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Acne Vulgaris
Open-data reference.
68 US clinical trials · 2 currently recruiting
Active & Recent Trials
Weekly Isotretinoin vs Tetracycline for Moderate Acne
Medical University of South Carolina
NCT06225570
Clascoterone for Steroid-related Acne Vulgaris in Transgender Male Patients Receiving Masculinizing Hormone Therapy
Stanford University
NCT05891795
Study to Evaluate the Safety and Efficacy of BF-200 ALA (Ameluz®) and BF-RhodoLED® in the Treatment of Moderate to Severe Acne Vulgaris With Photodynamic Therapy in Adults
Biofrontera
NCT05080764
A Post Market Device Study for the Treatment of Acne
Cutera
NCT06469398
Lipidome and Microbiome Profile of Acne
University of California, Davis
NCT02713607
Laser Treatment of Moderate to Severe Acne Vulgaris
Massachusetts General Hospital
NCT04466527
A Study to Assess Sebaceous Gland Changes and Constituents of Sebum (Skin Oil) Induced by Clascoterone 1% Cream in Acne Patients
Sun Pharmaceutical Industries Limited
NCT06425900
Randomized, Double-blind, Placebo-controlled Study to Evaluate Safety & Efficacy of Sarecycline in Treatment of Acne
Almirall, S.A.
NCT02322866
A Study Comparing Trifarotene Cream 0.005% to AKLIEF® CREAM (US REFERENCE LISTED DRUG), AKLIEF™ CREAM (CANADIAN REFERENCE PRODUCT) in the Treatment of Acne Vulgaris
Sun Pharmaceutical Industries
NCT06733402
A Study Comparing Adapalene Gel 0.1% and to Differin Gel in the Treatment of Acne Vulgaris
Sun Pharmaceutical Industries
NCT04797793
A Study Comparing Tretinoin Gel Microsphere, 0.1% and RETIN-A MICRO ® Gel Microsphere, 0.1% in the Treatment of Acne Vulgaris
Sun Pharmaceutical Industries
NCT04883736
A Study Comparing Trifarotene Cream 0.005% to AKLIEF® Cream in the Treatment of Acne Vulgaris
Sun Pharmaceutical Industries
NCT06063473
A Study of Olumacostat Glasaretil Gel in Subjects With Acne Vulgaris
Dermira
NCT03028363
A Long-term Safety Study of Olumacostat Glasaretil Gel in Subjects With Acne Vulgaris
Dermira
NCT03127956
A Study of Olumacostat Glasaretil Gel in Subjects With Acne Vulgaris
Dermira
NCT03073486
A Study to Evaluate the Safety and Efficacy of Tazarotene Foam, 0.1%, in Subjects With Common Facial Acne
Stiefel, a GSK Company
NCT01017120
Study to Compare the Safety and Efficacy of IDP-126 Gel to Epiduo® Forte Gel and Vehicle Gel
Bausch Health Americas
NCT04892706
Placebo Controlled Efficacy and Safety Study of CD2475/101 40 mg Tablets vs. Placebo and Doxycycline 100 mg Capsules Once Daily in the Treatment of Inflammatory Lesions of Acne Vulgaris
Galderma R&D
NCT01320033
An Open-Label, Long-Term Extension Study to Evaluate the Safety of CB-03-01 Cream, 1% in Participants With Acne Vulgaris
Cassiopea SpA
NCT02682264
P3 Long Term Safety Study of Once Daily SB204 in Acne
Novan
NCT02798120
Safety and Efficacy Study of Clindamycin/Benzoyl Peroxide/Tazarotene Cream in Subjects With Acne
Stiefel, a GSK Company
NCT00713609
Evaluate Safety and Efficacy of an OC Preparation vs Placebo for 6 Treatment Cycles in Women With Moderate Acne.
Bayer
NCT00651469
A Safety and Efficacy Evaluation of Topical Treatments for Moderate-Severe Facial Acne Vulgaris
Braintree Laboratories
NCT02604680
A Multi-Center Open-Label Evaluation of the Safety of Sarecycline Tablets in the Treatment of Acne Vulgaris
Almirall, S.A.
NCT02413346
A Study of S6G5T3 in the Treatment of Acne Vulgaris
Sol-Gel Technologies
NCT03761810
A Dose-ranging Study of DRM01 in Subjects With Acne Vulgaris
Dermira
NCT02431052
Clinical Trial in Subjects With Mild to Moderate Acne Vulgaris
AOBiome
NCT02832063
A Clinical Study Evaluating the Safety and Efficacy of IDP-107 in Patients With Acne Vulgaris
Dow Pharmaceutical Sciences
NCT00666900
Efficacy and Safety of IDP-120 Gel in the Treatment of Acne Vulgaris
Bausch Health Americas
NCT03003247
A Study to Evaluate the Safety and Efficacy of Omiganan (CLS001) Topical Gel Versus Vehicle in Female Subjects With Moderate to Severe Acne Vulgaris
Maruho Co.
NCT02571998
Dose Range Study of CD5789 in Acne Vulgaris
Galderma R&D
NCT01616654
Light Dose Ranging Study of Photodynamic Therapy (PDT) With Levulan + Blue Light Versus Vehicle + Blue Light in Severe Facial Acne
DUSA Pharmaceuticals
NCT00706433
BPX-01 Minocycline Topical Gel in the Treatment of Acne Vulgaris
BioPharmX
NCT02815332
Cultural Differences in Treatment Preferences and Perceptions of Acne
Northwestern University
NCT03192163
A Study to Compare Efficacy and Safety of Trifarotene Cream When Used With an Oral Antibiotic for the Treatment of Severe Acne Vulgaris (AV)
Galderma R&D
NCT04451330
A Phase 2 Study of ASC-J9 Cream in Acne Vulgaris
AndroScience
NCT00525499
A Treatment for Severe Inflammatory Acne Subjects
Galderma R&D
NCT02899000
Clinical Study Comparing the Efficacy and Safety of IDP-126 Gel in the Treatment of Acne Vulgaris
Bausch Health Americas
NCT04214639
Evaluation of Irritation That Potentially Could be Caused by Two Facial Gels Applied to Opposite Sides of the Face
Bausch Health Americas
NCT00952523
Efficacy and Safety Study of Gevokizumab to Treat Moderate to Severe Acne Vulgaris
XOMA (US)
NCT01498874
U0289-405: An Open-Label, 12-Week Study to Evaluate the Efficacy and Safety of the Acne System (Benzoyl Peroxide 2.5%, Salicylic Acid 0.5%) in Subjects With Acne
Stiefel, a GSK Company
NCT01446237
AkLief Evaluation in Acne-induced Post-Inflammatory Hyperpigmentation
Galderma R&D
NCT05089708
A Study to Evaluate the Efficacy and Safety of Imsidolimab (ANB019) in the Treatment of Participants With Acne Vulgaris
Vanda Pharmaceuticals
NCT04856917
Efficacy and Safety Study With Visonac Photodynamic Therapy (PDT)
Photocure
NCT00933543
Comparison Between Interactive Internet-based Education and Counseling for the Management of Acne With That of Internet-based Education Alone
University of California, Davis
NCT02031718
Long-term Follow-up Study of Subjects Who Completed Clinical Studies 755.1100_FA, 810.1100_FA, or 1064.1100_FA
Sienna Labs
NCT03039634
A Study of Dapsone Gel in Females With Skin of Color and Acne Vulgaris
Allergan
NCT02032407
Cutaneous Tolerability and Safety of NVN1000 Topical Gel in Healthy Volunteers
Novan
NCT01694810
A Thorough ECG Study in Subjects With Acne Vulgaris Treated With SB204
Novan
NCT02581072
Pharmacokinetic Study to Compare the Systemic Exposure of Differin® Gel, 0.3% or Differin® Gel, 0.1%
Galderma R&D
NCT00660985
Infrared Non-Cutting Laser Therapy for Acne
University of Michigan
NCT00110643
A Clinical In-Use Evaluation to Assess the Tolerability and Efficacy of a Moisturizer on Acne Prone Skin
Kenvue Brands
NCT07224633
A Study to Evaluate the Tolerance of an Acne Treatment in Sensitive Skin Subjects With Mild to Moderate Acne Vulgaris
Johnson & Johnson Consumer Inc. (J&JCI)
NCT03128723
A Study to Evaluate the Potential of Tazarotene Foam to Cause a Reaction When Applied to the Skin and Exposed to Light on Healthy Volunteers
Stiefel, a GSK Company
NCT01115322
Compare the Tolerance of Clindamycin 1% /Benzoyl Peroxide (BPO) 5% Gel to Clindamycin 1.2%/ BPO 2.5% Topical Medications
Stiefel, a GSK Company
NCT01015638
Assessment of Subjects' Efficacy and Experiences Using Adapalene BPO Gel in the Treatment of Acne Vulgaris
Galderma R&D
NCT01209949
Safety and Efficacy Of Drospirenone and Ethinyl Estradiol vs Placebo in the Treatment of Truncal Acne
Massachusetts General Hospital
NCT00722761
A Study to Evaluate the Bioavailability of Tazarotene Foam, 0.1%, and Tazorac Gel, 0.1%, in Subjects With Acne Vulgaris
Stiefel, a GSK Company
NCT01019603
An Evaluation of the Adrenal Suppression Potential and PK of CB-03-01 Cream in Pediatric Patients With Acne Vulgaris
Cassiopea SpA
NCT02720627
A Study That Evaluates the Decrease in Irritation When Using Additional Acne Treatment Products
Bausch Health Americas
NCT01313728
Evaluation of Irritation by Two Facial Gels Applied to Opposite Sides of the Face
Bausch Health Americas
NCT00919191
Adherence to Study Medication Compared to Generic Topical Clindamycin Plus Generic Topical Tretinoin in Subjects With Mild to Moderate Acne Vulgaris
Wake Forest University
NCT01047189
The Use of Onexton in Moderate Acne Vulgaris for Patients With Skin of Color
Derm Research, P
NCT03402893
Photodynamic Therapy (PDT) With Methyl Aminolevulinate (MAL) Cream in Patients With Skin Type V or IV With Acne Vulgaris
Photocure
NCT00673933
Aczone Gel 7.5% in the Treatment of Acne Vulgaris in Patients With Skin of Color
Icahn School of Medicine at Mount Sinai
NCT03681470
Study of Benzoyl Peroxide Cream for Mild to Moderate Acne Vulgaris
Northwestern University
NCT00558831
A Study of the Safety, Engraftment, and Action of NB01 in Adults With Moderate Acne
Naked Biome
NCT03450369
Timolol for the Treatment of Acne and Rosacea
Johns Hopkins University
NCT02774590
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 13 |
| Phase 2 | 20 |
| Phase 3 | 12 |
| Phase 4 | 14 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Acne Vulgaris Trial Landscape
ClinicalTrials.gov lists 68 US studies indexed under Acne Vulgaris, and 2 of those are currently open to recruitment — roughly 3% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Acne Vulgaris shows 26 late-stage studies (Phase 3 and Phase 4 combined) alongside 33 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Acne Vulgaris is led by Galderma R&D with 7 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 68 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Acne Vulgaris?
PlainTrial tracks 68 US clinical trials for Acne Vulgaris, of which 2 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Acne Vulgaris?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.