Exelixis

48 total trials 8 currently recruiting 17 completed

Exelixis sponsors 48 registered US clinical trials on ClinicalTrials.gov, 8 of them currently recruiting, and 17 completed. 11 of these trials are in Phase 3-4 (later-stage) and 37 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Renal Cell Carcinoma, with 4 trials.

Trial Pipeline

48 total, page 1 of 1

RECRUITING Phase 2

A Study of Zanzalintinib in Participants With Recurrent or Progressive Meningioma

NCT07428616

RECRUITING Phase 1

A Study of XB371 Administered in Participants With Locally Advanced or Metastatic Solid Tumors

NCT07123103

RECRUITING Phase 2

Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors

NCT06943755

RECRUITING Phase 1

Pharmacokinetics (PK) and Safety of Zanzalintinib in Participants With Moderate Hepatic Impairment (HI)

NCT06962332

RECRUITING Phase 1

A Study of XB628 in Participants With Recurrent Advanced or Metastatic Solid Tumors

NCT06952010

RECRUITING Phase 1

Study of XB010 in Subjects With Solid Tumors

NCT06545331

RECRUITING Phase 1

A Phase 1 Study of XL309 (ISM3091) Alone and in Combination in Participants With Advanced Solid Tumors

NCT05932862

RECRUITING Phase 1

Study of Zanzalintinib in Combination With Immuno-Oncology Agents in Participants With Solid Tumors

NCT05176483

ACTIVE NOT RECRUITING Phase 2

Study of Zanzalintinib (XL092) + Pembrolizumab vs Pembrolizumab in Subjects With PD-L1 Positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

NCT06082167

ACTIVE NOT RECRUITING Phase 3

Study of XL092 + Nivolumab vs Sunitinib in Subjects With Advanced or Metastatic Non-Clear Cell Renal Cell Carcinoma

NCT05678673

ACTIVE NOT RECRUITING Phase 3

Study of XL092 + Atezolizumab vs Regorafenib in Participants With Metastatic Colorectal Cancer

NCT05425940

ACTIVE NOT RECRUITING Phase 3

Study of Cabozantinib in Combination With Atezolizumab Versus Second NHT in Subjects With mCRPC

NCT04446117

ACTIVE NOT RECRUITING Phase 3

Study of Cabozantinib in Combination With Nivolumab and Ipilimumab in Patients With Previously Untreated Advanced or Metastatic Renal Cell Carcinoma

NCT03937219

ACTIVE NOT RECRUITING Phase 1

A Study of XL092 as Single-Agent and Combination Therapy in Subjects With Solid Tumors

NCT03845166

ACTIVE NOT RECRUITING Phase 3

A Study of Cabozantinib Compared With Placebo in Subjects With Radioiodine-refractory Differentiated Thyroid Cancer Who Have Progressed After Prior Vascular Endothelial Growth Factor Receptor (VEGFR) -Targeted Therapy

NCT03690388

ACTIVE NOT RECRUITING Phase 3

Study of Cabozantinib in Combination With Atezolizumab Versus Sorafenib in Participants With Advanced Hepatocellular Carcinoma (HCC) Who Have Not Received Previous Systemic Anticancer Therapy

NCT03755791

ACTIVE NOT RECRUITING Phase 1

Study of Cabozantinib Alone or in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors

NCT03170960

TERMINATED Phase 1

A Dose-escalation, Dose-finding, and Expansion Study of XL495 in Participants With Locally Advanced or Metastatic Solid Tumors

NCT06630247

TERMINATED Phase 1

Study of Zanzalintinib (XL092) + AB521 and Zanzalintinib + AB521 + Nivolumab in Participants With Advanced Clear Cell Renal Cell Carcinoma (ccRCC) or Other Advanced Solid Tumors (STELLAR-009)

NCT06191796

TERMINATED Phase 1

Study of XL114 in Subjects With Non-Hodgkin's Lymphoma

NCT05144347

COMPLETED Phase 1

Study of XB002 in Subjects With Solid Tumors (JEWEL-101)

NCT04925284

TERMINATED Phase 1

Study of XL102 as Single-Agent and Combination Therapy in Subjects With Solid Tumors (QUARTZ-101)

NCT04726332

TERMINATED Phase 2

Combo of Cabozantinib With Abiraterone in Chemotherapy-Naïve Subjects With Bone-Metastatic CRPC

NCT01995058

COMPLETED Phase 3

Study of Cabozantinib (XL184) vs Placebo in Subjects With Hepatocellular Carcinoma Who Have Received Prior Sorafenib

NCT01908426

COMPLETED Phase 3

A Study of Cabozantinib (XL184) vs Everolimus in Subjects With Metastatic Renal Cell Carcinoma

NCT01865747

COMPLETED Phase 1

A Single-Dose Study to Assess the Pharmacokinetics of Cabozantinib (XL184) Capsules in Subjects With Impaired Renal Function

NCT01761773

COMPLETED Phase 3

Study of Cabozantinib (XL184) Versus Prednisone in Men With Metastatic Castration-resistant Prostate Cancer Previously Treated With Docetaxel and Abiraterone or MDV3100

NCT01605227

TERMINATED Phase 3

Study of Cabozantinib (XL184) Versus Mitoxantrone Plus Prednisone in Men With Previously Treated Symptomatic Castration-resistant Prostate Cancer

NCT01522443

COMPLETED Phase 1

Study to Assess the Pharmacokinetics of Cabozantinib (XL184) in Hepatic Impaired Adult Subjects

NCT01493869

COMPLETED Phase 1

A Drug-Drug Interaction Study of the Effects of XL184 (Cabozantinib) on Rosiglitazone in Subjects With Solid Tumors

NCT01100619

TERMINATED Phase 2

Multiple Doses and Regimens of Cabozantinib in Subjects With Grade IV Astrocytic Tumors in First or Second Relapse

NCT01068782

COMPLETED Phase 2

Study of Cabozantinib (XL184) in Adults With Advanced Malignancies

NCT00940225

COMPLETED Phase 1

Safety Study of XL184 (Cabozantinib) in Combination With Temozolomide and Radiation Therapy in the Initial Treatment of Adults With Glioblastoma

NCT00960492

TERMINATED Phase 1

Safety Study of Pharmacokinetics of XL888 in Adults With Solid Tumors

NCT00796484

COMPLETED Phase 3

Efficacy of XL184 (Cabozantinib) in Advanced Medullary Thyroid Cancer

NCT00704730

COMPLETED Phase 2

Study of XL184 (Cabozantinib) in Adults With Glioblastoma Multiforme

NCT00704288

COMPLETED Phase 1

A Study of XL184 (Cabozantinib) With or Without Erlotinib in Subjects With Non-Small Cell Lung Cancer (NSCLC)

NCT00596648

COMPLETED Phase 2

A Phase 2 Study of XL820 in Adults With Advanced GIST Resistant to Imatinib and/or Sunitinib

NCT00570635

TERMINATED Phase 1

A Phase 1 Study of XL019 in Adults With Polycythemia Vera

NCT00595829

TERMINATED Phase 1

Study of XL228 Administered Intravenously to Subjects With Advanced Malignancies

NCT00526838

TERMINATED Phase 1

A Safety Study of XL019 in Adults With Myelofibrosis

NCT00522574

TERMINATED Phase 1

Study of XL228 in Subjects With Chronic Myeloid Leukemia or Philadelphia-Chromosome-Positive Acute Lymphocytic Leukemia

NCT00464113

TERMINATED Phase 1

A Study of XL844 Administered as a Single Agent and in Combination With Gemcitabine in Adults With Advanced Malignancies

NCT00475917

COMPLETED Phase 1

Study of XL281 in Adults With Solid Tumors

NCT00451880

COMPLETED Phase 1

Study of XL820 Given Orally Daily to Subjects With Solid Tumors

NCT00350831

COMPLETED Phase 1

Study of XL184 (Cabozantinib) in Adults With Advanced Malignancies

NCT00215605

COMPLETED Phase 1

Study of XL820 in Adults With Solid Tumors

NCT00129571

TERMINATED Phase 1

Safety Study of XL844 in Subjects With Chronic Lymphocytic Leukemia

NCT00234481

What the Pipeline for Exelixis Shows

According to the ClinicalTrials.gov registry, Exelixis is linked to 48 US clinical trials across every stage of research activity. Of those, 8 studies are currently recruiting, about 17% of the sponsor's indexed portfolio, and 17 are already marked complete, representing roughly 35% of the total.

The phase mix for Exelixis reports 11 late-stage studies (Phase 3 and Phase 4 combined) and 37 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for Exelixis is Renal Cell Carcinoma with 4 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.