Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Metastatic Melanoma

Open-data reference.

92 US clinical trials · 32 currently recruiting

Active & Recent Trials

RECRUITING Phase 3 670 participants

Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.

Iovance Biotherapeutics

NCT05727904

RECRUITING 500 participants

Evaluation of Anti-PD-1 Therapy by Monitoring T Cell Responses in Melanoma, Lung and Other Cancer Types

Mayo Clinic

NCT06075524

RECRUITING Phase 1 300 participants

MC1R-targeted Alpha-particle Monotherapy and Combination Therapy Trial With Nivolumab in Adults With Advanced Melanoma

Perspective Therapeutics

NCT05655312

RECRUITING Phase 3 269 participants

Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

NRG Oncology

NCT06500455

RECRUITING Phase 2 245 participants

Study of Autologous Tumor Infiltrating Lymphocytes in Patients With Solid Tumors

Iovance Biotherapeutics

NCT03645928

RECRUITING Phase 1 188 participants

STC-15 as a Part of Combination Therapy With Toripalimab in Selected Advanced Cancers

STORM Therapeutics

NCT06975293

RECRUITING NA 180 participants

In Vivo Liquid Biopsy of Melanoma (Cytophone)

Cytoastra

NCT06488365

RECRUITING Phase 2 112 participants

A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases

SWOG Cancer Research Network

NCT04511013

RECRUITING Phase 2 100 participants

A Study of Lifileucel (Tumor-infiltrating Lymphocytes) in Adults With Advanced Melanoma

Iovance Biotherapeutics

NCT07288203

RECRUITING Phase 2 92 participants

GB1211 and Pembrolizumab Versus Pembrolizumab and Placebo in Patients With Metastatic Melanoma and Head and Neck Squamous Cell Carcinoma

Providence Health & Services

NCT05913388

RECRUITING Phase 2 78 participants

Phase II Trial of Combination Anti-PD-1 and Aldesleukin for Metastatic Melanoma and Renal Cell Carcinoma

National Cancer Institute (NCI)

NCT05155033

RECRUITING Phase 2 54 participants

Ipilumumab and Nivolumab With or Without Hypofractionated Radiotherapy in Patients With Metastatic Melanoma

Abramson Cancer Center at Penn Medicine

NCT03646617

RECRUITING Phase 1 53 participants

A Study to Investigate the Efficacy and Safety of an Infusion of IOV-4001 in Adult Participants With Unresectable or Metastatic Melanoma or Stage III or IV Non-small-cell Lung Cancer

Iovance Biotherapeutics

NCT05361174

RECRUITING Phase 1 52 participants

Safety and Efficacy of OBX-115 in Advanced Solid Tumors

Obsidian Therapeutics

NCT06060613

RECRUITING 50 participants

A Study to Assess the Long-term Safety Outcomes in Patients Previously Treated With RP1, RP2, or RP3

Replimune

NCT06887348

RECRUITING Phase 2 50 participants

Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid Tumors

M.D. Anderson Cancer Center

NCT04771520

RECRUITING Phase 1 42 participants

A Study to Investigate the Safety and Efficacy of IOV-3001 in Adults With Advanced Melanoma Who Will Receive Lifileucel

Iovance Biotherapeutics

NCT06940739

RECRUITING NA 40 participants

Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME Trial

M.D. Anderson Cancer Center

NCT04693377

RECRUITING Phase 2 37 participants

Cryoablation+Ipilimumab+Nivolumab in Melanoma

Massachusetts General Hospital

NCT05779423

RECRUITING Phase 1 36 participants

Intralesional Influenza Vaccine for the Treatment of Stage I-IV Melanoma

Carlo Contreras

NCT04697576

RECRUITING Phase 2 35 participants

Binimetinib and Encorafenib for the Treatment of Metastatic Melanoma and Central Nervous System Metastases

M.D. Anderson Cancer Center

NCT05026983

RECRUITING Phase 1 33 participants

Memory-Like Natural Killer Cells With Nivolumab and Relatlimab in Advanced or Metastatic Melanoma After Progression on Checkpoint Inhibitors

Washington University School of Medicine

NCT05629546

RECRUITING Phase 1 30 participants

A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosing

National Cancer Institute (NCI)

NCT06066138

RECRUITING Phase 1 30 participants

A Study of LN-144 or LN-145 in People With Advanced Uveal Melanoma, Undifferentiated Pleomorphic Sarcoma, or Dedifferentiated Liposarcoma

Memorial Sloan Kettering Cancer Center

NCT05607095

RECRUITING Phase 1 30 participants

Natural Killer Cell Therapy (UD TGFbetai NK Cells) and Temozolomide for the Treatment of Stage IV Melanoma Metastatic to the Brain

Kari Kendra

NCT05588453

RECRUITING Phase 1 30 participants

NeoVax + CDX-301 and Nivolumab or Pembrolizumab in Melanoma

Dana-Farber Cancer Institute

NCT04930783

RECRUITING Phase 1 30 participants

Nilotinib Plus Dabrafenib/Trametinib or Encorafenib/Binimetinib in Metastatic Melanoma

Rina Plattner

NCT04903119

RECRUITING Phase 1 20 participants

Safety of AV-MEL-1 With Anti-PD-1 Therapy in Metastatic Melanoma

Aivita Biomedical

NCT03743298

RECRUITING Phase 1 18 participants

Gene Modified Immune Cells After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumors

Anusha Kalbasi

NCT04119024

RECRUITING Phase 1 16 participants

Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancer

National Cancer Institute (NCI)

NCT05896839

RECRUITING Phase 1 15 participants

Hepzato Kit and Opdualag for Metastatic Melanoma and Liver Metastasis

University of Wisconsin, Madison

NCT07281924

RECRUITING Phase 2 10 participants

Mirdametinib in Patients With Advanced NF1-mutant Melanoma

Kevin Kim, MD

NCT07237100

ACTIVE NOT RECRUITING Phase 1 733 participants

Safety, PK and Efficacy of ONC-392 in Monotherapy and in Combination of Anti-PD-1 in Advanced Solid Tumors and NSCLC

OncoC4

NCT04140526

ACTIVE NOT RECRUITING Phase 3 407 participants

IO102-IO103 in Combination With Pembrolizumab Versus Pembrolizumab Alone in Advanced Melanoma (IOB-013 / KN-D18)

IO Biotech

NCT05155254

ACTIVE NOT RECRUITING Phase 3 267 participants

Dabrafenib and Trametinib Followed by Ipilimumab and Nivolumab or Ipilimumab and Nivolumab Followed by Dabrafenib and Trametinib in Treating Patients With Stage III-IV BRAFV600 Melanoma

National Cancer Institute (NCI)

NCT02224781

ACTIVE NOT RECRUITING Phase 2 245 participants

Ipilimumab With or Without Sargramostim in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery

National Cancer Institute (NCI)

NCT01134614

ACTIVE NOT RECRUITING Phase 2 160 participants

Adjuvant, Combined Interleukin 2 (Proleukin) and DTIC (Dacarbazine) in High-risk Melanoma Patients

University of Louisville

NCT00553618

ACTIVE NOT RECRUITING Phase 1 125 participants

A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors

Sapience Therapeutics

NCT04478279

ACTIVE NOT RECRUITING Phase 1 75 participants

Testing the Addition of Navitoclax to the Combination of Dabrafenib and Trametinib in People Who Have BRAF Mutant Melanoma

National Cancer Institute (NCI)

NCT01989585

ACTIVE NOT RECRUITING Phase 1 71 participants

Intravenous and Intrathecal Nivolumab in Treating Patients With Leptomeningeal Disease

M.D. Anderson Cancer Center

NCT03025256

ACTIVE NOT RECRUITING Phase 2 70 participants

A Study to Evaluate Adaptive Dosing of Ipilimumab and Nivolumab Combination Immunotherapy

Memorial Sloan Kettering Cancer Center

NCT03122522

ACTIVE NOT RECRUITING Phase 1 70 participants

Aerosolized Aldesleukin in Treating Patients With Lung Metastases

M.D. Anderson Cancer Center

NCT01590069

ACTIVE NOT RECRUITING Phase 2 60 participants

Thermal Ablation and Spine Stereotactic Radiosurgery in Treating Patients With Spine Metastases at Risk for Compressing the Spinal Cord

M.D. Anderson Cancer Center

NCT02713269

ACTIVE NOT RECRUITING Phase 1 59 participants

Testing the PD-1 Antibody, MK3475, Given With Ziv-aflibercept in Patients With Advanced Cancer

National Cancer Institute (NCI)

NCT02298959

ACTIVE NOT RECRUITING Phase 2 52 participants

Nivolumab With Trametinib and Dabrafenib, or Encorafenib and Binimetinib in Treating Patients With BRAF Mutated Metastatic or Unresectable Stage III-IV Melanoma

M.D. Anderson Cancer Center

NCT02910700

ACTIVE NOT RECRUITING Phase 2 50 participants

Diet and Immune Effects Trial: DIET- A Randomized Double Blinded Dietary Intervention Study in Patients With Metastatic Melanoma Receiving Immunotherapy

M.D. Anderson Cancer Center

NCT04645680

ACTIVE NOT RECRUITING Phase 2 49 participants

Stereotactic Radiosurgery in Treating Patients With Greater Than 3 Melanoma Brain Metastases

M.D. Anderson Cancer Center

NCT01644591

ACTIVE NOT RECRUITING Phase 2 44 participants

Comparison of High-dose IL-2 and High-dose IL-2 With Radiation Therapy in Patients With Metastatic Melanoma.

Providence Health & Services

NCT01416831

ACTIVE NOT RECRUITING Phase 2 36 participants

PD-1 Antibody Therapy + Infliximab for Metastatic Melanoma

Massachusetts General Hospital

NCT05034536

ACTIVE NOT RECRUITING Phase 1 34 participants

Genetically Modified T-Cells Followed by Aldesleukin in Treating Patients With Stage III-IV Melanoma

M.D. Anderson Cancer Center

NCT01955460

ACTIVE NOT RECRUITING Phase 2 29 participants

Bevacizumab and Atezolizumab With or Without Cobimetinib in Treating Patients With Untreated Melanoma Brain Metastases

M.D. Anderson Cancer Center

NCT03175432

ACTIVE NOT RECRUITING Phase 1 27 participants

Study of the Selective PI3K-Beta Inhibitor GSK2636771 in Combination With Pembrolizumab in Patients With Metastatic Melanoma and PTEN Loss

M.D. Anderson Cancer Center

NCT03131908

ACTIVE NOT RECRUITING Phase 2 24 participants

Study of Oral Azacitidine (CC-486) in Combination With Pembrolizumab (MK-3475) in Patients With Metastatic Melanoma

M.D. Anderson Cancer Center

NCT02816021

ACTIVE NOT RECRUITING Phase 1 21 participants

Phase I, Open-Label, Study of Tumor Infiltrating Lymphocytes Engineered With Membrane Bound IL15 Plus Acetazolamide in Adult Patients With Metastatic Melanoma

M.D. Anderson Cancer Center

NCT05470283

ACTIVE NOT RECRUITING Phase 1 20 participants

Pembrolizumab and Ibrutinib in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed by Surgery

Mayo Clinic

NCT03021460

ACTIVE NOT RECRUITING Phase 1 19 participants

Cediranib Maleate and Selumetinib Sulfate in Treating Patients With Solid Malignancies

National Cancer Institute (NCI)

NCT01364051

ACTIVE NOT RECRUITING Phase 1 18 participants

UCDCC#272: IL-2, Radiotherapy, and Pembrolizumab in Patients Refractory to Checkpoint Blockade

Megan Daly, MD

NCT03474497

ACTIVE NOT RECRUITING Phase 2 18 participants

Ibrutinib in Treating Patients With Refractory Metastatic Cutaneous Melanoma

National Cancer Institute (NCI)

NCT02581930

ACTIVE NOT RECRUITING Phase 1 17 participants

Proof of Concept of TBio-4101, Lymphodepleting Chemo, IL-2 for Relapsed/Refractory Melanoma

H. Lee Moffitt Cancer Center and Research Institute

NCT05628883

ACTIVE NOT RECRUITING Phase 1 16 participants

Testing the Addition of the Anti-cancer Drug, Tazemetostat, to the Usual Treatment (Dabrafenib and Trametinib) for Metastatic Melanoma That Has Progressed on the Usual Treatment

National Cancer Institute (NCI)

NCT04557956

ACTIVE NOT RECRUITING Phase 2 16 participants

Abbreviated MAPK Targeted Therapy Plus Pembrolizumab in Melanoma

Massachusetts General Hospital

NCT03149029

ACTIVE NOT RECRUITING Phase 1 15 participants

Gene-Modified T Cells With or Without Decitabine in Treating Patients With Advanced Malignancies Expressing NY-ESO-1

Roswell Park Cancer Institute

NCT02650986

ACTIVE NOT RECRUITING Phase 1 14 participants

In Situ Immunomodulation With CDX-301, Radiation Therapy, CDX-1140 and Poly-ICLC in Patients w/ Unresectable and Metastatic Solid Tumors

University of Southern California

NCT04616248

ACTIVE NOT RECRUITING Phase 1 12 participants

Tacrolimus, Nivolumab, and Ipilimumab in Treating Kidney Transplant Recipients With Selected Unresectable or Metastatic Cancers

National Cancer Institute (NCI)

NCT03816332

ACTIVE NOT RECRUITING Phase 1 10 participants

A Study of LN-144 in People With Metastatic Melanoma to the Brain

Memorial Sloan Kettering Cancer Center

NCT05640193

ACTIVE NOT RECRUITING Phase 1 1 participants

Stereotactic Radiosurgery and Immune Checkpoint Inhibitors With NovoTTF-200M for the Treatment of Melanoma Brain Metastases

Emory University

NCT05341349

COMPLETED 160 participants

Long-term Data Collection for Subjects in MDX-010 Studies

Bristol-Myers Squibb

NCT00928031

COMPLETED Phase 1 140 participants

Nivolumab With or Without Ipilimumab in Treating Younger Patients With Recurrent or Refractory Solid Tumors or Sarcomas

National Cancer Institute (NCI)

NCT02304458

COMPLETED Phase 2 133 participants

Phase II Trial of Allovectin-7® for Metastatic Melanoma

Vical

NCT00044356

COMPLETED Phase 2 121 participants

A Study of INCMGA00012 in Participants With Selected Solid Tumors (POD1UM-203)

Incyte Corporation

NCT03679767

COMPLETED Phase 1 115 participants

A Phase I/Ib, Multicenter, Open-Label, Dose Escalation Study of E7080 in Patients With Solid Tumors and in Combination With Temozolomide in Patients With Advanced and/or Metastatic Melanoma

Eisai

NCT00121680

COMPLETED Phase 2 76 participants

Efficacy Study of Pharmacokinetic(PK)/Pharmacodynamic(PD) Relationship of Monotherapy MORAb-004 in Metastatic Melanoma

Eisai

NCT01335009

COMPLETED Phase 2 70 participants

Study of Everolimus With Paclitaxel and Carboplatin in Patients With Metastatic Melanoma

SCRI Development Innovations

NCT01014351

COMPLETED Phase 2 52 participants

Docetaxel and Vinorelbine Plus Sargramostim in Metastatic Malignant Melanoma

John P. Fruehauf

NCT00256282

COMPLETED Phase 1 50 participants

Phase I/II Trial of a Long Peptide Vaccine (LPV7) Plus TLR Agonists

Craig L Slingluff, Jr

NCT02126579

COMPLETED Phase 2 41 participants

RFT-5-dgA in Patients With Metastatic Melanoma

University of Texas Southwestern Medical Center

NCT00314093

COMPLETED Phase 1 37 participants

Dose Escalation Study of MLN4924 in Adults With Melanoma

Millennium Pharmaceuticals

NCT01011530

COMPLETED Phase 2 36 participants

Phase II Study of KW2871 Combined With High Dose Interferon-α2b in Patients With Metastatic Melanoma

Ludwig Institute for Cancer Research

NCT00679289

COMPLETED Phase 1 35 participants

Abexinostat in Combination With Pembrolizumab in Patients With Advanced Solid Tumor Malignancies

Rahul Aggarwal

NCT03590054

COMPLETED Phase 2 33 participants

Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Melanoma

National Cancer Institute (NCI)

NCT01993719

COMPLETED Phase 1 20 participants

The Use of Dendritic Cell/Tumor Hybridomas as a Novel Tumor Vaccine in Patients With Advance Melanoma

Beth Israel Deaconess Medical Center

NCT00626860

COMPLETED 20 participants

Melanoma Biomarker Study

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT00348088

COMPLETED Phase 1 20 participants

Phase I/II Study of High-Dose Calcitriol Plus Temodar for Patients With Metastatic Melanoma

Northwestern University

NCT00301067

COMPLETED Phase 2 19 participants

Study of MAGE-3/Melan-A/gp 100/NA17 and rhIL-12 With/Out Low Dose IL-2 in Metastatic Melanoma

University of Chicago

NCT00203879

COMPLETED Phase 2 18 participants

Pembrolizumab, Standard Chemotherapy, Tumor Infiltrating Lymphocytes, and High- or Low-Dose Aldesleukin in Treating Patients With Metastatic Melanoma

M.D. Anderson Cancer Center

NCT02500576

COMPLETED Phase 2 15 participants

Dendritic Cell Vaccines + Dasatinib for Metastatic Melanoma

Walter J. Storkus

NCT01876212

COMPLETED Phase 1 15 participants

Phase I Clinical Trial of Tremelimumab Plus MEDI3617 in Patients With Unresectable Stage III or Stage IV Melanoma

F. Stephen Hodi, MD

NCT02141542

COMPLETED Phase 1 14 participants

Melanoma Checkpoint and Gut Microbiome Alteration With Microbiome Intervention

Parker Institute for Cancer Immunotherapy

NCT03817125

COMPLETED Phase 1 12 participants

Immunotherapy of Melanoma With Tumor Antigen RNA and Small Inhibitory RNA Transfected Autologous Dendritic Cells

Scott Pruitt

NCT00672542

COMPLETED Phase 2 11 participants

Tumor-Infiltrating Lymphocytes After Combination Chemotherapy in Treating Patients With Metastatic Melanoma

Fred Hutchinson Cancer Center

NCT01807182

COMPLETED Phase 1 8 participants

STAT3 Inhibitor WP1066 in Treating Patients With Recurrent Malignant Glioma or Progressive Metastatic Melanoma in the Brain

M.D. Anderson Cancer Center

NCT01904123

COMPLETED Phase 2 4 participants

Radiation and Combination Immunotherapy for Melanoma

Masonic Cancer Center, University of Minnesota

NCT03850691

Phase Distribution

PhaseTrial count
Early Phase 1 46
Phase 2 36
Phase 3 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Metastatic Melanoma Trial Landscape

ClinicalTrials.gov lists 92 US studies indexed under Metastatic Melanoma, and 32 of those are currently open to recruitment — roughly 35% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Metastatic Melanoma shows 4 late-stage studies (Phase 3 and Phase 4 combined) alongside 82 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Metastatic Melanoma is led by M.D. Anderson Cancer Center with 16 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 92 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Metastatic Melanoma?

PlainTrial tracks 92 US clinical trials for Metastatic Melanoma, of which 32 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Metastatic Melanoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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