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Stress Disorders, Post-Traumatic
Open-data reference.
60 US clinical trials · 19 currently recruiting
Active & Recent Trials
An Evaluation of Two PTSD Assessments in an Active Duty and Military Veteran Sample
U.S. Army Medical Research and Development Command
NCT04180930
A Study of a Novel EEG Neurofeedback System for PTSD Treatment
Foundation for Atlanta Veterans Education and Research
NCT06770998
SMART Therapist Training: A Hybrid Factorial-SMART Design
VA Office of Research and Development
NCT07010770
Whole Health in VA Mental Health: Omnis Salutis
VA Office of Research and Development
NCT05400252
Manage Emotions to Reduce Aggression (MERA)
VA Office of Research and Development
NCT04793776
Massed Prolonged Exposure for PTSD in Substance Use Treatment
Veterans Medical Research Foundation
NCT06296186
Trauma-Informed Guilt Reduction Therapy Compared to Prolonged Exposure
Veterans Medical Research Foundation
NCT06296589
Computational Assessment of GABA Receptor Modulation in PTSD
VA Office of Research and Development
NCT06852469
Combining Stellate Ganglion Block With Prolonged Exposure for PTSD
The University of Texas Health Science Center at San Antonio
NCT05889741
Intervention to Enhance Coping and Help-seeking Among Youth in Foster Care
Portland State University
NCT06019377
Transcutaneous Vagal Nerve Stimulation in Veterans With Posttraumatic Stress Disorder
VA Office of Research and Development
NCT05517304
Mismatch vs. Standard Intervention During Memory Reconsolidation Blockade With Propranolol: Effect on Psychophysiological Reactivity During Traumatic Imagery
Massachusetts General Hospital
NCT05853627
Overcontrol and Suicide in PTSD
VA Office of Research and Development
NCT06355284
Computer Monitor vs Augmented Reality 3MDR for PTSD PTSD: A Randomized Controlled Trial
Uniformed Services University of the Health Sciences
NCT05244564
Enhancing PTSD Treatment Outcomes by Improving Patient-Provider Communication
Boston University
NCT06088303
Enhancing Memory in CPT for PTSD
VA Office of Research and Development
NCT06000475
Postpartum Care in the NICU (PeliCaN) Transitions
University of Pennsylvania
NCT06521398
MDMA for Co-occurring PTSD and OUD After Childbirth
University of New Mexi
NCT05219175
Healthy Recovery After Trauma Study
Christal L Badour
NCT04585685
Neuropsychological and Mental Outcomes of Operation Iraqi Freedom (OIF): A Longitudinal Cohort Study
VA Office of Research and Development
NCT00748995
Resettled Refugee Families for Healing
Washington University School of Medicine
NCT06176638
Using the Multiphase Optimization Strategy to Adapt Cognitive Processing Therapy
VA Office of Research and Development
NCT05220137
Multi-site, Longitudinal Trial Evaluating the Efficacy, Mechanisms, and Moderators of Service Dogs for Military Veterans With PTSD
University of Arizona
NCT05900479
A Randomized Controlled Trial of Doxazosin for Nightmares, Sleep Disturbance, and Non-Nightmare Clinical Symptoms in PTSD
San Francisco Veterans Affairs Medical Center
NCT03339258
Psilocybin for the Treatment of Veterans With Post-Traumatic Stress Disorder
Ohio State University
NCT05554094
Integrating Clinical Practice Guidelines for Smoking Cessation Into Mental Health Care for Veterans With Posttraumatic Stress Disorder
US Department of Veterans Affairs
NCT00118534
Development and Validation of a PTSD-Related Functional Impairment Scale
Boston VA Research Institute
NCT00651872
Cognitive Behavioral Therapy (CBT) for Posttraumatic Stress Disorder (PTSD) in Community Addiction Treatment
Dartmouth-Hitchcock Medical Center
NCT01457391
Homecoming Line: Telephone Support for Veterans
VA Palo Alto Health Care System
NCT02655991
Comparing Effects of a Holistic Yoga Program and a Wellness Program on PTSD Symptoms
VA Office of Research and Development
NCT02234622
Prolonged Exposure Therapy for Post Traumatic Stress Disorder Following Sexual Assault
University of Pennsylvania
NCT00057629
Project QueST 2023: Queer Survivors of Trauma
Syracuse University
NCT05569915
Clinical Trial of a Supporter-Targeted Intervention to Improve Outcomes in Recent Sexual Assault Survivors
University of Washington
NCT05345405
CPT-SMART for Treatment of PTSD and Cigarette Smoking
VA Office of Research and Development
NCT03978442
Implementation of CPT for PTSD in Diverse Communities
Massachusetts General Hospital
NCT01702168
Evaluation of a Mobile Phone App for Veterans With PTSD
VA Palo Alto Health Care System
NCT03199742
Prazosin for Treatment of Patients With Alcohol Dependence (AD) and Post Traumatic Stress Disorder (PTSD).
Yale University
NCT00744055
Mindfulness Meditation for the Treatment of Women With Comorbid PTSD and SUD
Medical University of South Carolina
NCT02755103
The Effects of Oxytocin on Startle Hyperreactivity in Patients With AUD and PTSD
University of California, San Francis
NCT02469259
Improving Mind/Body Health and Functioning With Integrative Exercise
VA Office of Research and Development
NCT02856412
Novel Therapeutics in Posttraumatic Stress Disorder (PTSD): A Randomized Clinical Trial of Mifepristone
VA Office of Research and Development
NCT01739335
Wraparound for High-risk Families with Substance Use Disorders: Examining Family, Child, and Parent Outcomes
Dartmouth-Hitchcock Medical Center
NCT04637581
Examining Effects of a Therapeutic Focus on Positive Memories on Post-Trauma Health
University of North Texas, Denton, TX
NCT05523453
The Effects of Home-Based Telemental Health for Rural Veterans With PTSD
VA Pacific Islands Health Care System
NCT02295410
Feasibility of Using Holographic Memory Resolution® (HMR) in Patients/Clients With Pain
Billings Clinic
NCT05001399
Trial of Paroxetine-CR for the Treatment of Patients With Post Traumatic Stress Disorder Remaining Symptomatic After Initial Exposure Therapy
Massachusetts General Hospital
NCT00121888
Investigation of the Freespira Breathing System in the Treatment of Post Traumatic Stress Disorder (PTSD)
Palo Alto Health Sciences
NCT03039231
Mindfulness Based Stress Reduction for Posttraumatic Stress Disorder: A Pilot Study
Seattle Institute for Biomedical and Clinical Research
NCT00880152
Meditation in Veterans With PTSD and Mild TBI
VA Office of Research and Development
NCT02280304
A Cognitive Behavioral Therapy and Yoga Program for Trauma Symptoms
Georgetown University
NCT02368444
Suicide and Trauma Reduction Initiative Among VEterans
University of Utah
NCT03933059
Ketamine as a Rapid Treatment for Post-traumatic Stress Disorder (PTSD)
Dennis Charney
NCT00749203
HIRREM in Military Personnel
Wake Forest University Health Sciences
NCT03230890
Adapting Treatment Delivery to Improve Retention in Evidence-Based PTSD Treatment
VA Office of Research and Development
NCT06335589
Ketamine Infusion Therapy for PTSD in Combat Veterans
Klarisana Physician Services P
NCT03088384
taVNS to Reduce PTSD Symptoms in WTC Responders
Northwell Health
NCT05212714
Wildlife and Wellbeing: An Animal-Assisted Intervention for Veterans With PTSD
University of Massachusetts, Worcester
NCT04116489
An Immersion Intervention for Symptoms of PTSD in Student Veterans
University of Nevada, Las Vegas
NCT05309031
Effectiveness of Prazosin in Bulimic Patients Experiencing Nightmares Due to PTSD
Milton S. Hershey Medical Center
NCT02382848
Fluoxetine vs EMDR to Treat Post-Traumatic Stress Disorder (PTSD)
Boston University
NCT00000379
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 2 |
| Phase 2 | 7 |
| Phase 3 | 3 |
| Phase 4 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Stress Disorders, Post-Traumatic Trial Landscape
ClinicalTrials.gov lists 60 US studies indexed under Stress Disorders, Post-Traumatic, and 19 of those are currently open to recruitment — roughly 32% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Stress Disorders, Post-Traumatic shows 6 late-stage studies (Phase 3 and Phase 4 combined) alongside 9 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Stress Disorders, Post-Traumatic is led by VA Office of Research and Development with 15 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 60 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Stress Disorders, Post-Traumatic?
PlainTrial tracks 60 US clinical trials for Stress Disorders, Post-Traumatic, of which 19 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Stress Disorders, Post-Traumatic?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.