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ClinicalTrials.gov 23 recruiting now official registry

Refractory Multiple Myeloma clinical trials

23 of 68 indexed Refractory Multiple Myeloma trials are currently recruiting.

68 US clinical trials · 23 currently recruiting

Refractory Multiple Myeloma is the subject of 68 registered US clinical trials on ClinicalTrials.gov, 23 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 63 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 35 of these trials.

The research picture

Refractory Multiple Myeloma has 68 registered US clinical trials, 23 of them open to new participants right now, about 34% of the total.

23
recruiting participants now
34%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
35
top sponsor: National Cancer Institute (NCI)
Phase 122Phase 241Phase 32

Active & Recent Trials

68 total, page 1 of 2

RECRUITING Phase 2 300 participants

MMRC Horizon One Adaptive Platform Trial Evaluating Therapies in RRMM

Multiple Myeloma Research Consortium

NCT06171685

RECRUITING Phase 1 130 participants

Study to Assess Safety and Tolerability of OPN-6602 in Subjects With Relapsed and/or Refractory Multiple Myeloma

Opna Bio

NCT06433947

RECRUITING Phase 2 130 participants

A Study to Evaluate Preventive Treatments for Talquetamab-related Oral Toxicity

Janssen Research & Development

NCT06500884

RECRUITING Phase 1 128 participants

IDP-023 as a Single Agent and in Combination With Antibody Therapies in Patients With Advanced Hematologic Cancers

Indapta Therapeutics

NCT06119685

RECRUITING Phase 2 62 participants

Alternate Doses and Dosing Schedules of Belantamab Mafodotin for Treatment of Triple-Class Refractory Multiple Myeloma

Mayo Clinic

NCT05847569

RECRUITING Phase 2 50 participants

Isatuximab, Bela Maf, Pom, and Dex in Relapsed/Refractory Multiple Myeloma

Massachusetts General Hospital

NCT05922501

RECRUITING NA 50 participants

Real World Insights During Treatment for Relapsed/Refractory Multiple Myeloma with Isatuximab

Pack Health

NCT05053607

RECRUITING Phase 1 49 participants

Elotuzumab + Iberdomide + Dexamethasone Post Ide-Cel in RRMM

Omar Nadeem, MD

NCT06518551

RECRUITING Phase 2 44 participants

Dasatinib and Quercetin With CAR-T Therapy for the Treatment of Patients With Relapsed or Refractory Multiple Myeloma

Mayo Clinic

NCT06940297

RECRUITING Phase 2 43 participants

Daratumumab, Carfilzomib, Pomalidomide, Dexamethasone In MM

Andrew Yee, MD

NCT04176718

RECRUITING Phase 1 32 participants

Talquetamab in Combination With Iberdomide and Dexamethasone for Relapsed or Refractory Multiple Myeloma

Alfred Chung, MD

NCT06348108

RECRUITING Phase 2 32 participants

Elranatamab in R/R Multiple Myeloma

Massachusetts General Hospital

NCT06138275

RECRUITING Phase 1 31 participants

Cilta-Talq Fusion Study: A Phase 1b Study of Talquetamab Bridging Therapy Followed by Ciltacabtagene Autoleucel in Patients With Relapsed/Refractory Multiple Myeloma

Medical College of Wisconsin

NCT07093554

RECRUITING Phase 1 30 participants

CRISPR Delivered Anti-BCMA Car-T Therapy for Relapsed or Refractory Multiple Myeloma

Thomas Martin, MD

NCT07340853

RECRUITING Phase 2 30 participants

Iberdomide, Daratumumab, Carfilzomib, and Dexamethasone (Iber-KDd) in Patients With Relapsed/Refractory Multiple Myeloma

Benjamin T Diamond, MD

NCT05896228

RECRUITING Phase 1 30 participants

Response-Based Dose Reduction of Linvoseltamab in the Treatment of Relapsed, Refractory, or Triple-Class Relapsed/Refractory Multiple Myeloma

Fred Hutchinson Cancer Center

NCT07181941

RECRUITING Phase 2 28 participants

Mezigdomide, Carfilzomib, and Dexamethasone for the Treatment of Relapsed or Refractory Multiple Myeloma in Patients With Extramedullary Disease

Roswell Park Cancer Institute

NCT06627751

RECRUITING Phase 1 27 participants

Elotuzumab, CC-92480, and Dexamethasone for the Treatment of Relapsed or Refractory Myeloma After CD38- and BCMA-Targeted Therapies

Abdullah Khan

NCT05981209

RECRUITING Phase 1 26 participants

Testing Teclistamab (TECVAYLI) in Combination With Iberdomide for Relapsed or Refractory Multiple Myeloma

National Cancer Institute (NCI)

NCT06465316

RECRUITING Phase 1 25 participants

A Phase 1 Study of Vaccination With Dendritic Cell (DC)/Multiple Myeloma (MM) Fusions in Combination With Elranatamab in Relapsed or Refractory Multiple Myeloma

David Avigan

NCT06799026

RECRUITING NA 20 participants

Prehabilitation With Aerobic and Resistance Exercise for Improving Physical Fitness and Quality of Life Outcomes in Older Patients Undergoing CAR-T Therapy for Relapsed or Refractory Multiple Myeloma

Mayo Clinic

NCT07045727

RECRUITING Phase 1 18 participants

TriPRIL CAR T Cells in Multiple Myeloma

Marcela V. Maus, M.D.,Ph.D.

NCT05020444

RECRUITING Phase 1 15 participants

SX-682 in Combination With Carfilzomib, Daratumumab-Hyaluronidase, and Dexamethasone in Patients With Relapsed or Refractory Multiple Myeloma

Roswell Park Cancer Institute

NCT06622005

ACTIVE NOT RECRUITING Phase 3 460 participants

Lenalidomide in Treating Patients With Multiple Myeloma Undergoing Autologous Stem Cell Transplant

National Cancer Institute (NCI)

NCT00114101

ACTIVE NOT RECRUITING Phase 2 70 participants

Testing GDC-0032 (Taselisib) as a Potential Targeted Treatment in Cancers With PIK3CA Genetic Changes (MATCH-Subprotocol I)

National Cancer Institute (NCI)

NCT04439175

ACTIVE NOT RECRUITING Phase 2 53 participants

Testing Binimetinib as a Potential Targeted Treatment in Cancers With NRAS Genetic Changes (MATCH-Subprotocol Z1A)

National Cancer Institute (NCI)

NCT04439344

ACTIVE NOT RECRUITING Phase 2 50 participants

Testing Trametinib as a Potential Targeted Treatment in Cancers With NF1 Genetic Changes (MATCH-Subprotocol S1)

National Cancer Institute (NCI)

NCT04439318

ACTIVE NOT RECRUITING Phase 2 49 participants

Testing MLN0128 (TAK-228) as Potentially Targeted Treatment in Cancers With TSC1 or TSC2 Genetic Changes (MATCH - Subprotocol M)

National Cancer Institute (NCI)

NCT06390865

ACTIVE NOT RECRUITING Phase 2 44 participants

Testing Crizotinib as Potentially Targeted Treatment in Cancers With MET Genetic Changes (MATCH - Subprotocol C1)

National Cancer Institute (NCI)

NCT06357975

ACTIVE NOT RECRUITING Phase 2 40 participants

Testing Afatinib as a Potential Targeted Treatment in Cancers With HER2 Genetic Changes (MATCH-Subprotocol B)

National Cancer Institute (NCI)

NCT04439136

ACTIVE NOT RECRUITING NA 40 participants

High Throughput Drug Sensitivity and Genomics Data in Developing Individualized Treatment in Patients With Relapsed or Refractory Multiple Myeloma or Plasma Cell Leukemia

University of Washington

NCT03389347

ACTIVE NOT RECRUITING Phase 1 39 participants

Selinexor, Pomalidomide, and Dexamethasone With or Without Carfilzomib for the Treatment of Patients With Relapsed Refractory Multiple Myeloma, The SCOPE Trial

Mayo Clinic

NCT04764942

ACTIVE NOT RECRUITING Phase 2 38 participants

Testing Ado-Trastuzumab Emtansine as a Potential Targeted Treatment in Cancers With HER2 Genetic Changes (MATCH-Subprotocol Q)

National Cancer Institute (NCI)

NCT04439110

ACTIVE NOT RECRUITING Phase 1 36 participants

CB-839 HCl in Combination With Carfilzomib and Dexamethasone in Treating Patients With Recurrent or Refractory Multiple Myeloma

National Cancer Institute (NCI)

NCT03798678

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing Copanlisib as Potentially Targeting Treatment in Cancers With PTEN Expression (MATCH - Subprotocol Z1H)

National Cancer Institute (NCI)

NCT06400238

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing LOXO-101 as Potentially Targeted Treatment in Cancers With NTRK Genetic Changes (MATCH - Subprotocol Z1E)

National Cancer Institute (NCI)

NCT06390852

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing AZD1775 as a Potential Targeted Treatment in Cancers With BRCA Genetic Changes (MATCH-Subprotocol Z1I)

National Cancer Institute (NCI)

NCT04439227

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing VS-6063 (Defactinib) as a Potential Targeted Treatment in Cancers With NF2 Genetic Changes (MATCH-Subprotocol U)

National Cancer Institute (NCI)

NCT04439331

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing GDC-0449 (Vismodegib) as Potentially Targeted Treatment in Cancers With Smoothened or Patched 1 Mutant Tumors (MATCH - Subprotocol T)

National Cancer Institute (NCI)

NCT06357988

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing GSK2636771 as a Potential Targeted Treatment in Cancers With PTEN Loss of Expression (MATCH-Subprotocol P)

National Cancer Institute (NCI)

NCT04439188

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing Trametinib as a Potential Targeted Treatment in Cancers With BRAF Genetic Changes (MATCH-Subprotocol R)

National Cancer Institute (NCI)

NCT04439279

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing Copanlisib as a Potential Targeted Treatment in Cancers With PIK3CA Mutations (MATCH-Subprotocol Z1F)

National Cancer Institute (NCI)

NCT05490771

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing JNJ-42756493 (Erdafitinib) as Potentially Targeting Treatment in Cancers With FGFR Amplifications (MATCH-Subprotocol K1)

National Cancer Institute (NCI)

NCT06308822

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing AZD5363 as a Potential Targeted Treatment in Cancers With AKT Genetic Changes (MATCH-Subprotocol Y)

National Cancer Institute (NCI)

NCT04439123

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing MLN0128 (TAK-228) as Potentially Targeted Treatment in Cancers With mTOR Genetic Changes (MATCH - Subprotocol L)

National Cancer Institute (NCI)

NCT06385496

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing BVD-523FB (Ulixertinib) as Potentially Targeted Treatment in Cancers With Genetic Changes (MATCH - Subprotocol Z1L)

National Cancer Institute (NCI)

NCT06400225

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing Trametinib and Dabrafenib as a Potential Targeted Treatment in Cancers With BRAF Genetic Changes (MATCH-Subprotocol H)

National Cancer Institute (NCI)

NCT04439292

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing Ipatasertib as Potentially Targeted Treatment in Cancers With AKT Genetic Changes (MATCH - Subprotocol Z1K)

National Cancer Institute (NCI)

NCT06400251

ACTIVE NOT RECRUITING Phase 2 30 participants

Isatuximab, Carfilzomib, Pomalidomide, and Dexamethasone for the Treatment of Relapsed or Refractory Multiple Myeloma

University of Washington

NCT04883242

ACTIVE NOT RECRUITING Phase 2 24 participants

Testing GSK2636771 as a Potential Targeted Treatment in Cancers With PTEN Genetic Changes (MATCH-Subprotocol N)

National Cancer Institute (NCI)

NCT04439149

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Phase Distribution

PhaseTrial count
Phase 1 22
Phase 2 41
Phase 3 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Refractory Multiple Myeloma Trial Landscape

68 indexed Refractory Multiple Myeloma studies · 23 recruiting (34%).

Phase mix: 2 late (III/IV) vs 63 early (I/II).

Top sponsor: National Cancer Institute (NCI) (35 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Refractory Multiple Myeloma?

PlainTrial tracks 68 US clinical trials for Refractory Multiple Myeloma, of which 23 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Refractory Multiple Myeloma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.