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Critical Illness: full-pipeline trial registry
41 of 92 indexed Critical Illness trials are currently recruiting.
Corpus placement: #148 of 28,707 conditions by registered trial count.
92 US clinical trials · 41 currently recruiting · #148 of 28,707 conditions by registered trial count
Critical Illness: 92 US clinical trials tracked, 41 recruiting.
Critical Illness is the subject of 92 registered US clinical trials on ClinicalTrials.gov, 41 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 8 in Phase 1-2 (earlier-stage). The most active sponsor is Vanderbilt University Medical Center, running 6 of these trials.
Enrollment posture brief
Registry condition critical-illness
OPEN 41 | RECR 45% | LATE 6 | EARLY 8 | RANK #148 | SPON 6
Volume-matched condition peers
Nearest open-share peer: Hepatocellular Carcinoma (45% recruiting · 146 trials)
Critical Illness lists 41 open slots (45% of 92 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Critical Illness on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Critical Illness is recruiting above its size-band peers.
41 of 92 indexed trials (44.6%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Critical Illness trials is spread across many organizations.
Vanderbilt University Medical Center accounts for 6 of 92 trials (6.5%). 52 distinct sponsors appear on at least one study for this condition label.
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Typical Critical Illness enrolment sits around 250 participants.
Median target enrolment is 250 among the 92 trials that report a genuine target (sentinel values excluded). 24 of those (26.1%) plan for fewer than 100 participants.
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Critical Illness research is mostly interventional.
70 interventional and 22 observational studies make up this index (76.1% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
92 total, page 1 of 2
Critical Health Assessment and Outcomes Score/Study
Johns Hopkins University
NCT02766166
Behavioral Economic & Staffing Strategies in the ICU
University of Nebraska
NCT06184945
SC2i Tissue and Data Repository Protocol
Henry M. Jackson Foundation for the Advancement of Military Medicine
NCT02182180
Real-time NOMA Evaluation
David T Huang
NCT06996626
Pediatric Prehospital Airway Resuscitation Trial
Ohio State University
NCT06364280
Embedded Palliative Care in the MICU
Washington University School of Medicine
NCT06574672
Clinical Effectiveness of the "PICU Up!" Multifaceted Early Mobility Intervention for Critically Ill Children
Johns Hopkins University
NCT04989790
End-Tidal Oxygen for Intubation in the Emergency Department
Sydney Local Health District
NCT06578468
RCT: Early Feeding After PEG Placement
Carilion Clinic
NCT04110613
Preoperative Fasting vs. Not Fasting in Critically Ill Patients
Massachusetts General Hospital
NCT06751043
Establishing Normative Data for Pupillometer Assessments in Neuro-Intensive Care
University of Texas Southwestern Medical Center
NCT02804438
Evaluating the Unmet Needs of Older Adults to Promote Functional Recovery After a Critical Illness
Yale University
NCT06006000
Pervasive Sensing and AI in Intelligent ICU
University of Florida
NCT05127265
Goal-Directed Sedation in Mechanically Ventilated Infants and Children
Vanderbilt University Medical Center
NCT04801589
Improving Needs Among Older Adults
Duke University
NCT06588556
The Role of Brain-Bone Marrow-Gut Interaction Following Major Trauma
University of Florida
NCT06606119
Effect of Giving Reduced Fluid in Children After Trauma
Columbia University
NCT04201704
Muscle Recovery After Critical Illness
Kirby Mayer
NCT05537298
PUSH-IT Continuing Enteral Feeds for Tracheostomy
State University of New York at Buffalo
NCT05906472
NIBP Validation Study
Philips Clinical & Medical Affairs Global
NCT05673408
Music Listening: A Mechanistic Trial
University of Pittsburgh
NCT05541029
Reestablishing Sleep and Circadian Alignment in Medical Intensive Care Unit (MICU) Patients Via a Mechanistic RCT of an Sleep Chronobundle
Yale University
NCT05551325
The "What Is Important to Us" Communication Intervention Pilot Clinical Trial
Seattle Children's Hospital
NCT06208332
Behavioral Health Collaborative Care Model in an ICU Recovery Clinic
Medical University of South Carolina
NCT07372586
REmotely Monitored, Mobile Health Supported Multidomain Rehabilitation Program With High Intensity Interval Training for COVID-19
Duke University
NCT05218083
The Effects of Endotracheal Suctioning on Pain and Serum Markers
Loma Linda University
NCT06692400
Assessment of Stroke Volume in Shock Using Echocardiography Versus Bioreactive Impedance
University of Nevada, Las Vegas
NCT07020637
Exhaled Breath: A Novel Technique for Rapid Diagnosis of Respiratory Diseases and Infections
Oregon Health and Science University
NCT06775106
VoiceLove: An App-Based COMMunication Tool Designed to Address DeliriUm and Improve Family ENgagement and PatIent/Family SatisfaCtion in CriticAlly Ill PaTiEnts (COMMUNICATE)
Vanderbilt University Medical Center
NCT06923462
Azithromycin for Critical Asthma - Pediatrics
Johns Hopkins All Children's Hospital
NCT06223828
A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors
University of Washington
NCT06411561
The Family Perspectives Project Pilot Trial
Matthew Modes
NCT06039501
Bright Light Exposure in Surgical Patients
University of Colorado, Denver
NCT03822949
Improving Psychological Outcomes for Acute Respiratory Failure Survivors Using a Self-Management Intervention
Johns Hopkins University
NCT06341972
Gastric US in ICU Patient
Dartmouth-Hitchcock Medical Center
NCT05526105
A Study of Healthy Microbiome, Healthy Mind
Mayo Clinic
NCT06020703
iNO300 Therapy in Critically Ill Patients With Pneumonia
Massachusetts General Hospital
NCT06950294
PICU-related Sleep and Circadian Dysregulation Pilot Study
State University of New York at Buffalo
NCT06505447
PK, Safety and Preliminary Efficacy Study of Montelukast in Critically Ill Infants With Developing Bronchopulmonary Dysplasia
Duke University
NCT07101640
12-hour Time Limited Feeding in Critical Care
University of Kansas Medical Center
NCT06741761
Safety and Feasibility of a Self-Balancing Exoskeleton for Rehabilitation in the Thoracic Surgical Intensive Care Unit: a Pilot Trial
Wandercraft
NCT07220733
Strategy to Avoid Excessive Oxygen for Critically Ill Trauma Patients
University of Colorado, Denver
NCT04534959
PICU Up!: A Pilot Stepped-wedge Trial of a Multicomponent Early Mobility Intervention for Critically Ill Children
Johns Hopkins University
NCT03860168
Strategy to Avoid Excessive Oxygen in Major Burn Patients
University of Colorado, Denver
NCT04534972
Integrated Supportive and Palliative Care for Older Adults in the ICU
University of Pittsburgh
NCT04921631
Multi-component Family Support Tool Intervention (FST)
University of Pittsburgh
NCT05019261
Vasopressor SAT Study
University of Chicago
NCT03182335
Post-Intensive Care Syndrome - Pediatrics (PICS-p): Longitudinal Cohort Study
University of Pennsylvania
NCT04967365
Bringing to Light the Risk Factors And Incidence of Neuropsychological Dysfunction in ICU Survivors, 2nd Study
Vanderbilt University Medical Center
NCT04305600
Alterations of the Microbiome During Critical Illness With Short and Long Term Clinical Outcomes
University of Chicago
NCT04552834
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 5 |
| Phase 3 | 6 |
Top Sponsors
Named interventions
Most-linked intervention names on Critical Illness records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Critical Illness trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Critical Illness page
92 registered trials, 41 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 41 Critical Illness trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Vanderbilt University Medical Center sponsors the most Critical Illness trials on record, review their full trial history before evaluating a specific study. See Vanderbilt University Medical Center's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Critical Illness condition card totals 92 registered trials; most-linked intervention Physiologically-balanced isotonic crystalloid; top US site state North Carolina. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.