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2026 data Public-data reference. official source

Stress Disorders, Post-Traumatic

Open-data reference.

60 US clinical trials · 19 currently recruiting

Active & Recent Trials

RECRUITING 950 participants

An Evaluation of Two PTSD Assessments in an Active Duty and Military Veteran Sample

U.S. Army Medical Research and Development Command

NCT04180930

RECRUITING NA 250 participants

A Study of a Novel EEG Neurofeedback System for PTSD Treatment

Foundation for Atlanta Veterans Education and Research

NCT06770998

RECRUITING NA 240 participants

SMART Therapist Training: A Hybrid Factorial-SMART Design

VA Office of Research and Development

NCT07010770

RECRUITING NA 238 participants

Whole Health in VA Mental Health: Omnis Salutis

VA Office of Research and Development

NCT05400252

RECRUITING NA 204 participants

Manage Emotions to Reduce Aggression (MERA)

VA Office of Research and Development

NCT04793776

RECRUITING NA 200 participants

Massed Prolonged Exposure for PTSD in Substance Use Treatment

Veterans Medical Research Foundation

NCT06296186

RECRUITING NA 158 participants

Trauma-Informed Guilt Reduction Therapy Compared to Prolonged Exposure

Veterans Medical Research Foundation

NCT06296589

RECRUITING Phase 4 150 participants

Computational Assessment of GABA Receptor Modulation in PTSD

VA Office of Research and Development

NCT06852469

RECRUITING Phase 2 140 participants

Combining Stellate Ganglion Block With Prolonged Exposure for PTSD

The University of Texas Health Science Center at San Antonio

NCT05889741

RECRUITING NA 106 participants

Intervention to Enhance Coping and Help-seeking Among Youth in Foster Care

Portland State University

NCT06019377

RECRUITING NA 80 participants

Transcutaneous Vagal Nerve Stimulation in Veterans With Posttraumatic Stress Disorder

VA Office of Research and Development

NCT05517304

RECRUITING Phase 4 80 participants

Mismatch vs. Standard Intervention During Memory Reconsolidation Blockade With Propranolol: Effect on Psychophysiological Reactivity During Traumatic Imagery

Massachusetts General Hospital

NCT05853627

RECRUITING 74 participants

Overcontrol and Suicide in PTSD

VA Office of Research and Development

NCT06355284

RECRUITING NA 60 participants

Computer Monitor vs Augmented Reality 3MDR for PTSD PTSD: A Randomized Controlled Trial

Uniformed Services University of the Health Sciences

NCT05244564

RECRUITING NA 54 participants

Enhancing PTSD Treatment Outcomes by Improving Patient-Provider Communication

Boston University

NCT06088303

RECRUITING NA 30 participants

Enhancing Memory in CPT for PTSD

VA Office of Research and Development

NCT06000475

RECRUITING NA 20 participants

Postpartum Care in the NICU (PeliCaN) Transitions

University of Pennsylvania

NCT06521398

RECRUITING Phase 2 15 participants

MDMA for Co-occurring PTSD and OUD After Childbirth

University of New Mexi

NCT05219175

RECRUITING NA 12 participants

Healthy Recovery After Trauma Study

Christal L Badour

NCT04585685

ACTIVE NOT RECRUITING 817 participants

Neuropsychological and Mental Outcomes of Operation Iraqi Freedom (OIF): A Longitudinal Cohort Study

VA Office of Research and Development

NCT00748995

ACTIVE NOT RECRUITING NA 308 participants

Resettled Refugee Families for Healing

Washington University School of Medicine

NCT06176638

ACTIVE NOT RECRUITING NA 270 participants

Using the Multiphase Optimization Strategy to Adapt Cognitive Processing Therapy

VA Office of Research and Development

NCT05220137

ACTIVE NOT RECRUITING NA 150 participants

Multi-site, Longitudinal Trial Evaluating the Efficacy, Mechanisms, and Moderators of Service Dogs for Military Veterans With PTSD

University of Arizona

NCT05900479

ACTIVE NOT RECRUITING Phase 2 80 participants

A Randomized Controlled Trial of Doxazosin for Nightmares, Sleep Disturbance, and Non-Nightmare Clinical Symptoms in PTSD

San Francisco Veterans Affairs Medical Center

NCT03339258

ACTIVE NOT RECRUITING Phase 2 15 participants

Psilocybin for the Treatment of Veterans With Post-Traumatic Stress Disorder

Ohio State University

NCT05554094

COMPLETED NA 943 participants

Integrating Clinical Practice Guidelines for Smoking Cessation Into Mental Health Care for Veterans With Posttraumatic Stress Disorder

US Department of Veterans Affairs

NCT00118534

COMPLETED 740 participants

Development and Validation of a PTSD-Related Functional Impairment Scale

Boston VA Research Institute

NCT00651872

COMPLETED Phase 3 443 participants

Cognitive Behavioral Therapy (CBT) for Posttraumatic Stress Disorder (PTSD) in Community Addiction Treatment

Dartmouth-Hitchcock Medical Center

NCT01457391

COMPLETED NA 358 participants

Homecoming Line: Telephone Support for Veterans

VA Palo Alto Health Care System

NCT02655991

COMPLETED NA 212 participants

Comparing Effects of a Holistic Yoga Program and a Wellness Program on PTSD Symptoms

VA Office of Research and Development

NCT02234622

COMPLETED Phase 2 187 participants

Prolonged Exposure Therapy for Post Traumatic Stress Disorder Following Sexual Assault

University of Pennsylvania

NCT00057629

COMPLETED NA 131 participants

Project QueST 2023: Queer Survivors of Trauma

Syracuse University

NCT05569915

COMPLETED NA 128 participants

Clinical Trial of a Supporter-Targeted Intervention to Improve Outcomes in Recent Sexual Assault Survivors

University of Washington

NCT05345405

COMPLETED Phase 4 120 participants

CPT-SMART for Treatment of PTSD and Cigarette Smoking

VA Office of Research and Development

NCT03978442

COMPLETED 107 participants

Implementation of CPT for PTSD in Diverse Communities

Massachusetts General Hospital

NCT01702168

COMPLETED NA 101 participants

Evaluation of a Mobile Phone App for Veterans With PTSD

VA Palo Alto Health Care System

NCT03199742

COMPLETED Phase 3 96 participants

Prazosin for Treatment of Patients With Alcohol Dependence (AD) and Post Traumatic Stress Disorder (PTSD).

Yale University

NCT00744055

COMPLETED NA 90 participants

Mindfulness Meditation for the Treatment of Women With Comorbid PTSD and SUD

Medical University of South Carolina

NCT02755103

COMPLETED Early Phase 1 88 participants

The Effects of Oxytocin on Startle Hyperreactivity in Patients With AUD and PTSD

University of California, San Francis

NCT02469259

COMPLETED NA 84 participants

Improving Mind/Body Health and Functioning With Integrative Exercise

VA Office of Research and Development

NCT02856412

COMPLETED Phase 2 81 participants

Novel Therapeutics in Posttraumatic Stress Disorder (PTSD): A Randomized Clinical Trial of Mifepristone

VA Office of Research and Development

NCT01739335

COMPLETED NA 73 participants

Wraparound for High-risk Families with Substance Use Disorders: Examining Family, Child, and Parent Outcomes

Dartmouth-Hitchcock Medical Center

NCT04637581

COMPLETED NA 70 participants

Examining Effects of a Therapeutic Focus on Positive Memories on Post-Trauma Health

University of North Texas, Denton, TX

NCT05523453

COMPLETED 66 participants

The Effects of Home-Based Telemental Health for Rural Veterans With PTSD

VA Pacific Islands Health Care System

NCT02295410

COMPLETED NA 60 participants

Feasibility of Using Holographic Memory Resolution® (HMR) in Patients/Clients With Pain

Billings Clinic

NCT05001399

COMPLETED Phase 1 60 participants

Trial of Paroxetine-CR for the Treatment of Patients With Post Traumatic Stress Disorder Remaining Symptomatic After Initial Exposure Therapy

Massachusetts General Hospital

NCT00121888

COMPLETED NA 55 participants

Investigation of the Freespira Breathing System in the Treatment of Post Traumatic Stress Disorder (PTSD)

Palo Alto Health Sciences

NCT03039231

COMPLETED NA 50 participants

Mindfulness Based Stress Reduction for Posttraumatic Stress Disorder: A Pilot Study

Seattle Institute for Biomedical and Clinical Research

NCT00880152

COMPLETED NA 46 participants

Meditation in Veterans With PTSD and Mild TBI

VA Office of Research and Development

NCT02280304

COMPLETED NA 45 participants

A Cognitive Behavioral Therapy and Yoga Program for Trauma Symptoms

Georgetown University

NCT02368444

COMPLETED NA 45 participants

Suicide and Trauma Reduction Initiative Among VEterans

University of Utah

NCT03933059

COMPLETED Phase 2 41 participants

Ketamine as a Rapid Treatment for Post-traumatic Stress Disorder (PTSD)

Dennis Charney

NCT00749203

COMPLETED NA 32 participants

HIRREM in Military Personnel

Wake Forest University Health Sciences

NCT03230890

COMPLETED NA 30 participants

Adapting Treatment Delivery to Improve Retention in Evidence-Based PTSD Treatment

VA Office of Research and Development

NCT06335589

COMPLETED 30 participants

Ketamine Infusion Therapy for PTSD in Combat Veterans

Klarisana Physician Services P

NCT03088384

COMPLETED NA 30 participants

taVNS to Reduce PTSD Symptoms in WTC Responders

Northwell Health

NCT05212714

COMPLETED NA 19 participants

Wildlife and Wellbeing: An Animal-Assisted Intervention for Veterans With PTSD

University of Massachusetts, Worcester

NCT04116489

COMPLETED NA 13 participants

An Immersion Intervention for Symptoms of PTSD in Student Veterans

University of Nevada, Las Vegas

NCT05309031

COMPLETED NA 9 participants

Effectiveness of Prazosin in Bulimic Patients Experiencing Nightmares Due to PTSD

Milton S. Hershey Medical Center

NCT02382848

COMPLETED Phase 3

Fluoxetine vs EMDR to Treat Post-Traumatic Stress Disorder (PTSD)

Boston University

NCT00000379

Phase Distribution

PhaseTrial count
Early Phase 1 2
Phase 2 7
Phase 3 3
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Stress Disorders, Post-Traumatic Trial Landscape

ClinicalTrials.gov lists 60 US studies indexed under Stress Disorders, Post-Traumatic, and 19 of those are currently open to recruitment — roughly 32% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Stress Disorders, Post-Traumatic shows 6 late-stage studies (Phase 3 and Phase 4 combined) alongside 9 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Stress Disorders, Post-Traumatic is led by VA Office of Research and Development with 15 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 60 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Stress Disorders, Post-Traumatic?

PlainTrial tracks 60 US clinical trials for Stress Disorders, Post-Traumatic, of which 19 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Stress Disorders, Post-Traumatic?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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