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NCT05337982 · ClinicalTrials.gov registry record · NA
Eccentric Muscle Training, Stimulation, and Biomarkers in SCI
A NA study of Healthy and Spinal Cord Injuries, sponsored by Ohio State University.
- Recruiting
- Registry status
- NA
- Development phase
- 49
- Enrollment target
- 2
- Study locations
NCT05337982: Recruiting NA study of Healthy and Spinal Cord Injuries, sponsored by Ohio State University.
NCT05337982 is a NA study of Healthy and Spinal Cord Injuries that is actively recruiting participants, run by Ohio State University. The registered enrollment target is 49 participants, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (92% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05337982, a NA study of Healthy and Spinal Cord Injuries, is actively recruiting participants, sponsored by Ohio State University.
- RECRUITING
- Registry status
- NA
- Development phase
- 49 participants
- Enrollment target
- 2
- Study locations
Study Summary
The investigators are studying a new rehabilitation treatment for individuals trying to recover walking after spinal cord injury (SCI). The investigators will test conditions in the blood and spinal fluid to determine the best time to start this new training program. This will include checking for certain features called biomarkers by testing participants' spinal fluid and blood and compare these features to individuals without SCI. These features will help investigators determine when to start the new training program, either right away or waiting for 3 months. The new training program uses walking downhill on a slight slope on a treadmill while muscles that are not working normally are stimulated to contract using low levels of electricity. Adding this stimulation will allow people to practice walking and other skills even though full muscle control has not recovered. This new program will be in addition to any other rehabilitation therapy and will not replace standard rehabilitation. The hope is to see if downhill training with muscle stimulation, when delivered at the most ideal time, will improve trunk and leg movement, walking, and overall function. This recovery of movement and function will be compared to people with SCI receiving standard rehabilitation alone. Certain regions of the brain and spinal cord will also be studied using MRI scans to determine if these are affected by the training and compare to individuals without SCI. The total length of the study for SCI participants will be up to 16 weeks if in the standard of care group and up to 33 weeks if in the trained group. Healthy control participants will be involved for 1-2 visits.
Primary Outcome
Muscle activation during weight acceptance while walking on a treadmill
Conditions Studied
Interventions
- OTHER Downhill Eccentric Treadmill Training with Electrical Stimulation
Study Locations (2)
Ohio
- The Ohio State University - Columbus
Other
- University of British Columbia - Vancouver
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 49 participants |
| Start Date | 2022-05-17 |
| Est. Completion | 2026-12-31 |
| Phase | NA |
What NCT05337982 shows while recruiting
NCT05337982 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 49 participants, a relatively small participant target, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (92% lower).
The record links to 2 conditions, with Healthy appearing as the primary indexed condition, and to 1 intervention - of which Downhill Eccentric Treadmill Training with Electrical Stimulation is the first listed.
NCT05337982 reports a single indexed study location in Ohio, Other.
Frequently Asked Questions
What is clinical trial NCT05337982 about?
NCT05337982 is a clinical study titled "Eccentric Muscle Training, Stimulation, and Biomarkers in SCI". The investigators are studying a new rehabilitation treatment for individuals trying to recover walking after spinal cord injury (SCI). The investigators will test conditions in the blood and spinal fluid to determine the best time to start this new training program. This will include checking for c...
What is the current status of trial NCT05337982?
This trial is currently recruiting. It is a NA study. The enrollment target is 49 participants. The study started on 2022-05-17. Estimated completion is 2026-12-31.
What conditions does trial NCT05337982 study?
This clinical trial studies the following conditions: Healthy, Spinal Cord Injuries.
What interventions are being tested in trial NCT05337982?
The interventions under investigation include: Downhill Eccentric Treadmill Training with Electrical Stimulation (OTHER).
Who is sponsoring clinical trial NCT05337982?
This trial is sponsored by Ohio State University, which has 552 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05337982 being conducted?
This trial has 2 study locations across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05337982's enrollment target sits among peer trials
49 474th of 1090 higher than 613 of 1,090 other Healthy trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Healthy trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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