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Sepsis clinical trials
33 of 91 indexed Sepsis trials are currently recruiting.
91 US clinical trials · 33 currently recruiting
Sepsis is the subject of 91 registered US clinical trials on ClinicalTrials.gov, 33 of them currently open to new participants. 10 are in Phase 3-4 (later-stage) and 14 in Phase 1-2 (earlier-stage). The most active sponsor is University of Florida, running 7 of these trials.
The research picture
Sepsis has 91 registered US clinical trials, 33 of them open to new participants right now, about 36% of the total.
- 33
- recruiting participants now
- 36%
- of trials open to enrollment
- 10
- in Phase 3–4 (later-stage)
- 7
- top sponsor: University of Florida
Active & Recent Trials
91 total, page 1 of 2
Safe and Explainable AI
Abramson Cancer Center at Penn Medicine
NCT06694181
Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis
Children's Hospital of Philadelphia
NCT05975671
Clean Trial - Chlorination to Reduce Enteric and Antibiotic Resistant Infections in Neonates
University of California, Berkeley
NCT06824350
Evaluation of Pediatric eCART Implementation
University of Wisconsin, Madison
NCT06771830
PIVO Use for Blood Cultures in the Emergency Department
Intermountain Health Care
NCT07348289
Biomarkers in Infection
Beth Israel Deaconess Medical Center
NCT02545478
The APS Phenotyping Study
Vanderbilt University Medical Center
NCT06521502
Clinical Microbial Species & Antibiotic Resistance ID in ED Patients Presenting With Infection - is Rapid ID Possible & Accurate?
Michigan State University
NCT01904188
Dynamics of Organ Damage and Immune Exhaustion During Sepsis
Mayo Clinic
NCT06817408
The RightCall: Implementing a Sepsis Diagnostic Toolkit to Improve Pediatric Diagnosis in ED Transfer Calls
University of Colorado, Denver
NCT07051668
Dysfunctional Myelopoiesis and Myeloid-Derived Suppressor Cells in Sepsis
University of Florida
NCT05110937
Limited Versus Extended Trophic Feeding (LET-FEED) Trial
University of Washington
NCT06893939
MID-STEP (MIDodrine for Sepsis Treatment and Early vasoPressor Weaning) Trial
Mayo Clinic
NCT06319248
Early Versus Late Adjunctive Vasopressin in Septic Shock
The Cleveland Clinic
NCT06709573
BLOOM: Pragmatic Feasibility Trial
Mayo Clinic
NCT07287332
TriVerity™ for Improved Management of Emergency Department (ED) Patients With Suspected Infections
Inflammatix
NCT06637904
Pathological Myeloid Activation After Sepsis and Trauma
University of Florida
NCT05616130
Senolytics To slOw Progression of Sepsis (STOP-Sepsis) Trial
University of Minnesota
NCT05758246
Prediction of Rehospitalization Following a Sepsis Admission Using a Wearable Biopatch
University of California, San Diego
NCT05806762
Assessing Immune Dysfunction in Sepsis
University of Minnesota
NCT07154615
A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kidney Injury.
AstraZeneca
NCT07215702
Role of Transposable Elements in Septic Immune Aging
University of California, San Francisco
NCT06809868
An Acupuncture Study for People At High Risk for Sepsis
Memorial Sloan Kettering Cancer Center
NCT06344819
Expression Profiles of Integrin αDβ2 on Neutrophils in Sepsis
Boston Children's Hospital
NCT04103281
Renin Angiotensin Aldosterone System In Septic Kids
Northwell Health
NCT06295393
Neutrophil Phenotypic Profiling and Organ Injury Assessment in Patients With Sepsis
Boston Children's Hospital
NCT04103268
Change in MAPSE During Treatment of Sepsis
University of Maryland, Baltimore
NCT05634733
Hemodynamic Response to Angiotensin-II When Used as the Second Vasopressor Agent for Septic Shock
Kingman Regional Medical Center
NCT06122987
A Phase III, Open Label, Randomized, Controlled Study of VBI-S in the Treatment of Hypovolemia in Patients With Septic Shock (VBI-S-02)
Vivacelle Bio
NCT06072430
Predicton of Sepsis Recovery Performance Subtypes Pilot Study
University of Alabama at Birmingham
NCT05912413
Virtual Reality in ICU - PARTNER
Kirby Mayer
NCT06876168
Vancomycin and Acute Kidney Injury in Sepsis Treatment - Intervention
Children's Hospital of Philadelphia
NCT07084129
External Drainage of Thoracic Duct Lymph to Reduce Inflammatory Cytokines in Septic Shock Patients
University of Pennsylvania
NCT04855786
Monocyte Distribution Width (MDW) in the General Population of Emergency Department Patients With and Without Bacteremia
Henry Ford Health System
NCT05296590
A Rapid Diagnostic of Risk in Hospitalized Patients Using Machine Learning
AgileMD
NCT05893420
An Observational Study in the United States to Learn How Venous Thromboembolism, Disseminated Intravascular Coagulation, and Sepsis Are Related
Bayer
NCT06765681
A Multicenter Prospective Observational Study to Derive and Verify the Performance of a Host-response Based Diagnostic Tool for Early Detection of Severe Infections.
MeMed Diagnostics
NCT06665542
PICS: Subtitle Cardiac Dysfunction in Older Sepsis Survivors
University of Florida
NCT02276417
Measuring Outcomes of Activity in Intensive Care
Vanderbilt University Medical Center
NCT03115840
The PASTDUe Nutrition Ecosystem Project (PASTDUe)
Duke University
NCT05127109
Sepsis Associated Encephalopathy (SAE) Biomarkers
University of Florida
NCT03133208
Persistent Inflammation, Immunosuppression and Catabolism Syndrome (PICS): A New Horizon for Surgical Critical Care and Induced Frailty
University of Florida
NCT02711709
Cardiovascular Magnetic Resonance Prognosticators in Pediatric Oncology Patients With Sepsis
St. Jude Children's Research Hospital
NCT05930418
A Validation Study of the Lab Clasp Device: A Point of Care Sepsis Risk Monitor
Brigham and Women's Hospital
NCT04796285
Safety Study of Inhaled Carbon Monoxide to Treat Pneumonia and Sepsis-Induced Acute Respiratory Distress Syndrome (ARDS)
Brigham and Women's Hospital
NCT04870125
Sepsis Electronic Prompting for Timely Intervention and Care for Emergency Department Patients
Columbia University
NCT06117605
Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness
Sunnybrook Health Sciences Centre
NCT03005145
Intravenous Immune Globulin (IVIG) to Prevent Neonatal Infection
NICHD Neonatal Research Network
NCT01203345
Predictive algoRithm for EValuation and Intervention in SEpsis
Dascena
NCT03235193
Glutamine Supplementation to Prevent Death or Infection in Extremely Premature Infants
NICHD Neonatal Research Network
NCT00005775
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 6 |
| Phase 2 | 8 |
| Phase 3 | 6 |
| Phase 4 | 4 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Sepsis Trial Landscape
91 indexed Sepsis studies · 33 recruiting (36%).
Phase mix: 10 late (III/IV) vs 14 early (I/II).
Top sponsor: University of Florida (7 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Sepsis?
PlainTrial tracks 91 US clinical trials for Sepsis, of which 33 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Sepsis?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.