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ClinicalTrials.gov 32 recruiting now official registry

Metastatic Melanoma clinical trials

32 of 92 indexed Metastatic Melanoma trials are currently recruiting.

92 US clinical trials · 32 currently recruiting

Metastatic Melanoma is the subject of 92 registered US clinical trials on ClinicalTrials.gov, 32 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 82 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 16 of these trials.

The research picture

Metastatic Melanoma has 92 registered US clinical trials, 32 of them open to new participants right now, about 35% of the total.

32
recruiting participants now
35%
of trials open to enrollment
4
in Phase 3–4 (later-stage)
16
top sponsor: M.D. Anderson Cancer Center
Phase 146Phase 236Phase 34

Active & Recent Trials

92 total, page 1 of 2

RECRUITING Phase 3 670 participants

Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.

Iovance Biotherapeutics

NCT05727904

RECRUITING 500 participants

Evaluation of Anti-PD-1 Therapy by Monitoring T Cell Responses in Melanoma, Lung and Other Cancer Types

Mayo Clinic

NCT06075524

RECRUITING Phase 1 300 participants

MC1R-targeted Alpha-particle Monotherapy and Combination Therapy Trial With Nivolumab in Adults With Advanced Melanoma

Perspective Therapeutics

NCT05655312

RECRUITING Phase 3 269 participants

Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

NRG Oncology

NCT06500455

RECRUITING Phase 2 245 participants

Study of Autologous Tumor Infiltrating Lymphocytes in Patients With Solid Tumors

Iovance Biotherapeutics

NCT03645928

RECRUITING Phase 1 188 participants

STC-15 as a Part of Combination Therapy With Toripalimab in Selected Advanced Cancers

STORM Therapeutics

NCT06975293

RECRUITING NA 180 participants

In Vivo Liquid Biopsy of Melanoma (Cytophone)

Cytoastra

NCT06488365

RECRUITING Phase 2 112 participants

A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases

SWOG Cancer Research Network

NCT04511013

RECRUITING Phase 2 100 participants

A Study of Lifileucel (Tumor-infiltrating Lymphocytes) in Adults With Advanced Melanoma

Iovance Biotherapeutics

NCT07288203

RECRUITING Phase 2 92 participants

GB1211 and Pembrolizumab Versus Pembrolizumab and Placebo in Patients With Metastatic Melanoma and Head and Neck Squamous Cell Carcinoma

Providence Health & Services

NCT05913388

RECRUITING Phase 2 78 participants

Phase II Trial of Combination Anti-PD-1 and Aldesleukin for Metastatic Melanoma and Renal Cell Carcinoma

National Cancer Institute (NCI)

NCT05155033

RECRUITING Phase 2 54 participants

Ipilumumab and Nivolumab With or Without Hypofractionated Radiotherapy in Patients With Metastatic Melanoma

Abramson Cancer Center at Penn Medicine

NCT03646617

RECRUITING Phase 1 53 participants

A Study to Investigate the Efficacy and Safety of an Infusion of IOV-4001 in Adult Participants With Unresectable or Metastatic Melanoma or Stage III or IV Non-small-cell Lung Cancer

Iovance Biotherapeutics

NCT05361174

RECRUITING Phase 1 52 participants

Safety and Efficacy of OBX-115 in Advanced Solid Tumors

Obsidian Therapeutics

NCT06060613

RECRUITING 50 participants

A Study to Assess the Long-term Safety Outcomes in Patients Previously Treated With RP1, RP2, or RP3

Replimune

NCT06887348

RECRUITING Phase 2 50 participants

Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid Tumors

M.D. Anderson Cancer Center

NCT04771520

RECRUITING Phase 1 42 participants

A Study to Investigate the Safety and Efficacy of IOV-3001 in Adults With Advanced Melanoma Who Will Receive Lifileucel

Iovance Biotherapeutics

NCT06940739

RECRUITING NA 40 participants

Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME Trial

M.D. Anderson Cancer Center

NCT04693377

RECRUITING Phase 2 37 participants

Cryoablation+Ipilimumab+Nivolumab in Melanoma

Massachusetts General Hospital

NCT05779423

RECRUITING Phase 1 36 participants

Intralesional Influenza Vaccine for the Treatment of Stage I-IV Melanoma

Carlo Contreras

NCT04697576

RECRUITING Phase 2 35 participants

Binimetinib and Encorafenib for the Treatment of Metastatic Melanoma and Central Nervous System Metastases

M.D. Anderson Cancer Center

NCT05026983

RECRUITING Phase 1 33 participants

Memory-Like Natural Killer Cells With Nivolumab and Relatlimab in Advanced or Metastatic Melanoma After Progression on Checkpoint Inhibitors

Washington University School of Medicine

NCT05629546

RECRUITING Phase 1 30 participants

A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosing

National Cancer Institute (NCI)

NCT06066138

RECRUITING Phase 1 30 participants

A Study of LN-144 or LN-145 in People With Advanced Uveal Melanoma, Undifferentiated Pleomorphic Sarcoma, or Dedifferentiated Liposarcoma

Memorial Sloan Kettering Cancer Center

NCT05607095

RECRUITING Phase 1 30 participants

Natural Killer Cell Therapy (UD TGFbetai NK Cells) and Temozolomide for the Treatment of Stage IV Melanoma Metastatic to the Brain

Kari Kendra

NCT05588453

RECRUITING Phase 1 30 participants

NeoVax + CDX-301 and Nivolumab or Pembrolizumab in Melanoma

Dana-Farber Cancer Institute

NCT04930783

RECRUITING Phase 1 30 participants

Nilotinib Plus Dabrafenib/Trametinib or Encorafenib/Binimetinib in Metastatic Melanoma

Rina Plattner

NCT04903119

RECRUITING Phase 1 20 participants

Safety of AV-MEL-1 With Anti-PD-1 Therapy in Metastatic Melanoma

Aivita Biomedical

NCT03743298

RECRUITING Phase 1 18 participants

Gene Modified Immune Cells After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumors

Anusha Kalbasi

NCT04119024

RECRUITING Phase 1 16 participants

Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancer

National Cancer Institute (NCI)

NCT05896839

RECRUITING Phase 1 15 participants

Hepzato Kit and Opdualag for Metastatic Melanoma and Liver Metastasis

University of Wisconsin, Madison

NCT07281924

RECRUITING Phase 2 10 participants

Mirdametinib in Patients With Advanced NF1-mutant Melanoma

Kevin Kim, MD

NCT07237100

ACTIVE NOT RECRUITING Phase 1 733 participants

Safety, PK and Efficacy of ONC-392 in Monotherapy and in Combination of Anti-PD-1 in Advanced Solid Tumors and NSCLC

OncoC4

NCT04140526

ACTIVE NOT RECRUITING Phase 3 407 participants

IO102-IO103 in Combination With Pembrolizumab Versus Pembrolizumab Alone in Advanced Melanoma (IOB-013 / KN-D18)

IO Biotech

NCT05155254

ACTIVE NOT RECRUITING Phase 3 267 participants

Dabrafenib and Trametinib Followed by Ipilimumab and Nivolumab or Ipilimumab and Nivolumab Followed by Dabrafenib and Trametinib in Treating Patients With Stage III-IV BRAFV600 Melanoma

National Cancer Institute (NCI)

NCT02224781

ACTIVE NOT RECRUITING Phase 2 245 participants

Ipilimumab With or Without Sargramostim in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery

National Cancer Institute (NCI)

NCT01134614

ACTIVE NOT RECRUITING Phase 2 160 participants

Adjuvant, Combined Interleukin 2 (Proleukin) and DTIC (Dacarbazine) in High-risk Melanoma Patients

University of Louisville

NCT00553618

ACTIVE NOT RECRUITING Phase 1 125 participants

A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors

Sapience Therapeutics

NCT04478279

ACTIVE NOT RECRUITING Phase 1 75 participants

Testing the Addition of Navitoclax to the Combination of Dabrafenib and Trametinib in People Who Have BRAF Mutant Melanoma

National Cancer Institute (NCI)

NCT01989585

ACTIVE NOT RECRUITING Phase 1 71 participants

Intravenous and Intrathecal Nivolumab in Treating Patients With Leptomeningeal Disease

M.D. Anderson Cancer Center

NCT03025256

ACTIVE NOT RECRUITING Phase 2 70 participants

A Study to Evaluate Adaptive Dosing of Ipilimumab and Nivolumab Combination Immunotherapy

Memorial Sloan Kettering Cancer Center

NCT03122522

ACTIVE NOT RECRUITING Phase 1 70 participants

Aerosolized Aldesleukin in Treating Patients With Lung Metastases

M.D. Anderson Cancer Center

NCT01590069

ACTIVE NOT RECRUITING Phase 2 60 participants

Thermal Ablation and Spine Stereotactic Radiosurgery in Treating Patients With Spine Metastases at Risk for Compressing the Spinal Cord

M.D. Anderson Cancer Center

NCT02713269

ACTIVE NOT RECRUITING Phase 1 59 participants

Testing the PD-1 Antibody, MK3475, Given With Ziv-aflibercept in Patients With Advanced Cancer

National Cancer Institute (NCI)

NCT02298959

ACTIVE NOT RECRUITING Phase 2 52 participants

Nivolumab With Trametinib and Dabrafenib, or Encorafenib and Binimetinib in Treating Patients With BRAF Mutated Metastatic or Unresectable Stage III-IV Melanoma

M.D. Anderson Cancer Center

NCT02910700

ACTIVE NOT RECRUITING Phase 2 50 participants

Diet and Immune Effects Trial: DIET- A Randomized Double Blinded Dietary Intervention Study in Patients With Metastatic Melanoma Receiving Immunotherapy

M.D. Anderson Cancer Center

NCT04645680

ACTIVE NOT RECRUITING Phase 2 49 participants

Stereotactic Radiosurgery in Treating Patients With Greater Than 3 Melanoma Brain Metastases

M.D. Anderson Cancer Center

NCT01644591

ACTIVE NOT RECRUITING Phase 2 44 participants

Comparison of High-dose IL-2 and High-dose IL-2 With Radiation Therapy in Patients With Metastatic Melanoma.

Providence Health & Services

NCT01416831

ACTIVE NOT RECRUITING Phase 2 36 participants

PD-1 Antibody Therapy + Infliximab for Metastatic Melanoma

Massachusetts General Hospital

NCT05034536

ACTIVE NOT RECRUITING Phase 1 34 participants

Genetically Modified T-Cells Followed by Aldesleukin in Treating Patients With Stage III-IV Melanoma

M.D. Anderson Cancer Center

NCT01955460

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Phase Distribution

PhaseTrial count
Phase 1 46
Phase 2 36
Phase 3 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Metastatic Melanoma Trial Landscape

92 indexed Metastatic Melanoma studies · 32 recruiting (35%).

Phase mix: 4 late (III/IV) vs 82 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (16 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Metastatic Melanoma?

PlainTrial tracks 92 US clinical trials for Metastatic Melanoma, of which 32 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Metastatic Melanoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.