Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 33 recruiting now official registry

Sepsis clinical trials

33 of 91 indexed Sepsis trials are currently recruiting.

91 US clinical trials · 33 currently recruiting

Sepsis is the subject of 91 registered US clinical trials on ClinicalTrials.gov, 33 of them currently open to new participants. 10 are in Phase 3-4 (later-stage) and 14 in Phase 1-2 (earlier-stage). The most active sponsor is University of Florida, running 7 of these trials.

The research picture

Sepsis has 91 registered US clinical trials, 33 of them open to new participants right now, about 36% of the total.

33
recruiting participants now
36%
of trials open to enrollment
10
in Phase 3–4 (later-stage)
7
top sponsor: University of Florida
Phase 16Phase 28Phase 36Phase 44

Active & Recent Trials

91 total, page 1 of 2

RECRUITING 300,000 participants

Safe and Explainable AI

Abramson Cancer Center at Penn Medicine

NCT06694181

RECRUITING NA 52,500 participants

Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis

Children's Hospital of Philadelphia

NCT05975671

RECRUITING NA 45,450 participants

Clean Trial - Chlorination to Reduce Enteric and Antibiotic Resistant Infections in Neonates

University of California, Berkeley

NCT06824350

RECRUITING NA 30,000 participants

Evaluation of Pediatric eCART Implementation

University of Wisconsin, Madison

NCT06771830

RECRUITING 10,000 participants

PIVO Use for Blood Cultures in the Emergency Department

Intermountain Health Care

NCT07348289

RECRUITING 4,200 participants

Biomarkers in Infection

Beth Israel Deaconess Medical Center

NCT02545478

RECRUITING 4,000 participants

The APS Phenotyping Study

Vanderbilt University Medical Center

NCT06521502

RECRUITING 2,500 participants

Clinical Microbial Species & Antibiotic Resistance ID in ED Patients Presenting With Infection - is Rapid ID Possible & Accurate?

Michigan State University

NCT01904188

RECRUITING 1,000 participants

Dynamics of Organ Damage and Immune Exhaustion During Sepsis

Mayo Clinic

NCT06817408

RECRUITING NA 500 participants

The RightCall: Implementing a Sepsis Diagnostic Toolkit to Improve Pediatric Diagnosis in ED Transfer Calls

University of Colorado, Denver

NCT07051668

RECRUITING 450 participants

Dysfunctional Myelopoiesis and Myeloid-Derived Suppressor Cells in Sepsis

University of Florida

NCT05110937

RECRUITING Phase 3 350 participants

Limited Versus Extended Trophic Feeding (LET-FEED) Trial

University of Washington

NCT06893939

RECRUITING Phase 2 308 participants

MID-STEP (MIDodrine for Sepsis Treatment and Early vasoPressor Weaning) Trial

Mayo Clinic

NCT06319248

RECRUITING Phase 4 300 participants

Early Versus Late Adjunctive Vasopressin in Septic Shock

The Cleveland Clinic

NCT06709573

RECRUITING NA 300 participants

BLOOM: Pragmatic Feasibility Trial

Mayo Clinic

NCT07287332

RECRUITING NA 300 participants

TriVerity™ for Improved Management of Emergency Department (ED) Patients With Suspected Infections

Inflammatix

NCT06637904

RECRUITING 255 participants

Pathological Myeloid Activation After Sepsis and Trauma

University of Florida

NCT05616130

RECRUITING Phase 2 220 participants

Senolytics To slOw Progression of Sepsis (STOP-Sepsis) Trial

University of Minnesota

NCT05758246

RECRUITING 200 participants

Prediction of Rehospitalization Following a Sepsis Admission Using a Wearable Biopatch

University of California, San Diego

NCT05806762

RECRUITING 150 participants

Assessing Immune Dysfunction in Sepsis

University of Minnesota

NCT07154615

RECRUITING Phase 2 124 participants

A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kidney Injury.

AstraZeneca

NCT07215702

RECRUITING 116 participants

Role of Transposable Elements in Septic Immune Aging

University of California, San Francisco

NCT06809868

RECRUITING Phase 2 78 participants

An Acupuncture Study for People At High Risk for Sepsis

Memorial Sloan Kettering Cancer Center

NCT06344819

RECRUITING 75 participants

Expression Profiles of Integrin αDβ2 on Neutrophils in Sepsis

Boston Children's Hospital

NCT04103281

RECRUITING 74 participants

Renin Angiotensin Aldosterone System In Septic Kids

Northwell Health

NCT06295393

RECRUITING 72 participants

Neutrophil Phenotypic Profiling and Organ Injury Assessment in Patients With Sepsis

Boston Children's Hospital

NCT04103268

RECRUITING 50 participants

Change in MAPSE During Treatment of Sepsis

University of Maryland, Baltimore

NCT05634733

RECRUITING Phase 4 50 participants

Hemodynamic Response to Angiotensin-II When Used as the Second Vasopressor Agent for Septic Shock

Kingman Regional Medical Center

NCT06122987

RECRUITING Phase 3 46 participants

A Phase III, Open Label, Randomized, Controlled Study of VBI-S in the Treatment of Hypovolemia in Patients With Septic Shock (VBI-S-02)

Vivacelle Bio

NCT06072430

RECRUITING 40 participants

Predicton of Sepsis Recovery Performance Subtypes Pilot Study

University of Alabama at Birmingham

NCT05912413

RECRUITING 32 participants

Virtual Reality in ICU - PARTNER

Kirby Mayer

NCT06876168

RECRUITING Phase 1 20 participants

Vancomycin and Acute Kidney Injury in Sepsis Treatment - Intervention

Children's Hospital of Philadelphia

NCT07084129

RECRUITING NA 10 participants

External Drainage of Thoracic Duct Lymph to Reduce Inflammatory Cytokines in Septic Shock Patients

University of Pennsylvania

NCT04855786

ACTIVE NOT RECRUITING 50,000 participants

Monocyte Distribution Width (MDW) in the General Population of Emergency Department Patients With and Without Bacteremia

Henry Ford Health System

NCT05296590

ACTIVE NOT RECRUITING NA 30,000 participants

A Rapid Diagnostic of Risk in Hospitalized Patients Using Machine Learning

AgileMD

NCT05893420

ACTIVE NOT RECRUITING 10,000 participants

An Observational Study in the United States to Learn How Venous Thromboembolism, Disseminated Intravascular Coagulation, and Sepsis Are Related

Bayer

NCT06765681

ACTIVE NOT RECRUITING 2,000 participants

A Multicenter Prospective Observational Study to Derive and Verify the Performance of a Host-response Based Diagnostic Tool for Early Detection of Severe Infections.

MeMed Diagnostics

NCT06665542

ACTIVE NOT RECRUITING 668 participants

PICS: Subtitle Cardiac Dysfunction in Older Sepsis Survivors

University of Florida

NCT02276417

ACTIVE NOT RECRUITING 312 participants

Measuring Outcomes of Activity in Intensive Care

Vanderbilt University Medical Center

NCT03115840

ACTIVE NOT RECRUITING Phase 4 300 participants

The PASTDUe Nutrition Ecosystem Project (PASTDUe)

Duke University

NCT05127109

ACTIVE NOT RECRUITING 90 participants

Sepsis Associated Encephalopathy (SAE) Biomarkers

University of Florida

NCT03133208

ACTIVE NOT RECRUITING 53 participants

Persistent Inflammation, Immunosuppression and Catabolism Syndrome (PICS): A New Horizon for Surgical Critical Care and Induced Frailty

University of Florida

NCT02711709

ACTIVE NOT RECRUITING NA 7 participants

Cardiovascular Magnetic Resonance Prognosticators in Pediatric Oncology Patients With Sepsis

St. Jude Children's Research Hospital

NCT05930418

ACTIVE NOT RECRUITING NA 6 participants

A Validation Study of the Lab Clasp Device: A Point of Care Sepsis Risk Monitor

Brigham and Women's Hospital

NCT04796285

ACTIVE NOT RECRUITING Phase 1 5 participants

Safety Study of Inhaled Carbon Monoxide to Treat Pneumonia and Sepsis-Induced Acute Respiratory Distress Syndrome (ARDS)

Brigham and Women's Hospital

NCT04870125

COMPLETED NA 25,668 participants

Sepsis Electronic Prompting for Timely Intervention and Care for Emergency Department Patients

Columbia University

NCT06117605

COMPLETED NA 3,622 participants

Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness

Sunnybrook Health Sciences Centre

NCT03005145

COMPLETED Phase 2 2,416 participants

Intravenous Immune Globulin (IVIG) to Prevent Neonatal Infection

NICHD Neonatal Research Network

NCT01203345

COMPLETED NA 2,296 participants

Predictive algoRithm for EValuation and Intervention in SEpsis

Dascena

NCT03235193

COMPLETED Phase 3 1,433 participants

Glutamine Supplementation to Prevent Death or Infection in Extremely Premature Infants

NICHD Neonatal Research Network

NCT00005775

Page 1 of 2 Next →

Phase Distribution

PhaseTrial count
Phase 1 6
Phase 2 8
Phase 3 6
Phase 4 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Sepsis Trial Landscape

91 indexed Sepsis studies · 33 recruiting (36%).

Phase mix: 10 late (III/IV) vs 14 early (I/II).

Top sponsor: University of Florida (7 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Sepsis?

PlainTrial tracks 91 US clinical trials for Sepsis, of which 33 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Sepsis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.