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2026 data Public-data reference. official source

Sepsis

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91 US clinical trials · 33 currently recruiting

Active & Recent Trials

RECRUITING 300,000 participants

Safe and Explainable AI

Abramson Cancer Center at Penn Medicine

NCT06694181
RECRUITING NA 52,500 participants

Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis

Children's Hospital of Philadelphia

NCT05975671
RECRUITING NA 45,450 participants

Clean Trial - Chlorination to Reduce Enteric and Antibiotic Resistant Infections in Neonates

University of California, Berkeley

NCT06824350
RECRUITING NA 30,000 participants

Evaluation of Pediatric eCART Implementation

University of Wisconsin, Madison

NCT06771830
RECRUITING 10,000 participants

PIVO Use for Blood Cultures in the Emergency Department

Intermountain Health Care

NCT07348289
RECRUITING 4,200 participants

Biomarkers in Infection

Beth Israel Deaconess Medical Center

NCT02545478
RECRUITING 4,000 participants

The APS Phenotyping Study

Vanderbilt University Medical Center

NCT06521502
RECRUITING 2,500 participants

Clinical Microbial Species & Antibiotic Resistance ID in ED Patients Presenting With Infection - is Rapid ID Possible & Accurate?

Michigan State University

NCT01904188
RECRUITING 1,000 participants

Dynamics of Organ Damage and Immune Exhaustion During Sepsis

Mayo Clinic

NCT06817408
RECRUITING NA 500 participants

The RightCall: Implementing a Sepsis Diagnostic Toolkit to Improve Pediatric Diagnosis in ED Transfer Calls

University of Colorado, Denver

NCT07051668
RECRUITING 450 participants

Dysfunctional Myelopoiesis and Myeloid-Derived Suppressor Cells in Sepsis

University of Florida

NCT05110937
RECRUITING Phase 3 350 participants

Limited Versus Extended Trophic Feeding (LET-FEED) Trial

University of Washington

NCT06893939
RECRUITING Phase 2 308 participants

MID-STEP (MIDodrine for Sepsis Treatment and Early vasoPressor Weaning) Trial

Mayo Clinic

NCT06319248
RECRUITING Phase 4 300 participants

Early Versus Late Adjunctive Vasopressin in Septic Shock

The Cleveland Clinic

NCT06709573
RECRUITING NA 300 participants

BLOOM: Pragmatic Feasibility Trial

Mayo Clinic

NCT07287332
RECRUITING NA 300 participants

TriVerity™ for Improved Management of Emergency Department (ED) Patients With Suspected Infections

Inflammatix

NCT06637904
RECRUITING 255 participants

Pathological Myeloid Activation After Sepsis and Trauma

University of Florida

NCT05616130
RECRUITING Phase 2 220 participants

Senolytics To slOw Progression of Sepsis (STOP-Sepsis) Trial

University of Minnesota

NCT05758246
RECRUITING 200 participants

Prediction of Rehospitalization Following a Sepsis Admission Using a Wearable Biopatch

University of California, San Diego

NCT05806762
RECRUITING 150 participants

Assessing Immune Dysfunction in Sepsis

University of Minnesota

NCT07154615
RECRUITING Phase 2 124 participants

A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kidney Injury.

AstraZeneca

NCT07215702
RECRUITING 116 participants

Role of Transposable Elements in Septic Immune Aging

University of California, San Francis

NCT06809868
RECRUITING Phase 2 78 participants

An Acupuncture Study for People At High Risk for Sepsis

Memorial Sloan Kettering Cancer Center

NCT06344819
RECRUITING 75 participants

Expression Profiles of Integrin αDβ2 on Neutrophils in Sepsis

Boston Children's Hospital

NCT04103281
RECRUITING 74 participants

Renin Angiotensin Aldosterone System In Septic Kids

Northwell Health

NCT06295393
RECRUITING 72 participants

Neutrophil Phenotypic Profiling and Organ Injury Assessment in Patients With Sepsis

Boston Children's Hospital

NCT04103268
RECRUITING 50 participants

Change in MAPSE During Treatment of Sepsis

University of Maryland, Baltimore

NCT05634733
RECRUITING Phase 4 50 participants

Hemodynamic Response to Angiotensin-II When Used as the Second Vasopressor Agent for Septic Shock

Kingman Regional Medical Center

NCT06122987
RECRUITING Phase 3 46 participants

A Phase III, Open Label, Randomized, Controlled Study of VBI-S in the Treatment of Hypovolemia in Patients With Septic Shock (VBI-S-02)

Vivacelle Bio

NCT06072430
RECRUITING 40 participants

Predicton of Sepsis Recovery Performance Subtypes Pilot Study

University of Alabama at Birmingham

NCT05912413
RECRUITING 32 participants

Virtual Reality in ICU - PARTNER

Kirby Mayer

NCT06876168
RECRUITING Phase 1 20 participants

Vancomycin and Acute Kidney Injury in Sepsis Treatment - Intervention

Children's Hospital of Philadelphia

NCT07084129
RECRUITING NA 10 participants

External Drainage of Thoracic Duct Lymph to Reduce Inflammatory Cytokines in Septic Shock Patients

University of Pennsylvania

NCT04855786
ACTIVE NOT RECRUITING 50,000 participants

Monocyte Distribution Width (MDW) in the General Population of Emergency Department Patients With and Without Bacteremia

Henry Ford Health System

NCT05296590
ACTIVE NOT RECRUITING NA 30,000 participants

A Rapid Diagnostic of Risk in Hospitalized Patients Using Machine Learning

AgileMD

NCT05893420
ACTIVE NOT RECRUITING 10,000 participants

An Observational Study in the United States to Learn How Venous Thromboembolism, Disseminated Intravascular Coagulation, and Sepsis Are Related

Bayer

NCT06765681
ACTIVE NOT RECRUITING 2,000 participants

A Multicenter Prospective Observational Study to Derive and Verify the Performance of a Host-response Based Diagnostic Tool for Early Detection of Severe Infections.

MeMed Diagnostics

NCT06665542
ACTIVE NOT RECRUITING 668 participants

PICS: Subtitle Cardiac Dysfunction in Older Sepsis Survivors

University of Florida

NCT02276417
ACTIVE NOT RECRUITING 312 participants

Measuring Outcomes of Activity in Intensive Care

Vanderbilt University Medical Center

NCT03115840
ACTIVE NOT RECRUITING Phase 4 300 participants

The PASTDUe Nutrition Ecosystem Project (PASTDUe)

Duke University

NCT05127109
ACTIVE NOT RECRUITING 90 participants

Sepsis Associated Encephalopathy (SAE) Biomarkers

University of Florida

NCT03133208
ACTIVE NOT RECRUITING 53 participants

Persistent Inflammation, Immunosuppression and Catabolism Syndrome (PICS): A New Horizon for Surgical Critical Care and Induced Frailty

University of Florida

NCT02711709
ACTIVE NOT RECRUITING NA 7 participants

Cardiovascular Magnetic Resonance Prognosticators in Pediatric Oncology Patients With Sepsis

St. Jude Children's Research Hospital

NCT05930418
ACTIVE NOT RECRUITING NA 6 participants

A Validation Study of the Lab Clasp Device: A Point of Care Sepsis Risk Monitor

Brigham and Women's Hospital

NCT04796285
ACTIVE NOT RECRUITING Phase 1 5 participants

Safety Study of Inhaled Carbon Monoxide to Treat Pneumonia and Sepsis-Induced Acute Respiratory Distress Syndrome (ARDS)

Brigham and Women's Hospital

NCT04870125
COMPLETED NA 25,668 participants

Sepsis Electronic Prompting for Timely Intervention and Care for Emergency Department Patients

Columbia University

NCT06117605
COMPLETED NA 3,622 participants

Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness

Sunnybrook Health Sciences Centre

NCT03005145
COMPLETED Phase 2 2,416 participants

Intravenous Immune Globulin (IVIG) to Prevent Neonatal Infection

NICHD Neonatal Research Network

NCT01203345
COMPLETED NA 2,296 participants

Predictive algoRithm for EValuation and Intervention in SEpsis

Dascena

NCT03235193
COMPLETED Phase 3 1,433 participants

Glutamine Supplementation to Prevent Death or Infection in Extremely Premature Infants

NICHD Neonatal Research Network

NCT00005775
COMPLETED 1,055 participants

Evaluation of the Heparin Binding Protein Levels in Sepsis

Christiana Care Health Services

NCT02533011
COMPLETED 815 participants

Early Identification of SEPsis SIGNs in Emergency Department

BioMérieux

NCT04261621
COMPLETED 544 participants

Evaluation of Immunoassay Measurements of Pancreatic Stone Protein Performed on abioSCOPE® Device With the PSP Assay on ICU Patients at Risk of Sepsis as an Aid in Identifying Sepsis

Abionic

NCT04105699
COMPLETED 500 participants

Indicators of Inflammation and Coagulation in Sepsis

University of Oklahoma

NCT01128283
COMPLETED 500 participants

Coagulation Factors, Cytokines and Tissue Injury Markers in Sepsis

University of Oklahoma

NCT01012115
COMPLETED 477 participants

Evaluation of Infection in Obstructing Urolithiasis

University of Texas Southwestern Medical Center

NCT04332861
COMPLETED Phase 3 438 participants

The MENDS2 Study, Maximizing the Efficacy of Sedation and Reducing Neurological Dysfunction and Mortality in Septic Patients With Acute Respiratory Failure

Vanderbilt University Medical Center

NCT01739933
COMPLETED 379 participants

VENUS: Septic Gene Expression Using SeptiCyte

Immunexpress

NCT02127502
COMPLETED 350 participants

SEP-SEQ Trial - Determining the Etiology of Sepsis Using an Infectious Disease Diagnostic Sequencing Assay

Karius

NCT02730468
COMPLETED NA 209 participants

A Culturally-Based Palliative Care Tele-consult Program for Rural Southern Elders

University of Alabama at Birmingham

NCT03767517
COMPLETED Phase 1 208 participants

Skin Cleansing With Chlorhexidine to Decrease Hospital Acquired Infections

Cook County Health

NCT00130221
COMPLETED NA 200 participants

Does Detailed Informed Consent for Cardiopulmonary Resuscitation and Mechanical Ventilation Impact Patients' Decisions and Outcomes?

Jewish Hospital, Cincinnati, Ohio

NCT01878968
COMPLETED 200 participants

Clinical Validation of HostDx Sepsis™ on NanoString; a Prospective Observational Validation Trial

Inflammatix

NCT04414189
COMPLETED Phase 3 200 participants

Extended Therapy of Drotrecogin Alfa (Activated) 4 vs 7 Days Infusion

Eli Lilly and Company

NCT00190788
COMPLETED NA 186 participants

Trial of Antimicrobial Restraint in Presumed Pneumonia

University of Kansas Medical Center

NCT04438187
COMPLETED 184 participants

Performance Evaluation of the Nanomix eLab® CRP, PCT, and LAC Assays With the Nanomix eLab System

Nanomix

NCT03876535
COMPLETED Phase 2 150 participants

Anti-TF Antibody (ALT-836) to Treat Septic Patients With Acute Lung Injury or Acute Respiratory Distress Syndrome

Altor BioScience

NCT00879606
COMPLETED 150 participants

Reference Range for abioSCOPE® Device With the PSP Assay in a Generally Healthy Adult Population

Abionic

NCT04409561
COMPLETED NA 145 participants

Using Biomarkers to Optimize Antibiotic Strategies in Sepsis

University of Pennsylvania

NCT02207114
COMPLETED NA 142 participants

Preemptive Resuscitation for Eradication of Septic Shock

Christiana Care Health Services

NCT01449721
COMPLETED 120 participants

Clinical Factors Associated With the Development of Severe Sepsis in Patients Being Treated for Acute Myeloid Leukemia

Ohio State University

NCT00806325
COMPLETED 100 participants

Gene Expression Objective Definition of Early Sepsis In Children

Seattle Children's Hospital

NCT06231862
COMPLETED Phase 2 95 participants

Thiamine as a Renal Protective Agent in Septic Shock

Beth Israel Deaconess Medical Center

NCT03550794
COMPLETED Phase 2 94 participants

Inulin for Infections in the Intensive Care Unit

Columbia University

NCT03865706
COMPLETED Phase 4 89 participants

Effect of Nebulized Bronchodilators on Heart Rate

Fahim Khorfan, MD

NCT01151579
COMPLETED 71 participants

REMISE Study: REMnant Biospecimen Investigation in SEpsis

University of Pittsburgh

NCT05684133
COMPLETED Phase 3 65 participants

A Prospective, Randomized, Phase III Trial of FLAC (5-Fluorouracil, Leucovorin, Adriamycin, Cytoxan) Chemotherapy With GM-CSF (Granulocyte-Macrophage Colony-Stimulating Factor) Versus PIXY 321 in Advanced Breast Cancer

National Cancer Institute (NCI)

NCT00001338
COMPLETED NA 60 participants

Pilot Trial of External Warming in Septic Patients

Washington University School of Medicine

NCT02706275
COMPLETED NA 58 participants

Novel Arm Restraint For Critically Ill Patients To Reduce Immobility, Sedation, Agitation and Cognitive Impairment

University of Vermont

NCT04067622
COMPLETED 58 participants

Role and Mechanisms of Lipid and Lipoprotein Dysregulation in Sepsis

University of Florida

NCT04576819
COMPLETED 52 participants

Longitudinal Gene Expression Profiling in Adults After Traumatic Injury

Stanford University

NCT02656459
COMPLETED 50 participants

Immune Suppression and Ventilator Associated Pneumonias

Matthew Exline

NCT01135277
COMPLETED 50 participants

Comparison of Non-Invasive Methods of Assessing Fluid Responsiveness in ED and ICU Patients

Olive View-UCLA Education & Research Institute

NCT02679625
COMPLETED NA 45 participants

Sepsis, Severe Sepsis and Septic Shock Detection by Breath Analysis

Landon Pediatric Foundation

NCT03497182
COMPLETED 45 participants

Methionine Metabolism in Enterally Fed Pediatric Sepsis

The Cleveland Clinic

NCT01889264
COMPLETED 26 participants

Digital Capillary Refill for Monitoring of Sepsis

Oregon Health and Science University

NCT04529655
COMPLETED Phase 1 18 participants

Phase I Study of Vasoactive Intestinal Peptide in Patients With Acute Respiratory Distress Syndrome and Sepsis

Stony Brook University

NCT00004494
COMPLETED Phase 1 18 participants

Effects of TNX-832 (Sunol cH36) in Subjects With Acute Lung Injury/Acute Respiratory Distress Syndrome

Altor BioScience

NCT01438853
COMPLETED 10 participants

Impact of Hydrocortisone Administration on White Blood Cell Gene Expression in Patients With Severe Sepsis

Stanford University

NCT00185783
COMPLETED Phase 1 9 participants

Imipenem-Relebactam Pharmacokinetics in Augmented Renal Clearance

Hartford Hospital

NCT04147221
COMPLETED NA 5 participants

Project 4B: Lower Extremity Strength Training in ICU Patients

University of Florida

NCT02467023

Phase Distribution

PhaseTrial count
Early Phase 1 6
Phase 2 8
Phase 3 6
Phase 4 4

Top Sponsors

University of Florida 7 trials
Mayo Clinic 3 trials
Vanderbilt University Medical Center 3 trials
Altor BioScience 2 trials
Abionic 2 trials
Inflammatix 2 trials
NICHD Neonatal Research Network 2 trials
Christiana Care Health Services 2 trials
Columbia University 2 trials
Brigham and Women's Hospital 2 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Sepsis Trial Landscape

ClinicalTrials.gov lists 91 US studies indexed under Sepsis, and 33 of those are currently open to recruitment — roughly 36% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Sepsis shows 10 late-stage studies (Phase 3 and Phase 4 combined) alongside 14 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Sepsis is led by University of Florida with 7 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 91 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Sepsis?

PlainTrial tracks 91 US clinical trials for Sepsis, of which 33 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Sepsis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

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Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Read our methodology — how this data is sourced, computed, and verified.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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