Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
A Study of Pazopanib With or Without Abexinostat in Patients With Locally Advanced or Metastatic Renal Cell Carcinoma (RENAVIV)
NCT03592472 · View on ClinicalTrials.gov ↗
Study Summary
This is a randomized, Phase 3, double-blind, placebo-controlled study of pazopanib plus abexinostat versus pazopanib plus placebo in patients with locally advanced unresectable or metastatic renal cell carcinoma (RCC).
Conditions Studied
Interventions
- OTHER Placebo
- DRUG Pazopanib
- DRUG Abexinostat
Study Locations (20)
Other
- Beijing Cancer Hospital — Beijing
- Zhongshan Hospital Affiliated to Fudan University — Shanghai
- Fondazione del Piemonte per l'Oncologia_Istituto di Candiolo, IRCCS_ Oncologia Medica — Candiolo
- A.O. Cannizzaro_UOS Oncologia Medica — Catania
- IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) UO Oncologia Medica — Meldola (FC)
- Istituto Europeo di Oncologia_Unità Oncologia Medica Urogenitale e Cervico Facciale — Milan
California
- University of California Davis Comprehensive Cancer Center — Sacramento
- UCSF Helen Diller Family Comphrensive Cancer Center - Hemato — San Francisco
Nebraska
- GU Research Network/Urology Cancer Center — Omaha
- Nebraska Cancer Specialists — Omaha
New York
- Northwell Health/Monter Cancer Center — Lake Success
- Mainstreet Physicans Care — Rochester
Arizona
- University Of UA Cancer Center(UACC)/DH-SJHMC — Phoenix
Kentucky
- Norton Cancer Institute, Norton Healthcare Pavilion — Louisville
Louisiana
- Ochsner Clinic Foundation — New Orleans
Ohio
- Precision Cancer Research/Dayton Physicians Network - Treatment — Kettering
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 413 participants |
| Start Date | 2018-07-17 |
| Est. Completion | 2028-06-30 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03592472
The ClinicalTrials.gov registry entry for NCT03592472 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 413 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Xynomic Pharmaceuticals, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Renal Cell Carcinoma appearing as the primary indexed condition, and to 3 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT03592472 reports 20 study locations spanning 12 distinct geographic areas — top geographies include Other, California, Nebraska. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT03592472 about?
NCT03592472 is a clinical study titled "A Study of Pazopanib With or Without Abexinostat in Patients With Locally Advanced or Metastatic Renal Cell Carcinoma (RENAVIV)". This is a randomized, Phase 3, double-blind, placebo-controlled study of pazopanib plus abexinostat versus pazopanib plus placebo in patients with locally advanced unresectable or metastatic renal cell carcinoma (RCC).
What is the current status of trial NCT03592472?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 413 participants. The study started on 2018-07-17. Estimated completion is 2028-06-30.
What conditions does trial NCT03592472 study?
This clinical trial studies the following conditions: Renal Cell Carcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT03592472?
The interventions under investigation include: Placebo (OTHER), Pazopanib (DRUG), Abexinostat (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT03592472?
This trial is sponsored by Xynomic Pharmaceuticals, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT03592472 being conducted?
This trial has 20 study locations across Arizona, California, Kentucky, Louisiana, Nebraska. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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