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Study of JANX008 in Subjects With Advanced or Metastatic Solid Tumor Malignancies
NCT05783622 · View on ClinicalTrials.gov ↗
Study Summary
This study is a first-in-human (FIH), Phase 1/1b, open-label, multicenter dose escalation and dose expansion study to assess the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary anti-tumor activity of JANX008 in adult subjects with advanced or metastatic carcinoma expressing EGFR.
Conditions Studied
Interventions
- DRUG JANX008
Study Locations (18)
California
- City of Hope Medical Center — Duarte
- University of California, Davis Comprehensive Cancer Center — Sacramento
- University of California San Diego Moores Cancer Center — San Diego
Michigan
- University of Michigan — Ann Arbor
- Henry Ford Health System — Detroit
Ohio
- The Christ Hospital Cancer Center — Cincinnati
- Ohio State University Hospital — Columbus
Pennsylvania
- University of Pennsylvania, Abramson Cancer Center — Philadelphia
- UPMC Hillman Cancer Center — Pittsburgh
Texas
- University of Texas Southwestern Medical Center — Dallas
- The University of Texas, MD Anderson Cancer Center — Houston
Georgia
- Winship Cancer Institute, Emory University — Atlanta
Illinois
- University of Chicago Medical Center — Chicago
Missouri
- Washington University — St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 130 participants |
| Start Date | 2023-04-19 |
| Est. Completion | 2027-10 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05783622
The ClinicalTrials.gov registry entry for NCT05783622 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 130 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Janux Therapeutics, which has 30 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 7 conditions, with Non-Small Cell Lung Cancer appearing as the primary indexed condition, and to 1 intervention — of which JANX008 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05783622 reports 18 study locations spanning 12 distinct geographic areas — top geographies include California, Michigan, Ohio. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05783622 about?
NCT05783622 is a clinical study titled "Study of JANX008 in Subjects With Advanced or Metastatic Solid Tumor Malignancies". This study is a first-in-human (FIH), Phase 1/1b, open-label, multicenter dose escalation and dose expansion study to assess the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary anti-tumor activity of JANX008 in adult subjects with advanced or metastatic carcinoma ...
What is the current status of trial NCT05783622?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 130 participants. The study started on 2023-04-19. Estimated completion is 2027-10.
What conditions does trial NCT05783622 study?
This clinical trial studies the following conditions: Non-Small Cell Lung Cancer, Renal Cell Carcinoma, Pancreatic Ductal Adenocarcinoma, Colorectal Carcinoma, Small Cell Lung Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05783622?
The interventions under investigation include: JANX008 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05783622?
This trial is sponsored by Janux Therapeutics, which has 30 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05783622 being conducted?
This trial has 18 study locations across California, Georgia, Illinois, Michigan, Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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