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NCT06213012 · ClinicalTrials.gov registry record · NA
Harnessing Neuroplasticity of Postural Sensorimotor Networks Using Non-Invasive Spinal Neuromodulation to Maximize Functional Recovery After Spinal Cord Injury
A NA study of Spinal Cord Injuries and Neuromodulation, sponsored by The Methodist Hospital Research Institute.
- Recruiting
- Registry status
- NA
- Development phase
- 60
- Enrollment target
- 1
- Study location
NCT06213012: Recruiting NA study of Spinal Cord Injuries and Neuromodulation, sponsored by The Methodist Hospital Research Institute.
NCT06213012 is a NA study of Spinal Cord Injuries and Neuromodulation that is actively recruiting participants, run by The Methodist Hospital Research Institute. The registered enrollment target is 60 participants, roughly in line with the 61-participant average among 202 other Spinal Cord Injuries trials with a reported enrollment target. The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06213012, a NA study of Spinal Cord Injuries and Neuromodulation, is actively recruiting participants, sponsored by The Methodist Hospital Research Institute.
- RECRUITING
- Registry status
- NA
- Development phase
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
It has been demonstrated that the human lumbosacral spinal cord can be neuromodulated with epidural (ESS) and transcutaneous (TSS) spinal cord stimulation to enable recovery of standing and volitional control of the lower limbs after complete motor paralysis due to spinal cord injury (SCI). The work proposed herein will examine and identify distinct electrophysiological mechanisms underlying transcutaneous spinal stimulation (TSS) and epidural spinal stimulation (ESS) to define how these approaches determine the ability to maintain self-assisted standing after SCI.
Primary Outcome
Neuromotor outcomes will be assessed during supine and upright standing, focusing on leg extension force output. Measurements will be taken under various conditions, including voluntary effort without spinal stimulation, and in the presence of Transcutaneous Spinal Stimulation (TSS), Epidural Spinal Stimulation (ESS), or Sham stimulation. The force output will be quantified in newtons (N). The magnitude of EMG signals will be quantified and expressed in millivolts (mV).
Conditions Studied
Interventions
- DEVICE Transcutaneous Spinal cord Stimulation
- DEVICE Epidural Spinal Stimulation (ESS)
Study Locations (1)
Texas
- Houston Methodist Hospital - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2023-12-06 |
| Est. Completion | 2027-08-31 |
| Phase | NA |
What NCT06213012 shows while recruiting
NCT06213012 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, roughly in line with the 61-participant average among 202 other Spinal Cord Injuries trials with a reported enrollment target.
The record links to 2 conditions, with Spinal Cord Injuries appearing as the primary indexed condition, and to 2 interventions - of which Transcutaneous Spinal cord Stimulation is the first listed.
NCT06213012 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT06213012 about?
NCT06213012 is a clinical study titled "Harnessing Neuroplasticity of Postural Sensorimotor Networks Using Non-Invasive Spinal Neuromodulation to Maximize Functional Recovery After Spinal Cord Injury". It has been demonstrated that the human lumbosacral spinal cord can be neuromodulated with epidural (ESS) and transcutaneous (TSS) spinal cord stimulation to enable recovery of standing and volitional control of the lower limbs after complete motor paralysis due to spinal cord injury (SCI). The work...
What is the current status of trial NCT06213012?
This trial is currently recruiting. It is a NA study. The enrollment target is 60 participants. The study started on 2023-12-06. Estimated completion is 2027-08-31.
What conditions does trial NCT06213012 study?
This clinical trial studies the following conditions: Spinal Cord Injuries, Neuromodulation.
What interventions are being tested in trial NCT06213012?
The interventions under investigation include: Transcutaneous Spinal cord Stimulation (DEVICE), Epidural Spinal Stimulation (ESS) (DEVICE).
Who is sponsoring clinical trial NCT06213012?
This trial is sponsored by The Methodist Hospital Research Institute, which has 126 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06213012 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Spinal Cord Injuries
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06213012's enrollment target sits among peer trials
60 48th of 202 higher than 145 of 202 other Spinal Cord Injuries trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Spinal Cord Injuries trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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