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ClinicalTrials.gov 33 recruiting now official registry

Sepsis clinical trials

33 of 91 indexed Sepsis trials are currently recruiting.

91 US clinical trials · 33 currently recruiting

Sepsis is the subject of 91 registered US clinical trials on ClinicalTrials.gov, 33 of them currently open to new participants. 10 are in Phase 3-4 (later-stage) and 14 in Phase 1-2 (earlier-stage). The most active sponsor is University of Florida, running 7 of these trials.

The research picture

Sepsis has 91 registered US clinical trials, 33 of them open to new participants right now, about 36% of the total.

33
recruiting participants now
36%
of trials open to enrollment
10
in Phase 3–4 (later-stage)
7
top sponsor: University of Florida
Phase 16Phase 28Phase 36Phase 44

Active & Recent Trials

91 total, page 2 of 2

COMPLETED 1,055 participants

Evaluation of the Heparin Binding Protein Levels in Sepsis

Christiana Care Health Services

NCT02533011

COMPLETED 815 participants

Early Identification of SEPsis SIGNs in Emergency Department

BioMérieux

NCT04261621

COMPLETED 544 participants

Evaluation of Immunoassay Measurements of Pancreatic Stone Protein Performed on abioSCOPE® Device With the PSP Assay on ICU Patients at Risk of Sepsis as an Aid in Identifying Sepsis

Abionic

NCT04105699

COMPLETED 500 participants

Indicators of Inflammation and Coagulation in Sepsis

University of Oklahoma

NCT01128283

COMPLETED 500 participants

Coagulation Factors, Cytokines and Tissue Injury Markers in Sepsis

University of Oklahoma

NCT01012115

COMPLETED 477 participants

Evaluation of Infection in Obstructing Urolithiasis

University of Texas Southwestern Medical Center

NCT04332861

COMPLETED Phase 3 438 participants

The MENDS2 Study, Maximizing the Efficacy of Sedation and Reducing Neurological Dysfunction and Mortality in Septic Patients With Acute Respiratory Failure

Vanderbilt University Medical Center

NCT01739933

COMPLETED 379 participants

VENUS: Septic Gene Expression Using SeptiCyte

Immunexpress

NCT02127502

COMPLETED 350 participants

SEP-SEQ Trial - Determining the Etiology of Sepsis Using an Infectious Disease Diagnostic Sequencing Assay

Karius

NCT02730468

COMPLETED NA 209 participants

A Culturally-Based Palliative Care Tele-consult Program for Rural Southern Elders

University of Alabama at Birmingham

NCT03767517

COMPLETED Phase 1 208 participants

Skin Cleansing With Chlorhexidine to Decrease Hospital Acquired Infections

Cook County Health

NCT00130221

COMPLETED NA 200 participants

Does Detailed Informed Consent for Cardiopulmonary Resuscitation and Mechanical Ventilation Impact Patients' Decisions and Outcomes?

Jewish Hospital, Cincinnati, Ohio

NCT01878968

COMPLETED 200 participants

Clinical Validation of HostDx Sepsis™ on NanoString; a Prospective Observational Validation Trial

Inflammatix

NCT04414189

COMPLETED Phase 3 200 participants

Extended Therapy of Drotrecogin Alfa (Activated) 4 vs 7 Days Infusion

Eli Lilly and Company

NCT00190788

COMPLETED NA 186 participants

Trial of Antimicrobial Restraint in Presumed Pneumonia

University of Kansas Medical Center

NCT04438187

COMPLETED 184 participants

Performance Evaluation of the Nanomix eLab® CRP, PCT, and LAC Assays With the Nanomix eLab System

Nanomix

NCT03876535

COMPLETED Phase 2 150 participants

Anti-TF Antibody (ALT-836) to Treat Septic Patients With Acute Lung Injury or Acute Respiratory Distress Syndrome

Altor BioScience

NCT00879606

COMPLETED 150 participants

Reference Range for abioSCOPE® Device With the PSP Assay in a Generally Healthy Adult Population

Abionic

NCT04409561

COMPLETED NA 145 participants

Using Biomarkers to Optimize Antibiotic Strategies in Sepsis

University of Pennsylvania

NCT02207114

COMPLETED NA 142 participants

Preemptive Resuscitation for Eradication of Septic Shock

Christiana Care Health Services

NCT01449721

COMPLETED 120 participants

Clinical Factors Associated With the Development of Severe Sepsis in Patients Being Treated for Acute Myeloid Leukemia

Ohio State University

NCT00806325

COMPLETED 100 participants

Gene Expression Objective Definition of Early Sepsis In Children

Seattle Children's Hospital

NCT06231862

COMPLETED Phase 2 95 participants

Thiamine as a Renal Protective Agent in Septic Shock

Beth Israel Deaconess Medical Center

NCT03550794

COMPLETED Phase 2 94 participants

Inulin for Infections in the Intensive Care Unit

Columbia University

NCT03865706

COMPLETED Phase 4 89 participants

Effect of Nebulized Bronchodilators on Heart Rate

Fahim Khorfan, MD

NCT01151579

COMPLETED 71 participants

REMISE Study: REMnant Biospecimen Investigation in SEpsis

University of Pittsburgh

NCT05684133

COMPLETED Phase 3 65 participants

A Prospective, Randomized, Phase III Trial of FLAC (5-Fluorouracil, Leucovorin, Adriamycin, Cytoxan) Chemotherapy With GM-CSF (Granulocyte-Macrophage Colony-Stimulating Factor) Versus PIXY 321 in Advanced Breast Cancer

National Cancer Institute (NCI)

NCT00001338

COMPLETED NA 60 participants

Pilot Trial of External Warming in Septic Patients

Washington University School of Medicine

NCT02706275

COMPLETED NA 58 participants

Novel Arm Restraint For Critically Ill Patients To Reduce Immobility, Sedation, Agitation and Cognitive Impairment

University of Vermont

NCT04067622

COMPLETED 58 participants

Role and Mechanisms of Lipid and Lipoprotein Dysregulation in Sepsis

University of Florida

NCT04576819

COMPLETED 52 participants

Longitudinal Gene Expression Profiling in Adults After Traumatic Injury

Stanford University

NCT02656459

COMPLETED 50 participants

Immune Suppression and Ventilator Associated Pneumonias

Matthew Exline

NCT01135277

COMPLETED 50 participants

Comparison of Non-Invasive Methods of Assessing Fluid Responsiveness in ED and ICU Patients

Olive View-UCLA Education & Research Institute

NCT02679625

COMPLETED NA 45 participants

Sepsis, Severe Sepsis and Septic Shock Detection by Breath Analysis

Landon Pediatric Foundation

NCT03497182

COMPLETED 45 participants

Methionine Metabolism in Enterally Fed Pediatric Sepsis

The Cleveland Clinic

NCT01889264

COMPLETED 26 participants

Digital Capillary Refill for Monitoring of Sepsis

Oregon Health and Science University

NCT04529655

COMPLETED Phase 1 18 participants

Phase I Study of Vasoactive Intestinal Peptide in Patients With Acute Respiratory Distress Syndrome and Sepsis

Stony Brook University

NCT00004494

COMPLETED Phase 1 18 participants

Effects of TNX-832 (Sunol cH36) in Subjects With Acute Lung Injury/Acute Respiratory Distress Syndrome

Altor BioScience

NCT01438853

COMPLETED 10 participants

Impact of Hydrocortisone Administration on White Blood Cell Gene Expression in Patients With Severe Sepsis

Stanford University

NCT00185783

COMPLETED Phase 1 9 participants

Imipenem-Relebactam Pharmacokinetics in Augmented Renal Clearance

Hartford Hospital

NCT04147221

COMPLETED NA 5 participants

Project 4B: Lower Extremity Strength Training in ICU Patients

University of Florida

NCT02467023

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Phase Distribution

PhaseTrial count
Phase 1 6
Phase 2 8
Phase 3 6
Phase 4 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Sepsis Trial Landscape

91 indexed Sepsis studies · 33 recruiting (36%).

Phase mix: 10 late (III/IV) vs 14 early (I/II).

Top sponsor: University of Florida (7 trials), 9 others listed. 41 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Sepsis?

PlainTrial tracks 91 US clinical trials for Sepsis, of which 33 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Sepsis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.