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Sepsis clinical trials
33 of 91 indexed Sepsis trials are currently recruiting.
91 US clinical trials · 33 currently recruiting
Sepsis is the subject of 91 registered US clinical trials on ClinicalTrials.gov, 33 of them currently open to new participants. 10 are in Phase 3-4 (later-stage) and 14 in Phase 1-2 (earlier-stage). The most active sponsor is University of Florida, running 7 of these trials.
The research picture
Sepsis has 91 registered US clinical trials, 33 of them open to new participants right now, about 36% of the total.
- 33
- recruiting participants now
- 36%
- of trials open to enrollment
- 10
- in Phase 3–4 (later-stage)
- 7
- top sponsor: University of Florida
Active & Recent Trials
91 total, page 2 of 2
Evaluation of the Heparin Binding Protein Levels in Sepsis
Christiana Care Health Services
NCT02533011
Early Identification of SEPsis SIGNs in Emergency Department
BioMérieux
NCT04261621
Evaluation of Immunoassay Measurements of Pancreatic Stone Protein Performed on abioSCOPE® Device With the PSP Assay on ICU Patients at Risk of Sepsis as an Aid in Identifying Sepsis
Abionic
NCT04105699
Indicators of Inflammation and Coagulation in Sepsis
University of Oklahoma
NCT01128283
Coagulation Factors, Cytokines and Tissue Injury Markers in Sepsis
University of Oklahoma
NCT01012115
Evaluation of Infection in Obstructing Urolithiasis
University of Texas Southwestern Medical Center
NCT04332861
The MENDS2 Study, Maximizing the Efficacy of Sedation and Reducing Neurological Dysfunction and Mortality in Septic Patients With Acute Respiratory Failure
Vanderbilt University Medical Center
NCT01739933
VENUS: Septic Gene Expression Using SeptiCyte
Immunexpress
NCT02127502
SEP-SEQ Trial - Determining the Etiology of Sepsis Using an Infectious Disease Diagnostic Sequencing Assay
Karius
NCT02730468
A Culturally-Based Palliative Care Tele-consult Program for Rural Southern Elders
University of Alabama at Birmingham
NCT03767517
Skin Cleansing With Chlorhexidine to Decrease Hospital Acquired Infections
Cook County Health
NCT00130221
Does Detailed Informed Consent for Cardiopulmonary Resuscitation and Mechanical Ventilation Impact Patients' Decisions and Outcomes?
Jewish Hospital, Cincinnati, Ohio
NCT01878968
Clinical Validation of HostDx Sepsis™ on NanoString; a Prospective Observational Validation Trial
Inflammatix
NCT04414189
Extended Therapy of Drotrecogin Alfa (Activated) 4 vs 7 Days Infusion
Eli Lilly and Company
NCT00190788
Trial of Antimicrobial Restraint in Presumed Pneumonia
University of Kansas Medical Center
NCT04438187
Performance Evaluation of the Nanomix eLab® CRP, PCT, and LAC Assays With the Nanomix eLab System
Nanomix
NCT03876535
Anti-TF Antibody (ALT-836) to Treat Septic Patients With Acute Lung Injury or Acute Respiratory Distress Syndrome
Altor BioScience
NCT00879606
Reference Range for abioSCOPE® Device With the PSP Assay in a Generally Healthy Adult Population
Abionic
NCT04409561
Using Biomarkers to Optimize Antibiotic Strategies in Sepsis
University of Pennsylvania
NCT02207114
Preemptive Resuscitation for Eradication of Septic Shock
Christiana Care Health Services
NCT01449721
Clinical Factors Associated With the Development of Severe Sepsis in Patients Being Treated for Acute Myeloid Leukemia
Ohio State University
NCT00806325
Gene Expression Objective Definition of Early Sepsis In Children
Seattle Children's Hospital
NCT06231862
Thiamine as a Renal Protective Agent in Septic Shock
Beth Israel Deaconess Medical Center
NCT03550794
Inulin for Infections in the Intensive Care Unit
Columbia University
NCT03865706
Effect of Nebulized Bronchodilators on Heart Rate
Fahim Khorfan, MD
NCT01151579
REMISE Study: REMnant Biospecimen Investigation in SEpsis
University of Pittsburgh
NCT05684133
A Prospective, Randomized, Phase III Trial of FLAC (5-Fluorouracil, Leucovorin, Adriamycin, Cytoxan) Chemotherapy With GM-CSF (Granulocyte-Macrophage Colony-Stimulating Factor) Versus PIXY 321 in Advanced Breast Cancer
National Cancer Institute (NCI)
NCT00001338
Pilot Trial of External Warming in Septic Patients
Washington University School of Medicine
NCT02706275
Novel Arm Restraint For Critically Ill Patients To Reduce Immobility, Sedation, Agitation and Cognitive Impairment
University of Vermont
NCT04067622
Role and Mechanisms of Lipid and Lipoprotein Dysregulation in Sepsis
University of Florida
NCT04576819
Longitudinal Gene Expression Profiling in Adults After Traumatic Injury
Stanford University
NCT02656459
Immune Suppression and Ventilator Associated Pneumonias
Matthew Exline
NCT01135277
Comparison of Non-Invasive Methods of Assessing Fluid Responsiveness in ED and ICU Patients
Olive View-UCLA Education & Research Institute
NCT02679625
Sepsis, Severe Sepsis and Septic Shock Detection by Breath Analysis
Landon Pediatric Foundation
NCT03497182
Methionine Metabolism in Enterally Fed Pediatric Sepsis
The Cleveland Clinic
NCT01889264
Digital Capillary Refill for Monitoring of Sepsis
Oregon Health and Science University
NCT04529655
Phase I Study of Vasoactive Intestinal Peptide in Patients With Acute Respiratory Distress Syndrome and Sepsis
Stony Brook University
NCT00004494
Effects of TNX-832 (Sunol cH36) in Subjects With Acute Lung Injury/Acute Respiratory Distress Syndrome
Altor BioScience
NCT01438853
Impact of Hydrocortisone Administration on White Blood Cell Gene Expression in Patients With Severe Sepsis
Stanford University
NCT00185783
Imipenem-Relebactam Pharmacokinetics in Augmented Renal Clearance
Hartford Hospital
NCT04147221
Project 4B: Lower Extremity Strength Training in ICU Patients
University of Florida
NCT02467023
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 6 |
| Phase 2 | 8 |
| Phase 3 | 6 |
| Phase 4 | 4 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Sepsis Trial Landscape
91 indexed Sepsis studies · 33 recruiting (36%).
Phase mix: 10 late (III/IV) vs 14 early (I/II).
Top sponsor: University of Florida (7 trials), 9 others listed. 41 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Sepsis?
PlainTrial tracks 91 US clinical trials for Sepsis, of which 33 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Sepsis?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.