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Sepsis: full-pipeline trial registry
33 of 91 indexed Sepsis trials are currently recruiting.
Corpus placement: #151 of 28,707 conditions by registered trial count.
91 US clinical trials · 33 currently recruiting · #151 of 28,707 conditions by registered trial count
Sepsis: 91 US clinical trials tracked, 33 recruiting.
Sepsis is the subject of 91 registered US clinical trials on ClinicalTrials.gov, 33 of them currently open to new participants. 10 are in Phase 3-4 (later-stage) and 14 in Phase 1-2 (earlier-stage). The most active sponsor is University of Florida, running 7 of these trials.
Enrollment posture brief
Registry condition sepsis
OPEN 33 | RECR 36% | LATE 10 | EARLY 14 | RANK #151 | SPON 7
Volume-matched condition peers
Nearest open-share peer: Acquired Brain Injury (36% recruiting · 11 trials)
Sepsis lists 33 open slots (36% of 91 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Sepsis on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Sepsis is recruiting below its size-band peers.
33 of 91 indexed trials (36.3%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Sepsis trials is spread across many organizations.
University of Florida accounts for 7 of 91 trials (7.7%). 65 distinct sponsors appear on at least one study for this condition label.
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Typical Sepsis enrolment sits around 186 participants.
Median target enrolment is 186 among the 91 trials that report a genuine target (sentinel values excluded). 35 of those (38.5%) plan for fewer than 100 participants.
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Sepsis splits between interventional and observational designs.
46 interventional and 45 observational studies make up this index (50.5% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
91 total, page 1 of 2
Safe and Explainable AI
Abramson Cancer Center at Penn Medicine
NCT06694181
Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis
Children's Hospital of Philadelphia
NCT05975671
Clean Trial - Chlorination to Reduce Enteric and Antibiotic Resistant Infections in Neonates
University of California, Berkeley
NCT06824350
Evaluation of Pediatric eCART Implementation
University of Wisconsin, Madison
NCT06771830
PIVO Use for Blood Cultures in the Emergency Department
Intermountain Health Care
NCT07348289
Biomarkers in Infection
Beth Israel Deaconess Medical Center
NCT02545478
The APS Phenotyping Study
Vanderbilt University Medical Center
NCT06521502
Clinical Microbial Species & Antibiotic Resistance ID in ED Patients Presenting With Infection - is Rapid ID Possible & Accurate?
Michigan State University
NCT01904188
Dynamics of Organ Damage and Immune Exhaustion During Sepsis
Mayo Clinic
NCT06817408
The RightCall: Implementing a Sepsis Diagnostic Toolkit to Improve Pediatric Diagnosis in ED Transfer Calls
University of Colorado, Denver
NCT07051668
Dysfunctional Myelopoiesis and Myeloid-Derived Suppressor Cells in Sepsis
University of Florida
NCT05110937
Limited Versus Extended Trophic Feeding (LET-FEED) Trial
University of Washington
NCT06893939
MID-STEP (MIDodrine for Sepsis Treatment and Early vasoPressor Weaning) Trial
Mayo Clinic
NCT06319248
Early Versus Late Adjunctive Vasopressin in Septic Shock
The Cleveland Clinic
NCT06709573
BLOOM: Pragmatic Feasibility Trial
Mayo Clinic
NCT07287332
TriVerity™ for Improved Management of Emergency Department (ED) Patients With Suspected Infections
Inflammatix
NCT06637904
Pathological Myeloid Activation After Sepsis and Trauma
University of Florida
NCT05616130
Senolytics To slOw Progression of Sepsis (STOP-Sepsis) Trial
University of Minnesota
NCT05758246
Prediction of Rehospitalization Following a Sepsis Admission Using a Wearable Biopatch
University of California, San Diego
NCT05806762
Assessing Immune Dysfunction in Sepsis
University of Minnesota
NCT07154615
A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kidney Injury.
AstraZeneca
NCT07215702
Role of Transposable Elements in Septic Immune Aging
University of California, San Francisco
NCT06809868
An Acupuncture Study for People At High Risk for Sepsis
Memorial Sloan Kettering Cancer Center
NCT06344819
Expression Profiles of Integrin αDβ2 on Neutrophils in Sepsis
Boston Children's Hospital
NCT04103281
Renin Angiotensin Aldosterone System In Septic Kids
Northwell Health
NCT06295393
Neutrophil Phenotypic Profiling and Organ Injury Assessment in Patients With Sepsis
Boston Children's Hospital
NCT04103268
Change in MAPSE During Treatment of Sepsis
University of Maryland, Baltimore
NCT05634733
Hemodynamic Response to Angiotensin-II When Used as the Second Vasopressor Agent for Septic Shock
Kingman Regional Medical Center
NCT06122987
A Phase III, Open Label, Randomized, Controlled Study of VBI-S in the Treatment of Hypovolemia in Patients With Septic Shock (VBI-S-02)
Vivacelle Bio
NCT06072430
Predicton of Sepsis Recovery Performance Subtypes Pilot Study
University of Alabama at Birmingham
NCT05912413
Virtual Reality in ICU - PARTNER
Kirby Mayer
NCT06876168
Vancomycin and Acute Kidney Injury in Sepsis Treatment - Intervention
Children's Hospital of Philadelphia
NCT07084129
External Drainage of Thoracic Duct Lymph to Reduce Inflammatory Cytokines in Septic Shock Patients
University of Pennsylvania
NCT04855786
Monocyte Distribution Width (MDW) in the General Population of Emergency Department Patients With and Without Bacteremia
Henry Ford Health System
NCT05296590
A Rapid Diagnostic of Risk in Hospitalized Patients Using Machine Learning
AgileMD
NCT05893420
An Observational Study in the United States to Learn How Venous Thromboembolism, Disseminated Intravascular Coagulation, and Sepsis Are Related
Bayer
NCT06765681
A Multicenter Prospective Observational Study to Derive and Verify the Performance of a Host-response Based Diagnostic Tool for Early Detection of Severe Infections.
MeMed Diagnostics
NCT06665542
PICS: Subtitle Cardiac Dysfunction in Older Sepsis Survivors
University of Florida
NCT02276417
Measuring Outcomes of Activity in Intensive Care
Vanderbilt University Medical Center
NCT03115840
The PASTDUe Nutrition Ecosystem Project (PASTDUe)
Duke University
NCT05127109
Sepsis Associated Encephalopathy (SAE) Biomarkers
University of Florida
NCT03133208
Persistent Inflammation, Immunosuppression and Catabolism Syndrome (PICS): A New Horizon for Surgical Critical Care and Induced Frailty
University of Florida
NCT02711709
Cardiovascular Magnetic Resonance Prognosticators in Pediatric Oncology Patients With Sepsis
St. Jude Children's Research Hospital
NCT05930418
A Validation Study of the Lab Clasp Device: A Point of Care Sepsis Risk Monitor
Brigham and Women's Hospital
NCT04796285
Safety Study of Inhaled Carbon Monoxide to Treat Pneumonia and Sepsis-Induced Acute Respiratory Distress Syndrome (ARDS)
Brigham and Women's Hospital
NCT04870125
Sepsis Electronic Prompting for Timely Intervention and Care for Emergency Department Patients
Columbia University
NCT06117605
Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness
Sunnybrook Health Sciences Centre
NCT03005145
Intravenous Immune Globulin (IVIG) to Prevent Neonatal Infection
NICHD Neonatal Research Network
NCT01203345
Predictive algoRithm for EValuation and Intervention in SEpsis
Dascena
NCT03235193
Glutamine Supplementation to Prevent Death or Infection in Extremely Premature Infants
NICHD Neonatal Research Network
NCT00005775
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 6 |
| Phase 2 | 8 |
| Phase 3 | 6 |
| Phase 4 | 4 |
Top Sponsors
Named interventions
Most-linked intervention names on Sepsis records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Sepsis trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Sepsis page
91 registered trials, 33 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 33 Sepsis trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- University of Florida sponsors the most Sepsis trials on record, review their full trial history before evaluating a specific study. See University of Florida's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Sepsis condition card totals 91 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.