Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Sepsis: full-pipeline trial registry
33 of 91 indexed Sepsis trials are currently recruiting.
Corpus placement: #151 of 28,707 conditions by registered trial count.
91 US clinical trials · 33 currently recruiting · #151 of 28,707 conditions by registered trial count
Sepsis: 91 US clinical trials tracked, 33 recruiting.
Sepsis is the subject of 91 registered US clinical trials on ClinicalTrials.gov, 33 of them currently open to new participants. 10 are in Phase 3-4 (later-stage) and 14 in Phase 1-2 (earlier-stage). The most active sponsor is University of Florida, running 7 of these trials.
Enrollment posture brief
Registry condition sepsis
OPEN 33 | RECR 36% | LATE 10 | EARLY 14 | RANK #151 | SPON 7
Volume-matched condition peers
Nearest open-share peer: Acquired Brain Injury (36% recruiting · 11 trials)
Sepsis lists 33 open slots (36% of 91 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Sepsis on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Sepsis is recruiting below its size-band peers.
33 of 91 indexed trials (36.3%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Sepsis trials is spread across many organizations.
University of Florida accounts for 7 of 91 trials (7.7%). 65 distinct sponsors appear on at least one study for this condition label.
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Typical Sepsis enrolment sits around 186 participants.
Median target enrolment is 186 among the 91 trials that report a genuine target (sentinel values excluded). 35 of those (38.5%) plan for fewer than 100 participants.
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Sepsis splits between interventional and observational designs.
46 interventional and 45 observational studies make up this index (50.5% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
91 total, page 2 of 2
Evaluation of the Heparin Binding Protein Levels in Sepsis
Christiana Care Health Services
NCT02533011
Early Identification of SEPsis SIGNs in Emergency Department
BioMérieux
NCT04261621
Evaluation of Immunoassay Measurements of Pancreatic Stone Protein Performed on abioSCOPE® Device With the PSP Assay on ICU Patients at Risk of Sepsis as an Aid in Identifying Sepsis
Abionic
NCT04105699
Indicators of Inflammation and Coagulation in Sepsis
University of Oklahoma
NCT01128283
Coagulation Factors, Cytokines and Tissue Injury Markers in Sepsis
University of Oklahoma
NCT01012115
Evaluation of Infection in Obstructing Urolithiasis
University of Texas Southwestern Medical Center
NCT04332861
The MENDS2 Study, Maximizing the Efficacy of Sedation and Reducing Neurological Dysfunction and Mortality in Septic Patients With Acute Respiratory Failure
Vanderbilt University Medical Center
NCT01739933
VENUS: Septic Gene Expression Using SeptiCyte
Immunexpress
NCT02127502
SEP-SEQ Trial - Determining the Etiology of Sepsis Using an Infectious Disease Diagnostic Sequencing Assay
Karius
NCT02730468
A Culturally-Based Palliative Care Tele-consult Program for Rural Southern Elders
University of Alabama at Birmingham
NCT03767517
Skin Cleansing With Chlorhexidine to Decrease Hospital Acquired Infections
Cook County Health
NCT00130221
Does Detailed Informed Consent for Cardiopulmonary Resuscitation and Mechanical Ventilation Impact Patients' Decisions and Outcomes?
Jewish Hospital, Cincinnati, Ohio
NCT01878968
Clinical Validation of HostDx Sepsis™ on NanoString; a Prospective Observational Validation Trial
Inflammatix
NCT04414189
Extended Therapy of Drotrecogin Alfa (Activated) 4 vs 7 Days Infusion
Eli Lilly and Company
NCT00190788
Trial of Antimicrobial Restraint in Presumed Pneumonia
University of Kansas Medical Center
NCT04438187
Performance Evaluation of the Nanomix eLab® CRP, PCT, and LAC Assays With the Nanomix eLab System
Nanomix
NCT03876535
Anti-TF Antibody (ALT-836) to Treat Septic Patients With Acute Lung Injury or Acute Respiratory Distress Syndrome
Altor BioScience
NCT00879606
Reference Range for abioSCOPE® Device With the PSP Assay in a Generally Healthy Adult Population
Abionic
NCT04409561
Using Biomarkers to Optimize Antibiotic Strategies in Sepsis
University of Pennsylvania
NCT02207114
Preemptive Resuscitation for Eradication of Septic Shock
Christiana Care Health Services
NCT01449721
Clinical Factors Associated With the Development of Severe Sepsis in Patients Being Treated for Acute Myeloid Leukemia
Ohio State University
NCT00806325
Gene Expression Objective Definition of Early Sepsis In Children
Seattle Children's Hospital
NCT06231862
Thiamine as a Renal Protective Agent in Septic Shock
Beth Israel Deaconess Medical Center
NCT03550794
Inulin for Infections in the Intensive Care Unit
Columbia University
NCT03865706
Effect of Nebulized Bronchodilators on Heart Rate
Fahim Khorfan, MD
NCT01151579
REMISE Study: REMnant Biospecimen Investigation in SEpsis
University of Pittsburgh
NCT05684133
A Prospective, Randomized, Phase III Trial of FLAC (5-Fluorouracil, Leucovorin, Adriamycin, Cytoxan) Chemotherapy With GM-CSF (Granulocyte-Macrophage Colony-Stimulating Factor) Versus PIXY 321 in Advanced Breast Cancer
National Cancer Institute (NCI)
NCT00001338
Pilot Trial of External Warming in Septic Patients
Washington University School of Medicine
NCT02706275
Novel Arm Restraint For Critically Ill Patients To Reduce Immobility, Sedation, Agitation and Cognitive Impairment
University of Vermont
NCT04067622
Role and Mechanisms of Lipid and Lipoprotein Dysregulation in Sepsis
University of Florida
NCT04576819
Longitudinal Gene Expression Profiling in Adults After Traumatic Injury
Stanford University
NCT02656459
Immune Suppression and Ventilator Associated Pneumonias
Matthew Exline
NCT01135277
Comparison of Non-Invasive Methods of Assessing Fluid Responsiveness in ED and ICU Patients
Olive View-UCLA Education & Research Institute
NCT02679625
Sepsis, Severe Sepsis and Septic Shock Detection by Breath Analysis
Landon Pediatric Foundation
NCT03497182
Methionine Metabolism in Enterally Fed Pediatric Sepsis
The Cleveland Clinic
NCT01889264
Digital Capillary Refill for Monitoring of Sepsis
Oregon Health and Science University
NCT04529655
Phase I Study of Vasoactive Intestinal Peptide in Patients With Acute Respiratory Distress Syndrome and Sepsis
Stony Brook University
NCT00004494
Effects of TNX-832 (Sunol cH36) in Subjects With Acute Lung Injury/Acute Respiratory Distress Syndrome
Altor BioScience
NCT01438853
Impact of Hydrocortisone Administration on White Blood Cell Gene Expression in Patients With Severe Sepsis
Stanford University
NCT00185783
Imipenem-Relebactam Pharmacokinetics in Augmented Renal Clearance
Hartford Hospital
NCT04147221
Project 4B: Lower Extremity Strength Training in ICU Patients
University of Florida
NCT02467023
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 6 |
| Phase 2 | 8 |
| Phase 3 | 6 |
| Phase 4 | 4 |
Top Sponsors
Named interventions
Most-linked intervention names on Sepsis records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Sepsis trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Sepsis page
91 registered trials, 33 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 33 Sepsis trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- University of Florida sponsors the most Sepsis trials on record, review their full trial history before evaluating a specific study. See University of Florida's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Sepsis condition card totals 91 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.