECRUITING Phase 4 350 participants

Randomized Evaluation of Nonhealing Diabetic Foot Ulcers With Exclusive Wound Therapy

Sequence LifeScience

NCT07086443

RECRUITING NA 350 participants

A Modified Platform Trial of Multiple CAMPs for the Management of Diabetic Foot Ulcers and Venous Leg Ulcers

Integra LifeSciences Corporation

NCT06453187

RECRUITING Phase 4 340 participants

Evaluating Several Cellular, Acellular, and Matrix-like Products (CAMPs) and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot and Venous Leg Ulcers.

Tiger Biosciences

NCT06826339

RECRUITING NA 324 participants

Modified Multi-Platform Trial Assessing Multiple CAMPs and SOC vs SOC Alone in the Treatment of DFU and VLUs

Stability Biologics

NCT06560502

RECRUITING NA 298 participants

EDX110 Randomized Control Trial for Treatment of DFUs

ConvaTec

NCT07209358

RECRUITING NA 270 participants

Comprehensive Assistance and Resources for Effective Diabetic Foot Navigation

Emory University

NCT07223268

RECRUITING NA 240 participants

Clinical Utility of an Amniotic Membrane Allograft for Diabetic Foot Ulcer Wound Management

Legacy Medical Consultants

NCT06420245

RECRUITING Phase 3 230 participants

A Study to Evaluate ENERGI-F703 GEL in Diabetic Foot Ulcer

Energenesis Biomedical Co.

NCT05930210

RECRUITING Phase 2 210 participants

Smart Boot Use to Measure Offloading Adherence

University of Southern California

NCT04460573

RECRUITING NA 180 participants

Study Assessing Complete Wound Healing by Comparing Surgenex® PelloGraft in Treating DFU and SanoGraft® in Treating VLU to SOC

Surgenex

NCT06515093

RECRUITING NA 180 participants

Real World Evidence with the Debritom+ TM Novel Micro Water Jet Technology At a Single Wound Center

Medaxis

NCT04920253

RECRUITING NA 175 participants

Orthotic Treatment of Diabetic Foot Ulcers

VA Office of Research and Development

NCT05094037

RECRUITING NA 170 participants

Modified Platform Trial Evaluating PpLHACM and SOC Versus SOC Alone in the Treatment of Nonhealing DFUs

MiMedx Group

NCT06600724

RECRUITING NA 170 participants

Evaluating the Efficacy of Perinatal Membrane Allografts in Addition to the Standard of Care for the Treatment of Non-healing Diabetic Foot Ulcers.

Samaritan Biologics

NCT06437028

RECRUITING NA 170 participants

A Study to Evaluate the Efficacy of a Purified Native Type 1 Collagen Extracellular Matrix With Polyhexamethylene Biguanide Antimicrobial (PCMP) and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot Ulcers

Organogenesis

NCT06618612

RECRUITING NA 150 participants

Derm-Maxx in Patients With Diabetic Foot Ulcers Unresponsive to Standard of Care Treatment Alone

Capsicure

NCT06455475

RECRUITING NA 150 participants

Amnio-Maxx in Patients With Diabetic Foot Ulcers Unresponsive to Standard of Care Treatment Alone

Capsicure

NCT06572839

RECRUITING NA 132 participants

Evaluating the Efficacy NeoThelium FT in the Treatment of Diabetic Foot Ulcers

NuScience Medical Biologics

NCT06938685

RECRUITING NA 130 participants

Evaluating the Efficacy of OCM™ (Omeza® Complete Matrix) in the Treatment of Diabetic Foot Ulcers

Omeza

NCT07161830

RECRUITING NA 124 participants

Evaluating the Efficacy of a Single Layer Placental-based Allograft and Standard of Care Versus Standard of Care

Applied Biologics

NCT06564831

RECRUITING NA 120 participants

Feasibility and Effectiveness of a Remote Monitoring Program for the Treatment of Diabetic Foot Ulcers

Johns Hopkins University

NCT05579743

RECRUITING Phase 4 120 participants

Nonhealing Diabetic Foot Ulcers Treated With Standard of Care (SOC) Alone or Standard of Care and Amnion-Intermediate-Chorion (AIC)

Cellution Biologics

NCT07014176

RECRUITING NA 100 participants

Total Contact Soft Cast in Diabetic Foot Ulcers

University of Minnesota

NCT04210089

RECRUITING NA 100 participants

Dehydrated Human Amnion Membrane and Standard of Care Versus Standard of Care Alone in Nonhealing Diabetic Foot Ulcers

Axolotl Biologix

NCT06550596

RECRUITING NA 69 participants

Noraxon myoRESEARCH™ Software Gait Analysis Evaluation and Orthotic Gait Correction in Reducing Diabetic Foot Ulceration Or Subsequent Amputation in Patients With a History of a Diabetic Foot Ulceration

Johns Hopkins University

NCT04164641

RECRUITING NA 68 participants

A Clinical Investigation to Follow the Progress of Exuding Chronic Wounds Using Mepilex® Up as the Primary Dressing.

Molnlycke Health Care AB

NCT05588583

RECRUITING Phase 4 60 participants

A Multicenter, Prospective, Controlled Clinical Trial Evaluating the Efficacy of a Single Layer Placental-based Allograft and Standard of Care in the Management of Nonhealing Diabetic Foot Ulcers

Applied Biologics

NCT07159282

RECRUITING NA 60 participants

Exercise Enhances Wound Healing in Patients With Diabetic Foot Ulcers

University of New Mexi

NCT04791449

RECRUITING NA 60 participants

Evaluating a Lifestyle Intervention to Prevent Recurrence of Diabetic Foot Ulcers

University of Southern California

NCT06487780

RECRUITING Phase 2 60 participants

A Phase 2a Proof of Concept Open-Label, Randomized, Controlled Study to Evaluate the Safety and Efficacy of MDI-1228-mesylate Gel Compared With Standard of Care Alone in Patients With Diabetic Foot Ulcers

Zhuhai Rui-Inno Pharmaceutical Technology Co.

NCT06852976

RECRUITING 50 participants

Evaluating the Durability of Closure for Diabetic Foot Ulcers Following a Randomized, Controlled, Modified Platform Trial.

Applied Biologics

NCT07360418

RECRUITING Phase 4 50 participants

A Multicenter, Prospective, Controlled Modified Multi-Platform Trial Assessing the Efficacy of Human Placental Membrane Products and Standard of Care in the Management of Nonhealing Diabetic Foot Ulcers and Venous Leg Ulcers.

BioLab Holdings

NCT07364630

RECRUITING Phase 1 40 participants

NOX1416 in Treatment of Chronic Non-Healing Diabetic Foot Ulcers

NOxy Health Products

NCT06402565

RECRUITING Phase 2 30 participants

Evaluate Use of Tropocells(R) Autologous Platelet-rich Fibrin (PRF) for Wagner Grade 1 and Grade 2, Mild to Mod Neuroischemic Plantar Diabetic Foot Ulcer Wound Care.

Estar Medical dba Medical Technologies

NCT06810726

RECRUITING NA 20 participants

Adapting Lifestyle Offloading for DFUs

University of Southern California

NCT06278935

RECRUITING 20 participants

Mirragen Diabetic Foot Ulcer Study

The University of Texas Health Science Center at San Antonio

NCT06598241

RECRUITING Phase 1 15 participants

Evaluation of ELU42 Topical Spray for the Treatment of Diabetic Foot Ulcers

Eluciderm

NCT07396376

RECRUITING NA 10 participants

Prospective Case Series Evaluating the Efficacy and Safety of NeoThelium FT for Diabetic Foot Ulcers

NuScience Medical Biologics

NCT07039396

ACTIVE NOT RECRUITING 2,500 participants

Geko™ Cross Therapy Registry - Wound

Firstkind

NCT05007301

ACTIVE NOT RECRUITING Phase 4 292 participants

Study Evaluating Several CAMPs in Nonhealing Diabetic Foot and Venous Leg Ulcers

Cellution Biologics

NCT06562296

ACTIVE NOT RECRUITING NA 222 participants

A Unique Micro Water Jet Technology Device Versus Standard Debridement in the Treatment of Diabetic Foot

Medaxis

NCT04564443

ACTIVE NOT RECRUITING NA 100 participants

Efficacy of ProgenaMatrix™ in the Management of DFUs

ProgenaCare Global

NCT06292026

ACTIVE NOT RECRUITING NA 100 participants

Omega3 Wound Fish Skin Graft in the Treatment of DFUs

Kerecis

NCT04133493

ACTIVE NOT RECRUITING NA 72 participants

Non-healing Diabetic Foot Ulcers Treated With Standard Care With or Without BR-AM

BioStem Technologies

NCT06565156

ACTIVE NOT RECRUITING NA 30 participants

Sterilised, Porcine Placental Tissue in the Treatment of Chronic Diabetic Foot Ulcers

ConvaTec

NCT05687656

COMPLETED 400 participants

Wound Assessment Using Spectral Imaging US

SpectralMD

NCT05415683

COMPLETED NA 202 participants

DermACELL in Subjects With Chronic Wounds of the Lower Extremities

LifeNet Health

NCT01970163

COMPLETED NA 143 participants

Clinical Study Evaluating Symphony™ Versus Standard of Care in the Treatment of Non-Healing Diabetic Foot Ulcers

Aroa Biosurgery Limited

NCT06035536

COMPLETED NA 135 participants

Diabetic Foot Ulcers-Comparing Transforming Powder to Standard of Care

ULURU

NCT05046158

COMPLETED Phase 3 120 participants

VA MERIT: A Comparative Efficacy Study: Treatment of Non-Healing Diabetic

VA Office of Research and Development

NCT01450943

COMPLETED NA 116 participants

AMNIOEXCEL® Plus vs A Marketed Comparator vs SOC in the Management of Diabetic Foot Ulcers

Integra LifeSciences Corporation

NCT03547635

COMPLETED NA 116 participants

Implementation of Telemedicine for Patient With Lower Extremity Wounds

University of California, Davis

NCT04440839

COMPLETED Phase 2 59 participants

Phase 2a Multi-Center Prospective, Randomized Trial to Evaluate the Safety & Efficacy of Topical PEP-TISSEEL for Diabetic Foot Ulcers (DFU)

Rion

NCT06319287

COMPLETED NA 44 participants

Diabetic Foot Ulcer (DFU) Rapid Pathogen Identification

University of Michigan

NCT06569238

COMPLETED NA 40 participants

Evaluation Of An Advanced Borderless Dressing

Smith & Nephew

NCT03146845

COMPLETED Phase 2 34 participants

Comparative Effectiveness of Two Acellular Matrices (Dermacell vs. Integra) for Management of Deep Diabetic Foot Ulcers

Baylor College of Medicine

NCT03476876

COMPLETED NA 29 participants

The Effects of Nutrition Supplementation and Education on the Healing of Diabetic Foot Ulcer (DFU)

Florida State University

NCT04055064

COMPLETED NA 26 participants

Evaluating The Efficacy Of A Keratin Graft In Treating Non-Healing Diabetic Foot Ulcers

ProgenaCare Global

NCT05797285

COMPLETED NA 25 participants

Comparative Study of Amniotic Membrane Wound Graft In the Management of Diabetic Foot Ulcers

MiMedx Group

NCT01552499

COMPLETED NA 24 participants

Clinical Study to Compare Two Skin Substitute Categories for Their Effectiveness to Treat Diabetic Foot Ulcers

Encoll

NCT06557122

COMPLETED 23 participants

Multi Center Site , Controlled Trial Comparing a Bioengineered Skin Substitute to a Human Skin Allograft

Solsys Medical

NCT01676272

COMPLETED Phase 2 15 participants

Topical PluroGel PN for the Treatment of Mildly Infected Diabetic Foot Ulcers

PluroGen Therapeutics

NCT02119754

COMPLETED NA 11 participants

Pilot Study of PHOENIX Wound Matrix® Impact on Chronic DFU Wound Microbiome

RenovoDerm

NCT04437537

COMPLETED NA 10 participants

Evaluating Clinical Acceptance of a NPWT Wound Care System

Medela

NCT03670225

Phase Distribution

PhaseTrial count
Early Phase 1 2
Phase 2 6
Phase 3 2
Phase 4 7

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Diabetic Foot Ulcer Trial Landscape

ClinicalTrials.gov lists 68 US studies indexed under Diabetic Foot Ulcer, and 42 of those are currently open to recruitment — roughly 62% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Diabetic Foot Ulcer shows 9 late-stage studies (Phase 3 and Phase 4 combined) alongside 8 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Diabetic Foot Ulcer is led by Applied Biologics with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 68 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Diabetic Foot Ulcer?

PlainTrial tracks 68 US clinical trials for Diabetic Foot Ulcer, of which 42 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Diabetic Foot Ulcer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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